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  1. Authors: Vanessa Rosas-Camargo, José Luis Rodríguez-Díaz, Olynka Vega-Vega, Aniela Méndez-Reguera, Daniela Morales Espinosa, Jorge Luis Martínez-Tlahuel, Armando Gamboa-Domínguez and Oscar Arrieta

    Citation: BMC Cancer 2007 7(Suppl 1):A33

    Content type: Meeting abstract

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  2. Authors: Myrna Candelaria, Dolores Gallardo-Rincón, Claudia Arce, Lucely Cetina, Jose Luis Aguilar-Ponce, Oscar Arrieta, Alberto Serrano, Carlos Perez-Plasencia, Aurora Gonzalez-Fierro, Erik de la Cruz-Hernandez, Alma Revilla-Vazquez, Alma Chavez-Blanco, Catalina Trejo-Becerril, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Maria F Camargo…

    Citation: BMC Cancer 2007 7(Suppl 1):A27

    Content type: Meeting abstract

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  3. Liarozole fumarate (liarozole – R85246) is a novel compound with characteristics of both aromatase inhibitor (AI) and a retinoic acid metabolism blocking agent (RAMBA). Our objective was to determine the effec...

    Authors: Paul E Goss, Kathrin Strasser-Weippl, Shangle Qi and Haiqing Hu

    Citation: BMC Cancer 2007 7:26

    Content type: Research article

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  4. Human papillomaviruses (HPV) are the etiological agents of cervical cancer. The viral E7 protein plays a crucial role in viral oncogenesis. Many strategies have been explored to block the E7 oncoprotein activi...

    Authors: Maria Gabriella Donà, Colomba Giorgi and Luisa Accardi

    Citation: BMC Cancer 2007 7:25

    Content type: Research article

    Published on:

  5. PUMA is a pro-apoptotic Bcl-2 family member that has been shown to be involved in apoptosis in many cell types. We sought to ascertain whether induction of PUMA plays a crucial role in E2F-1-induced apoptosis ...

    Authors: Hongying Hao, Yanbin Dong, Maria T Bowling, Jorge G Gomez-Gutierrez, H Sam Zhou and Kelly M McMasters

    Citation: BMC Cancer 2007 7:24

    Content type: Research article

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  6. This study investigated the effects of hyperoxic treatment on growth, angiogenesis, apoptosis, general morphology and gene expression in DMBA-induced rat mammary tumors.

    Authors: Anette Raa, Christine Stansberg, Vidar M Steen, Rolf Bjerkvig, Rolf K Reed and Linda EB Stuhr

    Citation: BMC Cancer 2007 7:23

    Content type: Research article

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  7. PC cell-derived growth factor (PCDGF), also called epithelin/granulin precursor (GEP), is an 88-kDa secreted glycoprotein with the ability to stimulate cell proliferation in an autocrine fashion. In addition, ...

    Authors: Yulan Liu, Ling Xi, Guoning Liao, Wei Wang, Xun Tian, Beibei Wang, Gang Chen, Zhiqiang Han, Mingfu Wu, Shixuan Wang, Jianfeng Zhou, Gang Xu, Yunping Lu and Ding Ma

    Citation: BMC Cancer 2007 7:22

    Content type: Research article

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  8. Euploid chromosome balance is vitally important for normal development, but is profoundly changed in many tumors. Is each tumor dependent on its own structurally and numerically changed chromosome complement t...

    Authors: Maria Kost-Alimova, Eva Darai-Ramqvist, Wing Lung Yau, Agneta Sandlund, Ludmila Fedorova, Ying Yang, Irina Kholodnyuk, Yue Cheng, Maria Li Lung, Eric Stanbridge, George Klein and Stefan Imreh

    Citation: BMC Cancer 2007 7:21

    Content type: Research article

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  9. Many studies have found socioeconomic differentials in cancer survival. Previous studies have generally demonstrated poorer cancer survival with decreasing socioeconomic status but mostly used only ecological ...

    Authors: Andrew Sloggett, Harriet Young and Emily Grundy

    Citation: BMC Cancer 2007 7:20

    Content type: Research article

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  10. With current treatment strategies, nearly half of all medulloblastoma (MB) patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulati...

    Authors: André O von Bueren, Tarek Shalaby, Julia Rajtarova, Duncan Stearns, Charles G Eberhart, Lawrence Helson, Alexandre Arcaro and Michael A Grotzer

    Citation: BMC Cancer 2007 7:19

    Content type: Research article

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  11. Brain metastases (BM) represent one of the most frequent complications related to cancer, and their treatment continues to evolve. We have evaluated the activity, toxicity and the impact on Quality of Life (Qo...

    Authors: Raffaele Addeo, Michele Caraglia, Vincenzo Faiola, Elena Capasso, Bruno Vincenzi, Liliana Montella, Rosario Guarrasi, Luigi Caserta and Salvatore Del Prete

    Citation: BMC Cancer 2007 7:18

    Content type: Research article

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  12. Fos-related antigen 1 (FRA-1) is an immediate early gene encoding a member of AP-1 family of transcription factors involved in cell proliferation, differentiation, apoptosis, and other biological processes. fra-1

    Authors: Gennaro Chiappetta, Angelo Ferraro, Gerardo Botti, Mario Monaco, Rosa Pasquinelli, Emilia Vuttariello, Liliane Arnaldi, Maurizio Di Bonito, Giuseppe D'Aiuto, Giovanna Maria Pierantoni and Alfredo Fusco

    Citation: BMC Cancer 2007 7:17

    Content type: Research article

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  13. Glutathione S-transferases are a group of enzymes that participate in detoxification and defense mechanisms against toxic carcinogens and other compounds. These enzymes play an important role in human carcinogene...

    Authors: Sang-Geun Jang, Il-Jin Kim, Hio Chung Kang, Hye-Won Park, Sun-A Ahn, Hyun-Ju Yoon, Kun Kim, Hai-Rim Shin, Jin Soo Lee and Jae-Gahb Park

    Citation: BMC Cancer 2007 7:16

    Content type: Research article

    Published on:

  14. Hyperglycemia or hyperinsulinemia contributes to poorer endometrial cancer survival. It was shown that P-LAP/IRAP translocates to the plasma membrane in response to insulin stimulation. Recently, we demonstrat...

    Authors: Kiyosumi Shibata, Hiroaki Kajiyama, Kazuhiko Ino, Akihiro Nawa, Seiji Nomura, Shigehiko Mizutani and Fumitaka Kikkawa

    Citation: BMC Cancer 2007 7:15

    Content type: Research article

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  15. The incidence of breast cancer (BC) in Arab women is lower compared to the incidence in the Jewish population in Israel; still, it is the most common malignancy among Arab women. There is a steep rise in breas...

    Authors: Luna Kadouri, Dani Bercovich, Arava Elimelech, Israela Lerer, Michal Sagi, Gila Glusman, Chen Shochat, Sigal Korem, Tamar Hamburger, Aviram Nissan, Nahil Abu-Halaf, Muhmud Badrriyah, Dvorah Abeliovich and Tamar Peretz

    Citation: BMC Cancer 2007 7:14

    Content type: Research article

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  16. Non-islet cell tumor induced hypoglycemia (NICTH) is a very rare phenomenon, but even more so in gastrointestinal stromal tumors. It tends to present in large or metastatic tumors, and can appear at any time i...

    Authors: Guillermo A Escobar, William A Robinson, Trevor L Nydam, Drew C Heiple, Glen J Weiss, Linda Buckley, Rene Gonzalez and Martin D McCarter

    Citation: BMC Cancer 2007 7:13

    Content type: Case report

    Published on:

  17. Stromelysin-3 (ST-3) is over-expressed in the majority of human carcinomas including breast carcinoma. Due to its known effect in promoting tumour formation, but its impeding effect on metastasis, a dual role of ...

    Authors: Grit Kasper, Matthias Reule, Miriam Tschirschmann, Niels Dankert, Karen Stout-Weider, Roland Lauster, Evelin Schrock, Detlev Mennerich, Georg N Duda and Kerstin E Lehmann

    Citation: BMC Cancer 2007 7:12

    Content type: Research article

    Published on:

  18. High-resolution magic angle proton magnetic resonance spectroscopy (HR 1H MAS MRS) provides a broad metabolic mapping of intact tumor samples and allows for microscopy investigations of the samples after spectra ...

    Authors: Heidi Lyng, Beathe Sitter, Tone F Bathen, Line R Jensen, Kolbein Sundfør, Gunnar B Kristensen and Ingrid S Gribbestad

    Citation: BMC Cancer 2007 7:11

    Content type: Research article

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  19. The aim of the present paper was to analyse cancer mortality in the Umbria region, from 1978 to 2004. Mortality trends depend on a number of factors including exposures, health system interventions, and possib...

    Authors: Fabrizio Stracci, Antonio Canosa, Liliana Minelli, Anna Maria Petrinelli, Tiziana Cassetti, Carlo Romagnoli and Francesco La Rosa

    Citation: BMC Cancer 2007 7:10

    Content type: Research article

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  20. Breast radiotherapy as practised in the 1970s and 1980s resulted in significant myocardial exposure, and this was higher when the left breast was treated. It has been proposed that this difference might result...

    Authors: Rahul Roychoudhuri, David Robinson, Venkata Putcha, Jack Cuzick, Sarah Darby and Henrik Møller

    Citation: BMC Cancer 2007 7:9

    Content type: Research article

    Published on:

  21. YM529 is a newly developed nitrogen-containing bisphosphonate (BP) classified as a third-generation BP that shows a 100-fold greater potency against bone resorption than pamidronate, a second-generation BP. Th...

    Authors: Ryuichiro Koshimune, Motoi Aoe, Shinichi Toyooka, Fumikata Hara, Mamoru Ouchida, Masaki Tokumo, Yoshifumi Sano, Hiroshi Date and Nobuyoshi Shimizu

    Citation: BMC Cancer 2007 7:8

    Content type: Research article

    Published on:

  22. The lymphatic vessels play a crucial role in a variety of human cancers since tumour cell lymphatic invasion significantly influences prognosis. It is not known if pre-existing lymphatics are enough for tumour...

    Authors: Giuseppe Sarli, Francesco Sassi, Barbara Brunetti, Antonio Rizzo, Laura Diracca and Cinzia Benazzi

    Citation: BMC Cancer 2007 7:7

    Content type: Research article

    Published on:

  23. The apparent dominant model of colorectal cancer (CRC) inheritance in several large families, without mutations in known CRC susceptibility genes, suggests the presence of so far unidentified genes with strong...

    Authors: Anneke Middeldorp, Shantie Jagmohan-Changur, Quinta Helmer, Heleen M van der Klift, Carli MJ Tops, Hans FA Vasen, Peter Devilee, Hans Morreau, Jeanine J Houwing-Duistermaat, Juul T Wijnen and Tom van Wezel

    Citation: BMC Cancer 2007 7:6

    Content type: Research article

    Published on:

  24. The sodium/iodide symporter (NIS) is a plasma membrane glycoprotein that mediates iodide (I-) transport in the thyroid, lactating breast, salivary glands, and stomach. Whereas NIS expression and regulation have b...

    Authors: Áron Altorjay, Orsolya Dohán, Anna Szilágyi, Monika Paroder, Irene L Wapnir and Nancy Carrasco

    Citation: BMC Cancer 2007 7:5

    Content type: Research article

    Published on:

  25. We have previously reported the potentiation of radiotherapy by the soy isoflavone genistein for prostate cancer using prostate tumor cells in vitro and orthotopic prostate tumor models in vivo. However, when gen...

    Authors: Gilda G Hillman, Yu Wang, Mingxin Che, Julian J Raffoul, Mark Yudelev, Omer Kucuk and Fazlul H Sarkar

    Citation: BMC Cancer 2007 7:4

    Content type: Research article

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  26. Oesophageal carcinoma is one of the most common cancers worldwide. Its incidence and mortality rates show a wide geographical variation at a world and regional level. Geographic mapping of age-standardized, ca...

    Authors: Nuria Aragonés, Rebeca Ramis, Marina Pollán, Beatriz Pérez-Gómez, Diana Gómez-Barroso, Virginia Lope, Elena Isabel Boldo, Javier García-Pérez and Gonzalo López-Abente

    Citation: BMC Cancer 2007 7:3

    Content type: Research article

    Published on:

  27. After curative treatment for breast cancer women frequently attend scheduled follow-up examinations. Usually the follow-up is most frequent in the first 2–3 years (2–4 times a year); thereafter the frequency i...

    Authors: Merel L Kimman, Adri C Voogd, Carmen D Dirksen, Paul Falger, Pierre Hupperets, Kristien Keymeulen, Marlene Hebly, Cary Dehing, Philippe Lambin and Liesbeth J Boersma

    Citation: BMC Cancer 2007 7:1

    Content type: Study protocol

    Published on:

  28. Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting ...

    Authors: Yuhua Song, Santai Song, Dong Zhang, Yan Zhang, Liyong Chen, Lu Qian, Ming Shi, Huibin Zhao, Zefei Jiang and Ning Guo

    Citation: BMC Cancer 2006 6:298

    Content type: Research article

    Published on:

  29. Breast cancer is the second leading cause of cancer deaths in women in the United States. Although the causes of this disease are incompletely understood, oxidative DNA damage is presumed to play a critical ro...

    Authors: Simon G Nyaga, Althaf Lohani, Pawel Jaruga, Andrzej R Trzeciak, Miral Dizdaroglu and Michele K Evans

    Citation: BMC Cancer 2006 6:297

    Content type: Research article

    Published on:

  30. The development of esophageal squamous cell carcinoma (ESCC) progresses a multistage process, collectively known as precursor lesions, also called dysplasia (DYS) and carcinoma in situ (CIS), subsequent invasive ...

    Authors: Li-yan Xue, Nan Hu, Yong-mei Song, Shuang-mei Zou, Jian-zhong Shou, Lu-xia Qian, Li-qun Ren, Dong-mei Lin, Tong Tong, Zu-gen He, Qi-min Zhan, Philip R Taylor and Ning Lu

    Citation: BMC Cancer 2006 6:296

    Content type: Research article

    Published on:

  31. The development of targeted therapies has created a pressing clinical need for the rapid and robust molecular characterisation of cancers. We describe here the application of high-resolution melting analysis (...

    Authors: Michael Krypuy, Genni M Newnham, David M Thomas, Matthew Conron and Alexander Dobrovic

    Citation: BMC Cancer 2006 6:295

    Content type: Research article

    Published on:

  32. Drug resistance to chemotherapy is often associated with increased malignancy in neuroblastoma (NB). One explanation for the link between resistance and malignancy might be that resistance facilitates cancer p...

    Authors: Roman A Blaheta, Frederick H Daher, Martin Michaelis, Christoph Hasenberg, Eva M Weich, Dietger Jonas, Rouslan Kotchetkov, Hans Willhelm Doerr and Jindrich Cinatl jr

    Citation: BMC Cancer 2006 6:294

    Content type: Research article

    Published on:

  33. A large number of renal cancer patients shows poor or partial response to chemotherapy and the mechanisms have not been still understood. Multi-drug resistance is the principal mechanism by which many cancers ...

    Authors: Chiara Mignogna, Stefania Staibano, Vincenzo Altieri, Gaetano De Rosa, Giuseppe Pannone, Angela Santoro, Rosanna Zamparese, Massimino D'Armiento, Romualdo Rocchetti, Ernesto Mezza, Mario Nasti, Viviana Strazzullo, Vittorino Montanaro, Massimo Mascolo and Pantaleo Bufo

    Citation: BMC Cancer 2006 6:293

    Content type: Research article

    Published on:

  34. Wee1 kinase plays a critical role in maintaining G2 arrest through its inhibitory phosphorylation of cdc2. In previous reports, a pyridopyrimidine molecule PD0166285 was identified to inhibit Wee1 activity at ...

    Authors: Osamu Hashimoto, Masako Shinkawa, Takuji Torimura, Toru Nakamura, Karuppaiyah Selvendiran, Masaharu Sakamoto, Hironori Koga, Takato Ueno and Michio Sata

    Citation: BMC Cancer 2006 6:292

    Content type: Research article

    Published on:

  35. Breast cancer in women is increasingly frequent, and care is complex, onerous and expensive, all of which lend urgency to improvements in care. Quality measurement is essential to monitor effectiveness and to ...

    Authors: Howard M Schachter, Vasil Mamaladze, Gabriela Lewin, Ian D Graham, Melissa Brouwers, Margaret Sampson, Andra Morrison, Li Zhang, Peter O'Blenis and Chantelle Garritty

    Citation: BMC Cancer 2006 6:291

    Content type: Research article

    Published on:

  36. Prognosis of esophageal cancer is poor despite curative surgery. The chemokine receptor CXCR4 has been proposed to distinctly contribute to tumor growth, dissemination and local immune escape in a limited numb...

    Authors: Ines Gockel, Carl C Schimanski, Christian Heinrich, T Wehler, K Frerichs, Daniel Drescher, Christian von Langsdorff, Mario Domeyer, Stefan Biesterfeld, Peter R Galle, Theodor Junginger and Markus Moehler

    Citation: BMC Cancer 2006 6:290

    Content type: Research article

    Published on:

  37. To date, there is no standard treatment for unresectable malignant peritoneal mesothelioma; either best supportive care or systemic chemotherapy with palliative intent are accepted options.

    Authors: Gianpiero Fasola, Fabio Puglisi, Alessandro Follador, Marianna Aita, Silvia Di Terlizzi and Ornella Belvedere

    Citation: BMC Cancer 2006 6:289

    Content type: Case report

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  38. Basic research of gefitinib (Iressa, ZD1839) has demonstrated the combination effects of gefitinib and chemotherapy were sequence-dependent. To evaluate the efficacy of sequential administration of gefitinib f...

    Authors: Jian Ming Xu, Yu Han, Yue Min Li, Chuan Hua Zhao, Yan Wang and Angelo Paradiso

    Citation: BMC Cancer 2006 6:288

    Content type: Research article

    Published on:

  39. Continuous exposure to various environmental carcinogens and genetic polymorphisms of xenobiotic-metabolizing enzymes (XME) are associated with many types of human cancers, including esophageal squamous cell c...

    Authors: Zemin Wang, Lili Tang, Guiju Sun, Yuntian Tang, Yin Xie, Shaokang Wang, Xu Hu, Weimin Gao, Stephen B Cox and Jia-Sheng Wang

    Citation: BMC Cancer 2006 6:287

    Content type: Research article

    Published on:

  40. Chronic injury deregulates cellular homeostasis and induces a number of alterations leading to disruption of cellular processes such as cell cycle checkpoints and apoptosis, driving to carcinogenesis. The stre...

    Authors: Cynthia C Castronuovo, Paula A Sacca, Roberto Meiss, Fabiana A Caballero, Alcira Batlle and Elba S Vazquez

    Citation: BMC Cancer 2006 6:286

    Content type: Research article

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  41. Anti-angiogenic treatment is believed to have at least cystostatic effects in highly vascularized tumours like pancreatic cancer. In this study, the treatment effects of the angiogenesis inhibitor Cilengitide ...

    Authors: Helmut Friess, Jan M Langrehr, Helmut Oettle, Jochen Raedle, Marco Niedergethmann, Christian Dittrich, Dieter K Hossfeld, Herbert Stöger, Bart Neyns, Peter Herzog, Pascal Piedbois, Frank Dobrowolski, Werner Scheithauer, Robert Hawkins, Frieder Katz, Peter Balcke…

    Citation: BMC Cancer 2006 6:285

    Content type: Research article

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  42. The aim of this paper is to analyze changes in thyroid cancer incidence trends in Lithuania during the period 1978–2003 using joinpoint regression models, with special attention to the period 1993–2003.

    Authors: Giedre Smailyte, Edita Miseikyte-Kaubriene and Juozas Kurtinaitis

    Citation: BMC Cancer 2006 6:284

    Content type: Research article

    Published on:

  43. Nasopharyngeal carcinomas (NPC) are consistently associated with the Epstein-Barr virus (EBV). Their malignant epithelial cells contain the viral genome and express several antigenic viral proteins. However, t...

    Authors: Cécile Keryer-Bibens, Catherine Pioche-Durieu, Cécile Villemant, Sylvie Souquère, Nozomu Nishi, Mitsuomi Hirashima, Jaap Middeldorp and Pierre Busson

    Citation: BMC Cancer 2006 6:283

    Content type: Research article

    Published on:

  44. Recently it has been reported that, toll-like receptors (TLRs) are expressed on a series of tumor cells, such as colon cancer, breast cancer, prostate cancer, melanoma and lung cancer. Although some cancer cel...

    Authors: Ferdaus Hassan, Shamima Islam, Gantsetseg Tumurkhuu, Yoshikazu Naiki, Naoki Koide, Isamu Mori, Tomoaki Yoshida and Takashi Yokochi

    Citation: BMC Cancer 2006 6:281

    Content type: Research article

    Published on:

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