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  1. The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were ...

    Authors: Marcello Tamburini, Laura Gangeri, Cinzia Brunelli, Paolo Boeri, Claudia Borreani, Marco Bosisio, Claude Fusco Karmann, Margherita Greco, Guido Miccinesi, Luciana Murru and Patrizia Trimigno
    Citation: BMC Cancer 2003 3:12
  2. Recent observations indicate that human tumorous breast tissue metabolizes progesterone differently than nontumorous breast tissue. Specifically, 5α-reduced metabolites (5α-pregnanes, shown to stimulate cell p...

    Authors: John P Wiebe and Michael J Lewis
    Citation: BMC Cancer 2003 3:9
  3. Uterine cervix carcinoma is the second most common female malignancy worldwide and a major health problem in Mexico, representing the primary cause of death among the Mexican female population. High risk human...

    Authors: Alfredo Hidalgo, Alberto Monroy, Rosa Ma Arana, Lucía Taja, Guelaguetza Vázquez and Mauricio Salcedo
    Citation: BMC Cancer 2003 3:8
  4. Kaposi's Sarcoma (KS) is a proliferation of aberrant vascular structures lined by spindle cells, and is caused by a gammaherpes virus (HHV8/KSHV). Its course is aggravated by co-infection with HIV-1, where the...

    Authors: Marion Cornelissen, Antoinette C van der Kuyl, Remco van den Burg, Fokla Zorgdrager, Carel JM van Noesel and Jaap Goudsmit
    Citation: BMC Cancer 2003 3:7
  5. RAD54L (OMIM 603615, Locus Link 8438) has been proposed as a candidate oncosupressor in tumours bearing a non-random deletion of 1p32, such as breast or colon carcinomas, lymphomas and meningiomas. In a search f...

    Authors: Paola E Leone, Marta Mendiola, Javier Alonso, César Paz-y-Miño and Angel Pestaña
    Citation: BMC Cancer 2003 3:6
  6. Although colorectal cancer death rates have been declining, this trend is not consistent across all ethnic groups. Biological, environmental, behavioral and socioeconomic explanations exist, but the reason for...

    Authors: Ian S Pagano, Shane Y Morita, Sanjaya Dhakal, Scott A Hundahl and Gertraud Maskarinec
    Citation: BMC Cancer 2003 3:5
  7. The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes for a multifunctional receptor involved in lysosomal enzyme trafficking, fetal organogenesis, cytotoxic T cell-induced apoptosis a...

    Authors: Timothy A Jamieson, David M Brizel, J Keith Killian, Yoshihiko Oka, Hong-Seok Jang, Xiaolong Fu, Robert W Clough, Robin T Vollmer, Mitchell S Anscher and Randy L Jirtle
    Citation: BMC Cancer 2003 3:4
  8. Microarray-based gene expression profiling is a powerful approach for the identification of molecular biomarkers of disease, particularly in human cancers. Utility of this approach to measure responses to ther...

    Authors: Samuel E DePrimo, Lily M Wong, Deepak B Khatry, Susan L Nicholas, William C Manning, Beverly D Smolich, Anne-Marie O'Farrell and Julie M Cherrington
    Citation: BMC Cancer 2003 3:3
  9. Many tumours undergo disregulation of polyamine homeostasis and upregulation of ornithine decarboxylase (ODC) activity, which can promote carcinogenesis. In animal models of colon carcinogenesis, inhibition of...

    Authors: E Ann Hudson, Lynne M Howells, Barbara Gallacher-Horley, Louise H Fox, Andreas Gescher and Margaret M Manson
    Citation: BMC Cancer 2003 3:2
  10. Although new endoscopic techniques can enhance the ability to detect a suspicious lung lesion, the primary diagnosis still depends on subjective visual assessment. We evaluated whether thermal heterogeneity of...

    Authors: Christodoulos Stefanadis, Christina Chrysohoou, Demosthenes B Panagiotakos, Elisabeth Passalidou, Vasiliki Katsi, Vlassios Polychronopoulos and Pavlos K Toutouzas
    Citation: BMC Cancer 2003 3:1
  11. Mortality estimates alone are not sufficient to understand the true magnitude of cancer burden. We present the detailed estimates of mortality and incidence by site as the basis for the future estimation of ca...

    Authors: Kenji Shibuya, Colin D Mathers, Cynthia Boschi-Pinto, Alan D Lopez and Christopher JL Murray
    Citation: BMC Cancer 2002 2:37

    The Erratum to this article has been published in BMC Cancer 2003 3:20

  12. The Global Burden of Disease 2000 (GBD 2000) study starts from an analysis of the overall mortality envelope in order to ensure that the cause-specific estimates add to the total all cause mortality by age and...

    Authors: Colin D Mathers, Kenji Shibuya, Cynthia Boschi-Pinto, Alan D Lopez and Christopher JL Murray
    Citation: BMC Cancer 2002 2:36
  13. Sodium/iodide symporter (NIS) is a key protein in iodide transport by thyroid cells and this activity is a prerequisite for effective radioiodide treatment of thyroid cancer. In the majority of thyroid cancers...

    Authors: Eusebio Chiefari, Antonio Brunetti, Franco Arturi, Jean-Michel Bidart, Diego Russo, Martin Schlumberger and Sebastiano Filetti
    Citation: BMC Cancer 2002 2:35
  14. A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosa...

    Authors: Vladimir Osipov, Khang-Che Ho, Hendrikus G Krouwer, Glenn Meyer and Vinod B Shidham
    Citation: BMC Cancer 2002 2:34
  15. Medulloblastomas, embryonal tumors arising in the cerebellum, commonly contain mutations that activate Wnt signaling. To determine whether increased Wnt signaling in the adult CNS is sufficient to induce tumor...

    Authors: John E Kratz, Duncan Stearns, David L Huso, Hilda H Slunt, Donald L Price, David R Borchelt and Charles G Eberhart
    Citation: BMC Cancer 2002 2:33
  16. The activity of the ribonucleoprotein enzyme telomerase is detectable in germ, stem and tumor cells. One major component of telomerase is human telomerase reverse transcriptase (hTERT), which encodes the catal...

    Authors: Mark Schrader, Angelika M Burger, Markus Müller, Hans Krause, Bernd Straub, Martin Schostak, Wolfgang Schulze, Heidrun Lauke and Kurt Miller
    Citation: BMC Cancer 2002 2:32
  17. Although a large number of epidemiological studies have examined the role of aspirin in the chemoprevention of colon cancer and other solid tumors, there is a limited body of research focusing on the associati...

    Authors: Kirsten B Moysich, Ravi J Menezes, Adrienne Ronsani, Helen Swede, Mary E Reid, K Michael Cummings, Karen L Falkner, Gregory M Loewen and Gerold Bepler
    Citation: BMC Cancer 2002 2:31
  18. Hepatocellular carcinoma (HCC) presents one of the major health threats in China today. A better understanding of the molecular genetics underlying malignant transformation of hepatocytes is critical to succes...

    Authors: Jian Yu, Min Ni, Jian Xu, Hongyu Zhang, Baomei Gao, Jianren Gu, Jianguo Chen, Lisheng Zhang, Mengchao Wu, Sushen Zhen and Jingde Zhu
    Citation: BMC Cancer 2002 2:29
  19. Psoriasin has been identified as a gene that is highly expressed in pre-invasive breast cancer, but is often downregulated with breast cancer progression. It is currently unknown whether psoriasin influences e...

    Authors: Ethan D Emberley, R Daniel Gietz, J Darren Campbell, Kent T HayGlass, Leigh C Murphy and Peter H Watson
    Citation: BMC Cancer 2002 2:28
  20. In cervical tumours the integration of human papilloma viruses (HPV) transcripts often results in the generation of transcripts that consist of hybrids of viral and cellular sequences. Mapping data using a var...

    Authors: Eugene Klimov, Svetlana Vinokourova, Elena Moisjak, Elian Rakhmanaliev, Vera Kobseva, Laimonis Laimins, Fjodor Kisseljov and Galina Sulimova
    Citation: BMC Cancer 2002 2:24
  21. This study was designed to evaluate if erythropoietin (EPO) is effective in the treatment of cancer related anemia, and if its effect remains unchanged when data are analyzed according to various clinical and ...

    Authors: Otavio Clark, Jared R Adams, Charles L Bennett and Benjamin Djulbegovic
    Citation: BMC Cancer 2002 2:23
  22. Drugs & used in anticancer chemotherapy have severe effects upon the cellular transcription and replication machinery. From in vitro studies it has become clear that these drugs can affect specific genes, as well...

    Authors: Antoinette C van der Kuyl, Remco van den Burg, Fokla Zorgdrager, John T Dekker, Jolanda Maas, Carel JM van Noesel, Jaap Goudsmit and Marion Cornelissen
    Citation: BMC Cancer 2002 2:21
  23. Loss or mutation of the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) has been found in breast cancer. However, whether or not decreased levels of functional M6P/IGF2R directly contrib...

    Authors: Zhihong Chen, Yinlin Ge, Natalie Landman and Jing X Kang
    Citation: BMC Cancer 2002 2:18
  24. Modulation of the expression of retinoic acid receptors (RAR) α and γ in adult rat prostate by testosterone (T) suggests that RAR signaling events might mediate some of the androgen effects on prostate cells.

    Authors: Ming-tang Li, Frank Richter, Chawnshang Chang, Robert J Irwin and Hosea FS Huang
    Citation: BMC Cancer 2002 2:16
  25. Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive activation of Akt, a kinase involved in cell survival...

    Authors: B Lynn Seely, Goli Samimi and Nicholas JG Webster
    Citation: BMC Cancer 2002 2:15
  26. Immunomagnetic enrichment followed by RT-PCR (immunobead RT-PCR) is an efficient methodology to identify disseminated carcinoma cells in the blood and bone marrow. The RT-PCR assays must be both specific for t...

    Authors: Michael Raynor, Sally-Anne Stephenson, David CA Walsh, Kenneth B Pittman and Alexander Dobrovic
    Citation: BMC Cancer 2002 2:14
  27. Surgical treatment of hypopharyngeal cancers with extension to the retrocricoid region generally requires a circumferential pharyngolaryngectomy followed by a reconstruction of the removed segment of the upper...

    Authors: Marco Benazzo, Antonio Occhini, Vanessa Rossi, Giuseppe Aresi and Mario Alessiani
    Citation: BMC Cancer 2002 2:13
  28. The timed-sequential chemotherapy regimen consisting of etoposide, mitoxantrone and cytarabine (EMA) is an effective therapy for relapsed or refractory acute myelogenous leukemia (AML). We postulated that gran...

    Authors: Xing-Yue He, Paul Elson, Brad Pohlman, Alan Lichtin, Mohamad Hussein, Steve Andresen and Matt Kalaycio
    Citation: BMC Cancer 2002 2:12
  29. 5-fluorouracil remains the standard therapy for patients with advanced/metastatic colorectal cancer. Pre-clinical studies have demonstrated the biological modulation of 5-fluorouracil by methotrexate and leuco...

    Authors: Shannon K Tomlinson, Susan A Melin, Vetta Higgs, Douglas R White, Paul Savage, Douglas Case and A William Blackstock
    Citation: BMC Cancer 2002 2:9
  30. The growth and metastasis of tumors depend on the development of an adequate blood supply via angiogenesis. Recent studies indicate that the inducible nitric oxide synthase (iNOS), vascular endothelial growth ...

    Authors: Chang Wei Feng, Li Dong Wang, Lian Hua Jiao, Bin Liu, Shu Zheng and Xin Ji Xie
    Citation: BMC Cancer 2002 2:8
  31. Acute Intermittent Porphyria is a genetic disorder of heme metabolism, characterized by increased levels of porphyrin precursors, δ-aminolevulinic acid (ALA) and porphobilinogen (PBG). ALA has been reported to...

    Authors: Adriana De Siervi, Elba S Vazquez, Carolina Rezaval, María V Rossetti and Alcira M del Batlle
    Citation: BMC Cancer 2002 2:6
  32. Bilharzia-associated bladder cancer (BAC) is a major health problem in countries where urinary schistosomiasis is endemic. Characterization of the genetic alterations in this cancer might enhance our understan...

    Authors: Imad Fadl-Elmula, Soili Kytola, Mona EL Leithy, Mohamed Abdel-Hameed, Nils Mandahl, Atif Elagib, Muntaser Ibrahim, Catharina Larsson and Sverre Heim
    Citation: BMC Cancer 2002 2:5
  33. Expression of the retinoic acid receptor β2 (RAR-β2), a putative tumor suppressor gene, is reduced in various human cancers, including squamous cell carcinomas (SCC) of the uterine cervix. The mechanism of the...

    Authors: Tatyana Ivanova, Anatolii Petrenko, Tatyana Gritsko, Svetlana Vinokourova, Ernest Eshilev, Vera Kobzeva, Fjodor Kisseljov and Natalia Kisseljova
    Citation: BMC Cancer 2002 2:4
  34. The present study aimed at evaluating the efficacy of Raltitrexed, a specific thymidilate synthase inhibitor, in patients with advanced colorectal cancer (ACC) in relapse (>8 weeks) after a prior response or d...

    Authors: Nicolas Tsavaris, Christos Kosmas, Maria Vadiaka and Christos Koufos
    Citation: BMC Cancer 2002 2:2
  35. Intraoperative radiation therapy (IORT) is one of the methods used to deliver a large single dose to the tumor tissue while reducing the exposure of normal surrounding tissue. However, the usefulness of intrao...

    Authors: Kenji Nemoto, Yoshihiro Ogawa, Haruo Matsushita, Ken Takeda, Yoshihiro Takai, Shogo Yamada and Toshihiro Kumabe
    Citation: BMC Cancer 2002 2:1
  36. The effectiveness of neoadjuvant treatment (NT) prior to resection of squamous cell carcinoma of the esophagus (SCCE) in terms of prolonged survival has not been proven by randomized trials. Facing considerabl...

    Authors: Joachim W Heise, Hansjörg Heep, Thomas Frieling, Mario Sarbia, Karl A Hartmann and Hans-Dietrich Röher
    Citation: BMC Cancer 2001 1:20

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