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  1. Silibinin, a biologically active compound of milk thistle, has chemopreventive effects on cancer cell lines. Recently it was reported that silibinin inhibited tumor growth through activation of the apoptotic s...

    Authors: Sang-Hun Kim, Kwang-Youn Kim, Sun-Nyoung Yu, Young-Kyo Seo, Sung-Sik Chun, Hak-Sun Yu and Soon-Cheol Ahn
    Citation: BMC Cancer 2016 16:452
    Content type: Research article Published on:

  2. Numerous case–control studies have been performed to investigate the association between three cyclooxygenase-2 (COX-2) polymorphisms (rs20417 (−765G > C), rs689466 (−1195G > A), and rs5275 (8473 T > C)) and t...

    Authors: Wei-Dong Leng, Xiu-Jie Wen, Joey S. W. Kwong, Wei Huang, Jian-Gang Chen and Xian-Tao Zeng
    Citation: BMC Cancer 2016 16:457
    Content type: Research article Published on:

  3. Endocannabinoids have recently drawn attention as promising anti-cancer agents. We previously observed that anandamide (AEA), one of the representative endocannabinoids, effectively inhibited the proliferation...

    Authors: Seok-Woo Park, J. Hun Hah, Sang-Mi Oh, Woo-Jin Jeong and Myung-Whun Sung
    Citation: BMC Cancer 2016 16:458
    Content type: Research article Published on:

  4. Mammography and ultrasound are the gold standard imaging techniques for preoperative assessment and for monitoring the efficacy of neoadjuvant chemotherapy in breast cancer. Maximum accuracy in predicting path...

    Authors: Roland Gregor Stein, Daniel Wollschläger, Rolf Kreienberg, Wolfgang Janni, Manfred Wischnewsky, Joachim Diessner, Tanja Stüber, Catharina Bartmann, Mathias Krockenberger, Jörg Wischhusen, Achim Wöckel, Maria Blettner and Lukas Schwentner
    Citation: BMC Cancer 2016 16:459
    Content type: Research article Published on:

  5. A survival paradox between Stage IIB/C and Stage IIIA colon cancers exists. It is unclear how adequate lymph nodes dissection (LN) and post-surgery chemotherapy contribute to the survival paradox. We intended ...

    Authors: Quyen D. Chu, Meijiao Zhou, Kaelen L. Medeiros, Prakash Peddi, Mindie Kavanaugh and Xiao-Cheng Wu
    Citation: BMC Cancer 2016 16:460
    Content type: Research article Published on:

  6. Cancer therapies that kill cancer cells without affecting normal cells is the ultimate mode of treating cancers. The VP3, an avian virus-derived protein, can specifically initiate cell death through several si...

    Authors: Ruzila Ismail, Zeenathul Nazariah Allaudin, Rasedee Abdullah, Mohd-Azmi Mohd Lila, Nik-Mohd-Afizan Nik Abd. Rahman and Sheikh-Omar Abdul Rahman
    Citation: BMC Cancer 2016 16:461
    Content type: Research article Published on:

  8. Rapidly growing cancer cells secrete growth-promoting polypeptides and have increased proteolytic activity, contributing to tumor progression and metastasis. Their presentation in malignant pleural effusion (M...

    Authors: Li-Han Hsu, Pei-Chi Hsu, Tien-Ling Liao, An-Chen Feng, Nei-Min Chu and Shu-Huei Kao
    Citation: BMC Cancer 2016 16:463
    Content type: Research article Published on:

  9. This phase I/II study aimed to determine the maximum tolerated dose (MTD) of nanoparticle albumin-bound paclitaxel (nab ®-paclitaxel) plus cisplatin as treatment for metastatic nasophar...

    Authors: Yan Huang, Wenhua Liang, Yunpeng Yang, Liping Zhao, Hongyun Zhao, Xuan Wu, Yuanyuan Zhao, Yang Zhang and Li Zhang
    Citation: BMC Cancer 2016 16:464
    Content type: Research article Published on:

  10. We aimed to evaluate the correlation between p16ink4a-overexpression and high risk (hr)HPV-DNA in vulvar squamous cell carcinoma (vSCC) tumors as well as the impact of both biomarkers on the prognosis of vSCC pat...

    Authors: Jacek J. Sznurkowski, Anton Żawrocki and Wojciech Biernat
    Citation: BMC Cancer 2016 16:465
    Content type: Research article Published on:

  11. To determine the appropriate time of concomitant chemotherapy administration after antiangiogenic treatment, we investigated the timing and effect of bevacizumab administration on vascular normalization of met...

    Authors: Bang-Bin Chen, Yen-Shen Lu, Ching-Hung Lin, Wei-Wu Chen, Pei-Fang Wu, Chao-Yu Hsu, Chih-Wei Yu, Shwu-Yuan Wei, Ann-Lii Cheng and Tiffany Ting-Fang Shih
    Citation: BMC Cancer 2016 16:466
    Content type: Research article Published on:

  12. TAS-102 (trifluridine and tipiracil hydrochloride; a novel combination oral nucleoside anti-tumor agent) has recently received regulatory approval for patients with refractory metastatic colorectal cancer (mCR...

    Authors: Pashtoon M. Kasi, Daisuke Kotani, Michael Cecchini, Kohei Shitara, Atsushi Ohtsu, Ramesh K. Ramanathan, Howard S. Hochster, Axel Grothey and Takayuki Yoshino
    Citation: BMC Cancer 2016 16:467
    Content type: Research article Published on:

  13. Patients with locally advanced esophageal cancer who are treated with trimodality therapy have a high recurrence rate. Preclinical evidence suggests that inhibition of cyclooxygenase 2 (COX2) increases the eff...

    Authors: James M. Cleary, Harvey J. Mamon, Jackie Szymonifka, Raphael Bueno, Noah Choi, Dean M. Donahue, Panos M. Fidias, Henning A. Gaissert, Michael T. Jaklitsch, Matthew H. Kulke, Thomas P. Lynch, Steven J. Mentzer, Jeffrey A. Meyerhardt, Richard S. Swanson, John Wain, Charles S. Fuchs…
    Citation: BMC Cancer 2016 16:468
    Content type: Research article Published on:

  14. Chemotherapy is one of the major treatment modalities for cancer. Metal-based compounds such as derivatives of cisplatin are in the front line of therapy against a subset of cancers, but their use is restricte...

    Authors: Theresa Pesch, Harald Schuhwerk, Philippe Wyrsch, Timo Immel, Wilhelm Dirks, Alexander Bürkle, Thomas Huhn and Sascha Beneke
    Citation: BMC Cancer 2016 16:469
    Content type: Research article Published on:

  15. Non-small cell lung cancer (NSCLC) is one of the most aggressive types of cancer. However, resistance to cisplatin (CDDP) remains a major challenge in NSCLC treatment. The purpose of this study was to investig...

    Authors: Jing Gao, Qingwei Meng, Yanbin Zhao, Xuesong Chen and Li Cai
    Citation: BMC Cancer 2016 16:470
    Content type: Research article Published on:

  16. To improve current treatment strategies for patients with aggressive colorectal cancer (CRC), the molecular understanding of subgroups of CRC with poor prognosis is of vast importance. SOX2 positive tumors hav...

    Authors: Ida V. Lundberg, Sofia Edin, Vincy Eklöf, Åke Öberg, Richard Palmqvist and Maria L. Wikberg
    Citation: BMC Cancer 2016 16:471
    Content type: Research article Published on:

  17. The Wnt/β-catenin pathway has a key role in regulating cellular processes and its aberrant signaling can lead to cancer development. The role of β-catenin expression in pancreatic ductal adenocarcinoma is some...

    Authors: Kapo Saukkonen, Jaana Hagström, Harri Mustonen, Anne Juuti, Stig Nordling, Pauliina Kallio, Kari Alitalo, Hanna Seppänen and Caj Haglund
    Citation: BMC Cancer 2016 16:472
    Content type: Research article Published on:

  18. Maintenance treatment (MTx) in responders following first-line treatment has been investigated and practiced for many cancers. Modeling and simulation may support interpretation of interim data and development...

    Authors: Kelong Han, Laurent Claret, Alan Sandler, Asha Das, Jin Jin and Rene Bruno
    Citation: BMC Cancer 2016 16:473
    Content type: Research article Published on:

  20. Chondrosarcoma is a malignant cartilage forming bone tumour for which no effective systemic treatment is available. Previous studies illustrate the need for a better understanding of the role of the IGF pathwa...

    Authors: Elisabeth F. P. Peterse, Arjen H. G. Cleven, Yvonne De Jong, Inge Briaire-de Bruijn, Jonathan A. Fletcher, Erik H. J. Danen, Anne-Marie Cleton-Jansen and Judith V. M. G. Bovée
    Citation: BMC Cancer 2016 16:475
    Content type: Research article Published on:

  21. The role of the microbiome has become synonymous with human health and disease. Bile acids, as essential components of the microbiome, have gained sustained credibility as potential modulators of cancer progre...

    Authors: J. P. Phelan, F. J. Reen, N. Dunphy, R. O’Connor and F. O’Gara
    Citation: BMC Cancer 2016 16:476
    Content type: Research article Published on:

  22. Circulating tumor cell (CTC)-filtration methods capture high numbers of CTCs in non-small-cell lung cancer (NSCLC) and metastatic prostate cancer (mPCa) patients, and hold promise as a non-invasive technique f...

    Authors: Emma Pailler, Marianne Oulhen, Fanny Billiot, Alexandre Galland, Nathalie Auger, Vincent Faugeroux, Corinne Laplace-Builhé, Benjamin Besse, Yohann Loriot, Maud Ngo-Camus, Merouan Hemanda, Colin R. Lindsay, Jean-Charles Soria, Philippe Vielh and Françoise Farace
    Citation: BMC Cancer 2016 16:477
    Content type: Technical advance Published on:

  23. The clinicopathological features and prognosis of gastric cancer in young patients are both limited and controversial. Therefore, the aim of this study was to define the clinicopathological features and progno...

    Authors: Shushang Liu, Fan Feng, Guanghui Xu, Zhen Liu, Yangzi Tian, Man Guo, Xiao Lian, Lei Cai, Daiming Fan and Hongwei Zhang
    Citation: BMC Cancer 2016 16:478
    Content type: Research article Published on:

  24. Trabectedin is reported to be particularly effective against translocation-related sarcoma. Recently, a randomized phase 2 study in patients with translocation-related sarcomas unresponsive or intolerable to s...

    Authors: Hideo Morioka, Shunji Takahashi, Nobuhito Araki, Hideshi Sugiura, Takafumi Ueda, Mitsuru Takahashi, Tsukasa Yonemoto, Hiroaki Hiraga, Toru Hiruma, Toshiyuki Kunisada, Akihiko Matsumine, Michiro Susa, Robert Nakayama, Kazumasa Nishimoto, Kazutaka Kikuta, Keisuke Horiuchi…
    Citation: BMC Cancer 2016 16:479
    Content type: Research article Published on:

  25. Platelet and blood coagulation abnormalities frequently occur in cancer patients. Fibrinogen is an important hemostatic factor that regulates the hemostatic pathway. Hyperfibrinogenemia is increasing recognize...

    Authors: Xuefeng Yu, Fulan Hu, Qiang Yao, Chunfeng Li, Hongfeng Zhang and Yingwei Xue
    Citation: BMC Cancer 2016 16:480
    Content type: Research article Published on:

  26. To our knowledge, the Alberta Moving Beyond Breast Cancer (AMBER) Study is the first and only prospective cohort study of breast cancer survivors that includes objectively-measured physical activity (PA), sede...

    Authors: Kerry S. Courneya, Margaret L. McNeely, S. Nicole Culos-Reed, Jeff K. Vallance, Gordon J. Bell, John R. Mackey, Charles E. Matthews, Andria R. Morielli, Diane Cook, Sarah MacLaughlin, Megan S. Farris, Stephanie Voaklander, Rachel O’Reilly and Christine M. Friedenreich
    Citation: BMC Cancer 2016 16:481
    Content type: Research article Published on:

  27. Osteopontin (OPN) and thrombospondin-1 (TSP-1) are extracellular matrix proteins secreted by stromal and tumor cells. These proteins appear to have a key role in the tumor microenvironment for cancer developme...

    Authors: Mathieu Rouanne, Julien Adam, Aïcha Goubar, Angélique Robin, Caroline Ohana, Emilie Louvet, Jiemin Cormier, Olaf Mercier, Peter Dorfmüller, Soly Fattal, Vincent Thomas de Montpreville, Thierry Lebret, Philippe Dartevelle, Elie Fadel, Benjamin Besse, Ken André Olaussen…
    Citation: BMC Cancer 2016 16:483
    Content type: Research article Published on:

  29. Patients with clear cell renal cell carcinoma (ccRCC) have few therapeutic options, as ccRCC is unresponsive to chemotherapy and is highly resistant to radiation. Recently targeted therapies have extended prog...

    Authors: Nazleen C. Lobo, Craig Gedye, Anthony J. Apostoli, Kevin R. Brown, Joshua Paterson, Natalie Stickle, Michael Robinette, Neil Fleshner, Robert J. Hamilton, Girish Kulkarni, Alexandre Zlotta, Andrew Evans, Antonio Finelli, Jason Moffat, Michael A. S. Jewett and Laurie Ailles
    Citation: BMC Cancer 2016 16:485
    Content type: Technical advance Published on:

  30. Identification of patients with oral dysplasia at high risk of cancer development and oral squamous cell carcinoma (OSCC) at increased risk of disease recurrence will enable rigorous personalized treatment. Re...

    Authors: Raj Thani Somasundaram, Jatinder Kaur, Iona Leong, Christina MacMillan, Ian J. Witterick, Paul G. Walfish and Ranju Ralhan
    Citation: BMC Cancer 2016 16:486
    Content type: Research article Published on:

  31. mTOR inhibition of aromatase inhibitor (AI)-resistant breast cancer is currently under evaluation in the clinic. Everolimus/RAD001 (Afinitor®) has had limited efficacy as a solo agent but is projected to becom...

    Authors: Asona Lui, Jacob New, Joshua Ogony, Sufi Thomas and Joan Lewis-Wambi
    Citation: BMC Cancer 2016 16:487
    Content type: Research article Published on:

  32. Chronic kidney disease (CKD) is an established risk factor for cardiovascular disease but the relevance of reduced kidney function to cancer risk is uncertain.

    Authors: Germaine Wong, Natalie Staplin, Jonathan Emberson, Colin Baigent, Robin Turner, John Chalmers, Sophia Zoungas, Carol Pollock, Bruce Cooper, David Harris, Jie Jin. Wang, Paul Mitchell, Richard Prince, Wai Hon. Lim, Joshua Lewis, Jeremy Chapman…
    Citation: BMC Cancer 2016 16:488
    Content type: Research article Published on:

  33. Molecules Interacting with CasL (MICAL1), a multidomain flavoprotein monoxygenase, is strongly involved in the mechanisms that promote cancer cell proliferation and survival. Activation of MICAL1 causes an up-...

    Authors: Wenjie Deng, Yueyuan Wang, Luo Gu, Biao Duan, Jie Cui, Yujie Zhang, Yan Chen, Shixiu Sun, Jing Dong and Jun Du
    Citation: BMC Cancer 2016 16:489
    Content type: Research article Published on:

  34. Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor mainly expressed by the cells of myeloid origin, where it mediates the innate immune response to bacterial formylated peptides. High expression ...

    Authors: Igor Snapkov, Carl Otto Öqvist, Yngve Figenschau, Per Kogner, John Inge Johnsen and Baldur Sveinbjørnsson
    Citation: BMC Cancer 2016 16:490
    Content type: Research article Published on:

  35. Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have become the standard care of patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC), development of acquired ...

    Authors: Ren Zhao, Shun Zhou, Bing Xia, Cui-ying Zhang, Ping Hai, Hong Zhe and Yan-yang Wang
    Citation: BMC Cancer 2016 16:491
    Content type: Research article Published on:

  36. The purpose of this retrospective study was to evaluate the efficacy of incorporating trans-arterial radioembolization (TARE) with systemic chemotherapy in the treatment of liver-dominant metastatic pancreatic...

    Authors: Alexander Y. Kim, Keith Unger, Hongkun Wang and Michael J. Pishvaian
    Citation: BMC Cancer 2016 16:492
    Content type: Research article Published on:

  37. Mantle cell lymphoma (MCL) is an aggressive disease with short median survival. Molecularly, MCL is defined by the t(11;14) translocation leading to overexpression of the CCND1 gene. However, recent data show tha...

    Authors: Venera Kuci Emruli, Roger Olsson, Fredrik Ek and Sara Ek
    Citation: BMC Cancer 2016 16:493
    Content type: Research article Published on:

  38. Matrixmetalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases which are involved in angiogenesis, tumor invasion and metastatic formation. Up to date, the prognostic relevance of MMPs in s...

    Authors: Fee Klupp, Lena Neumann, Christoph Kahlert, Johannes Diers, Niels Halama, Clemens Franz, Thomas Schmidt, Moritz Koch, Juergen Weitz, Martin Schneider and Alexis Ulrich
    Citation: BMC Cancer 2016 16:494
    Content type: Research article Published on:

  39. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated epithelial malignancy that exhibits distinct geographical and ethnic prevalence. Although the contemporary therapeutic approach of radio...

    Authors: Chartia Ching-Mei Cheung, Samantha Wei-Man Lun, Grace Tin-Yun Chung, Chit Chow, Carman Lo, Kwong-Wai Choy and Kwok-Wai Lo
    Citation: BMC Cancer 2016 16:495
    Content type: Research article Published on:

  40. EGFRvIII is a mutant form of the epidermal growth factor receptor gene (EGFR) that lacks exons 2–7. The resulting protein does not bind to ligands and is constitutively activated. The expression of EGFRvIII is li...

    Authors: Sonoko Atsumi, Chisato Nosaka, Hayamitsu Adachi, Tomoyuki Kimura, Yoshihiko Kobayashi, Hisashi Takada, Takumi Watanabe, Shun-ichi Ohba, Hiroyuki Inoue, Manabu Kawada, Masakatsu Shibasaki and Masabumi Shibuya
    Citation: BMC Cancer 2016 16:496
    Content type: Research article Published on:

  41. Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis of...

    Authors: N. J. O’Farrell, R. Feighery, S. L. Picardo, N. Lynam-Lennon, M. Biniecka, S. A. McGarrigle, J. J. Phelan, F. MacCarthy, D. O’Toole, E. J. Fox, N. Ravi, J. V. Reynolds and J. O’Sullivan
    Citation: BMC Cancer 2016 16:497
    Content type: Research article Published on:

  42. The 2010 guidelines of the French National Cancer Institute (INCa) classify patients with endometrial cancer into three risk groups for lymph node invasion and recurrence on the basis of MRI and histological a...

    Authors: Noemie Body, Vincent Lavoué, Olivier De Kerdaniel, Fabrice Foucher, Sébastien Henno, Aurélie Cauchois, Bruno Laviolle, Marc Leblanc and Jean Levêque
    Citation: BMC Cancer 2016 16:498
    Content type: Research article Published on:

  43. Patients with advanced stage non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) often experience multidimensional impairments, affecting quality of life during their course of disease. In lung...

    Authors: Joachim Wiskemann, Simone Hummler, Christina Diepold, Melanie Keil, Ulrich Abel, Karen Steindorf, Philipp Beckhove, Cornelia M. Ulrich, Martin Steins and Michael Thomas
    Citation: BMC Cancer 2016 16:499
    Content type: Study protocol Published on:

  44. Two-thirds of U.S. adult women are overweight or obese. High body mass index (BMI) and adult weight gain are risk factors for a number of chronic diseases, including postmenopausal breast cancer. The higher po...

    Authors: Jessica A. Martinez, Pavani Chalasani, Cynthia A. Thomson, Denise Roe, Maria Altbach, Jean-Philippe Galons, Alison Stopeck, Patricia A. Thompson, Diana Evelyn Villa-Guillen and H-H. Sherry Chow
    Citation: BMC Cancer 2016 16:500
    Content type: Study protocol Published on:

  45. To report the results of combined chemoradiation (CCRT) with cisplatin versus carboplatin in locally advanced cervical carcinoma.

    Authors: Ekkasit Tharavichitkul, Vicharn Lorvidhaya, Pimkhuan Kamnerdsupaphon, Vimol Sukthomya, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Bongkoch Supawongwattana, Nantaka Pukanhaphan, Razvan Galalae and Imjai Chitapanarux
    Citation: BMC Cancer 2016 16:501
    Content type: Research article Published on:

  46. The multifunctional β-galactoside-binding protein galectin-3 is found in many distinct subcellular compartments including the cell nucleus. Expression and distribution of galectin-3 between the cell nucleus an...

    Authors: Katharina Fritsch, Marco Mernberger, Andrea Nist, Thorsten Stiewe, Alexander Brehm and Ralf Jacob
    Citation: BMC Cancer 2016 16:502
    Content type: Research article Published on:

  47. Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality tr...

    Authors: Jens Hoeppner, Florian Lordick, Thomas Brunner, Torben Glatz, Peter Bronsert, Nadine Röthling, Claudia Schmoor, Dietmar Lorenz, Christian Ell, Ulrich T. Hopt and J. Rüdiger Siewert
    Citation: BMC Cancer 2016 16:503
    Content type: Study protocol Published on:

  48. Platinum-based chemotherapy is emerging as the first line of treatment for castration resistant prostate cancer. Among the family of platinum (IV)-based compounds, a member known as CPA-7 inhibits the growth o...

    Authors: Meihua Liang, Fei Zhan, Juan Zhao, Qi Li, Jiazi Wuyang, Guannan Mu, Dianjun Li, Yanqiao Zhang and Xiaoyi Huang
    Citation: BMC Cancer 2016 16:504
    Content type: Research article Published on:

  49. In treatment-refractory liver dominant metastatic colorectal cancer, the role of liver directed therapies still is unclear. We sought to determine a prognostic score for Y90 radioembolization in these patients.

    Authors: Robert Damm, Ricarda Seidensticker, Gerhard Ulrich, Leonie Breier, Ingo G. Steffen, Max Seidensticker, Benjamin Garlipp, Konrad Mohnike, Maciej Pech, Holger Amthauer and Jens Ricke
    Citation: BMC Cancer 2016 16:509
    Content type: Research article Published on:

  50. Primary melanocytic neoplasms are rare in the pediatric age. Among them, the pattern of neoplastic meningitis represents a peculiar diagnostic challenge since neuroradiological features may be subtle and cereb...

    Authors: Giulia Angelino, Maria Debora De Pasquale, Luigi De Sio, Annalisa Serra, Luca Massimi, Rita De Vito, Antonio Marrazzo, Laura Lancella, Andrea Carai, Manila Antonelli, Felice Giangaspero, Marco Gessi, Laura Menchini, Laura Scarciolla, Daniela Longo and Angela Mastronuzzi
    Citation: BMC Cancer 2016 16:512
    Content type: Case report Published on:

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