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  1. Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory malignancy with poor prognosis. It is urgent to identify novel and valid biomarkers to predict the progress and prognosis of PDAC. The S10...

    Authors: Hong-Bin Li, Jian-Li Wang, Xiao-Dong Jin, Lei Zhao, Hui-Li Ye, Yan-bei Kuang, Yong Ma, Xiang-Yan Jiang and Ze-Yuan Yu
    Citation: BMC Cancer 2021 21:1039
    Content type: Research Published on:

  2. To develop and validate multivariate models integrating endoscopic biopsy, tumor markers, and CT findings based on late arterial phase (LAP) to predict serosal invasion in gastric cancer (GC).

    Authors: Song Liu, Mengying Xu, Xiangmei Qiao, Changfeng Ji, Lin Li and Zhengyang Zhou
    Citation: BMC Cancer 2021 21:1038
    Content type: Research Published on:

  3. Optimising the care of individuals with cancer without imposing significant financial burden related to their anticancer treatment is becoming increasingly difficult. The American Society of Clinical Oncology ...

    Authors: Anupriya Agarwal, Ann Livingstone, Deme J. Karikios, Martin R. Stockler, Philip J. Beale and Rachael L. Morton
    Citation: BMC Cancer 2021 21:1036
    Content type: Research article Published on:

  4. Tumor protein p53 (TP53) is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSC), and TP53 mutations are associated with inhibited immune signatures and poor prognosis. We established ...

    Authors: Congyu Shi, Shan Liu, Xudong Tian, Xiaoyi Wang and Pan Gao
    Citation: BMC Cancer 2021 21:1035
    Content type: Research Published on:

  5. Despite research efforts, the causative factors that contribute to esophageal squamous cell carcinoma (ESCC) in high-risk areas have not yet been understood. In this study, we, therefore, aimed to describe the...

    Authors: Chen Niu, Yong Liu, Jialin Wang, Yuqin Liu, Shaokai Zhang, Yongzhen Zhang, Liwei Zhang, Deli Zhao, Fugang Liu, Lina Chao, Xinzheng Wang, Chunli Zhang, Guohui Song, Zhiyi Zhang, Youpeng Li, Zheng Yan…
    Citation: BMC Cancer 2021 21:1034
    Content type: Research Published on:

  6. Although cervical cancer is a preventable disease, screening coverage in Ethiopia is far below the target. There is limited evidence on uptake among the general population in Ethiopia. Thus, this study was con...

    Authors: Alemnew Destaw, Miresa Midaksa, Adamu Addissie, Eva Johanna Kantelhardt and Muluken Gizaw
    Citation: BMC Cancer 2021 21:1031
    Content type: Research Published on:

  7. Fluoropyrimidine plus platinum chemotherapy remains the standard first line treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD genotypes related to severe fluoropy...

    Authors: Miguel Cordova-Delgado, María Loreto Bravo, Elisa Cumsille, Charlotte N. Hill, Matías Muñoz-Medel, Mauricio P. Pinto, Ignacio N. Retamal, María A. Lavanderos, Juan Francisco Miquel, Maria Rodriguez-Fernandez, Yuwei Liao, Zhiguang Li, Alejandro H. Corvalán, Ricardo Armisén, Marcelo Garrido, Luis A. Quiñones…
    Citation: BMC Cancer 2021 21:1030
    Content type: Research Published on:

  8. Cytokine-induced killer cells induced with tumor antigen-pulsed dendritic cells (DC-CIK) immunotherapy is a promising strategy for the treatment of malignant tumors. However, it sefficacy is restricted by the ...

    Authors: Wu Wang, Xi Wang, Wenli Yang, Kai Zhong, Na He, Xuexia Li, Yanyang Pang, Zi Lu, Aiqun Liu and Xiaoling Lu
    Citation: BMC Cancer 2021 21:1029
    Content type: Research Published on:

  9. Prostate cancer is one of the most commonly diagnosed cancers among men. African Americans (AA) are at an increased risk of developing prostate cancer compared to European Americans (EA). miRNAs play a critica...

    Authors: Marisa Shiina, Yutaka Hashimoto, Priyanka Kulkarni, Pritha Dasgupta, Varahram Shahryari, Soichiro Yamamura, Yuichiro Tanaka and Rajvir Dahiya
    Citation: BMC Cancer 2021 21:1028
    Content type: Research Published on:

  10. Previous research found that the cancer history of an individual’s sibling may be a better indicator than that of the parents. We aim to provide recommendations for opportunistic screening for individuals whos...

    Authors: Ju Liu, Jian Yin, Yiwei Liu, Zhijian Xu and Kai Zhang
    Citation: BMC Cancer 2021 21:1027
    Content type: Research Published on:

  11. Current treatment methods for patients with triple-negative breast cancer (TNBC) are very limited, and the prognosis of TNBC is relatively poor. It has been reported that glucose transporter 1 (GLUT1) is overe...

    Authors: Xiaodan Zhang, Xiaocong Pang, Zhuo Zhang, Qianxin Liu, Hanxu Zhang, Qian Xiang and Yimin Cui
    Citation: BMC Cancer 2021 21:1026
    Content type: Research Published on:

  12. Mutations in driver genes such as IDH and BRAF have been identified in gliomas. Meanwhile, dysregulations in the p53, RB1, and MAPK and/or PI3K pathways are involved in the molecular pathogenesis of glioblastoma....

    Authors: Yasuhide Makino, Yoshiki Arakawa, Ema Yoshioka, Tomoko Shofuda, Sachiko Minamiguchi, Takeshi Kawauchi, Masahiro Tanji, Daisuke Kanematsu, Masahiro Nonaka, Yoshiko Okita, Yoshinori Kodama, Masayuki Mano, Takanori Hirose, Yohei Mineharu, Susumu Miyamoto and Yonehiro Kanemura
    Citation: BMC Cancer 2021 21:1025
    Content type: Research Published on:

  13. Authors: Christine Stürken, Volker Möbus, Karin Milde-Langosch, Sabine Schmatloch, Peter A. Fasching, Josef Rüschoff, Elmar Stickeler, Rolf-Peter Henke, Carsten Denkert, Lars Hanker, Christian Schem, Valentina Vladimirova, Thomas Karn, Valentina Nekljudova, Claus-Henning Köhne, Frederik Marmé…
    Citation: BMC Cancer 2021 21:1024
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2021 21:920

  14. Authors: Thomas Powles, Toni K. Choueiri, Robert J. Motzer, Eric Jonasch, Sumanta Pal, Nizar M. Tannir, Sabina Signoretti, Rajesh Kaldate, Christian Scheffold, Evelyn Wang, Dana T. Aftab, Bernard Escudier and Daniel J. George
    Citation: BMC Cancer 2021 21:1023
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2021 21:904

  15. Eukaryotic translation initiation factors (eIFs) are the key factors to synthesize translation initiation complexes during the synthesis of eukaryotic proteins. Besides, eIFs are especially important in regula...

    Authors: Qi Li, Mulun Xiao, Yibo Shi, Jinhao Hu, Tianxiang Bi, Chaoliang Wang, Liang Yan and Xiaoyan Li
    Citation: BMC Cancer 2021 21:1022
    Content type: Research Published on:

  16. Clinical effectiveness and safety data of pazopanib in patients with advanced or mRCC in real-world setting from Asia Pacific, North Africa, and Middle East countries are lacking.

    Authors: Mustafa Erman, Bivas Biswas, Pongwut Danchaivijitr, Lingwu Chen, Yoke Fui Wong, Tarek Hashem, Chun Sen Lim, Bulent Karabulut, Hsiao-Jen Chung, Chandrasekhar Chikatapu, Sara Ingles, Khemaies Slimane and Ravindran Kanesvaran
    Citation: BMC Cancer 2021 21:1021
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:1191

  17. There is currently no widely-accepted consensus for the management of hepatocellular carcinoma with portal vein tumor thrombus. We evaluate the safety and efficacy of ultrasound-guided percutaneous brachythera...

    Authors: Duo Hong, Yi Zhou, Xiaoting Wan, Hongying Su and Haibo Shao
    Citation: BMC Cancer 2021 21:1020
    Content type: Research article Published on:

  18. Patients who have breast cancer surgery are at risk of axillary web syndrome (AWS), an under-recognized postsurgical complication which can result in shoulder morbidity and functional impairment. Emerging stud...

    Authors: Matthew Rong Jie Tay, Chin Jung Wong and Hui Zhen Aw
    Citation: BMC Cancer 2021 21:1019
    Content type: Research Published on:

  19. An effective cross-cultural doctor-patient communication is vital for health literacy and patient compliance. Building a good relationship with medical staff is also relevant for the treatment decision-making ...

    Authors: D. Dimitrova, B. Naghavi, R. Richter, S. Nasser, R. Chekerov, E. I. Braicu, M. David, J. Blohmer, G. Inci, U. Torsten, G. Oskay-Özcelik, I. Blau, N. Fersis, A. Holzgreve, E. Keil, M. Keller…
    Citation: BMC Cancer 2021 21:1018
    Content type: Research Published on:

  20. Neutrophils are important for immune surveillance of tumour cells. Neutrophils may also be epigenetically programmed in the tumour microenvironment to promote tumour progression. In addition to the commonly kn...

    Authors: Chew Leng Lim and Valerie C.-L. Lin
    Citation: BMC Cancer 2021 21:1017
    Content type: Research Published on:

  21. This study aimed to evaluate the surgical outcome and quality of life (QoL) of totally laparoscopic total gastrectomy (TLTG) compared with laparoscopy-assisted total gastrectomy (LATG) in patients with clinica...

    Authors: Shin-Hoo Park, Yun-Suhk Suh, Tae-Han Kim, Yoon-Hee Choi, Jong-Ho Choi, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee and Han-Kwang Yang
    Citation: BMC Cancer 2021 21:1016
    Content type: Research Published on:

  22. Graft versus host disease (GvHD) is a frequent complication of allogeneic stem cell transplantation (alloSCT), significantly increasing mortality. Previous imaging studies focused on the assessment of intestin...

    Authors: Wolfgang Roll, Philipp Schindler, Max Masthoff, Rebecca Strotmann, Jörn Albring, Christian Reicherts, Matthias Weckesser, Benjamin Noto, Matthias Stelljes, Michael Schäfers and Georg Evers
    Citation: BMC Cancer 2021 21:1015
    Content type: Research Published on:

  23. Adjuvant immunotherapy is revolutionising care for patients with resected stage III and IV melanoma. However, immunotherapy may be associated with toxicity, making treatment decisions complicated. This study a...

    Authors: Ann Livingstone, Kathy Dempsey, Martin R. Stockler, Kirsten Howard, Georgina V. Long, Matteo S. Carlino, Alexander M. Menzies and Rachael L. Morton
    Citation: BMC Cancer 2021 21:1014
    Content type: Research Published on:

  24. When children and young people (CYP) are diagnosed with a brain tumour, Magnetic Resonance Imaging (MRI) is key to the clinical management of this condition. This can produce hundreds, and often thousands, of ...

    Authors: Natalie Tyldesley-Marshall, Sheila Greenfield, Susan J. Neilson, Martin English, Jenny Adamski and Andrew Peet
    Citation: BMC Cancer 2021 21:1013
    Content type: Research Published on:

  26. Flow cytometry plays a key role in detecting bone marrow (BM) involvement in patients with diffuse large B-cell lymphoma (DLBCL). To improve its detection sensitivity, we need to explore novel markers. In this...

    Authors: Wei Wang, Yan Li, Xavier Rivera Rivera, Linjun Zhao, Di Mei, Wenqing Hu and Bin Jiang
    Citation: BMC Cancer 2021 21:1011
    Content type: Research Published on:

  27. OptimalTTF-2 is a randomized, comparative, multi-center, investigator-initiated, interventional study aiming to test skull remodeling surgery in combination with Tumor Treating Fields therapy (TTFields) and be...

    Authors: N. Mikic, F. R. Poulsen, K. B. Kristoffersen, R. J. Laursen, T. L. Guldberg, J. Skjøth-Rasmussen, E. T. Wong, S. Møller, R. H. Dahlrot, J. C. H. Sørensen and A. R. Korshøj
    Citation: BMC Cancer 2021 21:1010
    Content type: Study protocol Published on:

  29. Evaluating the effect on primary lesions is important in determining treatment strategies for esophageal cancer. The Response Evaluation Criteria in Solid Tumors system, which employs the longest diameter for ...

    Authors: Yusuke Taniyama, Kentaro Murakami, Naoya Yoshida, Kozue Takahashi, Hisahiro Matsubara, Hideo Baba and Takashi Kamei
    Citation: BMC Cancer 2021 21:1008
    Content type: Research Published on:

  30. Cancer-testis antigens (CTAs) and tumour-associated antigens (TAAs) are frequently expressed in hepatocellular carcinoma (HCC); however, the role of tumour-antigen-specific T cell immunity in HCC progression i...

    Authors: Chaoran Zang, Yan Zhao, Ling Qin, Guihai Liu, Jianping Sun, Kang Li, Yanan Zhao, Shoupeng Sheng, Honghai Zhang, Ning He, Peng Zhao, Qi Wang, Xi Li, Yanchun Peng, Tao Dong and Yonghong Zhang
    Citation: BMC Cancer 2021 21:1007
    Content type: Research Published on:

  31. Hepatocellular carcinoma (HCC) is a major cause of cancer-related death. Paired related homeobox 1 (PRRX1) is a transcription factor that regulates cell growth and differentiation, but its importance in HCC is...

    Authors: Weronika Piorońska, Zeribe Chike Nwosu, Mei Han, Michael Büttner, Matthias Philip Ebert, Steven Dooley and Christoph Meyer
    Citation: BMC Cancer 2021 21:1006
    Content type: Research Published on:

  32. Weight changes are common among breast cancer patients. The majority of studies to date have focused on weight gain after a breast cancer diagnosis and its implications on health in survivors. Fewer studies ha...

    Authors: Jami Fukui, Kami White, Timothy B. Frankland, Caryn Oshiro and Lynne Wilkens
    Citation: BMC Cancer 2021 21:1005
    Content type: Research article Published on:

  33. Dysregulation of long non-coding RNAs (lncRNAs) has been identified in ovarian cancer. However, the expression and biological functions of LINC00852 in ovarian cancer are not understood.

    Authors: Zhi-wei Qiao, Ying Jiang, Ling Wang, Lei Wang, Jing Jiang, Jing-ru Zhang and Peng Mu
    Citation: BMC Cancer 2021 21:1004
    Content type: Research article Published on:

  34. Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in head and neck. Platinum-based chemotherapy is an important treatment for NPC. However, the molecular mechanism of resistance to platinum...

    Authors: Tian Xia, Hui Tian, Kaiwen Zhang, Siyu Zhang, Wenhui Chen, Si Shi and Yiwen You
    Citation: BMC Cancer 2021 21:1003
    Content type: Research article Published on:

  35. Leukemic cells facilitate the creation of the tumor-favorable microenvironment in the bone marrow niche using their secreted factors. There are not comprehensive details about immunosuppressive properties of c...

    Authors: Nazli Jafarzadeh, Mohammad Ali Gholampour, Mohammad-Reza Alivand, Saeideh Kavousi, Laleh Arzi, Fariba Rad, Majid Sadeghizadeh and Majid Pornour
    Citation: BMC Cancer 2021 21:1002
    Content type: Research Published on:

  36. The copper metabolism MURR1 domain (COMMD) protein family involved in tumor development and progression in several types of human cancer, but little is known about the function of COMMD proteins in hepatocellu...

    Authors: Xiaobo Wang, Shujiao He, Xin Zheng, Shanzhou Huang, Honghui Chen, Huadi Chen, Weixin Luo, Zhiyong Guo, Xiaoshun He and Qiang Zhao
    Citation: BMC Cancer 2021 21:1001
    Content type: Research article Published on:

  37. Currently, whether daily excess iodized salt intake increases the risk of thyroid nodules and even thyroid cancer remains controversial. Our research group aimed to provide a theoretical basis for the clinical...

    Authors: Yaohui Wang, Jiangang Wang, Zhihen Chen, Min Ma, Changwei Lin, Qingnan He and Mingzhu Ye
    Citation: BMC Cancer 2021 21:1000
    Content type: Research Published on:

  38. There are differences in survival between high-and low-grade Upper Tract Urothelial Carcinoma (UTUC). Our study aimed to develop a nomogram to predict overall survival (OS) of patients with high- and low-grade...

    Authors: Mengmeng Wang, Xin Ren, Ge Wang, Xiaomin Sun, Shifeng Tang, Baogang Zhang, Xiaoming Xing, Wenfeng Zhang, Guojun Gao, Jing Du, Shukun Zhang, Lijuan Liu, Xia Zheng, Zhenkun Zhang and Changgang Sun
    Citation: BMC Cancer 2021 21:999
    Content type: Research Published on:

  39. In Brazil, inequalities in access may interfere with cancer care. This study aimed to evaluate the influence of race on breast cancer mortality in the state of São Paulo, from 2000 to 2017, contextualizing wit...

    Authors: Ana Cláudia Marcelino, Bruno Gozzi, Cássio Cardoso-Filho, Helymar Machado, Luiz Carlos Zeferino and Diama Bhadra Vale
    Citation: BMC Cancer 2021 21:998
    Content type: Research Published on:

  40. miR-21, miR-26b, miR-221/222 and miR-126 play crucial roles in cervical cancer development. Studies have shown that polymorphisms in miRNA genes can affect miRNA expression, which might be associated with cancer ...

    Authors: Jia Yang, Zhiling Yan, Yingying Wang, Jinmei Xu, Rui Li, Chuanyin Li, Shuyuan Liu, Li Shi and Yufeng Yao
    Citation: BMC Cancer 2021 21:997
    Content type: Research Published on:

  41. Cancer mortality in the U.S. has fallen in recent decades; however, individuals with lower levels of education experienced a smaller decline than more highly educated individuals. This analysis aimed to measur...

    Authors: Alberto Barcelo, Linda Duffett-Leger, Maria Pastor-Valero, Juliana Pereira, Fernando A. B. Colugnati and Edward Trapido
    Citation: BMC Cancer 2021 21:907
    Content type: Research Published on:

  42. Esophageal cancer is a common malignant tumor and its 5-year survival rate is much lower than 30% due to its invasiveness and pronounced metastasis ability, as well as the difficulty in early diagnosis. This s...

    Authors: Rong Li, Xing-Feng Pang, Zhi-Guang Huang, Li-Hua Yang, Zhi-Gang Peng, Jie Ma and Rong-Quan He
    Citation: BMC Cancer 2021 21:996
    Content type: Research Published on:

  44. Many clinical trials have assessed the effect and safety of monoclonal antibodies (MAbs) in combination with proteasome inhibitors or immunomodulators plus dexamethasone/prednisone for the treatment of multipl...

    Authors: Wu Ye, Xia Wu, Xiaoyan Liu, Xue Zheng, Jili Deng and Yuping Gong
    Citation: BMC Cancer 2021 21:994
    Content type: Research article Published on:

  45. Selinexor is an oral, selective nuclear export inhibitor. STORM was a phase 2b, single-arm, open-label, multicenter trial of selinexor with low dose dexamethasone in patients with penta-exposed relapsed/refrac...

    Authors: Gabriel Tremblay, Patrick Daniele, Janis Breeze, Lingling Li, Jatin Shah, Sharon Shacham, Michael Kauffman, Monika Engelhardt, Ajaj Chari, Ajay Nooka, Dan Vogl, Maria Gavriatopoulou, Meletios-Athanasios Dimopoulos, Paul Richardson, Noa Biran, David Siegel…
    Citation: BMC Cancer 2021 21:993
    Content type: Research article Published on:

  46. Syntaxin4 (STX4) gene encodes the protein STX4, a member of soluble N-ethylmaleimide-sensitive factor attachment protein receptors protein, playing a vital role in cell invadopodium formation and invasion, whi...

    Authors: Lishan He, Huiming Jiang, Zhenqiang Lai, Zhixiong Zhong and Zhanqin Huang
    Citation: BMC Cancer 2021 21:992
    Content type: Research Published on:

  47. Gastrointestinal tumors are a leading cause of mortality worldwide. As shown in our previous study, miR-1290 is overexpressed in colorectal cancer (CRC) and promotes tumor progression. We therefore aimed to ex...

    Authors: Liyi Xu, Yangke Cai, Xiao Chen, Yongliang Zhu and Jianting Cai
    Citation: BMC Cancer 2021 21:989
    Content type: Research article Published on:

  48. Pneumocystis jirovecii pneumonia (PCP)-related risk factors among patients with solid tumors are not completely defined. Thus, we aimed to characterize PCP cases with underlying solid tumors, to highlight the fac...

    Authors: Koichi Takeda, Sohei Harada, Brian Hayama, Kosuke Hoashi, Taisuke Enokida, Toshiharu Sasaki, Koh Okamoto, Kenji Nakano and Daisuke Ohkushi
    Citation: BMC Cancer 2021 21:987
    Content type: Research article Published on:

  49. Prosthesis-related complications, after knee reconstruction with endoprosthesis during operation for tumors around the knee, remain an unresolved problem which necessitate a revision or even an amputational su...

    Authors: Cheng-gang Pang, Xiong-gang Yang, Yun-long Zhao, Yan-cheng Liu and Yong-cheng Hu
    Citation: BMC Cancer 2021 21:986
    Content type: Research article Published on:

  50. Lung cancer incidence and prevalence is increasing worldwide and there is a focus on prevention, early detection, and development of new treatments which will impact the epidemiological patterns of lung cancer...

    Authors: Erik Jakobsen, Karen Ege Olsen, Mette Bliddal, Malene Hornbak, Gitte F. Persson and Anders Green
    Citation: BMC Cancer 2021 21:985
    Content type: Research Published on:

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