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  1. Malignant mesotheliomas (MMs) are chemoresistant tumors related to exposure to asbestos fibers. The long latency period of MM (30-40 yrs) and heterogeneity of tumor presentation make MM difficult to diagnose a...

    Authors: Sherrill L Macura, Jeremy L Steinbacher, Maximilian B MacPherson, Melissa J Lathrop, Mutlay Sayan, Jedd M Hillegass, Stacie L Beuschel, Timothy N Perkins, Page C Spiess, Albert van der Vliet, Kelly J Butnor, Arti Shukla, Marilyn Wadsworth, Christopher C Landry and Brooke T Mossman
    Citation: BMC Cancer 2013 13:400
    Content type: Research article Published on:

  2. To identify predictors of long-term outcome for patients with clinical complete response (cCR) after definite chemoradiotherapy (CRT) or radiation therapy (RT) for oesophageal cancer (EC).

    Authors: Antoine Adenis, Emmanuelle Tresch, Sylvain Dewas, Olivier Romano, Mathieu Messager, Eric Amela, Stéphanie Clisant, Andrew Kramar, Christophe Mariette and Xavier Mirabel
    Citation: BMC Cancer 2013 13:413
    Content type: Research article Published on:

  3. Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading cause of cancer related death. Although the mortality rate of CRC is decreasing, finding novel targets for its therapy remains ...

    Authors: Xing-Hua Liang, Ling-ling Li, Geng-Gang Wu, Yi-Cheng Xie, Guang-Xian Zhang, Wei Chen, Hai-Feng Yang, Qi-Long Liu, Wen-Hong Li, Wen-guang He, Yan-Nian Huang and Xian-Cheng Zeng
    Citation: BMC Cancer 2013 13:412
    Content type: Research article Published on:

  4. Matrix metalloproteases and collagen are key participants in breast cancer, but their precise roles in cancer etiology and progression remain unclear. MMP13 helps regulate collagen structure and has been ascri...

    Authors: Seth W Perry, Jill M Schueckler, Kathleen Burke, Giuseppe L Arcuri and Edward B Brown
    Citation: BMC Cancer 2013 13:411
    Content type: Research article Published on:

  5. Molecular biomarkers are essential for monitoring treatment effects, predicting prognosis, and improving survival rate in oral squamous cell carcinoma. This study sought to verify the effectiveness of two inte...

    Authors: Masaki Nagata, Arhab A Noman, Kenji Suzuki, Hiroshi Kurita, Makoto Ohnishi, Tokio Ohyama, Nobutaka Kitamura, Takanori Kobayashi, Kohya Uematsu, Katsu Takahashi, Naoki Kodama, Tomoyuki Kawase, Hideyuki Hoshina, Nobuyuki Ikeda, Susumu Shingaki and Ritsuo Takagi
    Citation: BMC Cancer 2013 13:410
    Content type: Research article Published on:

  6. Breast cancer is the leading malignant disease among western women with incidence increasing over time. High mammographic density is a well-established risk factor for breast cancer. We explored trends in mamm...

    Authors: Sophie Sell Hellmann, Elsebeth Lynge, Walter Schwartz, Ilse Vejborg and Sisse Helle Njor
    Citation: BMC Cancer 2013 13:409
    Content type: Research article Published on:

  7. Prostate cancer is one of the leading causes of cancer related deaths. For diagnosis, predicting the outcome of the disease, and for assessing potential new biomarkers, pathologists and researchers routinely a...

    Authors: Giuseppe Lippolis, Anders Edsjö, Leszek Helczynski, Anders Bjartell and Niels Chr Overgaard
    Citation: BMC Cancer 2013 13:408
    Content type: Technical advance Published on:

  8. It is known that suboptimal adherence rates may affect endocrine treatments for breast cancer, but little information has been reported whether any efforts to improve treatment adherence have been successful. ...

    Authors: Volker Ziller, Ioannis Kyvernitakis, Dana Knöll, Astrid Storch, Olaf Hars and Peyman Hadji
    Citation: BMC Cancer 2013 13:407
    Content type: Research article Published on:

  9. Melanocortin-1 receptor (MC1R) gene variants are very common and are associated with melanoma risk, but their contribution to melanoma risk prediction compared with traditional risk factors is unknown. We aimed t...

    Authors: Anne E Cust, Chris Goumas, Kylie Vuong, John R Davies, Jennifer H Barrett, Elizabeth A Holland, Helen Schmid, Chantelle Agha-Hamilton, Bruce K Armstrong, Richard F Kefford, Joanne F Aitken, Graham G Giles, D Timothy Bishop, Julia A Newton-Bishop, John L Hopper, Graham J Mann…
    Citation: BMC Cancer 2013 13:406
    Content type: Research article Published on:

  10. Retrospective analyses in the West suggest that mutations in KRAS codons 61 and 146, BRAF, NRAS, and PIK3CA are negative predictive factors for cetuximab treatment in colorectal cancer patients. We developed a no...

    Authors: Hideaki Bando, Takayuki Yoshino, Eiji Shinozaki, Tomohiro Nishina, Kentaro Yamazaki, Kensei Yamaguchi, Satoshi Yuki, Shinya Kajiura, Satoshi Fujii, Takeharu Yamanaka, Katsuya Tsuchihara and Atsushi Ohtsu
    Citation: BMC Cancer 2013 13:405
    Content type: Technical advance Published on:

  11. The identification of new serum biomarkers with high sensitivity and specificity is an important priority in pancreatic cancer research. Through an extensive proteomics analysis of pancreatic cancer cell lines...

    Authors: Shalini Makawita, Apostolos Dimitromanolakis, Antoninus Soosaipillai, Ireena Soleas, Alison Chan, Steven Gallinger, Randy S Haun, Ivan M Blasutig and Eleftherios P Diamandis
    Citation: BMC Cancer 2013 13:404
    Content type: Research article Published on:

  12. Breast cancer is one of the leading causes of cancer deaths. Triple-negative breast cancer (TNBC), an immunophenotype defined by the absence of immunolabeling for estrogen receptor (ER), progesterone receptor ...

    Authors: David A Wiese, Tuddow Thaiwong, Vilma Yuzbasiyan-Gurkan and Matti Kiupel
    Citation: BMC Cancer 2013 13:403
    Content type: Research article Published on:

  13. Although implementation of temozolomide (TMZ) as a part of primary therapy for glioblastoma multiforme (GBM) has resulted in improved patient survival, the disease is still incurable. Previous studies have cor...

    Authors: Signe Regner Michaelsen, Ib Jarle Christensen, Kirsten Grunnet, Marie-Thérése Stockhausen, Helle Broholm, Michael Kosteljanetz and Hans Skovgaard Poulsen
    Citation: BMC Cancer 2013 13:402
    Content type: Research article Published on:

  14. Premature discontinuation of aromatase inhibitors (AIs) in breast cancer survivors compromises treatment outcomes. We aimed to evaluate whether patient-reported joint pain predicts premature discontinuation of...

    Authors: Kannie Chim, Sharon X Xie, Carrie T Stricker, Qing S Li, Robert Gross, John T Farrar, Angela DeMichele and Jun J Mao
    Citation: BMC Cancer 2013 13:401
    Content type: Research article Published on:

  16. The septin 9 gene (SEPT9) codes for a GTP-binding protein associated with filamentous structures and cytoskeleton formation. SEPT9 plays a role in multiple cancers as either an oncogene or a tumor suppressor g...

    Authors: Reinhold Wasserkort, Alexandra Kalmar, Gabor Valcz, Sandor Spisak, Manuel Krispin, Kinga Toth, Zsolt Tulassay, Andrew Z Sledziewski and Bela Molnar
    Citation: BMC Cancer 2013 13:398
    Content type: Research article Published on:

  17. To identify the radiation volume effect and significant dosimetric parameters for temporal lobe injury (TLI) and determine the radiation dose tolerance of the temporal lobe (TL) in nasopharyngeal carcinoma (NP...

    Authors: Ying Sun, Guan-Qun Zhou, Zhen-Yu Qi, Li Zhang, Shao-Min Huang, Li-Zhi Liu, Li Li, Ai-Hua Lin and Jun Ma
    Citation: BMC Cancer 2013 13:397
    Content type: Research article Published on:

  18. In recent decades it has been noted that trained dogs can detect specific odor molecules emitted by cancer cells. We have shown that the same odor can also be detected in the patient’s blood with high sensitiv...

    Authors: György Horvath, Håkan Andersson and Szilárd Nemes
    Citation: BMC Cancer 2013 13:396
    Content type: Research article Published on:

  19. Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be rel...

    Authors: Willemijn AM van Gemert, Jolein I Iestra, Albertine J Schuit, Anne M May, Tim Takken, Wouter B Veldhuis, Job van der Palen, Harriët Wittink, Petra HM Peeters and Evelyn M Monninkhof
    Citation: BMC Cancer 2013 13:395
    Content type: Study protocol Published on:

  20. Due to improved survival rate, gastric cancer (GC) patients have an increased risk of developing multiple primary cancer (MPC). The purpose of this study is to evaluate the clinicopathological features of MPC ...

    Authors: Chan Kim, Hong Jae Chon, Beodeul Kang, Kiyeol Kim, Hei-Cheul Jeung, Hyun Cheol Chung, Sung Hoon Noh and Sun Young Rha
    Citation: BMC Cancer 2013 13:394
    Content type: Research article Published on:

  21. A lot of empirical studies have been conducted to evaluate the prevalence of depression and anxiety among Chinese adults with cancer. We aimed to conduct a meta-analysis in order to evaluate the prevalence and...

    Authors: Yi-Long Yang, Li Liu, Yang Wang, Hui Wu, Xiao-Shi Yang, Jia-Na Wang and Lie Wang
    Citation: BMC Cancer 2013 13:393
    Content type: Research article Published on:

  22. The present study aimed to elucidate the clinicopathologic role of insulin-like growth factor-1 receptor (IGF1R) and IGF binding protein-3 (IGFBP3) in patients with pancreatic cancer. The function of IGFBP3 is...

    Authors: Toshiki Hirakawa, Masakazu Yashiro, Akihiro Murata, Keiichiro Hirata, Kenjiro Kimura, Ryosuke Amano, Nobuya Yamada, Bunzo Nakata and Kosei Hirakawa
    Citation: BMC Cancer 2013 13:392
    Content type: Research article Published on:

  24. Estrogen receptor (ER), progesterone receptor (PgR), HER2, and Ki67 have been increasingly evaluated by core needle biopsy (CNB) and are recommended for classifying breast cancer into molecular subtypes. Howev...

    Authors: Xiaosong Chen, Long Sun, Yan Mao, Siji Zhu, Jiayi Wu, Ou Huang, Yafen Li, Weiguo Chen, Jianhua Wang, Ying Yuan, Xiaochun Fei, Xiaolong Jin and Kunwei Shen
    Citation: BMC Cancer 2013 13:390
    Content type: Research article Published on:

  25. Global hypomethylation of repetitive DNA sequences is believed to occur early in tumorigenesis. There is a great interest in identifying factors that contribute to global DNA hypomethylation and associated can...

    Authors: Maki Inoue-Choi, Heather H Nelson, Kim Robien, Erland Arning, Teodoro Bottiglieri, Woon-Puay Koh and Jian-Min Yuan
    Citation: BMC Cancer 2013 13:389
    Content type: Research article Published on:

  26. Neoadjuvant radiochemotherapy has been proven superior to adjuvant treatment in reducing the rate of local recurrence without impairing cancer related survival or the incidence of distant metastases in standar...

    Authors: Leif Schiffmann, Gunther Klautke, Nicole Wedermann, Michael Gock, Friedrich Prall, Rainer Fietkau, Bettina Rau and Ernst Klar
    Citation: BMC Cancer 2013 13:388
    Content type: Research article Published on:

  27. Paediatric low-grade gliomas (LGGs) encompass a heterogeneous set of tumours of different histologies, site of lesion, age and gender distribution, growth potential, morphological features, tendency to progres...

    Authors: Samantha Mascelli, Annalisa Barla, Alessandro Raso, Sofia Mosci, Paolo Nozza, Roberto Biassoni, Giovanni Morana, Martin Huber, Cristian Mircean, Daniel Fasulo, Karin Noy, Gayle Wittemberg, Sara Pignatelli, Gianluca Piatelli, Armando Cama, Maria Luisa Garré…
    Citation: BMC Cancer 2013 13:387
    Content type: Research article Published on:

  28. Lipegfilgrastim is a novel glyco-pegylated granulocyte-colony stimulating factor in development for neutropenia prophylaxis in cancer patients receiving chemotherapy. This phase III, double-blind, randomized, ...

    Authors: Igor Bondarenko, Oleg A Gladkov, Reiner Elsaesser, Anton Buchner and Peter Bias
    Citation: BMC Cancer 2013 13:386
    Content type: Research article Published on:

  29. Current guidelines recommend anthracycline-based chemotherapy primarily with doxorubicin either as monotherapy or in combination with ifosfamide as the first-line treatment for most advanced STS subtypes. Ther...

    Authors: Sheetal Sharma, Shweta Takyar, Stephanie C Manson, Sarah Powell and Nicolas Penel
    Citation: BMC Cancer 2013 13:385
    Content type: Research article Published on:

  30. TNF-related apoptosis inducing ligand (TRAIL) belongs to the TNF-superfamily that induces apoptotic cell death in a wide range of neoplastic cells in vivo as well as in vitro. We identified two alternative TRAIL-...

    Authors: Andreas Krieg, Sabrina Mersch, Nadine Wolf, Nikolas H Stoecklein, Pablo E Verde, Jan Schulte am Esch 2nd, Sebastian Heikaus, Helmut E Gabbert, Wolfram T Knoefel and Csaba Mahotka
    Citation: BMC Cancer 2013 13:384
    Content type: Research article Published on:

  31. Heregulin (HRG; also known as neuregulin) is a ligand for ErbB3. One of its isotypes, HRG-β1, binds to ErbB3 and forms heterodimers with other ErbB family members, thereby enhancing the proliferation and tumor...

    Authors: Jinkyoung Kim, Hoiseon Jeong, Youngseok Lee, Chungyeul Kim, Hankyeom Kim and Aeree Kim
    Citation: BMC Cancer 2013 13:383
    Content type: Research article Published on:

  32. Cisplatin (CDDP) resistance in testicular germ cell tumors (GCTs) is still a clinical challenge, and one associated with poor prognosis. The purpose of this work was to test pazopanib, an anti-tumoral and anti...

    Authors: Mercè Juliachs, August Vidal, Xavier Garcia del Muro, Josep M Piulats, Enric Condom, Oriol Casanovas, Mariona Graupera, Jose R Germà, Alberto Villanueva and Francesc Viñals
    Citation: BMC Cancer 2013 13:382
    Content type: Research article Published on:

  33. The kidneys are a principal dose-limiting organ in radiotherapy for upper abdominal cancers. The current understanding of kidney radiation dose response is rudimentary. More precise dose-volume response models...

    Authors: Juanita Lopez-Gaitan, Martin A Ebert, Peter Robins, Jan Boucek, Trevor Leong, David Willis, Sean Bydder, Peter Podias, Gemma Waters, Brenton O’Mara, Julie Chu, Jessica Faggian, Luke Williams, Michael S Hofman and Nigel A Spry
    Citation: BMC Cancer 2013 13:381
    Content type: Study protocol Published on:

  34. Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioma stem cells (GSCs). Self-renewal is a complex biological process necessary for maintaining the gl...

    Authors: Jianhong Zhu, Handong Wang, Qing Sun, Xiangjun Ji, Lin Zhu, Zixiang Cong, Yuan Zhou, Huandong Liu and Mengliang Zhou
    Citation: BMC Cancer 2013 13:380
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:582

  35. Primary human papilloma virus (HPV) screening is more effective than cytology in reducing the risk of cervical cancer, but screening intervals should be extended in HPV-negative women. However, some Markov mod...

    Authors: Karl Ulrich Petry, Franziska Rinnau, Gerd Böhmer, Bettina Hollwitz, Alexander Luyten, Nina Buttmann, Martin Brünger and Thomas Iftner
    Citation: BMC Cancer 2013 13:379
    Content type: Research article Published on:

  36. Bronchial carcinoids are pulmonary neuroendocrine cell-derived tumors comprising typical (TC) and atypical (AC) malignant phenotypes. The 5-year survival rate in metastatic carcinoid, despite multiple current ...

    Authors: Reza Bayat Mokhtari, Sushil Kumar, Syed S Islam, Mehrdad Yazdanpanah, Khosrow Adeli, Ernest Cutz and Herman Yeger
    Citation: BMC Cancer 2013 13:378
    Content type: Research article Published on:

  37. Few studies have investigated the impact of urinary incontinence (UI) on health-related quality of life (HRQOL) among cancer survivors. UI is prevalent in the general population and can be both an indicator of...

    Authors: Alexandra J White, Bryce B Reeve, Ronald C Chen, Angela M Stover and Debra E Irwin
    Citation: BMC Cancer 2013 13:377
    Content type: Research article Published on:

  38. This paper presents the level of colorectal cancer awareness among multi-ethnic rural population in Malaysia.

    Authors: Tin Tin Su, Jun Yan Goh, Jackson Tan, Abdul Rahim Muhaimah, Yoganathan Pigeneswaren, Nasirin Sallamun Khairun, Abdul Wahab Normazidah, Devi Kunasekaran Tharisini and Hazreen Abd Majid
    Citation: BMC Cancer 2013 13:376
    Content type: Research article Published on:

  40. Drug resistance is a common cause of treatment failure in cancer patients and encompasses a multitude of different mechanisms. The aim of the present study was to identify drugs effective on multidrug resistan...

    Authors: Mårten Fryknäs, Joachim Gullbo, Xin Wang, Linda Rickardson, Malin Jarvius, Malin Wickström, Saadia Hassan, Claes Andersson, Mats Gustafsson, Gunnar Westman, Peter Nygren, Stig Linder and Rolf Larsson
    Citation: BMC Cancer 2013 13:374
    Content type: Research article Published on:

  42. New Zealand and Australia have the highest incidence and mortality rates from cutaneous melanoma in the world. The predominantly fair-skinned New Zealanders and Australians both enjoy sun, tanned skin and the ...

    Authors: Mary Jane Sneyd and Brian Cox
    Citation: BMC Cancer 2013 13:372
    Content type: Research article Published on:

  43. Uveal melanoma is a highly aggressive cancer with a strong propensity for metastasis, yet little is known about the biological mechanisms underlying this metastatic potential. We recently showed that most meta...

    Authors: Katie A Matatall, Olga A Agapova, Michael D Onken, Lori A Worley, Anne M Bowcock and J William Harbour
    Citation: BMC Cancer 2013 13:371
    Content type: Research article Published on:

  45. Thymidylate synthase (TYMS) is an important folate-dependent enzyme in DNA synthesis and an important target for cancer chemotherapy. High TYMS expression levels in tumors are generally associated with resista...

    Authors: Keisuke Gotanda, Takeshi Hirota, Nozomi Matsumoto and Ichiro Ieiri
    Citation: BMC Cancer 2013 13:369
    Content type: Research article Published on:

  46. We previously reported that Axin1 (Axin) is down-regulated in many cases of lung cancer, and X-ray irradiation increased Axin expression and inhibited lung cancer cells. The mechanisms, however, were not clear.

    Authors: Lian-He Yang, Yang Han, Guang Li, Hong-Tao Xu, Gui-Yang Jiang, Yuan Miao, Xiu-Peng Zhang, Huan-Yu Zhao, Zheng-Fan Xu, Maggie Stoecker, Endi Wang, Ke Xu and En-Hua Wang
    Citation: BMC Cancer 2013 13:368
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:268

  47. Investigating how the immune system functions during malignancies is crucial to developing novel therapeutic strategies. Natural killer (NK) cells, an important component of the innate immune system, play a vi...

    Authors: Rauf Bhat and Jean Rommelaere
    Citation: BMC Cancer 2013 13:367
    Content type: Research article Published on:

  48. The DEK protein is related to chromatin reconstruction and gene transcription, and plays an important role in cell apoptosis. High expression levels of the human DEK gene have been correlated with numerous hum...

    Authors: Lijuan Lin, Junjie Piao, Wenbin Gao, Yingshi Piao, Guang Jin, Yue Ma, Jinzi Li and Zhenhua Lin
    Citation: BMC Cancer 2013 13:366
    Content type: Research article Published on:

  49. We aimed to examine evidence for an infectious aetiology among teenagers and young adults (TYA) by analysing monthly seasonality of diagnosis and birth amongst 15–24 year olds diagnosed with cancer in England.

    Authors: Marlous van Laar, Sally E Kinsey, Susan V Picton and Richard G Feltbower
    Citation: BMC Cancer 2013 13:365
    Content type: Research article Published on:

  50. Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical...

    Authors: Lifen Deng, Zhenggang Ren, Qingan Jia, Weizhong Wu, Hujia Shen and Yanhong Wang
    Citation: BMC Cancer 2013 13:363
    Content type: Research article Published on:

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