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  1. This study aimed to evaluate the impact of postoperative complications on long-term survival in patients with peritoneal metastasis (PM) arising from colorectal cancer (CRC) treated with cytoreductive surgery ...

    Authors: Sicheng Zhou, Qiang Feng, Jing Zhang, Haitao Zhou, Zheng Jiang, Zheng Liu, Zhaoxu Zheng, Haipeng Chen, Zheng Wang, Jianwei Liang, Wei Pei, Qian Liu, Zhixiang Zhou and Xishan Wang
    Citation: BMC Cancer 2021 21:41
    Content type: Research article Published on:

  2. Rho-family GTPases, including Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42), are important modulators of cancer-relevant cell functions and are viewed as promis...

    Authors: Martha M. Grimes, S. Ray Kenney, Dayna R. Dominguez, Kathryn J. Brayer, Yuna Guo, Angela Wandinger-Ness and Laurie G. Hudson
    Citation: BMC Cancer 2021 21:40
    Content type: Research article Published on:

  3. To improve the efficiency of early diagnosis systems for cervical cancer, the use of cellular and viral markers for identifying precancerous lesions with a greater probability to progress to cancer has been pr...

    Authors: Oscar Del Moral-Hernández, Daniel Hernández-Sotelo, Luz del Carmen Alarcón-Romero, Miguel Angel Mendoza-Catalán, Eugenia Flores-Alfaro, Yaneth Castro-Coronel, Julio Ortiz-Ortiz, Marco Antonio Leyva-Vázquez, Carlos Ortuño-Pineda, Wendy Castro-Mora and Berenice Illades-Aguiar
    Citation: BMC Cancer 2021 21:39
    Content type: Research article Published on:

  4. Immune checkpoint inhibitors-induced myocarditis presents unique clinical challenges. Here, we assessed post-marketing safety of cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), programmed cell death-1 (P...

    Authors: Rulan Ma, Quanziang Wang, Deyu Meng, Kang Li and Yong Zhang
    Citation: BMC Cancer 2021 21:38
    Content type: Research article Published on:

  5. Our previous studies demonstrated that the administration of crude Polysaccharide from Panax notoginseng (CPPN) can effectively prolong the lifespan of tumor-bearing mice via boosting the host immune system as we...

    Authors: Yan-Hong Liu, Hua-Yan Qin, Yuan-Yuan Zhong, Shuang Li, Hua-Jing Wang, Hong Wang, Li-Ling Chen, Xiang Tang, Ya-Lin Li, Zhong-Yi Qian, Huai-Yu Li, Lei Zhang and Tong Chen
    Citation: BMC Cancer 2021 21:37
    Content type: Research article Published on:

  6. Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG)...

    Authors: Lizhen Liu, Kaimin Hu, Jingjing Feng, Huafang Wang, Shan Fu, Binsheng Wang, Limengmeng Wang, Yulin Xu, Xiaohong Yu and He Huang
    Citation: BMC Cancer 2021 21:36
    Content type: Research article Published on:

  7. The Oral Care BC-trial reported that professional oral care (POC) reduces the incidence and severity of oral mucositis in patients receiving everolimus (EVE) and exemestane (EXE). However, the effect of POC on...

    Authors: Katsuhiko Nakatsukasa, Naoki Niikura, Kosuke Kashiwabara, Takeshi Amemiya, Ken-ichi Watanabe, Hironobu Hata, Yuichiro Kikawa, Naoki Taniike, Takashi Yamanaka, Sachiyo Mitsunaga, Kazuhiko Nakagami, Moriyasu Adachi, Naoto Kondo, Yasuyuki Shibuya, Naoki Hayashi, Mariko Naito…
    Citation: BMC Cancer 2021 21:34
    Content type: Research article Published on:

  8. Anterior gradient-2 (AGR2) is a proto-oncogene involved in tumorigenesis and cancer progression. AGR2, predominantly localized in the endoplasmic reticulum (ER), is also a secreted protein detected in the extr...

    Authors: Xian Hong, Zhi-Xuan Li, Jie Hou, Hui-Yu Zhang, Chun-Yan Zhang, Jian Zhang, He Sun, Li-Hong Pang, Tao Wang and Zhi-Hui Deng
    Citation: BMC Cancer 2021 21:33
    Content type: Research article Published on:

  9. Aberrant expression of P-cadherin has been reported in various cancers, and has been attracting attention as a target for cancer treatment. Ovarian cancer, the leading cause of death among gynecologic malignan...

    Authors: Kayo Kayahashi, Yasunari Mizumoto, Ayumi Matsuoka, Takeshi Obata, Junpei Iwadare, Mitsuhiro Nakamura, Takiko Daikoku and Hiroshi Fujiwara
    Citation: BMC Cancer 2021 21:32
    Content type: Research article Published on:

  10. In recent years, the relationship between tumor-associated macrophages (TAMs) and solid tumors has become a research hotspot. This study aims to explore the close relationship of TAMs with metabolic reprogramm...

    Authors: Junyu Huo, Liqun Wu, Yunjin Zang, Hongjing Dong, Xiaoqiang Liu, Fu He and Xiao Zhang
    Citation: BMC Cancer 2021 21:31
    Content type: Research article Published on:

  11. Endometrial cancer (EC) is one of the most common gynecological malignancies worldwide. However, the molecular mechanisms and the prognostic prediction for EC patients remain unclear.

    Authors: Jinhui Liu, Pinping Jiang, Xucheng Chen, Yujie Shen, Guoliang Cui, Ziyan Ma, Shaojie Zhao and Yan Zhang
    Citation: BMC Cancer 2021 21:29
    Content type: Research article Published on:

  12. Contradictory and limited data are available about the presentation and outcomes of patients with RET-fusion positive metastatic NSCLC as compared to patients without RET fusions. This observational study utilizi...

    Authors: Lisa M. Hess, Yimei Han, Yajun Emily Zhu, Naleen Raj Bhandari and Anthony Sireci
    Citation: BMC Cancer 2021 21:28
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2023 23:382

  13. Ataxia telangiectasia-mutated (ATM) gene contributes to repair damaged DNA and to regulate cell cycle; therefore, ATM variants seem to increase breast cancer risk; however, the results are controversial. So we...

    Authors: Masoumeh Moslemi, Yousef Moradi, Hojat Dehghanbanadaki, Hamed Afkhami, Mansoor Khaledi, Najmeh Sedighimehr, Javad Fathi and Ehsan Sohrabi
    Citation: BMC Cancer 2021 21:27
    Content type: Research article Published on:

  14. In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin canc...

    Authors: Bayaki Saka, Sefako Abla Akakpo, Julienne Noude Teclessou, Piham Gnossike, Saliou Adam, Garba Mahamadou, Panawé Kassang, Yvette Elegbede, Abas Mouhari-Toure, Tchin Darre, Koussake Kombate and Palokinam Pitché
    Citation: BMC Cancer 2021 21:26
    Content type: Research article Published on:

  15. In Mainland China, advance directives (ADs) and end-of-life care for patients with tumours, especially patients with brain tumours who may have lost consciousness or the ability to speak at the early stage of ...

    Authors: Yixin Wang, Yongkang Zhang, Yang Hong, Ping Zeng, Zongtao Hu, Xiuli Xu and Hongzhi Wang
    Citation: BMC Cancer 2021 21:25
    Content type: Research article Published on:

  16. The growth- and plasticity-associated protein-43 (GAP43) is biasedly expressed in indigestive system and nervous system. Recent study has shown that GAP43 is responsible for the development of neuronal growth ...

    Authors: Xi Chen, Hongjin Wu, Jia Feng, Ying Li, Jiao Lv, Weikai Shi, Weiwei Fan, Li Xiao, Danmeng Sun, Mingfeng Jiang and Ming Shi
    Citation: BMC Cancer 2021 21:24
    Content type: Research article Published on:

  17. Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 an...

    Authors: Keisuke Miwa, Eiji Oki, Masanobu Enomoto, Keisuke Ihara, Koji Ando, Fumihiko Fujita, Masahiro Tominaga, Shinichiro Mori, Goro Nakayama, Mototsugu Shimokawa, Hiroshi Saeki, Hideo Baba, Masaki Mori and Yoshito Akagi
    Citation: BMC Cancer 2021 21:23
    Content type: Research article Published on:

  18. An accurate intraoperative prediction of lymph node metastatic risk can help surgeons in choosing precise surgical procedures. We aimed to develop and validate nomograms to intraoperatively predict patterns of...

    Authors: Fei Zhao, Rong-Xin Lu, Jin-Yuan Liu, Jun Fan, Hao-Ran Lin, Xiao-Yu Yang, Shu-Hui You, Qian-Ge Wu, Xue-Yun Qin, Yi Liu, Fu-Xi Zhen, Jin-Hua Luo and Wei Wang
    Citation: BMC Cancer 2021 21:22
    Content type: Research article Published on:

  20. Curing locally advanced gastric cancer through surgery alone is difficult. Adjuvant and neoadjuvant chemotherapy bring potential benefits to more patients with gastric cancer based on several clinical trials. ...

    Authors: Xinxin Wang, Shuo Li, Yihong Sun, Kai Li, Xian Shen, Yingwei Xue, Pin Liang, Guoli Li, Luchuan Chen, Qun Zhao, Guoxin Li, Weihua Fu, Han Liang, Hairong Xin, Jian Suo, Xuedong Fang…
    Citation: BMC Cancer 2021 21:20
    Content type: Study protocol Published on:

  21. Immune checkpoint blockades (ICBs) are characterized by a durable clinical response and better tolerability in patients with a variety of advanced solid tumors. However, we not infrequently encounter patients ...

    Authors: Seo Ree Kim, Sang Hoon Chun, Joo Ri Kim, Sang-Yeob Kim, Jun Young Seo, Chan Kwon Jung, Bo-Mi Gil, Jeong-Oh Kim, Yoon Ho Ko, In Sook Woo, Byoung Yong Shim, Sook-Hee Hong and Jin Hyoung Kang
    Citation: BMC Cancer 2021 21:19
    Content type: Research article Published on:

  22. Clear cell renal cell carcinoma is susceptible to ferroptosis, and immunotherapy is recently recommended as a priority for the initial treatment of metastatic clear cell renal carcinoma. Increased ferroptosis ...

    Authors: Yanhua Mou, Jinchun Wu, Yao Zhang, Omar Abdihamid, Chaojun Duan and Bin Li
    Citation: BMC Cancer 2021 21:18
    Content type: Research article Published on:

  24. Sequential inhibition of the vascular endothelial growth factor (VEGF) pathway with sorafenib could be useful for patients with metastatic renal cell carcinoma (RCC). Our aim was to determine the activity and ...

    Authors: Ana Elena Martín-Aguilar, Haidé Núñez-López and Juan C. Ramirez-Sandoval
    Citation: BMC Cancer 2021 21:16
    Content type: Research article Published on:

  25. Autophagy is a highly conserved homeostatic process in the human body that is responsible for the elimination of aggregated proteins and damaged organelles. Several autophagy-related genes (ARGs) contribute to...

    Authors: Lei Wu, Wen Quan, Guojun Yue, Qiong Luo, Dongxu Peng, Ying Pan and Guihai Zhang
    Citation: BMC Cancer 2021 21:15
    Content type: Research article Published on:

  26. Chronic obstructive pulmonary disease (COPD) and lung cancer are associated diseases. COPD is underdiagnosed and thus undertreated, but there is limited data on COPD diagnosis in the setting of lung cancer. We...

    Authors: Sophie Corriveau, Gregory R. Pond, Grace H. Tang and John R. Goffin
    Citation: BMC Cancer 2021 21:14
    Content type: Research article Published on:

  27. Kidney cancer (KC) is associated with cardiovascular regulation disorder and easily leads to cardiovascular and cerebrovascular death (CCD), which is one of the major causes of death in patients with KC, espec...

    Authors: Xiaofei Mo, Mingge Zhou, Hui Yan, Xueqin Chen and Yuetao Wang
    Citation: BMC Cancer 2021 21:13
    Content type: Research article Published on:

  29. We hypothesized that portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) increases portal pressure and causes esophageal varices and variceal bleedings. We examined the incidence of high-risk...

    Authors: Jihye Lim, Ha Il Kim, Eunju Kim, Jiyoon Kim, Jihyun An, Seheon Chang, Seon-Ok Kim, Han chu Lee, Yung Sang Lee and Ju Hyun Shim
    Citation: BMC Cancer 2021 21:11
    Content type: Research article Published on:

  30. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogenous group of tumors. Findings from the phase III NETTER-1 trial showed that treatment of unresectable/metastatic progressive gastroi...

    Authors: J. Smith-Palmer, O. R. Leeuwenkamp, J. Virk and N. Reed
    Citation: BMC Cancer 2021 21:10
    Content type: Research article Published on:

  31. At intensive care unit (ICU) admission, the issue about prognosis of critically ill cancer patients is of clinical interest, especially after ICU discharge. Our objective was to assess the factors associated w...

    Authors: Hubert Gheerbrant, Jean-François Timsit, Nicolas Terzi, Stéphane Ruckly, Mathieu Laramas, Matteo Giaj Levra, Emmanuelle Jacquet, Loic Falque, Denis Moro-Sibilot and Anne-Claire Toffart
    Citation: BMC Cancer 2021 21:9
    Content type: Research article Published on:

  32. Reproducible, high-quality surgery is a key point in the management of cancer patients. Quality indicators for surgical treatment of melanoma has been presented with benchmarks but data on morbidity are still ...

    Authors: Antonella Vecchiato, Simone Mocellin, Paolo Del Fiore, Giulio Tosti, Paolo A. Ascierto, Maria Teresa Corradin, Vincenzo De Giorgi, Giuseppe Giudice, Paola Queirolo, Caterina Ferreli, Marcella Occelli, Monica Giordano, Giusto Trevisan, Luigi Mascheroni, Alessandro Testori, Romina Spina…
    Citation: BMC Cancer 2021 21:8
    Content type: Research article Published on:

  33. The continual reassessment method (CRM) identifies the maximum tolerated dose (MTD) more efficiently and identifies the true MTD more frequently compared to standard methods such as the 3 + 3 method. An initia...

    Authors: G. D. James, S. Symeonides, J. Marshall, J. Young and G. Clack
    Citation: BMC Cancer 2021 21:7
    Content type: Research article Published on:

  34. Hepatocellular carcinoma (HCC) remains the most frequent liver cancer, accounting for approximately 90% of primary liver cancers worldwide. The recurrence-free survival (RFS) of HCC patients is a critical fact...

    Authors: Wenhua Wang, Lingchen Wang, Xinsheng Xie, Yehong Yan, Yue Li and Quqin Lu
    Citation: BMC Cancer 2021 21:6
    Content type: Research article Published on:

  35. Cutaneous adverse drug reactions (CADR) associated with oncology therapy involve 45–100% of patients receiving kinase inhibitors. Such adverse reactions may include skin inflammation, infection, pruritus and d...

    Authors: Nicolas Joly-Tonetti, Thomas Ondet, Mario Monshouwer and Georgios N. Stamatas
    Citation: BMC Cancer 2021 21:5
    Content type: Research article Published on:

  37. Immune checkpoint inhibitors and targeted therapies are approved for adjuvant treatment of patients with resected melanoma; however, they have not been compared in randomized controlled trials (RCTs). We compa...

    Authors: Kabirraaj Toor, Mark R. Middleton, Keith Chan, Adenike Amadi, Andriy Moshyk and Srividya Kotapati
    Citation: BMC Cancer 2021 21:3
    Content type: Research article Published on:

  38. MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aim...

    Authors: Jinchun Cong, Jian Gong, Chuanjia Yang, Zhixiu Xia and Hong Zhang
    Citation: BMC Cancer 2021 21:2
    Content type: Research article Published on:

  39. This study examined current physical activity levels and preferences for exercise settings and activities among adult survivors of childhood cancers as a strategy to inform the feasibility and design of such p...

    Authors: Denise Rokitka, Jennifer Heffler, Michael Zevon, Caleb Kitcho, Jennifer Schweitzer, Elisa M. Rodriguez and Martin C. Mahoney
    Citation: BMC Cancer 2021 21:1
    Content type: Research article Published on:

  40. Epithelial splicing regulatory protein 1 (ESRP1) and 2 (ESRP2) regulate alternative splicing events of various pre-mRNAs. Some of these targets play a role in cancer-associated processes, including cytoskeleto...

    Authors: Morton Freytag, Martina Kluth, Elena Bady, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Hans Heinzer, Doris Höflmayer, Sören Weidemann, Ria Uhlig, Hartwig Huland, Markus Graefen, Christian Bernreuther, Corinna Wittmer, Maria Christina Tsourlakis, Sarah Minner, David Dum…
    Citation: BMC Cancer 2020 20:1220
    Content type: Research article Published on:

  41. Studies of epigenomic alterations associated with diseases primarily focus on methylation profiles of promoter regions of genes, but not of other genomic regions. In our past work (Das et al. 2019) on patients...

    Authors: Srija Mukhopadhyay, Sahana Ghosh, Debodipta Das, P. Arun, Bidyut Roy, Nidhan K. Biswas, Arindam Maitra and Partha P. Majumder
    Citation: BMC Cancer 2020 20:1219
    Content type: Research article Published on:

  43. Metastases are the leading cause of breast cancer-related deaths. The tumor microenvironment impacts cancer progression and metastatic ability. Fibrillar collagen, a major extracellular matrix component, can b...

    Authors: Danielle E. Desa, Robert L. Strawderman, Wencheng Wu, Robert L. Hill, Marcel Smid, J. W. M. Martens, Bradley M. Turner and Edward B. Brown
    Citation: BMC Cancer 2020 20:1217
    Content type: Research article Published on:

  44. The prognosis of advanced oral cancer remains dismal. While multimodal therapy is beneficial, maintaining the quality of life of long-term survivors is important. Therefore, risk-adapted treatment regimens nee...

    Authors: Tomohiro Katagiri, Yoshio Ohyama, Hideo Miyamoto, Yuki Egawa, Toshiaki Moriki and Kazuki Hasegawa
    Citation: BMC Cancer 2020 20:1216
    Content type: Research article Published on:

  45. Iron is required for the proliferation of cancer cells, and its depletion suppresses tumor growth. Eribulin mesylate (eribulin), a non-taxane microtubule inhibitor, disrupts the tumor microenvironment via vasc...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Tamami Morisaki, Katsuyuki Takahashi, Hisakazu Fujita, Masatsune Shibutani, Ryosuke Amano, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2020 20:1215
    Content type: Research article Published on:

  46. Glypican-1 is a heparan sulfate proteoglycan that is overexpressed in prostate cancer (PCa), and a variety of solid tumors. Importantly, expression is restricted in normal tissue, making it an ideal tumor targ...

    Authors: Maria E. Lund, Christopher B. Howard, Kristofer J. Thurecht, Douglas H. Campbell, Stephen M. Mahler and Bradley J. Walsh
    Citation: BMC Cancer 2020 20:1214
    Content type: Research article Published on:

  47. Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic propert...

    Authors: Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer and John R. Henley
    Citation: BMC Cancer 2020 20:1213
    Content type: Research article Published on:

  48. Little is known about treatment expectations of patients with spinal metastases undergoing radiotherapy and/or surgery. Assuming that patients with spinal metastases share characteristics with patients who had...

    Authors: R. Gal, D. Oostinga, H. Wessels, J. J. Verlaan, R. Charest-Morin, C. G. Fisher, H. M. Verkooijen and A. L. Versteeg
    Citation: BMC Cancer 2020 20:1212
    Content type: Research article Published on:

  49. Malignant pleural mesothelioma (MPM) is traditionally characterized by local destructive spread of the pleura and surrounding tissues. Patient outcomes in MPM with distant metastatic dissemination are lacking.

    Authors: Dearbhaile Catherine Collins, Raghav Sundar, Anastasia Constantinidou, David Dolling, Timothy Anthony Yap, Sanjay Popat, Mary E. O’Brien, Udai Banerji, Johann Sebastian de Bono, Juanita Suzanne Lopez, Nina Tunariu and Anna Minchom
    Citation: BMC Cancer 2020 20:1210
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:245

  50. There were scarcely germline variants of familial lung cancer (LC) identified. We conducted an study with whole-exome sequencing of pedigrees with familial lung cancer to analyze the potential genetic suscepti...

    Authors: Huan Lin, Gong Zhang, Xu-chao Zhang, Xin-lei Lian, Wen-zhao Zhong, Jian Su, Shi-liang Chen and Yi-long Wu
    Citation: BMC Cancer 2020 20:1209
    Content type: Research article Published on:

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