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  1. Tissue Factor (TF) forms a proteolytically active complex together with coagulation factor VIIa (FVIIa) and functions as the trigger of blood coagulation or alternatively activates cell signaling. We recently ...

    Authors: Oskar Eriksson, Ã…sa Thulin, Anna Asplund, Geeta Hegde, Sanjay Navani and Agneta Siegbahn
    Citation: BMC Cancer 2016 16:341
    Content type: Research article Published on:

  2. Along with the marked increase in early gastric cancer (EGC) in the Eastern countries, there has been an effort to adopt the sentinel node concept in EGC to preserve gastric function and reduce the occurrence ...

    Authors: Ji Yeon Park, Young-Woo Kim, Keun Won Ryu, Byung-Ho Nam, Young Joon Lee, Sang Ho Jeong, Ji-Ho Park, Hoon Hur, Sang-Uk Han, Jae Seok Min, Ji Yeong An, Woo Jin Hyung, Gyu Seok Cho, Gui Ae Jeong, Oh Jeong, Young Kyu Park…
    Citation: BMC Cancer 2016 16:340
    Content type: Study protocol Published on:

  3. Patients with metastatic colorectal cancer whose disease has progressed on oxaliplatin- and irinotecan-containing regimens may benefit from EGFR-inhibiting monoclonal antibodies if they do not contain mutation...

    Authors: Eva Segelov, Paul Waring, Jayesh Desai, Kate Wilson, Val Gebski, Subotheni Thavaneswaran, Elena Elez, Craig Underhill, Nick Pavlakis, Lorraine Chantrill, Louise Nott, Michael Jefford, Mustafa Khasraw, Fiona Day, Harpreet Wasan, Fortunato Ciardiello…
    Citation: BMC Cancer 2016 16:339
    Content type: Study protocol Published on:

  4. We investigated the contribution of subsequent therapy for advanced hepatocellular carcinoma refractory or intolerant to sorafenib. Further, we investigated the impact of sorafenib on overall survival using in...

    Authors: Takeshi Terashima, Tatsuya Yamashita, Rika Horii, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda and Shuichi Kaneko
    Citation: BMC Cancer 2016 16:338
    Content type: Research article Published on:

  5. Because inheritance is recognized as playing a role in age at menarche and natural menopause, the development of chemotherapy-induced amenorrhea (CIA) might depend on inherited genetic factors; however, studie...

    Authors: Toralf Reimer, Sarah Kempert, Bernd Gerber, Hans-Jürgen Thiesen, Steffi Hartmann and Dirk Koczan
    Citation: BMC Cancer 2016 16:337
    Content type: Research article Published on:

  6. Studies over the past decade and half have identified cancer stem cells (CSCs) to be responsible for tumorigenesis, invasion, sustenance of metastatic disease, radio- and chemo-resistance and tumor relapse. Re...

    Authors: Veena Somasundaram, Sreelatha K Hemalatha, Krishnendu Pal, Sutapa Sinha, Asha S. Nair, Debabrata Mukhopadhyay and Priya Srinivas
    Citation: BMC Cancer 2016 16:336
    Content type: Research article Published on:

  7. Perturbed genotypes in cancer can now be identified by whole genome sequencing of large number of diverse tumor samples, and observed gene mutations can be used for prognosis and classification of cancer subty...

    Authors: Sarah Daakour, Leon Juvenal Hajingabo, Despoina Kerselidou, Aurelie Devresse, Richard Kettmann, Nicolas Simonis, Franck Dequiedt and Jean-Claude Twizere
    Citation: BMC Cancer 2016 16:335
    Content type: Research article Published on:

  8. To assess the importance of heredity in the etiology of inflammatory breast cancer (IBC), we compared IBC patients to several carefully chosen comparison groups with respect to the prevalence of first-degree f...

    Authors: Roxana Moslehi, Elizabeth Freedman, Nur Zeinomar, Carmela Veneroso and Paul H. Levine
    Citation: BMC Cancer 2016 16:334
    Content type: Research article Published on:

  9. The anti-tumour activity of cisplatin is thought to be a result of its capacity to form DNA adducts which prevent cellular processes such as DNA replication and transcription. These DNA adducts can effectively...

    Authors: Ben W. Johnson, Vincent Murray and Mark D. Temple
    Citation: BMC Cancer 2016 16:333
    Content type: Research article Published on:

  10. Recruitment of cofactors in the interaction of the androgen receptor (AR) and AR ligands plays a critical role in determining androgenic/antiandrogenic effects of the AR ligand on signaling, but the functions ...

    Authors: Keisuke Takeda, Noboru Hara, Tsutomu Nishiyama, Masayuki Tasaki, Fumio Ishizaki and Yoshihiko Tomita
    Citation: BMC Cancer 2016 16:332
    Content type: Research article Published on:

  11. Distant metastasis resulting from vascular dissemination of cancer cells is the primary cause of mortality from breast cancer. We have previously reported that E-selectin expression on the endothelial cell sur...

    Authors: Shin-Ae Kang, Celine A. Blache, Sandra Bajana, Nafis Hasan, Mohamed Kamal, Yoshihiro Morita, Vineet Gupta, Bilegtsaikhan Tsolmon, K. Stephen Suh, David G. Gorenstein, Wajeeha Razaq, Hallgeir Rui and Takemi Tanaka
    Citation: BMC Cancer 2016 16:331
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:370

  12. Alterations in the host cellular immune response allow persistent infections with High-Risk Human Papillomavirus (HR-HPV) and development of premalignant cervical lesions and cervical cancer (CC). Variations o...

    Authors: K. Torres-Poveda, A. I. Burguete-García, M. Bahena-Román, R. Méndez-Martínez, M. A. Zurita-Díaz, G. López-Estrada, K. Delgado-Romero, O. Peralta-Zaragoza, V. H. Bermúdez-Morales, D. Cantú, A. García-Carrancá and V. Madrid-Marina
    Citation: BMC Cancer 2016 16:330
    Content type: Research article Published on:

  13. Platelet to Lymphocyte ratio (PLR) is thought to be associated with a worse outcome in multiple types of cancer. However, the prognostic significance of PLR has not been investigated in the prostate cancer (PC...

    Authors: Yanqing Wang, Fan Xu, Jiahua Pan, Yinjie Zhu, Xiaoguang Shao, Jianjun Sha, Zezhou Wang, Yong Cai, Qiang Liu, Baijun Dong, Wei Xue and Yiran Huang
    Citation: BMC Cancer 2016 16:329
    Content type: Research article Published on:

  14. Thrombin activatable fibrinolysis inhibitor (TAFI) is a plasma zymogen, which can be converted to activated TAFI (TAFIa) through proteolytic cleavage by thrombin, plasmin, and most effectively thrombin in comp...

    Authors: Zainab A. Bazzi, Danielle Lanoue, Mouhanned El-Youssef, Rocco Romagnuolo, Janice Tubman, Dora Cavallo-Medved, Lisa A. Porter and Michael B. Boffa
    Citation: BMC Cancer 2016 16:328
    Content type: Research article Published on:

  15. Previous studies have shown left-sided colorectal cancer (LCRC) and right-sided colorectal cancer (RCRC) exhibit different molecular and clinicopathological features. We explored the association between the pr...

    Authors: Kuo-Hsing Chen, Yu-Yun Shao, Ho-Min Chen, Yu-Lin Lin, Zhong-Zhe Lin, Mei-Shu Lai, Ann-Lii Cheng and Kun-Huei Yeh
    Citation: BMC Cancer 2016 16:327
    Content type: Research article Published on:

  16. The synthesis of specific, potent progesterone antagonists adds potential agents to the breast cancer prevention and treatment armamentarium. The identification of individuals who will benefit from these agent...

    Authors: Susan E. Clare, Akash Gupta, MiRan Choi, Manish Ranjan, Oukseub Lee, Jun Wang, David Z. Ivancic, J. Julie Kim and Seema A. Khan
    Citation: BMC Cancer 2016 16:326
    Content type: Research article Published on:

  17. Transarterial chemoembolization is one of the most widely accepted interventional treatment options for treatment of hepatocellular carcinoma. Still there is a lack of a standard protocol regarding the injecte...

    Authors: Thomas J. Vogl, Elsie Oppermann, Jun Qian, Ulli Imlau, Andreas Tran, Yousef Hamidavi, Huedayi Korkusuz, Wolf Otto Bechstein, Nour-Eldin Abdel-Rehim Nour-Eldin, Tatjana Gruber-Rouh, Renate Hammerstingl and Nagy Naguib Naeem Naguib
    Citation: BMC Cancer 2016 16:325
    Content type: Research article Published on:

  18. Paraneoplastic neurological syndromes (PNS) are rare disorders associated with malignant tumours, which are triggered by autoimmune reactions. Paraneoplastic cerebellar degeneration (PCD) is the PNS type most ...

    Authors: Yaofeng Zhu, Shouzhen Chen, Songyu Chen, Jing Song, Fan Chen, Hu Guo, Zhenhua Shang, Yong Wang, Changkuo Zhou and Benkang Shi
    Citation: BMC Cancer 2016 16:324
    Content type: Case report Published on:

  19. Urinary, sexual and anorectal sequelae are frequent after rectal cancer surgery and were found to be related to intraoperative neurogenic impairment. Neuromonitoring methods have been developed to identify and...

    Authors: D. W. Kauff, K Kronfeld, S Gorbulev, D Wachtlin, H Lang and W Kneist
    Citation: BMC Cancer 2016 16:323
    Content type: Study protocol Published on:

  20. The incidence of Cholangiocellular Carcinoma (CCA) is increasing in the western world. The tumour has a high proportion of desmoplastic stroma and is correlated with a worse prognosis when cancer associated my...

    Authors: Nils Heits, Tillmann Heinze, Alexander Bernsmeier, Jannik Kerber, Charlotte Hauser, Thomas Becker, Holger Kalthoff, Jan-Hendrik Egberts and Felix Braun
    Citation: BMC Cancer 2016 16:322
    Content type: Research article Published on:

  21. Helicobacter pylori is an important pathogenic factor in gastric carcinogenesis. Angiogenesis (i.e., the growth of new blood vessels) is closely associated with the incidence and development of gastric cancer. Ou...

    Authors: Ningning Liu, Ning Zhou, Ni Chai, Xuan Liu, Haili Jiang, Qiong Wu and Qi Li
    Citation: BMC Cancer 2016 16:321
    Content type: Research article Published on:

  22. A high neutrophil-to-lymphocyte ratio (NLR) may be related to increased mortality in patients with lung, colorectal, stomach, liver, and pancreatic cancer. To date, the utility of NLR to predict the response t...

    Authors: Yi Chen, Kai Chen, Xiaoyun Xiao, Yan Nie, Shaohua Qu, Chang Gong, Fengxi Su and Erwei Song
    Citation: BMC Cancer 2016 16:320
    Content type: Research article Published on:

  23. Ovarian function suppression (OFS) has been shown to be effective as adjuvant endocrine therapy in premenopausal women with hormone receptor-positive breast cancer. However, it is currently unclear if addition...

    Authors: Hyun-Ah Kim, Sei Hyun Ahn, Seok Jin Nam, Seho Park, Jungsil Ro, Seock-Ah Im, Yong Sik Jung, Jung Han Yoon, Min Hee Hur, Yoon Ji Choi, Soo-Jung Lee, Joon Jeong, Se-Heon Cho, Sung Yong Kim, Min Hyuk Lee, Lee Su Kim…
    Citation: BMC Cancer 2016 16:319
    Content type: Study protocol Published on:

  24. Often curative treatment for locally advanced resectable esophageal or gastro-esophageal junctional cancer consists of concurrent neoadjuvant radiotherapy and chemotherapy followed by surgery. Currently, one o...

    Authors: Mathieu Messager, Xavier Mirabel, Emmanuelle Tresch, Amaury Paumier, Véronique Vendrely, Laetitia Dahan, Olivier Glehen, Frederique Vasseur, Thomas Lacornerie, Guillaume Piessen, Farid El Hajbi, William B. Robb, Stéphanie Clisant, Andrew Kramar, Christophe Mariette and Antoine Adenis
    Citation: BMC Cancer 2016 16:318
    Content type: Study protocol Published on:

  25. We have previously demonstrated that the hydroxylated biphenyl compound D6 (3E,3′E)-4,4′-(5,5′,6,6′-tetramethoxy-[1,1′-biphenyl]-3,3′-diyl)bis(but-3-en-2-one), a structural analogue of curcumin, exerts a stron...

    Authors: Marina Pisano, Antonio Palomba, Alessandro Tanca, Daniela Pagnozzi, Sergio Uzzau, Maria Filippa Addis, Maria Antonietta Dettori, Davide Fabbri, Giuseppe Palmieri and Carla Rozzo
    Citation: BMC Cancer 2016 16:317
    Content type: Research article Published on:

  26. The BRM and BRG1 tumor suppressor genes are mutually exclusive ATPase subunits of the SWI/SNF chromatin remodeling complex. The human adrenal carcinoma SW13 cell line can switch between a subtype which express...

    Authors: McKale R. Davis, Juliane J. Daggett, Agnes S. Pascual, Jessica M. Lam, Kathryn J. Leyva, Kimbal E. Cooper and Elizabeth E. Hull
    Citation: BMC Cancer 2016 16:316
    Content type: Research article Published on:

  27. MicroRNA-663a expression is downregulated in several tumors. However, its functions and mechanisms in human non-small cell lung (NSCLC) cancer remain obscure. The present study aimed to identify the expression...

    Authors: Yi Zhang, Xiaoman Xu, Meng Zhang, Xin Wang, Xue Bai, Hui Li, Liang Kan, Yong Zhou, Huiyan Niu and Ping He
    Citation: BMC Cancer 2016 16:315
    Content type: Research article Published on:

  28. Chronic Myeloid Leukemia was always referred as a unique cancer due to the apparent independence from tumor suppressors’ deletions/mutations in the early stages of the disease. However, it is now well document...

    Authors: Sabrina Crivellaro, Giovanna Carrà, Cristina Panuzzo, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio and Alessandro Morotti
    Citation: BMC Cancer 2016 16:314
    Content type: Review Published on:

  29. Hyaluronan is a large extracellular matrix molecule involved in several biological processes such as proliferation, migration and invasion. In many cancers, hyaluronan synthesis is altered, which implicates di...

    Authors: Mari Poukka, Andrey Bykachev, Hanna Siiskonen, Kristiina Tyynelä-Korhonen, Päivi Auvinen, Sanna Pasonen-Seppänen and Reijo Sironen
    Citation: BMC Cancer 2016 16:313
    Content type: Research article Published on:

  30. Oral cancer malignancy consists of uncontrolled division of cells primarily in and around the floor of the oral cavity, gingiva, oropharynx, lower lip and base of the tongue. According to GLOBOCAN 2012 report,...

    Authors: Muraleedharan Parvathy, Sreeharshan Sreeja, Rakesh Kumar and Madhavan Radhakrishna Pillai
    Citation: BMC Cancer 2016 16(Suppl 1):293
    Content type: Research Published on:

    This article is part of a Supplement: Volume 16 Supplement 1

  31. BRCA1 is a main component of homologous recombination and induces resistance to platinum in preclinical models. It has been studied as a potential predictive marker in lung cancer. Several proteins modulate th...

    Authors: Laura Bonanno, Carlota Costa, Margarita Majem, Jose-Javier Sanchez, Ignacio Rodriguez, Ana Gimenez-Capitan, Miquel Angel Molina-Vila, Alain Vergnenegre, Bartomeu Massuti, Adolfo Favaretto, Massimo Rugge, Cinta Pallares, Miquel Taron and Rafael Rosell
    Citation: BMC Cancer 2016 16:312
    Content type: Research article Published on:

  32. Serving military personnel are more likely to smoke, and to smoke more heavily, than civilians. The aim of our study was to examine whether veterans have an increased risk of a range of smoking-related cancers...

    Authors: Beverly P. Bergman, Daniel F. Mackay, David Morrison and Jill P. Pell
    Citation: BMC Cancer 2016 16:311
    Content type: Research article Published on:

  33. Glioblastoma multiforme is a highly aggressive brain tumor with a poor prognosis, and advances in treatment have led to only marginal increases in overall survival. We and others have shown previously that the...

    Authors: Danielle M. Lussier, Eric C. Woolf, John L. Johnson, Kenneth S. Brooks, Joseph N. Blattman and Adrienne C. Scheck
    Citation: BMC Cancer 2016 16:310
    Content type: Research article Published on:

  34. Pancreatic cancer is recognized as one of the most fatal tumors due to its aggressiveness and resistance to therapy. Statins were previously shown to inhibit the proliferation of cancer cells via various signalin...

    Authors: K. Vanova, S. Boukalova, H. Gbelcova, L. Muchova, J. Neuzil, R. Gurlich, T. Ruml and L. Vitek
    Citation: BMC Cancer 2016 16:309
    Content type: Research article Published on:

  35. Small molecule inhibitor of tyrosine kinase activity, compound SU11274, was reported to have antitumorigenic and antimetastatic effect in melanoma. In this study, we evaluated, whether similar effect could be ...

    Authors: Lucia Kucerova, Lucia Demkova, Svetlana Skolekova, Roman Bohovic and Miroslava Matuskova
    Citation: BMC Cancer 2016 16:308
    Content type: Research article Published on:

  36. The development of metastases is a negative prognostic parameter for the clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many affected women. The purpose of this re...

    Authors: Joachim Diessner, Manfred Wischnewsky, Tanja Stüber, Roland Stein, Mathias Krockenberger, Sebastian Häusler, Wolfgang Janni, Rolf Kreienberg, Maria Blettner, Lukas Schwentner, Achim Wöckel and Catharina Bartmann
    Citation: BMC Cancer 2016 16:307
    Content type: Research article Published on:

  37. The addition of bevacizumab to cytotoxic agents prolongs survival in patients with nonsquamous non-small cell lung cancer (NSCLC). To date, there is no evidence to suggest that treatment with a cytotoxic agent...

    Authors: Toshiyuki Kozuki, Naoyuki Nogami, Hiromoto Kitajima, Shunichiro Iwasawa, Emiko Sakaida, Yuichi Takiguchi, Satoshi Ikeda, Masahiro Yoshida, Terufumi Kato, Shingo Miyamoto, Kentaro Sakamaki, Tetsu Shinkai and Koshiro Watanabe
    Citation: BMC Cancer 2016 16:306
    Content type: Research article Published on:

  38. The CXCL12-CXCR4 signaling axis in malignant tumor biology has increased in importance, and these peptides are implicated in tumor growth, invasion and metastasis. The aim of our study was to examine the impor...

    Authors: Mamoru Morimoto, Yoichi Matsuo, Shuji Koide, Ken Tsuboi, Tomoya Shamoto, Takafumi Sato, Kenta Saito, Hiroki Takahashi and Hiromitsu Takeyama
    Citation: BMC Cancer 2016 16:305
    Content type: Research article Published on:

  39. Tamoxifen, a common anti-estrogen breast cancer medication, is a prodrug that undergoes bioactivation via cytochrome P450 enzymes, CYP2D6 and to a lesser degree, CYP3A4 to form the active metabolite endoxifen. Wi...

    Authors: Sara L. Henderson, Wendy A. Teft and Richard B. Kim
    Citation: BMC Cancer 2016 16:304
    Content type: Case report Published on:

  40. Gastrointestinal (GI) cancer is frequently diagnosed in people of working age, and many GI cancer patients experience work-related problems. Although these patients often experience difficulties returning to w...

    Authors: AnneClaire G.N.M. Zaman, Kristien M.A.J. Tytgat, Jean H.G. Klinkenbijl, Monique H.W. Frings-Dresen and Angela G.E.M. de Boer
    Citation: BMC Cancer 2016 16:303
    Content type: Study protocol Published on:

  41. Mitogen/extracellular signal-regulated kinase kinase-5 (MEK5) has been confirmed to play a pivotal role in tumor carcinogenesis and progression. However, few studies have investigated the role of MEK5 in color...

    Authors: Dechang Diao, Lei Wang, Jin Wan, Zhiqiang Chen, Junsheng Peng, Huanliang Liu, Xinlin Chen, Wei Wang and Liaonan Zou
    Citation: BMC Cancer 2016 16:302
    Content type: Research article Published on:

  42. The optimal conduct of follow-up (FU) of patients with osteosarcoma is uncertain. In the absence of any formal validation of optimal timing and method of surveillance, guidance is provided by oncology societie...

    Authors: Christian Rothermundt, Beatrice M. Seddon, Palma Dileo, Sandra J. Strauss, Joanne Coleman, Timothy W. Briggs, Sarah R. Haile and Jeremy S. Whelan
    Citation: BMC Cancer 2016 16:301
    Content type: Research article Published on:

  43. Circulating tumor cells (CTCs) are typically collected into CellSave fixative tubes, which kills the cells, but preserves their morphology. Currently, the clinical utility of CTCs is mostly limited to their en...

    Authors: Steingrimur Stefansson, Daniel L. Adams, William B. Ershler, Huyen Le and David H. Ho
    Citation: BMC Cancer 2016 16:300
    Content type: Technical advance Published on:

  44. Current surgical and ablative treatment options for prostate cancer (PCa) may result in a high incidence of (temporary) incontinence, erectile dysfunction and/or bowel damage. These side effects are due to pro...

    Authors: Matthijs J. V. Scheltema, Willemien van den Bos, Daniel M. de Bruin, Hessel Wijkstra, M. Pilar Laguna, Theo M. de Reijke and Jean JMCH de la Rosette
    Citation: BMC Cancer 2016 16:299
    Content type: Study protocol Published on:

  45. Chemokines are well known inflammatory factors critical for tumor development in diverse tissues, including lung cancer. Chemokine (C-C motif) Ligand 2 (CCL2) was one of such chemokines important for both prim...

    Authors: Xu Li, Fangcai Lin and Hong Zhou
    Citation: BMC Cancer 2016 16:298
    Content type: Research article Published on:

  46. Immunomodulatory drugs (IMiDs), such as lenalidomide, are therapeutically active compounds that bind and modulate the E3 ubiquitin ligase substrate recruiter cereblon, thereby affect steady-state levels of cer...

    Authors: Qinqin Xu, Yue-xian Hou, Paul Langlais, Patrick Erickson, James Zhu, Chang-Xin Shi, Moulun Luo, Yuanxiao Zhu, Ye Xu, Lawrence J. Mandarino, Keith Stewart and Xiu-bao Chang
    Citation: BMC Cancer 2016 16:297
    Content type: Research article Published on:

  47. The study aimed to compare urinary symptoms in patients with clinically localized prostate cancer after a combination of either low-dose-rate or high-dose-rate interstitial brachytherapy along with intensity-m...

    Authors: Satoshi Nakamura, Naoya Murakami, Koji Inaba, Akihisa Wakita, Kazuma Kobayashi, Kana Takahashi, Hiroyuki Okamoto, Rei Umezawa, Madoka Morota, Minako Sumi, Hiroshi Igaki, Yoshinori Ito and Jun Itami
    Citation: BMC Cancer 2016 16:296
    Content type: Research article Published on:

  48. Inhibitors of mutant BRAF are emerging as standard of care in patients with metastatic melanoma who carry relevant oncogenic mutations. However, BRAF inhibitors are found to induce cutaneous squamous cell carc...

    Authors: Haojie Li, Lars Pedersen, Mette Nørgaard, Sinna P. Ulrichsen, Sandra K. Thygesen and Jeanenne J. Nelson
    Citation: BMC Cancer 2016 16:295
    Content type: Research article Published on:

  49. No study has been conducted to investigate the spatial pattern and association of socioeconomic status (such as income) with breast and colorectal cancer incidence in Texas, United States. This study aimed to ...

    Authors: Zheyu Liu, Kai Zhang and Xianglin L. Du
    Citation: BMC Cancer 2016 16:294
    Content type: Research article Published on:

  50. This study was performed to design a predictive tool that allows the estimation of overall survival (OS) of elderly myeloma patients (aged ≥65 years) presenting with myeloma-induced spinal cord compression (SCC).

    Authors: Dirk Rades, Antonio Jose Conde-Moreno, Jon Cacicedo, Theo Veninga, Niklas Gebauer, Tobias Bartscht and Steven E. Schild
    Citation: BMC Cancer 2016 16:292
    Content type: Research article Published on:

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