Bissell M, Hines W. Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med. 2011;17:320–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
DeGregori J. Evolved tumor suppression: why are we so good at not getting cancer? Cancer Res. 2011;71:3739–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Caulin AF, Maley CC. Peto’s Paradox: evolution’s prescription for cancer prevention. Trends Ecol Evol. 2011;26:175–82.
Article
PubMed
PubMed Central
Google Scholar
Roche B, Hochberg ME, Caulin AF, Maley CC, Gatenby RA, Misse D, Thomas F. Natural resistance to cancers: a Darwinian hypothesis to explain Peto’s paradox. BMC Cancer. 2012;12:387-91.
Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C, Wedge DC, et al. The landscape of cancer genes and mutational processes in breast cancer. Nature. 2012;486:400–04.
Lee E, Iskow R, Yang L, Gokcumen O, Haseley P, Luquette III LJ, et al. Landscape of Somatic Retrotransposition in Human Cancers. Science. 2012;337:967–71.
Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, et al. Mutational landscape and significance across 12 major cancer types. Nature. 2013;502:333–9.
Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C, Wedge DC, et al. The landscape of cancer genes and mutational processes in breast cancer. Nature. 2012;486:400–4.
Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, et al. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature. 2013;499:346–9.
Thomas F, Fisher D, Fort P, Marie J-P, Daoust S, Roche B, et al. Applying ecological and evolutionary theory to cancer: a long and winding road. Evol Appl. 2013;6:1–10.
Galis F, Metz JAJ. Anti-cancer selection as a source of developmental and evolutionary constraints. Bioessays. 2003;25:1035–9.
Article
CAS
PubMed
Google Scholar
Leroi AM, Koufopanou V, Burt A. Cancer selection. Nat Rev Cancer. 2003;3:226–31.
Article
CAS
PubMed
Google Scholar
Domazet-Lošo T, Klimovich A, Anokhin B, Anton-Erxleben F, Hamm MJ, Lange C, et al. Naturally occurring tumours in the basal metazoan Hydra. Nat Commun. 2014;5:1–8.
Squires D. Neoplasia in a Coral? Science (80-). 1965;148:503–5.
Article
CAS
Google Scholar
Walker B, Figgs LW, Zahm SH. Differences in cancer incidence, mortality, and survival between African Americans and whites. Environ Health Perspect. 1995;103 Suppl (Table 2):275–81.
Gunnell D, Smith GD, Holly J, Frankel S. Leg length and risk of cancer in the Boyd Orr cohort. BMJ. 1998;317:1350–1.
Article
CAS
PubMed
PubMed Central
Google Scholar
Seluanov A, Hine C, Bozzella M. Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell. 2008;7:813–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Andervont HB, Dunn TB. Occurrence of tumors in wild house mice. J Natl Cancer Inst. 1962;28:1153–63.
CAS
PubMed
Google Scholar
Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, et al. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature. 2011;479:223–7.
Martineau D, Lemberger K, Dallaire A, Labelle P, Lipscomb TP, Michel P, et al. Cancer in wildlife, a case study: beluga from the St. Lawrence estuary, Québec, Canada. Environ Health Perspect. 2002;110:285–92.
Roche B, Sprouffske K, Hbid H, Missé D, Thomas F. Peto’s paradox revisited: theoretical evolutionary dynamics of cancer in wild populations. Evol Appl. 2013;6:109–16.
Article
PubMed
Google Scholar
Peto R, Roe FJ, Lee PN, Levy L, Clack J. Cancer and ageing in mice and men. Br J Cancer. 1975;32:411–26.
Article
CAS
PubMed
PubMed Central
Google Scholar
Graham J. Cancer Selection: The New Theory of Evolution. 1st edition. Aculeus; 1992.
Nunney L. The real war on cancer: the evolutionary dynamics of cancer suppression. Evol Appl. 2013;6:11–9.
Article
PubMed
Google Scholar
Nunney L. Lineage selection and the evolution of multistage carcinogenesis. Proc Biol Sci. 1999;266:493–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
McAloose D, Newton AL. Wildlife cancer: a conservation perspective. Nat Rev Cancer. 2009;9:517–26.
Article
CAS
PubMed
Google Scholar
Tomasetti C, Vogelstein B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science (80-). 2015;347:78–81.
Article
CAS
Google Scholar
Blanpain C, Horsley V, Fuchs E. Epithelial Stem Cells: Turning over New Leaves. Cell. 2007;128(3):445–58.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lander AD, Gokoffski KK, Wan FYM, Nie Q, Calof AL. Cell lineages and the logic of proliferative control. PLoS Biol. 2009;7:84-100.
Iyama T, Wilson DM. DNA repair mechanisms in dividing and non-dividing cells. DNA Repair (Amst). 2013;12:620–36.
Article
CAS
Google Scholar
Kavanagh K. Embedded molecular switches, anticancer selection, and effects on ontogenetic rates : A hypothesis of developmental constraint on morphogenesis and evolution. Evolution (N Y). 2003;57:939–48.
CAS
Google Scholar
Lui JC, Baron J. Mechanisms limiting body growth in mammals. Endocr Rev. 2011;32:422–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Maciak S, Michalak P. Cell size and cancer: a new solution to Peto’s paradox? Evol Appl. 2015;8:2–8.
Article
PubMed
Google Scholar
Kleiber M. Body size and metabolic rate. Physiol Rev. 1947;27:511–41.
CAS
PubMed
Google Scholar
Busuttil R, Garcia A, Reddick R. Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One. 2007;9:1–10.
Dang CV. A metabolic perspective of Peto’s paradox and cancer. Philos Trans R Soc Lond B Biol Sci. 2015;370:1-8.
Friedberg EC, Wagner R, Radman M. Specialized DNA polymerases, cellular survival, and the genesis of mutations. Science. 2002;296:1627–30.
Article
CAS
PubMed
Google Scholar
Wodarz D. Effect of stem cell turnover rates on protection against cancer and aging. J Theor Biol. 2007;245:449–58.
Article
CAS
PubMed
Google Scholar
Su TT. Cellular responses to DNA damage: one signal, multiple choices. Annu Rev Genet. 2006;40:187–208.
Article
CAS
PubMed
Google Scholar
Lynch M. Evolution of the mutation rate. Trends Genet. 2010;26:345–52.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dollé ME, Snyder WK, Gossen JA, Lohman PH, Vijg J. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proc Natl Acad Sci U S A. 2000;97:8403–8.
Article
PubMed
PubMed Central
Google Scholar
Di Noia JM, Neuberger MS. Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem. 2007;76:1–22.
Article
PubMed
Google Scholar
Vanasse GJ, Concannon P, Willerford DM. Regulated genomic instability and neoplasia in the lymphoid lineage. Blood. 1999;94:3997–4010.
CAS
PubMed
Google Scholar
Soto AM, Sonnenschein C. The somatic mutation theory of cancer: growing problems with the paradigm? Bioessays. 2004;26:1097–107.
Article
CAS
PubMed
Google Scholar
DePinho R. The age of cancer. Nature. 2000;408:248–54.
Article
CAS
PubMed
Google Scholar
Jackson AL, Loeb LA. The mutation rate and cancer. Genetics. 1998;148:1483–90.
CAS
PubMed
PubMed Central
Google Scholar
Busuttil R, Bahar R, Vijg J. Genome dynamics and transcriptional deregulation in aging. Neuroscience. 2007;145(4):1341–7.
Article
CAS
PubMed
Google Scholar
Loh ML, Sakai DS, Flotho C, Kang M, Fliegauf M, Archambeault S, et al. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood. 2009;114:1859–63.
Side BLE, Emanuel PD, Taylor B, Franklin J, Thompson P, Castleberry RP, et al. Mutations of the NF1 Gene in Children With Juvenile Myelomonocytic Leukemia Without Clinical Evidence of Neurofibromatosis, Type 1. Blood. 2014;1998:267–72.
Loh ML, Mullighan CG. Advances in the genetics of high-risk childhood B-progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy. Clin Cancer Res. 2012;18:2754–67.
Article
CAS
PubMed
Google Scholar
Mao L, Lee J, Kurie J. Clonal genetic alterations in the lungs of current and former smokers. J Natl Cancer Inst. 1997;89:857–62.
Article
CAS
PubMed
Google Scholar
Hocker T, Tsao H. Ultraviolet radiation and melanoma: A systematic review and analysis of reported sequence variants. Hum Mutat. 2007;28:578–88.
Article
CAS
PubMed
Google Scholar
Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353:2135–47.
Matsumura Y, Ananthaswamy HN. Toxic effects of ultraviolet radiation on the skin. Toxicol Appl Pharmacol. 2004;195:298–308.
Article
CAS
PubMed
Google Scholar
Pleasance ED, Stephens PJ, O’Meara S, McBride DJ, Meynert A, Jones D, et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature. 2010;463:184–90.
Bignell GR, Greenman CD, Davies H, Butler AP, Edkins S, Andrews JM, et al. Signatures of mutation and selection in the cancer genome. Nature. 2010;463:893–8.
Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415–21.
Komarova NL, Sengupta A, Nowak MA. Mutation-selection networks of cancer initiation: Tumor suppressor genes and chromosomal instability. J Theor Biol. 2003;223:433–50.
Article
CAS
PubMed
Google Scholar
Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004;10:789–99.
Article
CAS
PubMed
Google Scholar
Nowell PC. Tumor progression: A brief historical perspective. Semin Cancer Biol. 2002;12(4):261–6.
Article
CAS
PubMed
Google Scholar
Knudson A. Two genetic hits (more or less) to cancer. Nat Rev Cancer. 2001;1:637–41.
Article
Google Scholar
Feinberg AP. Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine. J Intern Med. 2014;276:5–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wolffe A, Matzke M. Epigenetics: Regulation through repression. Science (80-). 1999;286:481–6.
Article
CAS
Google Scholar
Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene. 2008;27:5904–12.
Article
CAS
PubMed
PubMed Central
Google Scholar
Barcellos-Hoff MH, Lyden D, Wang TC. The evolution of the cancer niche during multistage carcinogenesis. Nat Rev Cancer. 2013;13:511–8.
Article
CAS
PubMed
Google Scholar
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Purizaca J, Meza I, Pelayo R. Early lymphoid development and microenvironmental cues in B-cell acute lymphoblastic leukemia. Arch Med Res. 2012;43:89–101.
Article
PubMed
Google Scholar
Askmyr M, Quach J, Purton LE. Effects of the bone marrow microenvironment on hematopoietic malignancy. Bone. 2011;48:115–20.
Article
PubMed
Google Scholar
Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331(i):1565–70.
Article
CAS
PubMed
Google Scholar
Nagy JD, Victor EM, Cropper JH. Why don’t all whales have cancer? A novel hypothesis resolving Peto’s paradox. Integr Comp Biol. 2007;47:317–28.
Article
PubMed
Google Scholar
Reissmann M, Ludwig A. Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals. Semin Cell Dev Biol. 2013;24:576–86.
Article
CAS
PubMed
Google Scholar
Willett WC. Diet and cancer. Oncologist. 2000;5:393–404.
Article
CAS
PubMed
Google Scholar
Epstein S. Environmental Determinants of Human Cancer. Cancer Res. 1974;34(10):2425–35.
CAS
PubMed
Google Scholar
Aguirre AA, Bröjer C, Mörner T. Descriptive epidemiology of roe deer mortality in Sweden. J Wildl Dis. 1999;35:753–62.
Article
CAS
PubMed
Google Scholar
Bishop J. Viruses, genes and cancer. Amer Zool. 1989;29:653–66.
Article
CAS
Google Scholar
Muirhead CR, Kendall GM, Darby SC, Doll R, Haylock RGE, O’Hagan JA, et al. Epidemiological studies of UK test veterans: II. Mortality and cancer incidence. J Radiol Prot. 2004;24:219–41.
Mori H, Colman SM, Xiao Z, Ford AM, Healy LE, Donaldson C, et al. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci U S A. 2002;99:8242–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fernandez AA. A cancer-causing gene is positively correlated with male aggression in Xiphophorus cortezi. J Evol Biol. 2010;23:386–96.
Article
CAS
PubMed
Google Scholar
Archie EA, Altmann J, Alberts SC. Social status predicts wound healing in wild baboons. Proc Natl Acad Sci. 2012;109(23):9017–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Aktipis CA, Nesse RM. Evolutionary foundations for cancer biology. Evol Appl. 2013;6:144–59.
Article
PubMed
PubMed Central
Google Scholar
Black JJ, Baumann PC. Carcinogens and cancers in freshwater fishes. Environ Health Perspect. 1991;90:27–33.
Speakman JR. Body size, energy metabolism and lifespan. J Exp Biol. 2005;208(Pt 9):1717–30.
Article
PubMed
Google Scholar
Pérez V, Buffenstein R, Masamsetti V, Leonard S, Salmon AB, Mele J, et al. Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci. 2009,106:1–6.
Kirkwood TBL, Austad SN. Why do we age? Nature. 2000;408(6809):233–8.
Article
CAS
PubMed
Google Scholar
Faulkes CG, Davies KTJ, Rossiter SJ, Benette NC. Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance. Biol Lett. 2015;11(5):20150185.
Article
PubMed
PubMed Central
Google Scholar
Keane M, Craig T, Alfoldi J, Berlin AM, Johnson J, Seluanov A, et al. The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. Bioinformatics. 2014;30:3558–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ewald PW. An Evolutionary Perspective on Parasitism as a Cause of Cancer. Advances in Parasitology. 2009;68:21-43.
Menne S, Cote PJ. The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection. World J Gastroenterol. 2007;13:104–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Aguirre AA, Lutz P. Marine Turtles as Sentinels of Ecosystem Health: Is Fibropapillomatosis an Indicator? EcoHealth. 2004;1:275-83.
Guégan F, Lambert A, Lévêque C, Combes C, Euzet L. Can host body size explain the parasite species richness in tropical freshwater fishes ? Oecologia. 1992;90:197–204.
Article
Google Scholar
Morand S, Poulin R. Density, body mass and parasite species richness of terrestrial mammals. Evol Ecol. 1998;12:217-27.
Lindenfors P, Nunn CL, Jones KE, Cunningham AA, Sechrest W, Gittleman JL. Parasite species richness in carnivores: effects of host body mass, latitude, geographical range and population density. Glob Ecol Biogeogr. 2007;16:496–509.
Article
Google Scholar
Katzourakis A, Magiorkinis G, Lim AG, Gupta S, Belshaw R, Gifford R. Larger mammalian body size leads to lower retroviral activity. PLoS Pathog. 2014;10:e1004214.
Article
PubMed
PubMed Central
Google Scholar
Barnes G, Vernon T. Digestive organ morphology, diet, and guild structure of North American Anatidae. Can J Zool. 1987;65:1812–7.
Article
Google Scholar
O’Grady SP, Morando M, Avila L, Dearing MD. Correlating diet and digestive tract specialization: examples from the lizard family Liolaemidae. Zoology (Jena). 2005;108:201–10.
Article
Google Scholar
Aiello LC, Wheeler P. The expensive-tissue hypothesis. Curr Anthropol. 2014;36:199–221.
Article
Google Scholar
Kehoe P, Ankney D. Variation in digestive organ size among five species of diving ducks (Aythya spp.). Can J Zool. 1985;63:2339–42.
Article
Google Scholar
Hume I. Digestive strategies of mammals. Acta Zoologica Sinica. 2002;48:1-19.
Gregory TR, Nicol JA, Tamm H, Kullman B, Kullman K, Leitch IJ, et al. Eukaryotic genome size databases. Nucleic Acids Res. 2007;35:D332–8.
Article
CAS
PubMed
Google Scholar
Petrov DA. Evolution of genome size: new approaches to an old problem. Trends Genet. 2001;17:23–8.
Article
CAS
PubMed
Google Scholar
Albanes D, Winick M. Are Cell Numver and Cell Proliferation Risk Factores for Cancer? J Natl Cancer Inst. 1988;80:772–5.
Article
CAS
PubMed
Google Scholar
Stanger BZ, Tanaka AJ, Melton DA. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature. 2007;445:886–91.
Article
CAS
PubMed
Google Scholar
Vanharanta S, Massagué J. Origins of Metastatic Traits. Cancer Cell. 2013;24:410–21.
Petrucelli N, Daly MB, Feldman GL. Hereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2. Genet Med. 2010;12:245–59.
Article
CAS
PubMed
Google Scholar
Boffetta P. Human cancer from environmental pollutants: the epidemiological evidence. Mutat Res. 2006;608:157–62.
Article
CAS
PubMed
Google Scholar
Pope III CA. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate Air pollution. JAMA. 2002;287(9):1132–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625–38.
Article
PubMed
Google Scholar
Hursting SD, Nunez NP, Varticovski L, Vinson C. The obesity-cancer link: lessons learned from a fatless mouse. Cancer Res. 2007;67:2391–3.
Article
CAS
PubMed
Google Scholar