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  1. Lung adenocarcinoma (LUAD) is a major subtype of lung cancer and closely associated with poor prognosis. N6-methyladenosine (m6A), one of the most predominant modifications in mRNAs, is found to participate in...

    Authors: Hao Zhou, Miaosen Zheng, Muqi Shi, Jinjie Wang, Zhanghao Huang, Haijian Zhang, Youlang Zhou and Jiahai Shi
    Citation: BMC Cancer 2021 21:938
    Content type: Research Published on:

  2. Among patients with non-metastatic pancreatic cancer, 80% have high-risk, borderline resectable or locally advanced cancer, with a 5-year overall survival of 12%. MASTERPLAN evaluates the safety and activity o...

    Authors: Andrew Oar, Mark Lee, Hien Le, Kate Wilson, Chris Aiken, Lorraine Chantrill, John Simes, Nam Nguyen, Andrew Barbour, Jaswinder Samra, Katrin M. Sjoquist, Alisha Moore, David Espinoza, Val Gebski, Sonia Yip, Julie Chu…
    Citation: BMC Cancer 2021 21:936
    Content type: Study protocol Published on:

  3. Cervical cancer incidence is influenced by screening and risk factors in the population. The main risk factor for cervical cancer is sexually transmitted human papillomavirus (HPV), which is sexually transmitt...

    Authors: Bo T. Hansen, Suzanne Campbell and Mari Nygård
    Citation: BMC Cancer 2021 21:935
    Content type: Research Published on:

  4. The human microbiome is defined as the microorganisms that reside in or on the human body, such as bacteria, viruses, fungi, and protozoa, and their genomes. The human microbiome participates in the modulation...

    Authors: Zi-Kun Yu, Rui-Ling Xie, Rui You, You-Ping Liu, Xu-Yin Chen, Ming-Yuan Chen and Pei-Yu Huang
    Citation: BMC Cancer 2021 21:934
    Content type: Review Published on:

  6. Doublet chemotherapy in combination with a biologic agent has been a standard of care in patients with metastatic colorectal cancer for over a decade. The evidence for a “lighter” treatment approach is limited...

    Authors: Ho Wai Derrick Siu, Niall Tebbutt, Lorraine Chantrill, Chris Karapetis, Christopher Steer, Kate Wilson, David Espinoza, Lisa Bailey, Sonia Yip, Jeff Cuff, Nick Pavlakis, Subotheni Thavaneswaran, Karen Briscoe, Ratnesh Srivastav, Jennifer Shannon, Eva Segelov…
    Citation: BMC Cancer 2021 21:932
    Content type: Study protocol Published on:

  7. The mechanisms of endocrine resistance are complex, and deregulation of several oncogenic signalling pathways has been proposed. We aimed to investigate the role of the EGFR and Src-mediated STAT3 signalling p...

    Authors: Seo Yun Moon, Heejin Lee, Seoree Kim, Ji Hyung Hong, Sang Hoon Chun, Hee Yeon Lee, Keunsoo Kang, Ho Shik Kim, Hye Sung Won and Yoon Ho Ko
    Citation: BMC Cancer 2021 21:931
    Content type: Research article Published on:

  8. Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, current screening methods are either hampered by invasiveness or suboptimal performance, limiting their effectiveness as primary ...

    Authors: Ane Sørlie Kværner, Einar Birkeland, Cecilie Bucher-Johannessen, Elina Vinberg, Jan Inge Nordby, Harri Kangas, Vahid Bemanian, Pekka Ellonen, Edoardo Botteri, Erik Natvig, Torbjørn Rognes, Eivind Hovig, Robert Lyle, Ole Herman Ambur, Willem M. de Vos, Scott Bultman…
    Citation: BMC Cancer 2021 21:930
    Content type: Study protocol Published on:

  9. To assess the effects of Epstein–Barr virus (EBV) and human papillomavirus (HPV) infection on the tumor microenvironment, we examined the relationship between viral infection status, macrophage migration inhib...

    Authors: Guofei Feng, Yifei Xu, Ning Ma, Kaoru Midorikawa, Shinji Oikawa, Hatasu Kobayashi, Satoshi Nakamura, Hajime Ishinaga, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi and Mariko Murata
    Citation: BMC Cancer 2021 21:929
    Content type: Research Published on:

  10. As major regulators of DNA replication in eukaryotes, minichromosome maintenance (MCM) proteins play an important role in the initiation and extension of DNA replication. MCMs and their related genes may be ne...

    Authors: Baojie Wu and Shuyi Xi
    Citation: BMC Cancer 2021 21:928
    Content type: Research Published on:

  12. This study aimed to evaluate the possible role of human papillomavirus (HPV) and Epstein–Barr virus (EBV) coinfection as an etiological factor for prostate cancer (PCa) development.

    Authors: Javid Sadri Nahand, Khadijeh Khanaliha, Hamed Mirzaei, Mohsen Moghoofei, Hossein Bannazadeh Baghi, Maryam Esghaei, Ali Reza Khatami, Maryam Fatemipour and Farah Bokharaei-Salim
    Citation: BMC Cancer 2021 21:926
    Content type: Research Published on:

  13. The aim of this study was to analyze the frequencies of genotypes and alleles of Single Nucleotide Polymorphism (SNP) LEP-R c.668A>G (p.Gln223Arg, rs1137101) of leptin receptor gene and to assess the influence th...

    Authors: Jan Bieńkiewicz, Hanna Romanowicz, Miłosz Wilczyński, Grzegorz Jabłoński, Anna Stepowicz, Anna Obłękowska, Andrzej Malinowski and Beata Smolarz
    Citation: BMC Cancer 2021 21:925
    Content type: Research Published on:

  14. Nivolumab, an anti-programmed death 1 (PD-1) monoclonal antibody, has shown survival benefit in clinical trials of various malignant tumors. Nivolumab-induced pneumonitis is major immune-related adverse event ...

    Authors: Teppei Yamaguchi, Junichi Shimizu, Takaaki Hasegawa, Yoshitsugu Horio, Yoshitaka Inaba, Nobuhiro Hanai, Kei Muro and Toyoaki Hida
    Citation: BMC Cancer 2021 21:924
    Content type: Research article Published on:

  15. Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. Human epidermal growth factor receptor 2 (HER2) amplification occurs in approximately 13–23% of all GC cases and patients wi...

    Authors: Gang Ning, Qihui Zhu, Wonyoung Kang, Hamin Lee, Leigh Maher, Yun-Suhk Suh, Michael Michaud, Mayerlin Silva, Jee Young Kwon, Chengsheng Zhang and Charles Lee
    Citation: BMC Cancer 2021 21:923
    Content type: Research Published on:

  16. Tongue and mouth floor squamous cell carcinoma (T/MF SCC) exhibits a high rate of local recurrence and cervical lymph node metastasis. The effect of the tumor microenvironment on T/MF SCC remains unclear.

    Authors: Xuejie Li, Zheqi Liu, Wenkai Zhou, Xiaofang Liu and Wei Cao
    Citation: BMC Cancer 2021 21:922
    Content type: Research Published on:

  18. Breast cancer (BC) is the most frequent female cancer and preferentially metastasizes to bone. The transcription factor TGFB-induced factor homeobox 1 (TGIF) is involved in bone metabolism. However, it is not ...

    Authors: Christine Stürken, Volker Möbus, Karin Milde-Langosch, Sabine Schmatloch, Peter A. Fasching, Josef Rüschoff, Elmar Stickeler, Rolf-Peter Henke, Carsten Denkert, Lars Hanker, Christian Schem, Valentina Vladimirova, Thomas Karn, Valentina Nekljudova, Claus-Henning Köhne, Frederik Marmé…
    Citation: BMC Cancer 2021 21:920
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:1024

  19. To assess the efficacies and potential predictors of a corticosteroid switch in metastatic castration-resistant prostate cancer (mCRPC) patients with biochemical progression on abiraterone acetate plus prednis...

    Authors: Zhenyu Yang, Yuchao Ni, Diwei Zhao, Yijun Zhang, Jun Wang, Lijuan Jiang, Dong Chen, Zhiming Wu, Yanjun Wang, Liru He, Yanxia Shi, Fangjian Zhou, Hao Zeng and Yonghong Li
    Citation: BMC Cancer 2021 21:919
    Content type: Research Published on:

  20. Breast cancer (BC) is a complex disease with high heterogeneity, which often leads to great differences in treatment results. Current common molecular typing method is PAM50, which shows positive results for p...

    Authors: Yan Zhang, Denan Zhang, Qingkang Meng, Ziqi Liu, Hongbo Xie, Lei Liu, Fei Xu and Xiujie Chen
    Citation: BMC Cancer 2021 21:918
    Content type: Research Published on:

  21. Lung cancer is the most common oncological cause of death in the Western world. Early diagnosis is critical for successful treatment. However, no effective screening methods exist. A promising approach could b...

    Authors: Charlotte Feil, Frank Staib, Martin R. Berger, Thorsten Stein, Irene Schmidtmann, Andreas Forster and Carl C. Schimanski
    Citation: BMC Cancer 2021 21:917
    Content type: Research Published on:

  22. Acute Limb Ischemia (ALI) carries a high morbidity and mortality rate that is compounded in the cancer patient. Though it is a relatively uncommon event, it is of extremely high adverse impact and carries poor...

    Authors: Yolanda Bryce, Amoateng Emmanuel Jr, Christopher Agrusa, Etay Ziv, Christopher Harnain, Samantha Huq and Ernesto Santos Martin
    Citation: BMC Cancer 2021 21:916
    Content type: Research Published on:

  23. Intracranial hemangiopericytoma is a rare disease and surgery is the mainstay treatment. Although postoperative adjuvant radiotherapy is often used, there are no reports comparing different radiotherapy techni...

    Authors: Jianbiao Xiao, Lanwei Xu, Yi Ding, Wei Wang, Fen Chen, Yangshu Zhou, Fengjiao Zhang, Qiyuan Zhou, Xuehui Wu, Junpeng Li, Li Liang and Yee-Min Jen
    Citation: BMC Cancer 2021 21:915
    Content type: Research article Published on:

  25. Although spread through air spaces (STAS) is a robust biomarker in surgically resected lung cancer, its application to biopsies is challenging. Moreover, limited resection is not an effective treatment for STA...

    Authors: Lanqing Cao, Meng Jia, Ping-Li Sun and Hongwen Gao
    Citation: BMC Cancer 2021 21:913
    Content type: Research article Published on:

  26. Intake time of diet has recently been demonstrated to be associated with the internal clock and circadian pattern. However, whether and how the intake time of minerals would influence the natural course of can...

    Authors: Xiaoqing Xu, Wei Wei, Jiaxu Xu, Jiaxin Huang, Li Li, Tianshu Han, Jiayue Qi, Changhao Sun, Ying Li and Wenbo Jiang
    Citation: BMC Cancer 2021 21:912
    Content type: Research article Published on:

  27. Total mesorectal excision (TME) and lateral lymph node dissection (LLND) without radiotherapy (RT) are standard treatment for lower cT3/4 rectal cancers in Eastern countries. In comparative studies, both TME +...

    Authors: Masayoshi Yasui, Masayuki Ohue, Shingo Noura, Norikatsu Miyoshi, Yusuke Takahashi, Chu Matsuda, Junichi Nishimura, Naotsugu Haraguchi, Hajime Ushigome, Nozomu Nakai, Shiki Fujino, Keijiro Sugimura, Hiroshi Wada, Hidenori Takahashi, Takeshi Omori and Hiroshi Miyata
    Citation: BMC Cancer 2021 21:911
    Content type: Research article Published on:

  28. Screening is defined as the identification of unrecognized disease in an apparently healthy population. Symptomatic individuals are recommended to contact a physician instead of participating in screening. How...

    Authors: Mette Bach Larsen, Heidi Heinsen Bachmann, Bo Søborg, Tinne Laurberg, Katrine J. Emmertsen, Søren Laurberg and Berit Andersen
    Citation: BMC Cancer 2021 21:910
    Content type: Research Published on:

  30. To compare the value of interim 18F-FLT-PET and 18F-FDG-PET for predicting treatment outcomes in patients with metastatic breast cancer after salvage therapy.

    Authors: Tzu-Pei Su, Jen-Seng Huang, Pei-Hung Chang, Kar-Wai Lui, Jason Chia-Hsun Hsieh, Shu-Hang Ng and Sheng-Chieh Chan
    Citation: BMC Cancer 2021 21:908
    Content type: Research Published on:

  31. A plethora of prognostic biomarkers for esophageal squamous cell carcinoma (ESCC) that have hitherto been reported are challenged with low reproducibility due to high molecular heterogeneity of ESCC. The purpo...

    Authors: Meng-Xiang Li, Xiao-Meng Sun, Wei-Gang Cheng, Hao-Jie Ruan, Ke Liu, Pan Chen, Hai-Jun Xu, She-Gan Gao, Xiao-Shan Feng and Yi-Jun Qi
    Citation: BMC Cancer 2021 21:906
    Content type: Research article Published on:

  32. The tumor microenvironment (TME) has significantly correlation with tumor occurrence and prognosis. Our study aimed to identify the prognostic immune-related genes (IRGs)in the tumor microenvironment of colore...

    Authors: Yuanyuan Wang, Wei Li, Xiaojing Jin, Xia Jiang, Shang Guo, Fei Xu, Xingkai Su, Guiqi Wang, Zengren Zhao and Xiaosong Gu
    Citation: BMC Cancer 2021 21:905
    Content type: Research Published on:

  33. In the phase 3 METEOR trial, cabozantinib improved progression-free survival (PFS) and overall survival (OS) versus everolimus in patients with advanced RCC after prior antiangiogenic therapy.

    Authors: Thomas Powles, Toni K. Choueiri, Robert J. Motzer, Eric Jonasch, Sumanta Pal, Nizar M. Tannir, Sabina Signoretti, Rajesh Kaldate, Christian Scheffold, Evelyn Wang, Dana T. Aftab, Bernard Escudier and Daniel J. George
    Citation: BMC Cancer 2021 21:904
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:1023

  34. 5-Fluorouracil (5-FU) is regarded as the first line treatment for colorectal cancer; however, its effectiveness is limited by drug resistance. The ultimate goal of cancer therapy is induction of cancer cell de...

    Authors: Hojatolla Nikravesh, Mohammad Javad Khodayar, Babak Behmanesh, Masoud Mahdavinia, Ali Teimoori, Soheila Alboghobeish and Leila Zeidooni
    Citation: BMC Cancer 2021 21:903
    Content type: Research Published on:

  35. D-limonene and its derivatives have demonstrated potential chemopreventive and anticancer activity in preclinical and clinical studies. The aim of this scoping review was to assess and critically appraise curr...

    Authors: Joy J. Chebet, John E. Ehiri, Deborah Jean McClelland, Douglas Taren and Iman A. Hakim
    Citation: BMC Cancer 2021 21:902
    Content type: Research article Published on:

  36. Triple-negative mammary carcinoma (TNBC) is an aggressive breast cancer subtype associated with dismal prognosis. The interaction between the immune system and the cancer cells plays a crucial role in tumor de...

    Authors: Monique C. Tavares, Cristina D. Sampaio, Geraldine E. Lima, Victor P. Andrade, Daniel G. Gonçalves, Mariana P. Macedo and Vladmir C. Cordeiro de Lima
    Citation: BMC Cancer 2021 21:901
    Content type: Research Published on:

  37. This study aimed to assess the utility of deep learning analysis using pretreatment FDG-PET images to predict local treatment outcome in oropharyngeal squamous cell carcinoma (OPSCC) patients.

    Authors: Noriyuki Fujima, V. Carlota Andreu-Arasa, Sara K. Meibom, Gustavo A. Mercier, Minh Tam Truong, Kenji Hirata, Koichi Yasuda, Satoshi Kano, Akihiro Homma, Kohsuke Kudo and Osamu Sakai
    Citation: BMC Cancer 2021 21:900
    Content type: Research article Published on:

  38. Residual breast cancer after neo-adjuvant chemotherapy (NACT) predicts disease outcome and is a surrogate for survival in aggressive breast cancer (BC) subtypes. Pathological complete response (pCR) rate, howe...

    Authors: Alex De Caluwé, Laurence Buisseret, Philip Poortmans, Dirk Van Gestel, Roberto Salgado, Christos Sotiriou, Denis Larsimont, Marianne Paesmans, Ligia Craciun, Drisis Stylianos, Christophe Vandekerckhove, Fabien Reyal, Veys Isabelle, Daniel Eiger, Martine Piccart, Emanuela Romano…
    Citation: BMC Cancer 2021 21:899
    Content type: Study protocol Published on:

  39. Radical surgery is the first line treatment for localized prostate cancer (PC), however, several studies have demonstrated that surgical procedures induce tumor cell mobilization from the primary tumor into th...

    Authors: Nerymar Ortiz-Otero, Jocelyn R. Marshall, Antonio Glenn, Jubin Matloubieh, Jean Joseph, Deepak M. Sahasrabudhe, Edward M. Messing and Michael R. King
    Citation: BMC Cancer 2021 21:898
    Content type: Research article Published on:

  41. In clear cell renal cell carcinoma, 80% of cases have biallelic inactivation of the VHL gene, leading to constitutive activation of both HIF1α and HIF2α. As HIF2α is the driver of the disease promoting tumour gro...

    Authors: Esther Arnaiz, Ana Miar, Esther Bridges, Naveen Prasad, Stephanie B. Hatch, Daniel Ebner, Charles H. Lawrie and Adrian L. Harris
    Citation: BMC Cancer 2021 21:896
    Content type: Research Published on:

  42. Research recommends the development and evaluation of interventions to support women with breast cancer in returning to, or managing, work. Despite this, there has historically been a paucity of rehabilitation...

    Authors: Naomi Algeo, Kathleen Bennett and Deirdre Connolly
    Citation: BMC Cancer 2021 21:895
    Content type: Research Published on:

  43. Because lenvatinib is well known to induce proteinuria by blocking the vascular endothelial growth factor (VEGF) pathway, renal function is a concern with long-term administration of lenvatinib. The long-term ...

    Authors: Chie Masaki, Kiminori Sugino, Sakiko Kobayashi, Yoshie Hosoi, Reiko Ono, Haruhiko Yamazaki, Junko Akaishi, Kiyomi Y. Hames, Chisato Tomoda, Akifumi Suzuki, Kenichi Matsuzu, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama and Koichi Ito
    Citation: BMC Cancer 2021 21:894
    Content type: Research Published on:

  45. Malignant Pleural Mesothelioma (MPM) is a rare but aggressive neoplasia that usually presents at advanced stages. Even though some advances have been achieved in the management of patients with MPM, this malig...

    Authors: Wendy Muñoz-Montaño, Sae Muñiz-Hernández, Alejandro Avilés-Salas, Rodrigo Catalán, Luis Lara-Mejía, Suraj Samtani-Bassarmal, Andres F. Cardona, Jorge Mendoza-Desión, Daniel Hernández-Cueto, Altagracia Maldonado, Guillermina Baay-Guzmán, Sara Huerta-Yepes and Oscar Arrieta
    Citation: BMC Cancer 2021 21:892
    Content type: Research article Published on:

  46. Colon cancer is largely implicated in elderly patients (age ≥ 60 years). The prognosis of patients diagnosed with the M1b stage is vastly poor. Marital and insurance status has been considered important progno...

    Authors: Chenghui Zhou, Yiwei Zhang, Xi Hu, Min Fang and Shuai Xiao
    Citation: BMC Cancer 2021 21:891
    Content type: Research Published on:

  47. Although many intratumoral biomarkers have been reported to predict clear cell renal cell carcinoma (ccRCC) patient prognosis, combining intratumoral and clinical indicators could predict ccRCC prognosis more ...

    Authors: Chao Wang, Keqin Dong, Yuning Wang, Guang Peng, Xu Song, Yongwei Yu, Pei Shen and Xingang Cui
    Citation: BMC Cancer 2021 21:890
    Content type: Research Published on:

  48. The prognostic roles of three lymph node classifications, number of positive lymph nodes (NPLN), log odds of positive lymph nodes (LODDS), and lymph node ratio (LNR) in lung adenocarcinoma are unclear. We aim ...

    Authors: Suyu Wang, Yue Yu, Wenting Xu, Xin Lv, Yufeng Zhang and Meiyun Liu
    Citation: BMC Cancer 2021 21:653
    Content type: Research Published on:

  49. Identifying ineffective practices that have been used in oncology is important in reducing wasted resources and harm. We sought to examine the prevalence of practices that are being used but have been shown in...

    Authors: Alyson Haslam, Jennifer Gill, Tyler Crain, Diana Herrera-Perez, Emerson Y. Chen, Talal Hilal, Myung S. Kim and Vinay Prasad
    Citation: BMC Cancer 2021 21:889
    Content type: Research Published on:

  50. The study aimed to assess resilience and its associated factors in head and neck cancer patients, post-treatment in a low middle income country (LMIC) such as Pakistan.

    Authors: Nida Zahid, Wajeeha Zahid, Wardah Khalid, Iqbal Azam, Mubasher Ikram, Aneesa Hassan, Haissan Iftikar, Shireen Shehzad Bhamani, Adnan Abdul Jabbar, Shabbir Akhtar, Moghira Iqbaluddin Siddiqui, Mohammad Sohail Awan, Nargis Asad and Khabir Ahmad
    Citation: BMC Cancer 2021 21:888
    Content type: Research Published on:

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