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  2. Published findings suggest sex differences in lung cancer risk and a potential role for sex steroid hormones. Our aim was to perform a meta-analysis to investigate the effects of sex steroid hormone exposure s...

    Authors: Hui Zeng, Zhuoyu Yang, Jiang Li, Yan Wen, Zheng Wu, Yadi Zheng, Yiwen Yu, Yongjie Xu, Shugeng Gao, Fengwei Tan, Ni Li, Qi Xue and Jie He
    Citation: BMC Cancer 2021 21:690
    Content type: Research article Published on:

  3. Currently biomarkers play an essential role in diagnosis, treatment, and management of cancer. In non-small cell lung cancer (NSCLC) determination of biomarkers such as ALK, EGFR, ROS1 or PD-L1 is mandatory fo...

    Authors: Ernest Nadal, Dolores Bautista, Luis Cabezón-Gutiérrez, Ana Laura Ortega, Héctor Torres, David Carcedo, Lucía Ruiz de Alda, J. Francisco Garcia, Paula Vieitez and Federico Rojo
    Citation: BMC Cancer 2021 21:689
    Content type: Research article Published on:

  4. The baculoviral IAP repeat containing 5 (BIRC5) related to epithelial-mesenchymal transition (EMT) plays a crucial role in the pathogenesis of hepatocellular carcinoma (HCC). However, it remains unclear whethe...

    Authors: Rongzhong Xu, Liubing Lin, Bo Zhang, Jian Wang, Fanchen Zhao, Xiaolin Liu, Yiping Li and Yan Li
    Citation: BMC Cancer 2021 21:687
    Content type: Research article Published on:

  5. Testicular Self-Examination (TSE) causes earlier diagnosis of Testicular cancer (TC). Hence, all men aged between15 to 35 years should perform TSE every month. This study aims to survey the effect of education...

    Authors: Ali Khani Jeihooni, Hanieh Jormand, Mehdi Ansari, Pooyan Afzali Harsini and Tayebeh Rakhshani
    Citation: BMC Cancer 2021 21:685
    Content type: Research Published on:

  6. Access to childhood cancer medicines is a critical global health challenge. There is a lack of sufficient context-specific data in Ghana on access to essential medicines for treating childhood cancers. Here, w...

    Authors: Kofi Boamah Mensah, Adwoa Bemah Boamah Mensah, Varsha Bangalee, Neelaveni Padayachee and Frasia Oosthuizen
    Citation: BMC Cancer 2021 21:683
    Content type: Research Published on:

  7. Prolactin receptor (PRLR) is an attractive antibody therapeutic target with expression across a broad population of breast cancers. Antibody efficacy, however, may be limited to subtypes with either PRLR overe...

    Authors: Mark G. Anderson, Qian Zhang, Luis E. Rodriguez, Claudie M. Hecquet, Cherrie K. Donawho, Peter J. Ansell and Edward B. Reilly
    Citation: BMC Cancer 2021 21:681
    Content type: Research article Published on:

  8. Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or p...

    Authors: Fang Yu, Babu Gajendran, Ning Wang, Klarke M. Sample, Wuling Liu, Chunlin Wang, Anling Hu, Eldad Zacksenhaus, Xiaojiang Hao and Yaacov Ben-David
    Citation: BMC Cancer 2021 21:680
    Content type: Research article Published on:

  12. Information about survival by stage in bladder cancer is scarce, as well as about survival of non-invasive bladder cancer. The aims of this study are: 1) to find out the distribution of bladder cancer by stage...

    Authors: J. Ripoll, M. Ramos, J. Montaño, J. Pons, A. Ameijide and P. Franch
    Citation: BMC Cancer 2021 21:676
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:956

  13. The association between SOX14 and cancer has been reported. The aim of this study was to identify and validate the potential value of SOX14 methylation in the early detection of cervical cancer.

    Authors: Jing Zhao, Huiling Cao, Wenfan Zhang, Yongjuan Fan, Shujuan Shi and Rong Wang
    Citation: BMC Cancer 2021 21:675
    Content type: Research article Published on:

  14. Previous clinical trials have demonstrated the potential efficacy of rechallenge with anti- epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) for patients with RAS/BRAF V600E wild-type metastat...

    Authors: Hiromichi Nakajima, Daisuke Kotani, Hideaki Bando, Takeshi Kato, Eiji Oki, Eiji Shinozaki, Yu Sunakawa, Kentaro Yamazaki, Satoshi Yuki, Yoshiaki Nakamura, Takeharu Yamanaka, Takayuki Yoshino, Takashi Ohta, Hiroya Taniguchi and Yoshinori Kagawa
    Citation: BMC Cancer 2021 21:674
    Content type: Study protocol Published on:

  15. miRNAs and lncRNAs can regulate cellular biological processes both under physiological and pathological conditions including tumour initiation and progression. Interactions between differentially expressed div...

    Authors: Brigitta László, László Antal, Eszter Gyöngyösi, Anita Szalmás, Szilárd Póliska, György Veress and József Kónya
    Citation: BMC Cancer 2021 21:673
    Content type: Research article Published on:

  16. Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that lack of effective therapeutic drugs. K-001 is an oral antitumor drug made from active ingredients of marine microorganisms. The current study ai...

    Authors: Jiujie Cui, Haiyan Yang, Jue Liu, Donghui Chen, Jiong Hu, Haiyan Zhang, Yu Wang, Ting Han, Tiebo Mao, Feng Jiao, Ewelina Biskup, Yaotian Pan, Min Liu and Liwei Wang
    Citation: BMC Cancer 2021 21:672
    Content type: Research article Published on:

  17. Integrated social care may help to mitigate social risk factors in order to achieve more equitable health outcomes. In cancer centers certified according to the criteria set out by the German Cancer Society, e...

    Authors: Clara Breidenbach, Simone Wesselmann, Nora Tabea Sibert, Olaf Ortmann, Katrin Blankenburg, Cindy Stoklossa, Gerhard Gebauer, Marina dos Santos Guilherme, Christoph Lindner, Susanne Peschel, Friedemann Schad, Paul Strecker, Lorenz Rieger, Julia Ferencz, Sebastian Dieng and Christoph Kowalski
    Citation: BMC Cancer 2021 21:671
    Content type: Research article Published on:

  18. The second most common cancer among females in Bangladesh is cervical cancer. The national strategy for cervical cancer needs monitoring to ensure that patients have access to care. In order to provide accurat...

    Authors: Shagoofa Rakhshanda, Koustuv Dalal, Hasina Akhter Chowdhury, Cinderella Akbar Mayaboti, Progga Paromita, A. K. M. Fazlur Rahman, A. H. M. Eanayet Hussain and Saidur Rahman Mashreky
    Citation: BMC Cancer 2021 21:670
    Content type: Research article Published on:

  20. Patients diagnosed with Barcelona Clinic Liver Cancer (BCLC) intermediate stage hepatocellular carcinoma (HCC) encompass a broad clinical population. Kinki criteria subclassifications have been proposed to bet...

    Authors: Masateru Yamamoto, Tsuyoshi Kobayashi, Masakazu Hashimoto, Shintaro Kuroda, Tomokazu Kawaoka, Hiroshi Aikata, Kazuaki Chayama and Hideki Ohdan
    Citation: BMC Cancer 2021 21:668
    Content type: Research Published on:

  21. Cervical cancer is one of the most common malignancies among women. Appropriate and timely treatment of these patients can reduce the complications and increase their survival. The objective of this study was ...

    Authors: Setareh Akhavan, Abbas Alibakhshi, Mahdieh Parsapoor, Abbas Alipour and Elahe Rezayof
    Citation: BMC Cancer 2021 21:667
    Content type: Research Published on:

  22. Early-stage non-small lung cancer patients may survive long enough to develop second primary lung cancers. However, few studies have accurately described the therapeutic method, evaluation or prognostic factor...

    Authors: Congcong Chen, Zixiang Wu, Ziheng Wu, Chuanqiang Wu, Qi Wang, Tianwei Zhan, Lingjun Dong, Shuai Fang and Ming Wu
    Citation: BMC Cancer 2021 21:666
    Content type: Research Published on:

  23. An important number of breast and ovarian cancer cases is due to a strong genetic predisposition. The main tool for identifying individuals at risk is recognizing a suggestive family history of cancer. We pres...

    Authors: Urska Kotnik, Borut Peterlin and Luca Lovrecic
    Citation: BMC Cancer 2021 21:665
    Content type: Research article Published on:

  24. Fenofibrate is a fibric acid derivative known to have a lipid-lowering effect. Although fenofibrate-induced peroxisome proliferator-activated receptor alpha (PPARα) transcription activation has been shown to p...

    Authors: Wei Zhu, Hongyang Zhao, Fenfen Xu, Bin Huang, Xiaojing Dai, Jikui Sun, Alphonce M. K. Nyalali, Kailiang Zhang and Shilei Ni
    Citation: BMC Cancer 2021 21:664
    Content type: Research Published on:

  26. Melanoma is a malignant cancer that affects melanocytes and is considered the most aggressive skin-type cancer. The prevalence for melanoma cancer for the last five year is about one million cases. The impact ...

    Authors: Mariana Nobre Farias de Franca, Raquel Geralda Isidório, João Henrique Oliveira Bonifacio, Edmilson Willian Propheta dos Santos, Jileno Ferreira Santos, Flaviano Melo Ottoni, Waldecy de Lucca Junior, Ricardo Scher, Ricardo José Alves and Cristiane Bani Corrêa
    Citation: BMC Cancer 2021 21:662
    Content type: Research Published on:

  27. To evaluate the effectiveness and safety of pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) in preventing neutropenia during chemoradiotherapy in patients with cervical cancer.

    Authors: Dongling Zou, Mingfang Guo and Qi Zhou
    Citation: BMC Cancer 2021 21:661
    Content type: Research article Published on:

  28. Head and Neck Cancer (HNC) survivors are at increased risk of developing a second primary cancer (SPC). Along with the environmental risk factors, genetic factors have been associated with a potential increase...

    Authors: Ilda Hoxhaj, Vladimir Vukovic, Stefania Boccia and Roberta Pastorino
    Citation: BMC Cancer 2021 21:660
    Content type: Research article Published on:

  29. In the phase III ALCYONE trial, daratumumab plus bortezomib/melphalan/prednisone (D-VMP) significantly improved overall response rate and progression-free status compared with VMP alone in transplant-ineligibl...

    Authors: Stefan Knop, Maria-Victoria Mateos, Meletios A. Dimopoulos, Kenshi Suzuki, Andrzej Jakubowiak, Chantal Doyen, Paulo Lucio, Zsolt Nagy, Ganna Usenko, Ludek Pour, Mark Cook, Sebastian Grosicki, Andre Crepaldi, Anna Marina Liberati, Philip Campbell, Tatiana Shelekhova…
    Citation: BMC Cancer 2021 21:659
    Content type: Research article Published on:

  30. The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy).

    Authors: Christer Borgfeldt, Erik Holmberg, Janusz Marcickiewicz, Karin Stålberg, Bengt Tholander, Elisabeth Åvall Lundqvist, Angelique Flöter-Rådestad, Maria Bjurberg, Pernilla Dahm-Kähler, Kristina Hellman, Elisabet Hjerpe, Preben Kjölhede, Per Rosenberg and Thomas Högberg
    Citation: BMC Cancer 2021 21:658
    Content type: Research article Published on:

  31. Long non-coding RNAs exert vital roles in several types of cancer. The objective of this study was to explore the role of LINC_00355 in gastric cancer (GC) progression and its potential mechanism.

    Authors: Jishui Zhang, Wenhao Lv, Yagang Liu, Weihua Fu, Baosheng Chen, Qiutong Ma and Xin Gao
    Citation: BMC Cancer 2021 21:657
    Content type: Research article Published on:

  32. Nutritional complications in patients with locally advanced head and neck cancer (LA-HNC) treated by concurrent chemoradiotherapy (CCRT) often lead to placement of a prophylactic gastrostomy (PG) tube, while i...

    Authors: Tatiana Dragan, Fréderic Duprez, André Van Gossum, Akos Gulyban, Sylvie Beauvois, Antoine Digonnet, Yassine Lalami and Dirk Van Gestel
    Citation: BMC Cancer 2021 21:656
    Content type: Research article Published on:

  33. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and circulating tumor cells (CTCs) have been associated with survival in castration-resistant prostate cancer (CRPC). However, no study h...

    Authors: Weelic Chong, Zhenchao Zhang, Rui Luo, Jian Gu, Jianqing Lin, Qiang Wei, Bingshan Li, Ronald Myers, Grace Lu-Yao, William Kevin Kelly, Chun Wang and Hushan Yang
    Citation: BMC Cancer 2021 21:655
    Content type: Research Published on:

  34. Updated response assessment in neuro-oncology (RANO) does not consider peritumoral non-enhancing lesion (NEL) and baseline (residual) contrast enhancement (CE) volume. The objective of this study is to explore...

    Authors: Hye Hyeon Moon, Ho Sung Kim, Ji Eun Park, Young-Hoon Kim and Jeong Hoon Kim
    Citation: BMC Cancer 2021 21:654
    Content type: Research Published on:

  35. Even though targeted therapies are available for cancers expressing oncogenic epidermal growth receptor (EGFR) and (or) human EGFR2 (HER2), acquired or intrinsic resistance often confounds therapy success. Com...

    Authors: Luis D. Borrero-García, Maria del Mar Maldonado, Julia Medina-Velázquez, Angel L. Troche-Torres, Luis Velazquez, Nilmary Grafals-Ruiz and Suranganie Dharmawardhane
    Citation: BMC Cancer 2021 21:652
    Content type: Research article Published on:

  37. Advances in the early detection of cancer and its treatment have resulted in an increasing number of people living with and beyond breast cancer. Multimorbidity is also becoming more common in this population ...

    Authors: Murray Foster and Claire L. Niedzwiedz
    Citation: BMC Cancer 2021 21:650
    Content type: Research Published on:

  38. Clinical practice guidelines recommend active surveillance as the preferred treatment option for low-risk prostate cancer, but only a minority of eligible men receive active surveillance, and practice variatio...

    Authors: Shellie D. Ellis, Soohyun Hwang, Emily Morrow, Kim S. Kimminau, Kelly Goonan, Laurie Petty, Edward Ellerbeck and J. Brantley Thrasher
    Citation: BMC Cancer 2021 21:649
    Content type: Research article Published on:

  40. In estrogen receptor (ER)-positive breast cancer (BC), young age is associated with poor prognosis. While very young patients respond better to chemotherapy, chemotherapy is less effective in ER-positive tumor...

    Authors: Joohyun Woo, Se Jeong Oh, Jeong-Yoon Song, Byung Joo Chae, Jung Eun Choi, Jeeyeon Lee, Heung Kyu Park and Woosung Lim
    Citation: BMC Cancer 2021 21:647
    Content type: Research article Published on:

  41. The tumour microenvironment (TME) not only plays a role during tumour progression and metastasis but also profoundly influences treatment efficacy. Environment-mediated drug resistance is a result of crosstalk...

    Authors: Xintong Lyu, Ping Wang, Qiao Qiao and Yuanjun Jiang
    Citation: BMC Cancer 2021 21:646
    Content type: Research article Published on:

  42. Breast cancer (BRCA) is a malignant tumor with high morbidity and mortality, which is a threat to women’s health worldwide. Ferroptosis is closely related to the occurrence and development of breast cancer. He...

    Authors: Ding Wang, Guodong Wei, Ju Ma, Shuai Cheng, Longyuan Jia, Xinyue Song, Ming Zhang, Mingyi Ju, Lin Wang, Lin Zhao and Shijie Xin
    Citation: BMC Cancer 2021 21:645
    Content type: Research article Published on:

  43. Triple-negative breast cancer (TNBC) is a highly heterogeneous subtype of breast cancer, showing aggressive clinical behaviors and poor outcomes. It urgently needs new therapeutic strategies to improve the pro...

    Authors: Yiduo Liu, Linxin Teng, Shiyi Fu, Guiyang Wang, Zhengjun Li, Chao Ding, Haodi Wang and Lei Bi
    Citation: BMC Cancer 2021 21:644
    Content type: Research Published on:

  44. Exercise is efficacious for people living after a cancer diagnosis. However, implementation of exercise interventions in real-world settings is challenging. Implementation outcomes are defined as ‘the effects ...

    Authors: Louise Czosnek, Justin Richards, Eva Zopf, Prue Cormie, Simon Rosenbaum and Nicole M. Rankin
    Citation: BMC Cancer 2021 21:643
    Content type: Research article Published on:

  45. The prognosis of patients with small cell lung cancer (SCLC) is poor, most of them are in the extensive stage at the time of diagnosis, and are prone to brain metastasis. In this study, we established a nomogr...

    Authors: Qinge Shan, Jianxiang Shi, Xiaohui Wang, Jun Guo, Xiao Han, Zhehai Wang and Haiyong Wang
    Citation: BMC Cancer 2021 21:640
    Content type: Research article Published on:

  46. Trials of risk estimation in breast cancer screening programmes, in order to identify women at higher risk and offer extra screening/preventive measures, are ongoing. It may also be feasible to introduce less ...

    Authors: Lorna McWilliams, Victoria G. Woof, Louise S. Donnelly, Anthony Howell, D. Gareth Evans and David P. French
    Citation: BMC Cancer 2021 21:637
    Content type: Research Published on:

  47. Sinonasal Undifferentiated Carcinoma (SNUC) is a rare and aggressive skull base tumor with poor survival and limited treatment options. To date, targeted sequencing studies have identified IDH2 and SMARCB1 as pot...

    Authors: Molly E. Heft Neal, Andrew C. Birkeland, Apurva D. Bhangale, Jingyi Zhai, Aditi Kulkarni, Susan K. Foltin, Brittany M. Jewell, Megan L. Ludwig, Lisa Pinatti, Hui Jiang, Jonathan B. McHugh, Lawence Marentette, Erin L. McKean and J. Chad Brenner
    Citation: BMC Cancer 2021 21:636
    Content type: Research Published on:

  48. Bladder cancer (BC) is the fourth most prevalent neoplasm in men and is associated with high tumour recurrence rates, leading to major treatment challenges. Lysine-specific demethylase 6A (KDM6A) is frequently mu...

    Authors: Xingxing Chen, Xuehua Lin, Guofu Pang, Jian Deng, Qun Xie and Zhengrong Zhang
    Citation: BMC Cancer 2021 21:635
    Content type: Research Published on:

  49. Immunotherapy is becoming a standard of care for non-small cell lung cancer (NSCLC). Checkpoint inhibitor-associated pneumonia (CIP) is a rare and potentially life-threatening event that can occur at any time ...

    Authors: Aiben Huang, Yang Xu, Xuelei Zang, Chongchong Wu, Jie Gao, Xiaoli Sun, Mei Xie, Xidong Ma, Hui Deng, Jialin Song, Fangping Ren, Li Pang, Jin Qian, Zhaofeng Yu, Shiyu Wan, Yuanyuan Chen…
    Citation: BMC Cancer 2021 21:634
    Content type: Research Published on:

  50. The purpose of this study was to determine the validity of the ultrasound features as well as patient characteristics assigned to B3 (uncertain malignant potential) breast lesions before vacuum-assisted excisi...

    Authors: Liang Zheng, Fufu Zheng, Zhaomin Xing, Yunjian Zhang, Yongxin Li, Hongbiao Xu, Yuanhui Lai, Jie Li and Wenjian Wang
    Citation: BMC Cancer 2021 21:633
    Content type: Research Published on:

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