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  1. Familial Adenomatous Polyposis (FAP) is caused by germline mutations in the APC (Adenomatous Polyposis Coli) gene. The vast majority of APC mutations are point mutations or small insertions / deletions which lead...

    Authors: Markos Mihalatos, Angela Apessos, Hans Dauwerse, Voula Velissariou, Aristidis Psychias, Alexander Koliopanos, Konstantinos Petropoulos, John K Triantafillidis, Ioannis Danielidis, George Fountzilas, Niki J Agnantis and Georgios Nasioulas

    Citation: BMC Cancer 2005 5:40

    Content type: Research article

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  2. Aberrant expression of myeloid antigens (MyAgs) on acute lymphoblastic leukemia (ALL) cells is a well-documented phenomenon, although its regulating mechanisms are unclear. MyAgs in ALL are interpreted e.g. as...

    Authors: Tomas Kalina, Martina Vaskova, Ester Mejstrikova, Jozef Madzo, Jan Trka, Jan Stary and Ondrej Hrusak

    Citation: BMC Cancer 2005 5:38

    Content type: Research article

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  3. After surgical intervention with curative intention in specialised centres the five-year survival of patients with carcinoma of the exocrine pancreas is only 15%. The ESPAC-1 trial showed an increased five-yea...

    Authors: HP Knaebel, A Märten, J Schmidt, K Hoffmann, C Seiler, K Lindel, H Schmitz-Winnenthal, S Fritz, T Herrmann, H Goldschmidt, R Krempien, U Mansmann, J Debus, V Diehl and MW Büchler

    Citation: BMC Cancer 2005 5:37

    Content type: Study protocol

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  4. The role of genes involved in the control of progression from the G1 to the S phase of the cell cycle in melanoma tumors in not fully known. The aim of our study was to analyse mutations in TP53, CDKN1A, CDKN2...

    Authors: José Luis Soto, Carmen M Cabrera, Salvio Serrano and Miguel Ángel López-Nevot

    Citation: BMC Cancer 2005 5:36

    Content type: Research article

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  5. There appear to be geographical differences in decisions to perform mastectomy or breast conserving surgery for early-stage breast cancer. This study was carried out to evaluate general surgeons' preferences i...

    Authors: Massoome Najafi, Mandana Ebrahimi, Ahmad Kaviani, Esmat Hashemi and Ali Montazeri

    Citation: BMC Cancer 2005 5:35

    Content type: Research article

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  6. There are very few studies that report the incidence of acute leukemias in children in Latin America. This work assesses the incidence of acute leukemias, between 1996 and 2000, in children from 0–14 years old...

    Authors: Juan Manuel Mejía-Aranguré, Miguel Bonilla, Rodolpho Lorenzana, Servando Juárez-Ocaña, Gladys de Reyes, María Luisa Pérez-Saldivar, Guadalupe González-Miranda, Roberto Bernáldez-Ríos, Antonio Ortiz-Fernández, Manuel Ortega-Alvarez, María del Carmen Martínez-García and Arturo Fajardo-Gutiérrez

    Citation: BMC Cancer 2005 5:33

    Content type: Research article

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  7. HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. Large studies have however failed to demonstrate any significant b...

    Authors: Pierre A Robe, Minh Nguyen-Khac, Olivier Jolois, Bernard Rogister, Marie-Paule Merville and Vincent Bours

    Citation: BMC Cancer 2005 5:32

    Content type: Research article

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  8. There is controversy about the effect of the timing of intraperitoneal administration of chemotherapeutic agents on the healing of intestinal anastomosis. We have investigated the effect on intestinal wound he...

    Authors: Ali Uzunkoy, Cengiz Bolukbas, Mehmet Horoz, Fusun F Bolukbas and Abdurrahim Kocyigit

    Citation: BMC Cancer 2005 5:31

    Content type: Research article

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  9. Few data are available on compliance and safety of adjuvant chemotherapy when indicated in elderly breast cancer patients; CMF (cyclophosphamide, methotrexate, fluorouracil) can be reasonably considered the mo...

    Authors: Ermelinda De Maio, Adriano Gravina, Carmen Pacilio, Gerardo Amabile, Vincenzo Labonia, Gabriella Landi, Francesco Nuzzo, Emanuela Rossi, Giuseppe D'Aiuto, Immacolata Capasso, Massimo Rinaldo, Brunello Morrica, Massimo Elmo, Massimo Di Maio, Francesco Perrone and Andrea de Matteis

    Citation: BMC Cancer 2005 5:30

    Content type: Research article

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  10. Activation of the phosphatidylinositol 3-kinase (PI3K) through mutational inactivation of PTEN tumour suppressor gene is common in diverse cancer types, but rarely reported in gastric cancer. Recently, mutations ...

    Authors: Vivian Sze Wing Li, Chi Wai Wong, Tsun Leung Chan, Agnes Sze Wah Chan, Wei Zhao, Kent-Man Chu, Samuel So, Xin Chen, Siu Tsan Yuen and Suet Yi Leung

    Citation: BMC Cancer 2005 5:29

    Content type: Research article

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  11. Sentinel lymph node (SLN) biopsy is an effective tool for axillary staging in patients with invasive breast cancer. This procedure has been recently proposed as part of the treatment for patients with ductal c...

    Authors: Giorgio Zavagno, Paolo Carcoforo, Renato Marconato, Zeno Franchini, Giuliano Scalco, Paolo Burelli, Paolo Pietrarota, Mario Lise, Roberto Mencarelli, Giovanni Capitanio, Andrea Ballarin, Maria Elena Pierobon, Giorgia Marconato and Donato Nitti

    Citation: BMC Cancer 2005 5:28

    Content type: Research article

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  12. The advent of prostate specific antigen (PSA) testing in the United States of America (USA) has led to a dramatic increase in the incidence of prostate cancer in the United States as well as the number of men ...

    Authors: Richard M Hoffman, S Noell Stone, David Espey and Arnold L Potosky

    Citation: BMC Cancer 2005 5:27

    Content type: Research article

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  13. Epidemiological studies have shown that individuals who regularly consume NSAIDs have lower rates of mortality associated with colorectal cancer. Because COX-2 inhibitors prevent tumor growth through some mech...

    Authors: Hirotoshi Kobayashi, Hiroyuki Uetake, Tetsuro Higuchi, Masayuki Enomoto and Kenichi Sugihara

    Citation: BMC Cancer 2005 5:26

    Content type: Research article

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  14. Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge...

    Authors: Vasilis Karavasilis, Vasiliki Malamou-Mitsi, Evangelos Briasoulis, Elena Tsanou, Evangelia Kitsou, Haralambos Kalofonos, George Fountzilas, Theodore Fotsis and Nicholas Pavlidis

    Citation: BMC Cancer 2005 5:25

    Content type: Research article

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  15. To identify early symptoms of familial adenomatous polyposis with a view to improve early diagnosis and treatment. Diagnosis on the basis of genetic testing is usually limited to where there is a known family ...

    Authors: Roland S Croner, Wolfgang M Brueckl, Bertram Reingruber, Werner Hohenberger and Klaus Guenther

    Citation: BMC Cancer 2005 5:24

    Content type: Research article

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  16. Upper urothelial cancer (UUC), i.e. transitional cell carcinomas of the renal pelvis and the ureter, occur at an increased frequency in patients with hereditary nonpolyposis colorectal cancer (HNPCC). Defectiv...

    Authors: Kajsa M Ericson, Anna P Isinger, Björn L Isfoss and Mef C Nilbert

    Citation: BMC Cancer 2005 5:23

    Content type: Research article

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  17. Desmoid tumour is a benign, non metastasising neoplasm characterised by an elevated deposition of organic macromolecules in the extracellular matrix (ECM). The matrix metalloproteinases (MMPs) are a family of ...

    Authors: Chiara Balducci, Cinzia Lilli, Giordano Stabellini, Lorella Marinucci, Giammario Giustozzi, Alessio Becchetti, Lucio Cagini and Paola Locci

    Citation: BMC Cancer 2005 5:22

    Content type: Research article

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  18. Patients with metastatic breast cancer (MBC) are frequently exposed to high cumulative doses of anthracyclines and are at risk of resistance and cardiotoxicity. This phase II trial evaluated the efficacy and t...

    Authors: Se Hoon Park, Eun Kyung Cho, Soo-Mee Bang, Dong Bok Shin, Jae Hoon Lee and Young Don Lee

    Citation: BMC Cancer 2005 5:21

    Content type: Research article

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  19. Leukemia is a clonal disorder characterized by uncontrolled proliferation of haematopoietic cells, and represents the most common form of cancer in children. Advances in therapy for childhood leukemia have rel...

    Authors: Silvija Jarnjak-Jankovic, Rolf D Pettersen, Stein Sæbøe-Larssen, Finn Wesenberg and Gustav Gaudernack

    Citation: BMC Cancer 2005 5:20

    Content type: Research article

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  20. p53 mutations are relatively uncommon in medulloblastoma, but abnormalities in this cell cycle pathway have been associated with anaplasia and worse clinical outcomes. We correlated p53 protein expression with...

    Authors: Charles G Eberhart, Aneeka Chaudhry, Richard W Daniel, Leila Khaki, Keerti V Shah and Patti E Gravitt

    Citation: BMC Cancer 2005 5:19

    Content type: Research article

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  21. There is a growing awareness among providers of the symptom burden experienced by cancer patients. Systematic symptom screening is difficult. Our plan was to evaluate a technology-based symptom screening proce...

    Authors: Ma'n Abdullah, Dale E Theobald, Donna Butler, Kurt Kroenke, Anthony Perkins, Sara Edgerton and William M Dugan Jr

    Citation: BMC Cancer 2005 5:18

    Content type: Research article

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  22. The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of t...

    Authors: Meghan Webb, Ethan D Emberley, Michael Lizardo, Salem Alowami, Gefei Qing, Abdullah Alfia'ar, Linda J Snell-Curtis, Yulian Niu, Alberto Civetta, Yvonne Myal, Robert Shiu, Leigh C Murphy and Peter H Watson

    Citation: BMC Cancer 2005 5:17

    Content type: Research article

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  23. Serine-threonine kinases of the Raf family (A-Raf, B-Raf, C-Raf) are central players in cellular signal transduction, and thus often causally involved in the development of cancer when mutated or over-expresse...

    Authors: Ivaylo Gentschev, Joachim Fensterle, Andreas Schmidt, Tamara Potapenko, Jakob Troppmair, Werner Goebel and Ulf R Rapp

    Citation: BMC Cancer 2005 5:15

    Content type: Research article

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  24. Modeling the complex development and growth of tumor angiogenesis using mathematics and biological data is a burgeoning area of cancer research. Architectural complexity is the main feature of every anatomical...

    Authors: Fabio Grizzi, Carlo Russo, Piergiuseppe Colombo, Barbara Franceschini, Eldo E Frezza, Everardo Cobos and Maurizio Chiriva-Internati

    Citation: BMC Cancer 2005 5:14

    Content type: Research article

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  25. Recent studies relating to the association between DNA repair-gene polymorphisms and colorectal cancer risk would, to the best of our knowledge, appear to be very limited. This study was designed to examine th...

    Authors: Chih-Ching Yeh, Fung-Chang Sung, Reiping Tang, Chung Rong Chang-Chieh and Ling-Ling Hsieh

    Citation: BMC Cancer 2005 5:12

    Content type: Research article

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  26. Suction drains are routinely used after modified radical mastectomy and are an important factor contributing to increased hospital stay as the patients are often discharged only after their removal. Amongst va...

    Authors: Chintamani, Vinay Singhal, JP Singh, Anju Bansal and Sunita Saxena

    Citation: BMC Cancer 2005 5:11

    Content type: Research article

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  27. Both paclitaxel (P) and carboplatin (C) have significant activity in non-small cell lung cancer (NSCLC). The weekly administration of P is active, dose intense, and has a favorable toxicity profile. We retrosp...

    Authors: Perran F Yumuk, Nazim S Turhal, Mahmut Gumus, Nilgun F Hatabay, Orhan Turken, Alper Ozkan, Taflan Salepci, Mehmet Aliustaoglu and Rengin Ahiskali

    Citation: BMC Cancer 2005 5:10

    Content type: Research article

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  28. Insulin-like growth factor binding protein (IGFBP)-3 functions as a carrier of insulin-like growth factors (IGFs) in circulation and a mediator of the growth suppression signal in cells. There are two reported...

    Authors: Tadashi Hanafusa, Toshiyuki Shinji, Hidenori Shiraha, Kazuhiro Nouso, Yoshiaki Iwasaki, Eichiro Yumoto, Toshiro Ono and Norio Koide

    Citation: BMC Cancer 2005 5:9

    Content type: Research article

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  29. Molecular markers for localized colon tumours and for prognosis following therapy are needed. Proteomics research is currently producing numerous biomarker studies with clinical potential. We investigate the p...

    Authors: Jakob Albrethsen, Rikke Bøgebo, Steen Gammeltoft, Jesper Olsen, Benny Winther and Hans Raskov

    Citation: BMC Cancer 2005 5:8

    Content type: Research article

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  30. Both Taxotere and Capecitabine have shown anti-cancer activity against various cancers including prostate cancer. In combination, Taxotere plus Capecitabine has demonstrated higher anti-cancer activity in adva...

    Authors: Yiwei Li, Maha Hussain, Sarah H Sarkar, James Eliason, Ran Li and Fazlul H Sarkar

    Citation: BMC Cancer 2005 5:7

    Content type: Research article

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  31. We have previously demonstrated that NF-Y and Sp1 interact with the human telomerase RNA (hTR) promoter and play a central role in its regulation. We have also shown that pRB activates the hTR promoter, but th...

    Authors: Jiangqin Zhao, Alan Bilsland, Katrina Jackson and W Nicol Keith

    Citation: BMC Cancer 2005 5:6

    Content type: Research article

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  32. TRAIL (tumor necrosis factor related apoptosis inducing ligand) is an apoptosis inducing ligand with high specificity for malignant cell systems. Combined treatment modalities using TRAIL and cytotoxic drugs reve...

    Authors: Patrizia Marini, Angelika Schmid, Verena Jendrossek, Heidrun Faltin, Peter T Daniel, Wilfried Budach and Claus Belka

    Citation: BMC Cancer 2005 5:5

    Content type: Research article

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  33. Tumor development remains one of the major obstacles following organ transplantation. Immunosuppressive drugs such as cyclosporine and tacrolimus directly contribute to enhanced malignancy, whereas the influen...

    Authors: Tobias Engl, Jasmina Makarević, Borna Relja, Iyad Natsheh, Iris Müller, Wolf-Dietrich Beecken, Dietger Jonas and Roman A Blaheta

    Citation: BMC Cancer 2005 5:4

    Content type: Research article

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  34. Prostate cancer is a significant health problem among American men. Treatment strategies for androgen-independent cancer are currently not available. Tumor necrosis factor-related apoptosis-inducing ligand (Ap...

    Authors: Ahmed El-Zawahry, John McKillop and Christina Voelkel-Johnson

    Citation: BMC Cancer 2005 5:2

    Content type: Research article

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  35. Recently, several members of a vertebrate protein family containing a six trans-membrane (6TM) domain and involved in apoptosis and cancer (e.g. STEAP, STAMP1, TSAP6), have been identified in Golgi and cytopla...

    Authors: Luis Sanchez-Pulido, Ana M Rojas, Alfonso Valencia, Carlos Martinez-A and Miguel A Andrade

    Citation: BMC Cancer 2004 4:98

    Content type: Research article

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  36. Colorectal cancer is a common malignancy of the gastrointestinal tract. It is the second cancer cause of death in females and third in males. Production of prolactin has been reported with several tumours. How...

    Authors: Ahmad Reza Soroush, Hosein Mahmood zadeh, Mehrnush Moemeni, Behnam Shakiba and Sara Elmi

    Citation: BMC Cancer 2004 4:97

    Content type: Research article

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  37. Splenic metastases occur in rare cases with a few case reports of patients in the literature. Generally, splenic metastases mean late dissemination of a disease. Solitary splenic metastases from solid tumors a...

    Authors: Yang Seok Koh, Jung Chul Kim and Chol Kyoon Cho

    Citation: BMC Cancer 2004 4:96

    Content type: Case report

    Published on:

  38. We describe a patient who underwent transurethral resection of the prostate for urinary obstructive symptoms and had histological findings of adenocarcinoma of the prostate with prostatic localization of chron...

    Authors: Riccardo Ballario, Paolo Beltrami, Stefano Cavalleri, Lorenzo Ruggera, Maria Grazia Zorzi and Walter Artibani

    Citation: BMC Cancer 2004 4:95

    Content type: Case report

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  39. Uncertainty regarding comorbid illness, and ability to tolerate aggressive therapy has led to minimal enrollment of elderly cancer patients into clinical trials and often substandard treatment. Increasingly, c...

    Authors: William H Hall, Ramanathan Ramachandran, Samir Narayan, Ashesh B Jani and Srinivasan Vijayakumar

    Citation: BMC Cancer 2004 4:94

    Content type: Software

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  40. Previous research has indicated that at various organ sites there is a subset of adenocarcinomas that is regulated by beta-adrenergic and arachidonic acid-mediated signal transduction pathways. We wished to de...

    Authors: Howard K Plummer III, Qiang Yu, Yavuz Cakir and Hildegard M Schuller

    Citation: BMC Cancer 2004 4:93

    Content type: Research article

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  41. Colon adenocarcinomas are refractory to a number of widely used anticancer agents. Multifactorial mechanisms have been implicated in this intrinsically resistant phenotype, including deregulation of cell death...

    Authors: Raffaella Ravizza, Marzia B Gariboldi, Laura Passarelli and Elena Monti

    Citation: BMC Cancer 2004 4:92

    Content type: Research article

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  42. Almost one-third of all penile metastases are detected at the same time as a primary tumor, whereas the remaining two-thirds are detected a mean of 18 months after the discovery of the primary tumor. Cutaneous...

    Authors: Giorgio Pomara, Ilaria Pastina, Maurizio Simone, Paolo Casale, Gabriella Marchetti and Francesco Francesca

    Citation: BMC Cancer 2004 4:90

    Content type: Case report

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  43. Hepatocellular carcinoma is a common malignancy for which chronic hepatitis B infection has been defined as the most common etiologic factor. The most frequent metastatic sites are the lung, bone, lymphatics, ...

    Authors: Şahin Çoban, Osman Yüksel, Seyfettin Köklü, Koray Ceyhan, Meltem Baykara and Abdulkadir Dökmeci

    Citation: BMC Cancer 2004 4:89

    Content type: Case report

    Published on:

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