Volume 7 Supplement 1

24thAnnual Meeting of the National Cancer Institute of Mexico

Open Access

Major complications following exenteration in cases of pelvic malignancy: an 18-year experience

  • Horacio Lopez-Basave1Email author,
  • Flavia Morales-Vasquez2,
  • Esmeralda Ochoa1,
  • Patricia Ochoa1 and
  • Juan Ruiz-Molina1
BMC Cancer20077(Suppl 1):A37

https://doi.org/10.1186/1471-2407-7-S1-A37

Published: 5 February 2007

Background

Despite radical surgery, up to 33% of patients with rectal cancer will develop locoregional relapse. The management of these patients is particularly challenging. Surgery is the mainstay of treatment for those with a mobile recurrence. However, the majority of patients develop recurrence involving the pelvic wall. In these patients, multimodality therapy including radical surgery and intraoperative radiotherapy have been reported with 5-year survival of up to 31% and local control rates of 50–71%. The most important factor for obtaining long-term local control and survival is R0 resection. Extended surgery such as abdomino-sacral resection has not been popular because of 5-year survival rates of 16–31%, and significant postoperative morbidity. Re-recurrence following surgery occurs locally and in the lung, and remains a significant problem. In surgical treatment for local recurrence, surgeon-related factors are crucial. A staging system using degree of fixation and other prognostic factors should be developed so that appropriate treatment modalities are applied to each case. Despite radical surgery, up to 33% of patients with rectal cancer will develop locoregional relapse. The management of these patients is particularly challenging. Surgery is the mainstay of treatment for those with a mobile recurrence. However, the majority of patients develop recurrence involving the pelvic wall. In these patients, multimodality therapy including radical surgery and intraoperative radiotherapy have been reported with 5-year survival of up to 31% and local control rates of 50–71%. The most important factor for obtaining long-term local control and survival is R0 resection. Objective: To analyze the major complications after exenteration of colo-rectal and canal anal malignancies.

Materials and methods

Fifty nine patients with colo-rectal and canal anal malignancies underwent pelvic exenteration (PE) between 1984 and 2002. 48 patients underwent posterior pelvic exenteration PPE, 8 total pelvic exenteration and 3 posterior supraelevadora exenteration were performed.

Results

Major complications in the operative field involving the urinary tract infection or the wound dehiscence occurred in 29 patients (49.15%). The mortality rate was 3.3%. Major complications often occurred in advanced primary colorectal cancer affecting those with recurrent malignancies.

Conclusion

PE is more beneficial to patients with colorectal and canal anal cancer recurrence than to those with recurrent cancer. Knowledge of the inherent complications and morbidity of PE is essential.

Authors’ Affiliations

(1)
Department of Gastroenterology
(2)
Medical Oncology Department

Copyright

© Lopez-Basave et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.

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