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  1. Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously ...

    Authors: Synnove Norvoll Magnussen, Elin Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane Cavalcanti Jacobsen, Bente Mortensen, Tuula Salo, Inigo Martinez-Zubiaurre, Jan-Olof Winberg, Lars Uhlin-Hansen and Gunbjorg Svineng
    Citation: BMC Cancer 2017 17:350
    Content type: Research article Published on:

  2. Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. ...

    Authors: Mary Wells, Patricia Aitchison, Fiona Harris, Gozde Ozakinci, Andrew Radley, Linda Bauld, Vikki Entwistle, Alastair Munro, Sally Haw, Bill Culbard and Brian Williams
    Citation: BMC Cancer 2017 17:348
    Content type: Research article Published on:

  3. Anxiety and depression can be a long-term strain in cancer survivors. Little is known about the emotional situation of cancer survivors who have to deal with work- and family-related issues. The purpose of thi...

    Authors: Laura Inhestern, Volker Beierlein, Johanna Christine Bultmann, Birgit Möller, Georg Romer, Uwe Koch and Corinna Bergelt
    Citation: BMC Cancer 2017 17:347
    Content type: Research article Published on:

  4. The optimal extent of gastrectomy for middle-third gastric cancer remains controversial. In our study, the short-term effects and longer-term survival outcomes of distal subtotal gastrectomy and total gastrect...

    Authors: Xin Ji, Yan Yan, Zhao-De Bu, Zi-Yu Li, Ai-Wen Wu, Lian-Hai Zhang, Xiao-Jiang Wu, Xiang-Long Zong, Shuang-Xi Li, Fei Shan, Zi-Yu Jia and Jia-Fu Ji
    Citation: BMC Cancer 2017 17:345
    Content type: Research article Published on:

  5. Agricultural workers may be exposed to potential carcinogens including pesticides, sensitizing agents and solar radiation. Previous studies indicate increased risks of hematopoietic cancers and decreased risks...

    Authors: Linda Kachuri, M. Anne Harris, Jill S. MacLeod, Michael Tjepkema, Paul A. Peters and Paul A. Demers
    Citation: BMC Cancer 2017 17:343
    Content type: Research article Published on:

  6. Health benefits of the Mediterranean Diet (MD) have been shown in different at-risk populations. A German translation of the Mediterranean Diet Adherence Screener (MEDAS) from the PREvención con DIeta MEDiterr...

    Authors: Katrin Hebestreit, Maryam Yahiaoui-Doktor, Christoph Engel, Walter Vetter, Michael Siniatchkin, Nicole Erickson, Martin Halle, Marion Kiechle and Stephan C. Bischoff
    Citation: BMC Cancer 2017 17:341
    Content type: Research article Published on:

  7. There is inadequate evidence for the carcinogenicity of cobalt and cobalt compounds in humans. Consequently, the International Agency for Research on Cancer (IARC) has evaluated cobalt metal without tungsten c...

    Authors: Riitta Sauni, Panu Oksa, Jukka Uitti, Asko Linna, Raimo Kerttula and Eero Pukkala
    Citation: BMC Cancer 2017 17:340
    Content type: Research article Published on:

  8. Colorectal cancer is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related death globally. It is the second most common cancer among both males and females in Malaysia. Th...

    Authors: Bello Arkilla Magaji, Foong Ming Moy, April Camilla Roslani and Chee Wei Law
    Citation: BMC Cancer 2017 17:339
    Content type: Research article Published on:

  10. Providing an estimate of the percentage of cancer in Lebanon by 2018 that is due to the exposure to risk factors in 2008. Factors include: smoking, body mass index (BMI), physical inactivity, dietary factors, ...

    Authors: Maya A. Charafeddine, Sara H. Olson, Deborah Mukherji, Sally N. Temraz, Ghassan K. Abou-Alfa and Ali I. Shamseddine
    Citation: BMC Cancer 2017 17:337
    Content type: Research article Published on:

  11. Cosmetic result following breast conserving surgery (BCS) for cancer influences quality of life and psychosocial functioning in breast cancer patients. A preoperative prediction of expected cosmetic result fol...

    Authors: M. Lagendijk, E. L. Vos, A. H. J. Koning, M. G. M. Hunink, J. P. Pignol, E. M. L. Corten, C. de Monye, C. H. M. van Deurzen, J. H. van Dam, W. W. Vrijland, C. M. E. Contant, C. Verhoef, W. van Lankeren and L. B. Koppert
    Citation: BMC Cancer 2017 17:336
    Content type: Study protocol Published on:

  12. Lymphatic vessel density and lymphovascular invasion are commonly assessed to identify the clinicopathological outcomes in breast cancer. However, the prognostic values of them on patients’ survival are still ...

    Authors: Song Zhang, Dong Zhang, Mingfu Gong, Li Wen, Cuiwei Liao and Liguang Zou
    Citation: BMC Cancer 2017 17:335
    Content type: Research article Published on:

  13. The prognosis of synovial sarcoma (SS), an aggressive soft tissue sarcoma, remains poor. We previously reported that c-MET or platelet-derived growth factor receptor α (PDGFRα) signalling pathway is related to...

    Authors: Shutaro Yamada, Yoshinori Imura, Takaaki Nakai, Sho Nakai, Naohiro Yasuda, Keiko Kaneko, Hidetatsu Outani, Satoshi Takenaka, Kenichiro Hamada, Akira Myoui, Nobuhito Araki, Takafumi Ueda, Kazuyuki Itoh, Hideki Yoshikawa and Norifumi Naka
    Citation: BMC Cancer 2017 17:334
    Content type: Research article Published on:

  14. Blockade of the PD-1/PD-L1 immune checkpoint pathway is emerging as a promising immunotherapeutic approach for the management and treatment of head and neck cancer patients who do not respond to 1st/2nd line t...

    Authors: Arutha Kulasinghe, Chris Perry, Liz Kenny, Majid E. Warkiani, Colleen Nelson and Chamindie Punyadeera
    Citation: BMC Cancer 2017 17:333
    Content type: Case report Published on:

  15. In the primary analysis of the ERIVANCE BCC trial, vismodegib, the first US Food and Drug Administration–approved Hedgehog pathway inhibitor, showed objective response rates (ORRs) by independent review facili...

    Authors: Aleksandar Sekulic, Michael R. Migden, Nicole Basset-Seguin, Claus Garbe, Anja Gesierich, Christopher D. Lao, Chris Miller, Laurent Mortier, Dedee F. Murrell, Omid Hamid, Jorge F. Quevedo, Jeannie Hou, Edward McKenna, Natalie Dimier, Sarah Williams, Dirk Schadendorf…
    Citation: BMC Cancer 2017 17:332
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:366

  16. Mucinous appendiceal adenocarcinomas (AAs) are the most common histological subset of AAs. Nonmucinous AAs have been infrequently studied. We performed a single-center retrospective study to investigate this h...

    Authors: Marc Uemura, Wei Qiao, Keith Fournier, Jeffrey Morris, Paul Mansfield, Cathy Eng, Richard E Royal, Robert A Wolff, Kanwal Raghav, Gary N Mann and Michael J Overman
    Citation: BMC Cancer 2017 17:331
    Content type: Research article Published on:

  18. Breast cancer is the most globally diagnosed female cancer, with the triple negative breast cancer (TNBC) being the most aggressive subtype of the disease. In this study we aimed at comparing the effect of BRC...

    Authors: Danielle Bogan, Lucio Meile, Ahmed El Bastawisy, Hend F. Yousef, Abdel-Rahman N. Zekri, Abeer A. Bahnassy and Wael M. ElShamy
    Citation: BMC Cancer 2017 17:329
    Content type: Research article Published on:

  19. Genetic factors may influence an individual’s sensitivity to ionising radiation and therefore modify his/her risk of developing papillary thyroid carcinoma (PTC). Previously, we reported that common single nuc...

    Authors: Christine Lonjou, Francesca Damiola, Monika Moissonnier, Geoffroy Durand, Irina Malakhova, Vladimir Masyakin, Florence Le Calvez-Kelm, Elisabeth Cardis, Graham Byrnes, Ausrele Kesminiene and Fabienne Lesueur
    Citation: BMC Cancer 2017 17:328
    Content type: Research article Published on:

  20. Paraneoplastic acral vascular syndrome (PAVS) is a rare phenomenon which is observed in patients with adenocarcinomas and other malignancies. Various potential pathogenic mechanisms such as tumour invasion of ...

    Authors: Thilo Gambichler, Stefanie Strutzmann, Andrea Tannapfel and Laura Susok
    Citation: BMC Cancer 2017 17:327
    Content type: Case report Published on:

  21. Survival of childhood, adolescent and young adult (CAYA) cancers has increased with progress in the management of the treatments and has reached more than 80% at 5 years. Nevertheless, these survivors are at g...

    Authors: Charlotte Demoor-Goldschmidt, Delphine Drui, Isabelle Doutriaux, Gérard Michel, Pascal Auquier, Agnès Dumas, Claire Berger, Valérie Bernier, Sandrine Bohrer, Pierre-Yves Bondiau, Bruno Filhon, Brice Fresneau, Claire Freycon, Dinu Stefan, Sylvie Helfre, Angela Jackson…
    Citation: BMC Cancer 2017 17:326
    Content type: Study protocol Published on:

  22. Neoadjuvant fluoropirimidine (5FU)-based chemoradiotherapy (CRT) has been considered the standard of care for locally advanced rectal cancer (LARC). Whether addition of oxaliplatin (OXP) will further improve c...

    Authors: Francesca De Felice, Ilaria Benevento, Anna Lisa Magnante, Daniela Musio, Nadia Bulzonetti, Rossella Caiazzo and Vincenzo Tombolini
    Citation: BMC Cancer 2017 17:325
    Content type: Research article Published on:

  23. Metastasis of breast cancer displays site-specificity towards bone. Recently, studies have emerged indicating that primary tumors may remotely influence creation of a pre-metastatic niche. In this study, we us...

    Authors: Karis Chin-Quee and Henry J. Donahue
    Citation: BMC Cancer 2017 17:324
    Content type: Research article Published on:

  24. Non-muscle invasive bladder cancer (NMIBC) is usually treated with local therapy including transurethral resection of the bladder tumor and intravesical therapy depending on the stage of the tumor. NMIBC is a ...

    Authors: Diego Teyssonneau, Amaury Daste, Vincent Dousset, Jean-Luc Hoepffner, Alain Ravaud and Marine Gross-Goupil
    Citation: BMC Cancer 2017 17:323
    Content type: Case report Published on:

  25. Based on promising results from a Phase I study of hepatic arterial infusion chemotherapy using a combination of miriplatin and cisplatin powder (DDP-H) for unresectable hepatocellular carcinoma (UMIN-CTR00000...

    Authors: Kenya Kamimura, Takeshi Suda, Takeshi Yokoo, Hiroteru Kamimura, Tsutomu Kanefuji, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Nobuo Waguri, Satoshi Yamagiwa and Shuji Terai
    Citation: BMC Cancer 2017 17:322
    Content type: Research article Published on:

  26. The association between lymphovascular invasion and lymphatic or hematogenous metastasis has been suspected, with conflicting evidence. We have investigated the association between the risk of biochemical recu...

    Authors: Yong Jin Kang, Hyun-Soo Kim, Won Sik Jang, Jong Kyou Kwon, Cheol Yong Yoon, Joo Yong Lee, Kang Su Cho, Won Sik Ham and Young Deuk Choi
    Citation: BMC Cancer 2017 17:321
    Content type: Research article Published on:

  27. Breast cancer is one of the most important neoplasia among women. It was recently suggested that biological agents could be the etiological cause, particularly Human Papilloma Virus (HPV). The aim of this stud...

    Authors: Silvia Delgado-García, Juan-Carlos Martínez-Escoriza, Alfonso Alba, Tina-Aurora Martín-Bayón, Hortensia Ballester-Galiana, Gloria Peiró, Pablo Caballero and Jose Ponce-Lorenzo
    Citation: BMC Cancer 2017 17:320
    Content type: Research article Published on:

  28. Estrogen receptor (ER) β has been suggested to affect ovarian carcinogenesis. We examined the effects of four ERβ agonists on proliferation and gene expression of two ovarian cancer cell lines.

    Authors: Susanne Schüler-Toprak, Christoph Moehle, Maciej Skrzypczak, Olaf Ortmann and Oliver Treeck
    Citation: BMC Cancer 2017 17:319
    Content type: Research article Published on:

  29. eRAPID (electronic patient self-Reporting of Adverse-events: Patient Information and aDvice) is an internet based system for patients to self-report symptoms and side effects (adverse events or AE) of cancer t...

    Authors: Kate Absolom, Patricia Holch, Lorraine Warrington, Faye Samy, Claire Hulme, Jenny Hewison, Carolyn Morris, Leon Bamforth, Mark Conner, Julia Brown and Galina Velikova
    Citation: BMC Cancer 2017 17:318
    Content type: Study protocol Published on:

  30. To evaluate the procedures and complications of diaphragm peritonectomy (DP) and diaphragm full-thickness resection (DFTR) during primary cytoreduction for advanced stage epithelial ovarian cancer.

    Authors: Shuang Ye, Tiancong He, Shanhui Liang, Xiaojun Chen, Xiaohua Wu, Huijuan Yang and Libing Xiang
    Citation: BMC Cancer 2017 17:317
    Content type: Research article Published on:

  31. Exosomes or extracellular vesicles have the potential as a diagnostic marker for various diseases including cancer. In order to identify novel exosomal markers for prostate cancer (PC), we performed proteomic ...

    Authors: Kyojiro Kawakami, Yasunori Fujita, Yoko Matsuda, Tomio Arai, Kengo Horie, Koji Kameyama, Taku Kato, Koichi Masunaga, Yutaka Kasuya, Masashi Tanaka, Kosuke Mizutani, Takashi Deguchi and Masafumi Ito
    Citation: BMC Cancer 2017 17:316
    Content type: Research article Published on:

  32. To determine the proportion of “true” interval cancers and tumor characteristics of interval breast cancers prior to, during and after the transition from screen-film mammography screening (SFM) to full-field ...

    Authors: Rob M. G. van Bommel, Roy Weber, Adri C. Voogd, Joost Nederend, Marieke W. J. Louwman, Dick Venderink, Luc J. A. Strobbe, Matthieu J. C. Rutten, Menno L. Plaisier, Paul N. Lohle, Marianne J. H. Hooijen, Vivianne C.G. Tjan-Heijnen and Lucien E. M. Duijm
    Citation: BMC Cancer 2017 17:315
    Content type: Research article Published on:

  33. Recent preclinical and phase I studies have reported that rebamipide decreased the severity of chemoradiotherapy-induced oral mucositis in patients with oral cancer. This placebo-controlled randomized phase II...

    Authors: T. Yokota, T. Ogawa, S. Takahashi, K. Okami, T. Fujii, K. Tanaka, S. Iwae, I. Ota, T. Ueda, N. Monden, K. Matsuura, H. Kojima, S. Ueda, K. Sasaki, Y. Fujimoto, Y. Hasegawa…
    Citation: BMC Cancer 2017 17:314
    Content type: Research article Published on:

  34. Thromboembolism (TE) is a serious complication in children with acute lymphoblastic leukemia (ALL). The incidence of symptomatic thromboembolism is as high as 14% and case fatality rate of ~15%. Further, devel...

    Authors: Uma H. Athale, Caroline Laverdiere, Trishana Nayiager, Yves-Line Delva, Gary Foster, Lehana Thabane and Anthony KC Chan
    Citation: BMC Cancer 2017 17:313
    Content type: Study protocol Published on:

  35. Ethnic differences in colon cancer (CC) care were shown in the United States, but results are not directly applicable to European countries due to fundamental healthcare system differences. This is the first s...

    Authors: M. Lamkaddem, M. A. G. Elferink, M. C. Seeleman, E. Dekker, C. J. A. Punt, O. Visser and M. L. Essink-Bot
    Citation: BMC Cancer 2017 17:312
    Content type: Research article Published on:

  36. The molecular profiles of tumors may inform the selection of appropriate targeted therapies. Circulating tumor cells (CTCs) reflect the real-time status of tumor genotypes. CTCs exhibit high genetic heterogene...

    Authors: Yuurin Kondo, Kazuhiko Hayashi, Kazuyuki Kawakami, Yukari Miwa, Hiroshi Hayashi and Masakazu Yamamoto
    Citation: BMC Cancer 2017 17:311
    Content type: Research article Published on:

  37. Fibroblast growth factor receptors (FGFRs) are well-known proto-oncogenes in several human malignancies and are currently therapeutically targeted in clinical trials. Among glioma subtypes, activating FGFR1 al...

    Authors: Birgitta Lehtinen, Annina Raita, Juha Kesseli, Matti Annala, Kristiina Nordfors, Olli Yli-Harja, Wei Zhang, Tapio Visakorpi, Matti Nykter, Hannu Haapasalo and Kirsi J. Granberg
    Citation: BMC Cancer 2017 17:310
    Content type: Research article Published on:

  38. Mesothelioma is resistant to conventional treatments and is often defective in p53 pathways. We then examined anti-tumor effects of metformin, an agent for type 2 diabetes, and combinatory effects of metformin...

    Authors: Kengo Shimazu, Yuji Tada, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Hideaki Shimada, Kenzo Hiroshima, Takao Namiki, Koichiro Tatsumi and Masatoshi Tagawa
    Citation: BMC Cancer 2017 17:309
    Content type: Research article Published on:

  39. Neo-adjuvant chemotherapy followed by radical cystectomy with extended pelvic lymph node dissection is considered to be the treatment of choice for patients with muscle invasive bladder cancer (MIBC). Despite ...

    Authors: Valérie Fonteyne, Piet Dirix, Sara Junius, Elke Rammant, Piet Ost, Gert De Meerleer, Martijn Swimberghe and Karel Decaestecker
    Citation: BMC Cancer 2017 17:308
    Content type: Study protocol Published on:

  40. Glabridin (GLA), a major component extracted from licorice root, has anti-inflammatory and antioxidant activities, but few studies report its mechanism of inhibition of angiogenesis. This study was an extensio...

    Authors: Juan Mu, Dongmei Zhu, Zhaoxia Shen, Shilong Ning, Yun Liu, Juan Chen, Yuan Li and Zhong Li
    Citation: BMC Cancer 2017 17:307
    Content type: Research article Published on:

  41. Neoadjuvant chemotherapy is a key component of breast cancer treatment regimens and pathologic complete response to this therapy varies among patients. This is presumably due to differences in the molecular me...

    Authors: Kenneth M. K. Mark, Frederick S. Varn, Matthew H. Ung, Feng Qian and Chao Cheng
    Citation: BMC Cancer 2017 17:306
    Content type: Research article Published on:

  42. MicroRNAs are non-coding RNAs which regulate a variety of cellular functions in the development of tumors. Among the numerous microRNAs, microRNA-30a (miR-30a) is thought to play an important role in the proce...

    Authors: Minghao Xie, Huabo Qin, Qianxin Luo, Qunsheng Huang, Xiaosheng He, Zihuan Yang, Ping Lan and Lei Lian
    Citation: BMC Cancer 2017 17:305
    Content type: Research article Published on:

  43. Vascular invasion, including microvascular invasion (MVI) and portal vein tumor thrombus (PVTT), is associated with the postoperative recurrence of hepatocellular carcinoma (HCC). We aimed to investigate the p...

    Authors: Xubiao Wei, Nan Li, Shanshan Li, Jie Shi, Weixing Guo, Yaxin Zheng and Shuqun Cheng
    Citation: BMC Cancer 2017 17:304
    Content type: Research article Published on:

  44. To characterize the expression of the membrane transporter NaPi2b and antigen targeted by the MX35 antibody in ovarian tumor samples. The current interest to develop monoclonal antibody based therapy of ovaria...

    Authors: Kristina Levan, Matin Mehryar, Constantina Mateoiu, Per Albertsson, Tom Bäck and Karin Sundfeldt
    Citation: BMC Cancer 2017 17:303
    Content type: Research article Published on:

  45. Interstitial lung diseases induced by anticancer agents (ILD-AA) are rare adverse effects of anticancer therapy. However, prognostic biomarkers for ILD-AA have not been identified in patients with advanced lun...

    Authors: Kota Nakamura, Motoyasu Kato, Takehito Shukuya, Keita Mori, Yasuhito Sekimoto, Hiroaki Ihara, Ryota Kanemaru, Ryo Ko, Rina Shibayama, Ken Tajima, Ryo Koyama, Naoko Shimada, Osamu Nagashima, Fumiyuki Takahashi, Shinichi Sasaki and Kazuhisa Takahashi
    Citation: BMC Cancer 2017 17:302
    Content type: Research article Published on:

  46. Annual low dose CT (LDCT) screening of individuals at high demographic risk reduces lung cancer mortality by more than 20%. However, subjects selected for screening based on demographic criteria typically have...

    Authors: Jiyoun Yeo, Erin L. Crawford, Xiaolu Zhang, Sadik Khuder, Tian Chen, Albert Levin, Thomas M. Blomquist and James C. Willey
    Citation: BMC Cancer 2017 17:301
    Content type: Research article Published on:

  48. Rapid and accurate cancer staging following diagnosis underpins patient management, in particular the identification of distant metastatic disease. Current staging guidelines recommend sequential deployment of...

    Authors: Stuart A. Taylor, Sue Mallett, Anne Miles, Sandy Beare, Gauraang Bhatnagar, John Bridgewater, Rob Glynne-Jones, Vicky Goh, Ashley M. Groves, Sam M. Janes, Dow Mu Koh, Steve Morris, Alison Morton, Neal Navani, Alf Oliver, Anwar R. Padhani…
    Citation: BMC Cancer 2017 17:299
    Content type: Study protocol Published on:

  49. We aimed to evaluate the potential benefits of the Leadership and Coaching for Health (LEACH) program on physical activity (PA), dietary habits, and distress management in cancer survivors.

    Authors: Young Ho Yun, Young Ae Kim, Myung Kyung Lee, Jin Ah Sim, Byung-Ho Nam, Sohee Kim, Eun Sook Lee, Dong-Young Noh, Jae-Young Lim, Sung Kim, Si-Young Kim, Chi-Heum Cho, Kyung Hae Jung, Mison Chun, Soon Nam Lee, Kyong Hwa Park…
    Citation: BMC Cancer 2017 17:298
    Content type: Research article Published on:

  50. The aim of the present study was to investigate the long-term survival outcomes and toxicities associated with our experienced early administration of adjuvant concurrent chemoradiotherapy (CCRT).

    Authors: Sang-Won Kim, Mison Chun, Hee-Sug Ryu, Suk-Joon Chang, Tae Wook Kong, Young-Taek Oh and Seung Hee Kang
    Citation: BMC Cancer 2017 17:297
    Content type: Research article Published on:

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