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  1. Osteopontin (OPN) and thrombospondin-1 (TSP-1) are extracellular matrix proteins secreted by stromal and tumor cells. These proteins appear to have a key role in the tumor microenvironment for cancer developme...

    Authors: Mathieu Rouanne, Julien Adam, Aïcha Goubar, Angélique Robin, Caroline Ohana, Emilie Louvet, Jiemin Cormier, Olaf Mercier, Peter Dorfmüller, Soly Fattal, Vincent Thomas de Montpreville, Thierry Lebret, Philippe Dartevelle, Elie Fadel, Benjamin Besse, Ken André Olaussen…
    Citation: BMC Cancer 2016 16:483
    Content type: Research article Published on:

  2. To our knowledge, the Alberta Moving Beyond Breast Cancer (AMBER) Study is the first and only prospective cohort study of breast cancer survivors that includes objectively-measured physical activity (PA), sede...

    Authors: Kerry S. Courneya, Margaret L. McNeely, S. Nicole Culos-Reed, Jeff K. Vallance, Gordon J. Bell, John R. Mackey, Charles E. Matthews, Andria R. Morielli, Diane Cook, Sarah MacLaughlin, Megan S. Farris, Stephanie Voaklander, Rachel O’Reilly and Christine M. Friedenreich
    Citation: BMC Cancer 2016 16:481
    Content type: Research article Published on:

  3. Platelet and blood coagulation abnormalities frequently occur in cancer patients. Fibrinogen is an important hemostatic factor that regulates the hemostatic pathway. Hyperfibrinogenemia is increasing recognize...

    Authors: Xuefeng Yu, Fulan Hu, Qiang Yao, Chunfeng Li, Hongfeng Zhang and Yingwei Xue
    Citation: BMC Cancer 2016 16:480
    Content type: Research article Published on:

  4. Trabectedin is reported to be particularly effective against translocation-related sarcoma. Recently, a randomized phase 2 study in patients with translocation-related sarcomas unresponsive or intolerable to s...

    Authors: Hideo Morioka, Shunji Takahashi, Nobuhito Araki, Hideshi Sugiura, Takafumi Ueda, Mitsuru Takahashi, Tsukasa Yonemoto, Hiroaki Hiraga, Toru Hiruma, Toshiyuki Kunisada, Akihiko Matsumine, Michiro Susa, Robert Nakayama, Kazumasa Nishimoto, Kazutaka Kikuta, Keisuke Horiuchi…
    Citation: BMC Cancer 2016 16:479
    Content type: Research article Published on:

  5. The clinicopathological features and prognosis of gastric cancer in young patients are both limited and controversial. Therefore, the aim of this study was to define the clinicopathological features and progno...

    Authors: Shushang Liu, Fan Feng, Guanghui Xu, Zhen Liu, Yangzi Tian, Man Guo, Xiao Lian, Lei Cai, Daiming Fan and Hongwei Zhang
    Citation: BMC Cancer 2016 16:478
    Content type: Research article Published on:

  6. Circulating tumor cell (CTC)-filtration methods capture high numbers of CTCs in non-small-cell lung cancer (NSCLC) and metastatic prostate cancer (mPCa) patients, and hold promise as a non-invasive technique f...

    Authors: Emma Pailler, Marianne Oulhen, Fanny Billiot, Alexandre Galland, Nathalie Auger, Vincent Faugeroux, Corinne Laplace-Builhé, Benjamin Besse, Yohann Loriot, Maud Ngo-Camus, Merouan Hemanda, Colin R. Lindsay, Jean-Charles Soria, Philippe Vielh and Françoise Farace
    Citation: BMC Cancer 2016 16:477
    Content type: Technical advance Published on:

  8. Chondrosarcoma is a malignant cartilage forming bone tumour for which no effective systemic treatment is available. Previous studies illustrate the need for a better understanding of the role of the IGF pathwa...

    Authors: Elisabeth F. P. Peterse, Arjen H. G. Cleven, Yvonne De Jong, Inge Briaire-de Bruijn, Jonathan A. Fletcher, Erik H. J. Danen, Anne-Marie Cleton-Jansen and Judith V. M. G. Bovée
    Citation: BMC Cancer 2016 16:475
    Content type: Research article Published on:

  10. Maintenance treatment (MTx) in responders following first-line treatment has been investigated and practiced for many cancers. Modeling and simulation may support interpretation of interim data and development...

    Authors: Kelong Han, Laurent Claret, Alan Sandler, Asha Das, Jin Jin and Rene Bruno
    Citation: BMC Cancer 2016 16:473
    Content type: Research article Published on:

  11. The Wnt/β-catenin pathway has a key role in regulating cellular processes and its aberrant signaling can lead to cancer development. The role of β-catenin expression in pancreatic ductal adenocarcinoma is some...

    Authors: Kapo Saukkonen, Jaana Hagström, Harri Mustonen, Anne Juuti, Stig Nordling, Pauliina Kallio, Kari Alitalo, Hanna Seppänen and Caj Haglund
    Citation: BMC Cancer 2016 16:472
    Content type: Research article Published on:

  12. To improve current treatment strategies for patients with aggressive colorectal cancer (CRC), the molecular understanding of subgroups of CRC with poor prognosis is of vast importance. SOX2 positive tumors hav...

    Authors: Ida V. Lundberg, Sofia Edin, Vincy Eklöf, Åke Öberg, Richard Palmqvist and Maria L. Wikberg
    Citation: BMC Cancer 2016 16:471
    Content type: Research article Published on:

  13. Non-small cell lung cancer (NSCLC) is one of the most aggressive types of cancer. However, resistance to cisplatin (CDDP) remains a major challenge in NSCLC treatment. The purpose of this study was to investig...

    Authors: Jing Gao, Qingwei Meng, Yanbin Zhao, Xuesong Chen and Li Cai
    Citation: BMC Cancer 2016 16:470
    Content type: Research article Published on:

  14. Chemotherapy is one of the major treatment modalities for cancer. Metal-based compounds such as derivatives of cisplatin are in the front line of therapy against a subset of cancers, but their use is restricte...

    Authors: Theresa Pesch, Harald Schuhwerk, Philippe Wyrsch, Timo Immel, Wilhelm Dirks, Alexander Bürkle, Thomas Huhn and Sascha Beneke
    Citation: BMC Cancer 2016 16:469
    Content type: Research article Published on:

  15. Patients with locally advanced esophageal cancer who are treated with trimodality therapy have a high recurrence rate. Preclinical evidence suggests that inhibition of cyclooxygenase 2 (COX2) increases the eff...

    Authors: James M. Cleary, Harvey J. Mamon, Jackie Szymonifka, Raphael Bueno, Noah Choi, Dean M. Donahue, Panos M. Fidias, Henning A. Gaissert, Michael T. Jaklitsch, Matthew H. Kulke, Thomas P. Lynch, Steven J. Mentzer, Jeffrey A. Meyerhardt, Richard S. Swanson, John Wain, Charles S. Fuchs…
    Citation: BMC Cancer 2016 16:468
    Content type: Research article Published on:

  16. TAS-102 (trifluridine and tipiracil hydrochloride; a novel combination oral nucleoside anti-tumor agent) has recently received regulatory approval for patients with refractory metastatic colorectal cancer (mCR...

    Authors: Pashtoon M. Kasi, Daisuke Kotani, Michael Cecchini, Kohei Shitara, Atsushi Ohtsu, Ramesh K. Ramanathan, Howard S. Hochster, Axel Grothey and Takayuki Yoshino
    Citation: BMC Cancer 2016 16:467
    Content type: Research article Published on:

  17. To determine the appropriate time of concomitant chemotherapy administration after antiangiogenic treatment, we investigated the timing and effect of bevacizumab administration on vascular normalization of met...

    Authors: Bang-Bin Chen, Yen-Shen Lu, Ching-Hung Lin, Wei-Wu Chen, Pei-Fang Wu, Chao-Yu Hsu, Chih-Wei Yu, Shwu-Yuan Wei, Ann-Lii Cheng and Tiffany Ting-Fang Shih
    Citation: BMC Cancer 2016 16:466
    Content type: Research article Published on:

  18. We aimed to evaluate the correlation between p16ink4a-overexpression and high risk (hr)HPV-DNA in vulvar squamous cell carcinoma (vSCC) tumors as well as the impact of both biomarkers on the prognosis of vSCC pat...

    Authors: Jacek J. Sznurkowski, Anton Żawrocki and Wojciech Biernat
    Citation: BMC Cancer 2016 16:465
    Content type: Research article Published on:

  19. This phase I/II study aimed to determine the maximum tolerated dose (MTD) of nanoparticle albumin-bound paclitaxel (nab ®-paclitaxel) plus cisplatin as treatment for metastatic nasophar...

    Authors: Yan Huang, Wenhua Liang, Yunpeng Yang, Liping Zhao, Hongyun Zhao, Xuan Wu, Yuanyuan Zhao, Yang Zhang and Li Zhang
    Citation: BMC Cancer 2016 16:464
    Content type: Research article Published on:

  20. Rapidly growing cancer cells secrete growth-promoting polypeptides and have increased proteolytic activity, contributing to tumor progression and metastasis. Their presentation in malignant pleural effusion (M...

    Authors: Li-Han Hsu, Pei-Chi Hsu, Tien-Ling Liao, An-Chen Feng, Nei-Min Chu and Shu-Huei Kao
    Citation: BMC Cancer 2016 16:463
    Content type: Research article Published on:

  22. Cancer therapies that kill cancer cells without affecting normal cells is the ultimate mode of treating cancers. The VP3, an avian virus-derived protein, can specifically initiate cell death through several si...

    Authors: Ruzila Ismail, Zeenathul Nazariah Allaudin, Rasedee Abdullah, Mohd-Azmi Mohd Lila, Nik-Mohd-Afizan Nik Abd. Rahman and Sheikh-Omar Abdul Rahman
    Citation: BMC Cancer 2016 16:461
    Content type: Research article Published on:

  23. A survival paradox between Stage IIB/C and Stage IIIA colon cancers exists. It is unclear how adequate lymph nodes dissection (LN) and post-surgery chemotherapy contribute to the survival paradox. We intended ...

    Authors: Quyen D. Chu, Meijiao Zhou, Kaelen L. Medeiros, Prakash Peddi, Mindie Kavanaugh and Xiao-Cheng Wu
    Citation: BMC Cancer 2016 16:460
    Content type: Research article Published on:

  24. Mammography and ultrasound are the gold standard imaging techniques for preoperative assessment and for monitoring the efficacy of neoadjuvant chemotherapy in breast cancer. Maximum accuracy in predicting path...

    Authors: Roland Gregor Stein, Daniel Wollschläger, Rolf Kreienberg, Wolfgang Janni, Manfred Wischnewsky, Joachim Diessner, Tanja Stüber, Catharina Bartmann, Mathias Krockenberger, Jörg Wischhusen, Achim Wöckel, Maria Blettner and Lukas Schwentner
    Citation: BMC Cancer 2016 16:459
    Content type: Research article Published on:

  25. Endocannabinoids have recently drawn attention as promising anti-cancer agents. We previously observed that anandamide (AEA), one of the representative endocannabinoids, effectively inhibited the proliferation...

    Authors: Seok-Woo Park, J. Hun Hah, Sang-Mi Oh, Woo-Jin Jeong and Myung-Whun Sung
    Citation: BMC Cancer 2016 16:458
    Content type: Research article Published on:

  26. Numerous case–control studies have been performed to investigate the association between three cyclooxygenase-2 (COX-2) polymorphisms (rs20417 (−765G > C), rs689466 (−1195G > A), and rs5275 (8473 T > C)) and t...

    Authors: Wei-Dong Leng, Xiu-Jie Wen, Joey S. W. Kwong, Wei Huang, Jian-Gang Chen and Xian-Tao Zeng
    Citation: BMC Cancer 2016 16:457
    Content type: Research article Published on:

  27. In the context of early detection of head and neck cancers (HNC), the aim of this study was to describe how people sought medical consultation during the year prior to diagnosis and the impact on the stage of ...

    Authors: Karine Ligier, Olivier Dejardin, Ludivine Launay, Emmanuel Benoit, Emmanuel Babin, Simona Bara, Bénédicte Lapôtre-Ledoux, Guy Launoy and Anne-Valérie Guizard
    Citation: BMC Cancer 2016 16:456
    Content type: Research article Published on:

  28. Approximately 80 % of mesothelioma specimens have the wild-type p53 gene, whereas they contain homozygous deletions in the INK4A/ARF locus that encodes p14 ARF ...

    Authors: Yuanyuan Jiang, Boya Zhong, Kiyoko Kawamura, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima and Masatoshi Tagawa
    Citation: BMC Cancer 2016 16:455
    Content type: Research article Published on:

  30. Renal cell carcinoma (RCC) incidence is highest in highly developed countries and it is the seventh most common neoplasm diagnosed. RCC management include nephrectomy and targeted therapies. Type 1 insulin-lik...

    Authors: Adam F. Tracz, Cezary Szczylik, Camillo Porta and Anna M. Czarnecka
    Citation: BMC Cancer 2016 16:453
    Content type: Debate Published on:

  31. Silibinin, a biologically active compound of milk thistle, has chemopreventive effects on cancer cell lines. Recently it was reported that silibinin inhibited tumor growth through activation of the apoptotic s...

    Authors: Sang-Hun Kim, Kwang-Youn Kim, Sun-Nyoung Yu, Young-Kyo Seo, Sung-Sik Chun, Hak-Sun Yu and Soon-Cheol Ahn
    Citation: BMC Cancer 2016 16:452
    Content type: Research article Published on:

  32. Stereotactic body radiation therapy (SBRT) has been an emerging non-invasive treatment modality for patients with hepatocellular carcinoma (HCC) when curative treatments cannot be applied. In this study, we re...

    Authors: Jenny Que, Hsing-Tao Kuo, Li-Ching Lin, Kuei-Li Lin, Chia-Hui Lin, Yu-Wei Lin and Ching-Chieh Yang
    Citation: BMC Cancer 2016 16:451
    Content type: Research article Published on:

  33. Diagnosing breast cancer during the early stage may be helpful for decreasing cancer-related mortality. In Western developed countries, mammographies have been the gold standard for breast cancer detection. Ho...

    Authors: Xiuyan Yu, Guoming Hu, Zhigang Zhang, Fuming Qiu, Xuan Shao, Xiaochen Wang, Hongwei Zhan, Yiding Chen, Yongchuan Deng and Jian Huang
    Citation: BMC Cancer 2016 16:450
    Content type: Research article Published on:

  34. Our aim was to investigate the influence of FTS on human cellular and humoral immunity using a randomized controlled clinical study in esophageal cancer patients.

    Authors: Lantao Chen, Lixin Sun, Yaoguo Lang, Jun Wu, Lei Yao, Jinfeng Ning, Jinfeng Zhang and Shidong Xu
    Citation: BMC Cancer 2016 16:449
    Content type: Research article Published on:

  35. The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical s...

    Authors: Chel Hun Choi, Joon-Yong Chung, Eun Joo Chung, John D. Sears, Jeong-Won Lee, Duk-Soo Bae and Stephen M. Hewitt
    Citation: BMC Cancer 2016 16:448
    Content type: Research article Published on:

  36. Intraocular iris rhabdomyosarcoma is extremely rare, and in the 3 cases reported to date occurred as the primary site of tumour growth. We report a case of rhabdomyosarcoma of the foot metastasizing to the iris.

    Authors: Ido Didi Fabian, G. Darius Hildebrand, Shaun Wilson, Tina Foord and Mandeep S. Sagoo
    Citation: BMC Cancer 2016 16:447
    Content type: Case report Published on:

  37. Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown.

    Authors: Samson Okello, Cristina Churchill, Rogers Owori, Benson Nasasira, Christine Tumuhimbise, Charles Lagoro Abonga, David Mutiibwa, David C. Christiani and Kathleen E. Corey
    Citation: BMC Cancer 2016 16:446
    Content type: Research article Published on:

  38. Colorectal cancer is a common malignancy and a leading cause of cancer-related death. Half of patients with colorectal cancer initially present with non-specific or vague symptoms. In the need for a safe low-c...

    Authors: Jakob Søgaard Juul, Flemming Bro, Nete Hornung, Berit Sanne Andersen, Søren Laurberg, Frede Olesen and Peter Vedsted
    Citation: BMC Cancer 2016 16:445
    Content type: Study protocol Published on:

  39. Multiple myeloma osteolytic disease affecting the spine results in vertebral compression fractures. These are painful, result in kyphosis, and impact respiratory function and quality of life. We explore the im...

    Authors: Karan Malhotra, Joseph S. Butler, Hai Ming Yu, Susanne Selvadurai, Shirley D’Sa, Neil Rabin, Charalampia Kyriakou, Kwee Yong and Sean Molloy
    Citation: BMC Cancer 2016 16:444
    Content type: Research article Published on:

  40. A randomized clinical trial has found that the addition of erlotinib to gemcitabine (GEM-E) for pancreatic cancer led to a modest increase in survival. The aim of this national population-based retrospective s...

    Authors: Sangjin Shin, Chan Mi Park, Hanbyeol Kwon and Kyung-Hun Lee
    Citation: BMC Cancer 2016 16:443
    Content type: Research article Published on:

  41. Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that belongs to the nuclear hormone receptor superfamily. PPARγ is essential in adipocyte differentiation fro...

    Authors: Akihiko Takeuchi, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Shinji Miwa, Seiichi Munesue, Yasuhiko Yamamoto and Hiroyuki Tsuchiya
    Citation: BMC Cancer 2016 16:442
    Content type: Research article Published on:

  42. Osteopontin is a marker for breast cancer progression, which in previous studies has also been associated with resistance to certain anti-cancer therapies. It is not known which splice variants may mediate tre...

    Authors: Krzysztof Zduniak, Anil Agrawal, Siddarth Agrawal, Md Monir Hossain, Piotr Ziolkowski and Georg F. Weber
    Citation: BMC Cancer 2016 16:441
    Content type: Research article Published on:

  43. Previous work has demonstrated immunomodulatory, anti-tumor, anti-metastatic and anti-angiogenic effects of the small molecule quinoline-3-carboxamide tasquinimod in pre-clinical cancer models. To better under...

    Authors: Adnan Deronic, Sahar Tahvili, Tomas Leanderson and Fredrik Ivars
    Citation: BMC Cancer 2016 16:440
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:610

  44. The natural compound triptolide has been shown to decrease cell proliferation and induce apoptosis and cellular senescence. We previously demonstrated that triptolide decreases tumor formation and metastasis o...

    Authors: Theresa A. Reno, Sun-Wing Tong, Jun Wu, John M. Fidler, Rebecca Nelson, Jae Y. Kim and Dan J. Raz
    Citation: BMC Cancer 2016 16:439
    Content type: Research article Published on:

  45. The total intake of dietary antioxidants may reduce prostate cancer risk but available data are sparse and the possible role of supplements unclear. We investigated the potential association between total and ...

    Authors: Kjell M. Russnes, Elisabeth Möller, Kathryn M. Wilson, Monica Carlsen, Rune Blomhoff, Sigbjørn Smeland, Hans-Olov Adami, Henrik Grönberg, Lorelei A. Mucci and Katarina Bälter
    Citation: BMC Cancer 2016 16:438
    Content type: Research article Published on:

  46. To compare definitive radiochemotherapy with weekly administration of 30–40 mg/m2 of cisplatin to 100 mg/m2 of cisplatin on days 1, 22 and 43 for outcomes and toxicity in patients with squamous cell carcinoma of ...

    Authors: Dirk Rades, Daniel Seidl, Stefan Janssen, Amira Bajrovic, Katarina Karner, Primoz Strojan and Steven E Schild
    Citation: BMC Cancer 2016 16:437
    Content type: Research article Published on:

  47. The purpose of this study was to evaluate socio-demographic characteristics of clients claiming genetic counseling for hereditary breast and ovarian cancer (HBOC) in Austria. Furthermore, changes of these para...

    Authors: Christine Staudigl, Georg Pfeiler, Katharina Hrauda, Romana Renz, Andreas Berger, Renate Lichtenschopf, Christian F. Singer and Muy-Kheng M. Tea
    Citation: BMC Cancer 2016 16:436
    Content type: Research article Published on:

  48. The PD-1/PD-L1 axis plays a paramount role in the immune escape of tumor cells by negative regulation of T-cell functions. The aim of the present study was to characterize the PD-L1 expression pattern and its ...

    Authors: Chan Kim, Eun Kyung Kim, Hun Jung, Hong Jae Chon, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha…
    Citation: BMC Cancer 2016 16:434
    Content type: Research article Published on:

  49. Ovarian cancer is a metastatic disease and one of the leading causes of gynaecology malignancy-related deaths in women. Cancer stem cells (CSCs) are key contributors of cancer metastasis and relapse. Integrins...

    Authors: Chantel Samardzija, Rodney B. Luwor, Michael A. Quinn, George Kannourakis, Jock K. Findlay and Nuzhat Ahmed
    Citation: BMC Cancer 2016 16:432
    Content type: Research article Published on:

  50. The 5-year overall survival rates for head and neck cancer (HNC) relies on distant metastasis. Importantly, the epithelial-mesenchymal transition (EMT) is believed to be an initial step of metastasis. However,...

    Authors: Li-Hsuen Chen, Wen-Lin Hsu, Yen-Ju Tseng, Dai-Wei Liu and Ching-Feng Weng
    Citation: BMC Cancer 2016 16:431
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:595

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