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  1. Current evidence supports a diverting stoma in patients undergoing low anterior resection with total mesorectal excision for rectal cancer as it reduces clinical severity of anastomotic leakage. However, relev...

    Authors: Flavius Sandra-Petrescu, Florian Herrle, Axel Hinke, Inga Rossion, Heiko Suelberg, Stefan Post, Ralf-Dieter Hofheinz and Peter Kienle
    Citation: BMC Cancer 2015 15:923
    Content type: Study protocol Published on:

  2. Cell fusion is a natural process in normal development and tissue regeneration. Fusion between cancer cells and macrophages generates metastatic hybrids with genetic and phenotypic characteristics from both ma...

    Authors: Ivan Shabo, Kristine Midtbö, Henrik Andersson, Emma Åkerlund, Hans Olsson, Pia Wegman, Cecilia Gunnarsson and Annelie Lindström
    Citation: BMC Cancer 2015 15:922
    Content type: Research article Published on:

  3. Socioeconomic position (SEP) has been associated with breast cancer incidence and survival. We examined the associations between two socioeconomic indicators and long-term breast cancer incidence and survival ...

    Authors: Mandy Goldberg, Ronit Calderon-Margalit, Ora Paltiel, Wiessam Abu Ahmad, Yechiel Friedlander, Susan Harlap and Orly Manor
    Citation: BMC Cancer 2015 15:921
    Content type: Research article Published on:

  4. Glutathione S-transferase P1 (GSTP1) has been reported to function as a tumor suppressor gene in various types of human cancers. Aberrant methylation of tumor-related genes at the promoter regions can inactivate ...

    Authors: Cheng Fang, Xue-Mei Wei, Xian-Tao Zeng, Fu-Bing Wang, Hong Weng and Xinghua Long
    Citation: BMC Cancer 2015 15:920
    Content type: Research article Published on:

  5. Colorectal cancer is the third most common malignancy in humans and novel therapeutic approaches are urgently needed. Autophagy is an evolutionarily highly conserved cellular process by which cells collect unn...

    Authors: Bruno Christian Koehler, Adam Jassowicz, Anna-Lena Scherr, Stephan Lorenz, Praveen Radhakrishnan, Nicole Kautz, Christin Elssner, Johanna Weiss, Dirk Jaeger, Martin Schneider and Henning Schulze-Bergkamen
    Citation: BMC Cancer 2015 15:919
    Content type: Research article Published on:

  6. Papillary thyroid cancer is the most common endocrine malignancy. The most sensitive and specific diagnostic tool for thyroid nodule diagnosis is fine-needle aspiration (FNA) biopsy with cytological evaluation...

    Authors: Federica Panebianco, Chiara Mazzanti, Sara Tomei, Paolo Aretini, Sara Franceschi, Francesca Lessi, Giancarlo Di Coscio, Generoso Bevilacqua and Ivo Marchetti
    Citation: BMC Cancer 2015 15:918
    Content type: Research article Published on:

  7. Standardized chemotherapy used in cancer patients with severe kidney insufficiency is ineffective. Although there are some pharmacokinetic studies on cyclophosphamide in kidney insufficiency patients, to the b...

    Authors: Liu Yang, Xiao-chen Zhang, Su-feng Yu, Hua-Qing Zhu, Ai-ping Hu, Jian Chen and Peng Shen
    Citation: BMC Cancer 2015 15:917
    Content type: Case report Published on:

  9. There is limited information about the clinical and biological significance of prostate specific G protein coupled receptor (PSGR) in prostate cancer (PCa) initiation and progression. Here, we evaluated the ex...

    Authors: Wenqing Cao, Faqian Li, Jorge Yao and Jiangzhou Yu
    Citation: BMC Cancer 2015 15:915
    Content type: Research article Published on:

  10. Paraneoplastic neurological syndrome (PNS) is a heterogeneous group of disorders affecting any part of the nervous system, in a patient affected by cancer. PNS is estimated to occur in 0.01 to 8 % of cancer pa...

    Authors: Maria Pia Brizzi, Cristina Sonetto, Marco Tampellini, Massimo Di Maio, Marco Volante and Giorgio V. Scagliotti
    Citation: BMC Cancer 2015 15:914
    Content type: Case report Published on:

  11. Abnormal glucose and lipids levels may impact survival after breast cancer (BC) diagnosis, but their association to other causes of mortality such as cardiovascular (CV) disease may result in a competing risk ...

    Authors: Wahyu Wulaningsih, Mariam Vahdaninia, Mark Rowley, Lars Holmberg, Hans Garmo, Håkan Malmstrom, Mats Lambe, Niklas Hammar, Göran Walldius, Ingmar Jungner, Anthonius C. Coolen and Mieke Van Hemelrijck
    Citation: BMC Cancer 2015 15:913
    Content type: Research article Published on:

  12. Current knowledge of the aetiology of hereditary breast cancer in the four main South African population groups (black, coloured, Indian and white) is limited. Risk assessments in the black, coloured and India...

    Authors: F. Z. Francies, T. Wainstein, K. De Leeneer, A. Cairns, M. Murdoch, S. Nietz, H. Cubasch, B. Poppe, T. Van Maerken, B. Crombez, I. Coene, R. Kerr, J. P. Slabbert, A. Vral, A. Krause, A. Baeyens…
    Citation: BMC Cancer 2015 15:912
    Content type: Research article Published on:

  14. Exportin 1 (XPO1) is a well-characterized nuclear export protein whose expression is up-regulated in many types of cancers and functions to transport key tumor suppressor proteins (TSPs) from the nucleus. Kary...

    Authors: Marsha Crochiere, Trinayan Kashyap, Ori Kalid, Sharon Shechter, Boris Klebanov, William Senapedis, Jean-Richard Saint-Martin and Yosef Landesman
    Citation: BMC Cancer 2015 15:910
    Content type: Research article Published on:

  15. Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the third most lethal cancer worldwide. The epithelial to mesenchymal transition (EMT) describes the transformation of well-differenti...

    Authors: Philipp Wittmann, Markus Grubinger, Christian Gröger, Heidemarie Huber, Wolfgang Sieghart, Markus Peck-Radosavljevic and Wolfgang Mikulits
    Citation: BMC Cancer 2015 15:909
    Content type: Research article Published on:

  16. The aim of this study was to detect the epidermal growth factor receptor (EGFR)-activating mutations and other oncogene alterations in patients with non-small-cell lung cancers (NSCLC) who experienced a treatm...

    Authors: Katsuhiro Masago, Shiro Fujita, Miho Muraki, Akito Hata, Chiyuki Okuda, Kyoko Otsuka, Reiko Kaji, Jumpei Takeshita, Ryoji Kato, Nobuyuki Katakami and Yukio Hirata
    Citation: BMC Cancer 2015 15:908
    Content type: Research article Published on:

  17. Disadvantaged populations face many barriers to cancer care, including limited support in navigating through the complexities of the healthcare system. Family members play an integral role in caring for patien...

    Authors: Olive Mbah, Jean G. Ford, Miaozhen Qiu, Jennifer Wenzel, Lee Bone, Janice Bowie, Ahmed Elmi, Jimmie L. Slade, Michele Towson and Adrian S. Dobs
    Citation: BMC Cancer 2015 15:907
    Content type: Study protocol Published on:

  18. Nasopharyngeal carcinoma (NPC), also known as Cantonese cancer, is rare worldwide, but has particularly high incidence in North Africa and Southeast Asia, especially in Guangdong, China, such as Guangzhou. Tob...

    Authors: Jia-Huang Lin, Chao-Qiang Jiang, Sai-Yin Ho, Wei-Sen Zhang, Zhi-Ming Mai, Lin Xu, Ching-Man Lo and Tai-Hing Lam
    Citation: BMC Cancer 2015 15:906
    Content type: Research article Published on:

  19. BRF2 is a transcription factor required for synthesis of a small group of non-coding RNAs by RNA polymerase III. Overexpression of BRF2 can transform human mammary epithelial cells. In both breast and lung can...

    Authors: Jana Koo, Stephanie Cabarcas-Petroski, John L. Petrie, Nicole Diette, Robert J. White and Laura Schramm
    Citation: BMC Cancer 2015 15:905
    Content type: Research article Published on:

  20. The aim of the trial is to demonstrate that with the use of modern IMRT/IGRT and reduction of safety margins postoperative wound complications can be reduced.

    Authors: Barbara Röper, Christine Heinrich, Victoria Kehl, Hans Rechl, Katja Specht, Klaus Wörtler, Andreas Töpfer, Michael Molls, Severin Kampfer, Rüdiger von Eisenharth-Rothe and Stephanie E. Combs
    Citation: BMC Cancer 2015 15:904
    Content type: Study protocol Published on:

  21. Although postoperative adjuvant chemoradiotherapies prevent recurrence for some patients with ampullary cancer, the recurrence rate is as high as 29 % in patients with stage I cancer. In an effort to identify ...

    Authors: Cheng-Lin Wu, Ying-Jui Chao, Ta-Ming Yang, Yi-Ling Chen, Kung-Chao Chang, Hui-Ping Hsu, Yan-Shen Shan and Ming-Derg Lai
    Citation: BMC Cancer 2015 15:903
    Content type: Research article Published on:

  22. The purpose of this study was to review patient characteristics and evaluate the potential factors affecting prognosis in cases of brain metastasis (BM) from colorectal cancer (CRC).

    Authors: Xiao-Dong Gu, Yan-Tao Cai, Yi-Ming Zhou, Zhen-Yang Li, Jian-Bin Xiang and Zong-You Chen
    Citation: BMC Cancer 2015 15:902
    Content type: Research article Published on:

  23. AXL is a well-characterized, protumorigenic receptor tyrosine kinase that is highly expressed and activated in numerous human carcinomas and sarcomas, including aggressive subtypes of liposarcoma. However, the...

    Authors: Caitlin D. May, Jeannine Garnett, XiaoYan Ma, Sharon M. Landers, Davis R. Ingram, Elizabeth G. Demicco, Ghadah A. Al Sannaa, Tona Vu, Lixia Han, Yi Zhang, Christine M. Kivlin, Svetlana Bolshakov, Azad Abul Kalam, Juehui Liu, Fuguo Zhou, Dominique Broccoli…
    Citation: BMC Cancer 2015 15:901
    Content type: Research article Published on:

  24. Antiangiogenic treatments have been shown to increase blood perfusion and oxygenation in some experimental tumors, and to reduce blood perfusion and induce hypoxia in others. The purpose of this preclinical st...

    Authors: Jon-Vidar Gaustad, Trude G. Simonsen, Ragnhild Smistad, Catherine S. Wegner, Lise Mari K. Andersen and Einar K. Rofstad
    Citation: BMC Cancer 2015 15:900
    Content type: Research article Published on:

  25. Return-to-work (RTW)-interventions support cancer survivors in resuming work, but come at additional healthcare costs. The objective of this study was to assess the budget impact of a RTW-intervention, consist...

    Authors: Janne C. Mewes, Lotte M. G. Steuten, Iris F. Groeneveld, Angela G. E. M. de Boer, Monique H. W. Frings-Dresen, Maarten J. IJzerman and Wim H. van Harten
    Citation: BMC Cancer 2015 15:899
    Content type: Research article Published on:

  26. Irisin is a recently discovered myokine, involved in the browning of white adipose tissue. To date, its function has been mainly associated with energy homeostasis and metabolism, and it has been proposed as a...

    Authors: Xeni Provatopoulou, Georgia P. Georgiou, Eleni Kalogera, Vasileios Kalles, Maira A. Matiatou, Ioannis Papapanagiotou, Alexandros Sagkriotis, George C. Zografos and Antonia Gounaris
    Citation: BMC Cancer 2015 15:898
    Content type: Research article Published on:

  28. Disseminated tumor cells (DTCs) can be detected using ultrasensitive immunocytochemical assays and their presence in the bone marrow can predict the subsequent occurrence of overt metastasis formation and meta...

    Authors: Stefan Werner, Hauke Stamm, Mutiha Pandjaitan, Dirk Kemming, Benedikt Brors, Klaus Pantel and Harriet Wikman
    Citation: BMC Cancer 2015 15:896
    Content type: Research article Published on:

  33. Chondrosarcoma is characterized for its lack of response to conventional cytotoxic chemotherapy, propensity for developing lung metastases, and low rates of survival. Research within the field of development a...

    Authors: Birgit Lohberger, Andreas Leithner, Nicole Stuendl, Heike Kaltenegger, Werner Kullich and Bibiane Steinecker-Frohnwieser
    Citation: BMC Cancer 2015 15:891
    Content type: Research article Published on:

  34. To summarize data on long-term ipsilateral local recurrence (LR) and breast cancer death rate (BCDR) for patients with ductal carcinoma in situ (DCIS) who received different treatments.

    Authors: Kirsty E. Stuart, Nehmat Houssami, Richard Taylor, Andrew Hayen and John Boyages
    Citation: BMC Cancer 2015 15:890
    Content type: Research article Published on:

  35. Ovarian cancer is a possibly lethal gynecological malignancy and this study utilized phage display technology to screen and identify peptides that specifically bind to ovarian cancer cells and explored the eff...

    Authors: Cong Zhou, Jiali Kang, Xiaoxia Wang, Wei Wei and Wenyan Jiang
    Citation: BMC Cancer 2015 15:889
    Content type: Research article Published on:

  36. In humans, sex-determining region-Y (SRY) related high-mobility-group box 4 (SOX4) is linked to development and tumorigenesis. SOX4 is over-expressed in several cancers and has prognostic significance. This st...

    Authors: Tae Mi Yoon, Sun-Ae Kim, Wan Seok Cho, Dong Hoon Lee, Joon Kyoo Lee, Young-Lan Park, Kyung-Hwa Lee, Jae Hyuk Lee, Sun-Seog Kweon, Ik-Joo Chung, Sang Chul Lim and Young-Eun Joo
    Citation: BMC Cancer 2015 15:888
    Content type: Research article Published on:

  37. Approximately 10–15 % of gastrointestinal stromal tumors (GISTs) lack gain of function mutations in the KIT and platelet-derived growth factor receptor alpha (PDGFRA) genes. An alternate mechanism of oncogenesis ...

    Authors: Martin G. Belinsky, Lori Rink, Kathy Q. Cai, Stephen J. Capuzzi, Yen Hoang, Jeremy Chien, Andrew K. Godwin and Margaret von Mehren
    Citation: BMC Cancer 2015 15:887
    Content type: Research article Published on:

  38. USP18 (ubiquitin-specific protease 18) removes ubiquitin-like modifier interferon stimulated gene 15 (ISG15) from conjugated proteins. USP18 null mice in a FVB/N background develop tumors as early as 2 months ...

    Authors: Fadzai Chinyengetere, David J. Sekula, Yun Lu, Andrew J. Giustini, Aarti Sanglikar, Masanori Kawakami, Tian Ma, Sandra S. Burkett, Burton L. Eisenberg, Wendy A. Wells, Paul J. Hoopes, Elizabeth G. Demicco, Alexander J Lazar, Keila E. Torres, Vincent Memoli, Sarah J. Freemantle…
    Citation: BMC Cancer 2015 15:886
    Content type: Research article Published on:

  39. Cyclin-dependent protein kinase-5 (CDK5) is an unusual member of the CDK family as it is not cell cycle regulated. However many of its substrates have roles in cell growth and oncogenesis, raising the possibil...

    Authors: Nicola J. Grant, Philip J. Coates, Yvonne L. Woods, Susan E. Bray, Nicholas A. Morrice, C. James Hastie, Douglas J. Lamont, Francis A. Carey and Calum Sutherland
    Citation: BMC Cancer 2015 15:885
    Content type: Research article Published on:

  40. Mucinous adenocarcinoma (MAC) represents 6-19 % of all colorectal carcinoma. It is associated with poorer response to chemotherapy and chemoradiotherapy.

    Authors: Karolina Vernmark, Maria Albertsson, Bergthor Björnsson, Thomas Gasslander, Per Sandström, Xiao-Feng Sun and Annika Holmqvist
    Citation: BMC Cancer 2015 15:884
    Content type: Case report Published on:

  41. The development of androgen resistance is a major limitation to androgen deprivation treatment in prostate cancer. We have developed an in vitro model of androgen-resistance to characterise molecular changes occu...

    Authors: Sujitra Detchokul, Aparna Elangovan, Edmund J. Crampin, Melissa J. Davis and Albert G. Frauman
    Citation: BMC Cancer 2015 15:883
    Content type: Research article Published on:

  42. Recurrence of colorectal cancer (CRC) may arise due to the persistence of drug-resistant and cancer-initiating cells that survive exposure to chemotherapy. Proteins responsible for this recurrence include the ...

    Authors: Murray J. Cutler, Erica L. Lowthers, Cynthia L. Richard, Dagmar M. Hajducek, Paul A. Spagnuolo and Jonathan Blay
    Citation: BMC Cancer 2015 15:882
    Content type: Research article Published on:

  43. We aimed to estimate the effect of alcohol consumption on breast cancer risk and to test whether overweight and obesity modifies this association.

    Authors: Aesun Shin, Sven Sandin, Marie Lof, Karen L. Margolis, Kyeezu Kim, Elisabeth Couto, Hans Olov Adami and Elisabete Weiderpass
    Citation: BMC Cancer 2015 15:881
    Content type: Research article Published on:

  44. Aberrant sialylated carbohydrate synthesis is frequently noted in various cancers. Sialyltransferase ST3GAL-1, which adds a sialic acid in an α-2,3 linkage to Gal β1,3 GalNAc, preforms an important role in mod...

    Authors: Qi Bai, Li Liu, Yu Xia, Qilai Long, Jiajun Wang, Jiejie Xu and Jianming Guo
    Citation: BMC Cancer 2015 15:880
    Content type: Research article Published on:

  45. Adult Langerhans cell histiocytosis (LCH) is an orphan disease. Chemotherapy is usually reserved to patients presenting with single system multifocal (SS-m) or multisystem (MS) disease but due to the lack of r...

    Authors: Enrico Derenzini, Vittorio Stefoni, Cinzia Pellegrini, Letizia Gandolfi, Alessandro Broccoli, Beatrice Casadei, Federica Quirini, Lisa Argnani, Lorenzo Tonialini and Pier Luigi Zinzani
    Citation: BMC Cancer 2015 15:879
    Content type: Research article Published on:

  46. CHEK2*1100delC is a moderate-risk breast cancer susceptibility allele with a high prevalence in the Netherlands. We performed copy number and gene expression profiling to investigate whether CHEK2*1100delC breast...

    Authors: Maarten P. G. Massink, Irsan E. Kooi, John W. M. Martens, Quinten Waisfisz and Hanne Meijers-Heijboer
    Citation: BMC Cancer 2015 15:877
    Content type: Research article Published on:

  47. Little is known about sex-specific trends in lung cancer mortality and years of potential life lost (YPLL) attributable to lung cancer over more than five decades. The aim of the present study was to describe ...

    Authors: Ulrich John and Monika Hanke
    Citation: BMC Cancer 2015 15:876
    Content type: Research article Published on:

  48. The enhancer of zeste-homolog 2 (EZH2) is involved in cancer development through gene silencing by trimethylation of lysine 27 of histone 3 (H3K27me3). The C/C genotype for the EZH2 rs3757441 single-nucleotide po...

    Authors: Lorenzo Fornaro, Pinuccia Faviana, Veronica De Gregorio, Caterina Vivaldi, Elisa Paolicchi, Gianluca Masi, Fotios Loupakis, Elisa Sensi, Cristiana Lupi, Gabriella Fontanini, Yuzhuo Wang, Romano Danesi, Alfredo Falcone and Francesco Crea
    Citation: BMC Cancer 2015 15:874
    Content type: Research article Published on:

  49. With the advent of new and more efficient anti-androgen drugs targeting androgen receptor (AR) in breast cancer (BC) is becoming an increasingly important area of investigation. This would potentially be most ...

    Authors: André Grogg, Mafalda Trippel, Katrin Pfaltz, Claudia Lädrach, Raoul A. Droeser, Nikola Cihoric, Bodour Salhia, Martin Zweifel and Coya Tapia
    Citation: BMC Cancer 2015 15:872
    Content type: Research article Published on:

  50. Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration (clo...

    Authors: Ömer Acar, Ezgi Özkurt, Gulfem Demir, Hilal Saraç, Can Alkan, Tarık Esen, Mehmet Somel and Nathan A. Lack
    Citation: BMC Cancer 2015 15:871
    Content type: Research article Published on:

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