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  1. The clinical course of human papillomavirus (HPV) associated with Bowenoid papulosis and condyloma acuminatum of anogenital tumors are still unknown. Here we evaluated molecules that are relevant to cellular p...

    Authors: Tsuyoshi Mitsuishi, Yukie Iwabu, Kenzo Tokunaga, Tetsutaro Sata, Takehiko Kaneko, Kuniaki Ohara, Ikuroh Ohsawa, Fumino Oda, Yuko Yamada, Seiji Kawana, Kohji Ozaki, Mayuka Nakatake and Osamu Yamada
    Citation: BMC Cancer 2010 10:118
  2. Based on the well-recognized etiological role of human papillomavirus (HPV) in cervical, anogenital and oropharyngeal carcinogenesis, a potential role of HPV in colorectal carcinogenesis has been suggested. Fo...

    Authors: Vanessa Deschoolmeester, Veerle Van Marck, Marc Baay, Christine Weyn, Peter Vermeulen, Eric Van Marck, Filip Lardon, Veronique Fontaine and Jan B Vermorken
    Citation: BMC Cancer 2010 10:117
  3. Some human cancers demonstrate cellular hierarchies in which tumor-initiating cancer stem cells generate progeny cells with reduced tumorigenic potential. This cancer stem cell population is proposed to be a s...

    Authors: Xiaohua Jiang, Ynnez Gwye, Darren Russell, Christine Cao, Dorothea Douglas, Long Hung, Heinrich Kovar, Timothy J Triche and Elizabeth R Lawlor
    Citation: BMC Cancer 2010 10:116
  4. Birth size, and particularly birth length, is positively associated with breast cancer risk in adulthood. The objective of this study was to examine whether birth size is associated with survival among breast ...

    Authors: Bjørn O Mæhle, Lars J Vatten and Steinar Tretli
    Citation: BMC Cancer 2010 10:115
  5. Breast cancer is one of the leading causes of women's death worldwide. It is important to discover a reliable biomarker for the detection of breast cancer. Plasma is the most ideal source for cancer biomarker ...

    Authors: Un-Beom Kang, Younghee Ahn, Jong Won Lee, Yong-Hak Kim, Joon Kim, Myeong-Hee Yu, Dong-Young Noh and Cheolju Lee
    Citation: BMC Cancer 2010 10:114
  6. Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous...

    Authors: Fernando SF Guimarães, Lucas F Andrade, Sharon T Martins, Ana PR Abud, Reginaldo V Sene, Carla Wanderer, Inés Tiscornia, Mariela Bollati-Fogolín, Dorly F Buchi and Edvaldo S Trindade
    Citation: BMC Cancer 2010 10:113
  7. Tumor-associated macrophages (TAMs) play an important role in growth, progression and metastasis of tumors. In non-small cell lung cancer (NSCLC), TAMs' anti-tumor or pro-tumor role is not determined. Macropha...

    Authors: Junliang Ma, Lunxu Liu, Guowei Che, Nanbin Yu, Fuqiang Dai and Zongbing You
    Citation: BMC Cancer 2010 10:112
  8. In the HPV FOCAL trial, we will establish the efficacy of hr-HPV DNA testing as a stand-alone screening test followed by liquid based cytology (LBC) triage of hr-HPV-positive women compared to LBC followed by ...

    Authors: Gina S Ogilvie, Dirk J van Niekerk, Mel Krajden, Ruth E Martin, Thomas G Ehlen, Kathy Ceballos, Stuart J Peacock, Laurie W Smith, Lisa Kan, Darrel A Cook, Wendy Mei, Gavin CE Stuart, Eduardo L Franco and Andrew J Coldman
    Citation: BMC Cancer 2010 10:111
  9. Circadian genes continue to gain attention as important transcriptional regulators with the potential to influence a variety of biological pathways, including many cancer-related processes. The core circadian ...

    Authors: Aaron E Hoffman, Tongzhang Zheng, Yue Ba, Richard G Stevens, Chun-Hui Yi, Derek Leaderer and Yong Zhu
    Citation: BMC Cancer 2010 10:110
  10. The discovery of small non-coding RNAs and the subsequent analysis of microRNA expression patterns in human cancer specimens have provided completely new insights into cancer biology. Genetic and epigenetic da...

    Authors: Ulrich Lehmann, Thomas Streichert, Benjamin Otto, Cord Albat, Britta Hasemeier, Henriette Christgen, Elisa Schipper, Ursula Hille, Hans H Kreipe and Florian Länger
    Citation: BMC Cancer 2010 10:109
  11. Over-expression of HER2 in a subset of breast cancers (HER2+) is associated with high histological grade and aggressive clinical course. Despite these distinctive features, the differences in response of HER2+ pa...

    Authors: David G Hicks, Bagi R Janarthanan, Ramya Vardarajan, Swati A Kulkarni, Thaer Khoury, Daniel Dim, G Thomas Budd, Brian J Yoder, Raymond Tubbs, Marshall T Schreeder, Noel C Estopinal, Rodney A Beck, Yanling Wang, Brian Z Ring, Robert S Seitz and Douglas T Ross
    Citation: BMC Cancer 2010 10:108
  12. Clusterin is a secreted glycoprotein that is upregulated in a variety of cell lines in response to stress, and enhances cell survival. A second nuclear isoform of clusterin that is associated with cell death h...

    Authors: Louise Flanagan, Lorna Whyte, Namita Chatterjee and Martin Tenniswood
    Citation: BMC Cancer 2010 10:107
  13. Multicellular tumour sphere models have been shown to closely mimic phenotype characteristics of in vivo solid tumours, or to allow in vitro propagation of cancer stem cells (CSCs). CSCs are usually characterized...

    Authors: Louis-Bastien Weiswald, Jean-Marc Guinebretière, Sophie Richon, Dominique Bellet, Bruno Saubaméa and Virginie Dangles-Marie
    Citation: BMC Cancer 2010 10:106
  14. Cancer, heart failure and stroke are among the most common causes of death worldwide. Investigation of the prognostic impact of each disease is important, especially for a better understanding of competing ris...

    Authors: Vasileios Askoxylakis, Christian Thieke, Sven T Pleger, Patrick Most, Judith Tanner, Katja Lindel, Hugo A Katus, Jürgen Debus and Marc Bischof
    Citation: BMC Cancer 2010 10:105
  15. Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatm...

    Authors: Anna Martirosyan, James W Clendening, Carolyn A Goard and Linda Z Penn
    Citation: BMC Cancer 2010 10:103
  16. The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with...

    Authors: Wen-Shan Liu, Chung-Han Hsin, Ying-Hsiang Chou, Jung-Tung Liu, Ming-Fang Wu, Szu-Wen Tseng, Jong-Kang Lee, Hsien-Chun Tseng, Tzu-Hwei Wang, Mao-Chang Su and Huei Lee
    Citation: BMC Cancer 2010 10:102
  17. An increasing number of studies show that genetic markers can aid in refining prognostic information and predicting the benefit from systemic therapy. Our goal was to develop a high throughput, cost-effective ...

    Authors: Debora Fumagalli, Patrick G Gavin, Yusuke Taniyama, Seung-Il Kim, Hyun-Joo Choi, Soonmyung Paik and Katherine L Pogue-Geile
    Citation: BMC Cancer 2010 10:101
  18. Previous population-based studies showed differences in international and within country colorectal cancer survival estimates, but few investigated the role of prognostic factors. Using a "high resolution appr...

    Authors: Maria Theresa Redaniel, Adriano Laudico, Maria Rica Mirasol-Lumague, Adam Gondos, Gemma Uy and Hermann Brenner
    Citation: BMC Cancer 2010 10:100
  19. BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clini...

    Authors: Adam Naguib, Panagiota N Mitrou, Laura J Gay, James C Cooke, Robert N Luben, Richard Y Ball, Alison McTaggart, Mark J Arends and Sheila A Rodwell
    Citation: BMC Cancer 2010 10:99
  20. In the present study, we determined the gene hypermethylation profiles of normal tissues adjacent to invasive breast carcinomas and investigated whether these are associated with the gene hypermethylation prof...

    Authors: Ilse Van der Auwera, Catherine Bovie, Cecilia Svensson, Xuan B Trinh, Ridha Limame, Peter van Dam, Steven J van Laere, Eric A van Marck, Luc Y Dirix and Peter B Vermeulen
    Citation: BMC Cancer 2010 10:97
  21. Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. For effective treatment, local control of the tumor is absolutely critical, because the chances of long term survival a...

    Authors: Claudia Blattmann, Susanne Oertel, Daniela Schulz-Ertner, Stefan Rieken, Sabine Haufe, Volker Ewerbeck, Andreas Unterberg, Irini Karapanagiotou-Schenkel, Stephanie E Combs, Anna Nikoghosyan, Marc Bischof, Oliver Jäkel, Peter Huber, Andreas E Kulozik and Jürgen Debus
    Citation: BMC Cancer 2010 10:96
  22. Invasiveness and metastasis are the most common characteristics of non small cell lung cancer (NSCLC) and causes of tumour-related morbidity and mortality. Mitogen-activated protein kinases (MAPKs) signalling ...

    Authors: Cheng-Jeng Tai, Alexander TH Wu, Jeng-Feng Chiou, Hsun-Jin Jan, Hon-Jian Wei, Chung-Huei Hsu, Che-Tong Lin, Wen-Ta Chiu, Cheng-Wen Wu, Horng-Mo Lee and Win-Ping Deng
    Citation: BMC Cancer 2010 10:95
  23. Remodeling of the extracellular matrix (ECM) has been implicated in ovarian cancer, and we hypothesize that these alterations may provide a better optical marker of early disease than currently available imagi...

    Authors: Oleg Nadiarnykh, Ronald B LaComb, Molly A Brewer and Paul J Campagnola
    Citation: BMC Cancer 2010 10:94
  24. The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding...

    Authors: Manuela Eppenberger, Inti Zlobec, Daniel Baumhoer, Luigi Terracciano and Alessandro Lugli
    Citation: BMC Cancer 2010 10:93
  25. Squamous cell carcinoma of the head and neck (SCCHN) are highly invasive tumours with frequent local and distant recurrence. Metastasis formation requires degradation of the extracellular matrix, which is fulf...

    Authors: Pamela Zengel, Diana Ramp, Brigitte Mack, Stefan Zahler, Alexander Berghaus, Bernd Muehlenweg, Olivier Gires and Suna Schmitz
    Citation: BMC Cancer 2010 10:92
  26. Glioblastoma multiforme (GBM) is the most aggressive and frequent brain tumor, albeit without cure. Although patient survival is limited to one year on average, significant variability in outcome is observed. ...

    Authors: Marie-Claude Amoureux, Béma Coulibaly, Olivier Chinot, Anderson Loundou, Philippe Metellus, Geneviève Rougon and Dominique Figarella-Branger
    Citation: BMC Cancer 2010 10:91
  27. The purpose of our study was to compare differences in the prognosis of breast cancer (BC) patients at high (H) risk or intermediate slightly (IS) increased risk based on family history and those without a fam...

    Authors: Laura Cortesi, Cristina Masini, Claudia Cirilli, Veronica Medici, Isabella Marchi, Giovanna Cavazzini, Giuseppe Pasini, Daniela Turchetti and Massimo Federico
    Citation: BMC Cancer 2010 10:90
  28. Ovarian cancer still has a relatively poor prognosis due to the frequent occurrence of drug resistance, making the identification of new therapeutic targets an important goal. We have studied the role of HOX gene...

    Authors: Richard Morgan, Lynn Plowright, Kevin J Harrington, Agnieszka Michael and Hardev S Pandha
    Citation: BMC Cancer 2010 10:89
  29. Single nucleotide polymorphism (SNP) 309 resulting in a T or G allele in the promoter of MDM2, the negative regulator of p53, has been suggested to affect cancer predisposition and age of onset, primarily in fema...

    Authors: Hui Wan Chua, Daniel Ng, Serena Choo, San San Lum, Huihua Li, Li Ying Soh, Kanaga Sabapathy and Adeline Seow
    Citation: BMC Cancer 2010 10:88
  30. Dendritic cells (DCs) isolated from tumor bearing animals or from individuals with solid tumors display functional abnormalities and the DC impairment has emerged as one mechanism for tumor evasion from the co...

    Authors: Vegard Tjomsland, Per Sandström, Anna Spångeus, Davorka Messmer, Johan Emilsson, Ursula Falkmer, Sture Falkmer, Karl-Eric Magnusson, Kurt Borch and Marie Larsson
    Citation: BMC Cancer 2010 10:87
  31. Cachexia is a common problem in patients (pts) suffering from upper gastrointestinal cancer. In addition, most of these patients suffer from malabsorption and stenosis of the gastrointestinal tract due to thei...

    Authors: Uwe Pelzer, Dirk Arnold, Mehmet Goevercin, Jens Stieler, Bernd Doerken, Hanno Riess and Helmut Oettle
    Citation: BMC Cancer 2010 10:86
  32. To improve the efficacy of first-line therapy for advanced non-small cell lung cancer (NSCLC), additional maintenance chemotherapy may be given after initial induction chemotherapy in patients who did not prog...

    Authors: Luis G Paz-Ares, Sedat Altug, Alexandra Thareau Vaury, Jesús Corral Jaime, Francesca Russo and Carla Visseren-Grul
    Citation: BMC Cancer 2010 10:85
  33. Aberrant ErbB receptor signaling is associated with various types of malignancies. γ-Tocotrienol is a member of the vitamin E family of compounds that displays potent anticancer activity that is associated wit...

    Authors: Sunitha V Bachawal, Vikram B Wali and Paul W Sylvester
    Citation: BMC Cancer 2010 10:84
  34. The hepaCAM gene encodes a new immunoglobulin-like cell adhesion molecule, and its expression is suppressed in a variety of human cancers. Additionally, hepaCAM possesses properties often observed in tumor sup...

    Authors: Yunfeng He, Xiaohou Wu, Chunli Luo, Lie Wang and Jie Lin
    Citation: BMC Cancer 2010 10:83
  35. The local and systemic activation and regulation of the immune system by malignant cells during carcinogenesis is highly complex with involvement of the innate and acquired immune system. Despite the fact that...

    Authors: Martin Grimm, Martin Gasser, Marco Bueter, Johanna Strehl, Johann Wang, Ekaterina Nichiporuk, Detlef Meyer, Christoph T Germer, Ana M Waaga-Gasser and Andreas Thalheimer
    Citation: BMC Cancer 2010 10:82
  36. Mitochondrial membrane complexes (MMCs) are key mediators of cellular oxidative phosphorylation, and inhibiting them could lead to cell death. No published data are available on the relative abundance of MMCs ...

    Authors: Mark M Aloysius, Abed M Zaitoun, Timothy E Bates, Mohammad Ilyas, Dumitru Constantin-Teodosiu, Brian J Rowlands and Dileep N Lobo
    Citation: BMC Cancer 2010 10:80
  37. Zic zinc finger proteins are present in the developing rodent meninges and are required for cell proliferation and differentiation of meningeal progenitors. Although human ZIC genes are known to be molecular mark...

    Authors: Jun Aruga, Yayoi Nozaki, Minoru Hatayama, Yuri S Odaka and Naoki Yokota
    Citation: BMC Cancer 2010 10:79
  38. Increased transcription of oncogenes like the epidermal growth factor receptor (EGFR) is frequently caused by amplification of the whole gene or at least of regulatory sequences. Aim of this study was to pinpo...

    Authors: Konstantin Agelopoulos, Burkhard Greve, Hartmut Schmidt, Heike Pospisil, Stefan Kurtz, Kai Bartkowiak, Antje Andreas, Marek Wieczorek, Eberhard Korsching, Horst Buerger and Burkhard Brandt
    Citation: BMC Cancer 2010 10:78
  39. Several different gene expression signatures have been proposed to predict response to therapy and clinical outcome in lung adenocarcinoma. Herein, we investigate if elements of published gene sets can be repr...

    Authors: Jens Neumann, Friedrich Feuerhake, Gian Kayser, Thorsten Wiech, Konrad Aumann, Bernward Passlick, Paul Fisch, Martin Werner and Axel zur Hausen
    Citation: BMC Cancer 2010 10:77
  40. HAX-1 has been described as a protein potentially involved in carcinogenesis and especially metastasis. Its involvement in regulation of apoptosis and cell migration along with some data indicating its overexp...

    Authors: Alicja Trebinska, Alina Rembiszewska, Karolina Ciosek, Konrad Ptaszynski, Sebastian Rowinski, Jolanta Kupryjanczyk, Janusz A Siedlecki and Ewa A Grzybowska
    Citation: BMC Cancer 2010 10:76
  41. The short arm of human chromosome 3 is involved in the development of many cancers including lung cancer. Three bona fide lung cancer tumor suppressor genes namely RBSP3 (AP20 region),NPRL2 and RASSF1A (LUCA regi...

    Authors: Vera N Senchenko, Ekaterina A Anedchenko, Tatiana T Kondratieva, George S Krasnov, Alexei A Dmitriev, Veronika I Zabarovska, Tatiana V Pavlova, Vladimir I Kashuba, Michael I Lerman and Eugene R Zabarovsky
    Citation: BMC Cancer 2010 10:75
  42. Gastric cancer is one of the most common malignancies worldwide and the second most common cause of cancer related death. Gene copy number alterations play an important role in the development of gastric cance...

    Authors: Siina Junnila, Arto Kokkola, Marja-Liisa Karjalainen-Lindsberg, Pauli Puolakkainen and Outi Monni
    Citation: BMC Cancer 2010 10:73
  43. The release of proteins from tumors can trigger an immune response in cancer patients involving T lymphocytes and B lymphocytes, which results in the generation of antibodies to tumor-derived proteins. Many st...

    Authors: Susanne Klein-Scory, Salwa Kübler, Hanna Diehl, Christina Eilert-Micus, Anke Reinacher-Schick, Kai Stühler, Bettina Warscheid, Helmut E Meyer, Wolff Schmiegel and Irmgard Schwarte-Waldhoff
    Citation: BMC Cancer 2010 10:70
  44. Chronic inflammation is considered to be implicated in the development of prostate cancer. In this study we are the first to investigate a potential association between variants in an autoimmune related region...

    Authors: Elizabeth A Tindall, Hoa N Hoang, Melissa C Southey, Dallas R English, John L Hopper, Graham G Giles, Gianluca Severi and Vanessa M Hayes
    Citation: BMC Cancer 2010 10:69
  45. There is increasing evidence that cancers contain their own stem-like cells, and particular attention has been paid to one subset of cancer-stem cells termed side population (SP). Stem cells under normal physi...

    Authors: Jun-Xia Cao, Yu-Xin Cui, Zi-Jie Long, Zhong-Min Dai, Ji-Yan Lin, Yi Liang, Fei-Meng Zheng, Yi-Xin Zeng and Quentin Liu
    Citation: BMC Cancer 2010 10:68

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