Skip to main content

Articles

3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

Page 71 of 79

  1. In case of locally advanced and/or non-metastatic unresectable esophageal cancer, definitive chemoradiotherapy (CRT) delivering 50 Gy in 25 daily fractions in combination with platinum-based regimen remains th...

    Authors: Anouchka Modesto, David Tougeron, Pierre Tremolières, Philippe Ronchin, Ariane Darut Jouve, Delphine Argo Leignel, Véronique Vendrely, Olivier Riou, Jérôme Martin-Babau, Samuel Le Sourd, Xavier Mirabel, Thomas Leroy, Florence Huguet, Lucile Montaigne, Isabelle Baumgaertner, Marion Deslandres…
    Citation: BMC Cancer 2023 23:966
    Content type: Study protocol Published on:

  2. There are no standard third-line treatment options for metastatic pancreatic ductal adenocarcinoma (mPDAC). Trametinib in combination with hydroxychloroquine (HCQ) or CDK4/6 inhibitors for pancreatic adenocarc...

    Authors: Hui Tang, Yuping Ge, Tingting You, Xiaoyuan Li, Yingyi Wang, Yuejuan Cheng and Chunmei Bai
    Citation: BMC Cancer 2023 23:958
    Content type: Research Published on:

  3. Anti-programmed cell death receptor-1 (PD-1) monotherapy is the standard treatment for metastatic melanoma in current. Camrelizumab is a humanized IgG4 anti-PD-1 monoclonal antibody whose safety and efficacy h...

    Authors: Li Zhou, Xiaowen Wu, Zhihong Chi, Lu Si, Xinan Sheng, Yan Kong, Lili Mao, Bin Lian, Bixia Tang, Xieqiao Yan, Xuan Wang, Xue Bai, Siming Li, Xiaoting Wei, Juan Li, Qing Yang…
    Citation: BMC Cancer 2022 22:565
    Content type: Research Published on:

  4. Pemetrexed, a multitargeted antifolate cytotoxic agent, is currently used primarily in combination with cisplatin for metastatic non-small cell lung cancer and for malignant mesothelioma. Acute renal toxicity ...

    Authors: Maureen Assayag, Philippe Rouvier, Marion Gauthier, Ghania Costel, Philippe Cluzel, Lucile Mercadal, Gilbert Deray and Corinne Isnard Bagnis
    Citation: BMC Cancer 2017 17:770
    Content type: Case report Published on:

  5. Increased mesenchymal–epithelial transition factor gene (c-MET) expression in several human malignancies is related to increased tumour progression. The aim of the present study is to explore the relationship ...

    Authors: Jaudah Al-Maghrabi, Eman Emam, Wafaey Gomaa, Moaath Saggaf, Abdelbaset Buhmeida, Mohammad Al-Qahtani and Mahmoud Al-Ahwal
    Citation: BMC Cancer 2015 15:676
    Content type: Research article Published on:

  6. Malignant melanoma is an aggressive type of skin cancer, and despite recent advances in treatment, the survival rate of the metastatic form remains low. Nifuroxazide analogues are drugs based on the substituti...

    Authors: C. F. Farias, M. H. Massaoka, N. Girola, R. A. Azevedo, A. K. Ferreira, S. D. Jorge, L. C. Tavares, C. R. Figueiredo and L. R. Travassos
    Citation: BMC Cancer 2015 15:807
    Content type: Research article Published on:

  7. Eliminating cancer stem cells (CSCs) has been suggested for prevention of tumor recurrence and metastasis. Honokiol, an active compound of Magnolia officinalis, had been proposed to be a potential candidate drug ...

    Authors: Jhy-Shrian Huang, Chih-Jung Yao, Shuang-En Chuang, Chi-Tai Yeh, Liang-Ming Lee, Ruei-Ming Chen, Wan-Ju Chao, Jacqueline Whang-Peng and Gi-Ming Lai
    Citation: BMC Cancer 2016 16:245
    Content type: Research article Published on:

  8. The prognostic role of pretreatment serum lactate dehydronegase (LDH) has been well established in many malignant tumors, albeit it remains under-discussed in pancreatic cancer. In the present study, we aimed ...

    Authors: Yuanyuan Xiao, Wen Chen, Zhihui Xie, Zhenyi Shao, Hua Xie, Guoyou Qin and Naiqing Zhao
    Citation: BMC Cancer 2017 17:25
    Content type: Research article Published on:

  9. Primary mucosal melanoma (MM) is a rare subtype of melanoma that arises from melanocytes in the mucosa. MM has not been well profiled for mutations and its etiology is not well understood, rendering current tr...

    Authors: Yuuki Iida, Matthew P. Salomon, Keisuke Hata, Kevin Tran, Shuichi Ohe, Chester F. Griffiths, Sandy C. Hsu, Nellie Nelson and Dave S. B. Hoon
    Citation: BMC Cancer 2018 18:1054
    Content type: Research article Published on:

  10. Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as s...

    Authors: Nguyen Truong Duc Hoang, Ghmkin Hassan, Tomoya Suehiro, Yuichi Mine, Tohru Matsuki and Makiko Fujii
    Citation: BMC Cancer 2022 22:984
    Content type: Research Published on:

  12. Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3,...

    Authors: Paula Lázcoz, Jorge Muñoz, Manuel Nistal, Ángel Pestaña, Ignacio Encío and Javier S Castresana
    Citation: BMC Cancer 2006 6:254
    Content type: Research article Published on:

  13. TP300, a recently developed synthetic camptothecin analogue, is a highly selective topoisomerase I inhibitor. A phase I study showed good safety and tolerability. As camptothecins have proven active in oesopha...

    Authors: David Propper, Keith Jones, D. Alan Anthoney, Wasat Mansoor, Daniel Ford, Martin Eatock, Roshan Agarwal, Michiyasu Inatani, Tomohisa Saito, Masaichi Abe and T. R. Jeffry Evans
    Citation: BMC Cancer 2016 16:779
    Content type: Research article Published on:

  14. Innovative therapies have improved the overall survival in melanoma, although a high number of patients still experience disease progression or recurrence. Ex-vivo culture of circulating tumour cells (CTCs) re...

    Authors: Claudia Felici, Francesco Mannavola, Luigia Stefania Stucci, Loren Duda, Paola Cafforio, Camillo Porta and Marco Tucci
    Citation: BMC Cancer 2022 22:754
    Content type: Research Published on:

  15. Cancer affects older adults disproportionately. The disease is often difficult to diagnose and treat due to co-morbidities and performance status, and patients tend to discontinue chemotherapy prematurely. The...

    Authors: Rong Hu, Yong Wu, Xiaoying Jiang, Wenteng Zhang and Le Xu
    Citation: BMC Cancer 2011 11:224
    Content type: Research article Published on:

  16. CC-chemokine receptor 7 (CCR7), a known lymph node homing receptor for immune cells, has been reported as a key molecule in lymph node metastasis. We hypothesized a clinicopathological correlation and function...

    Authors: Tomoyuki Irino, Hiroya Takeuchi, Sachiko Matsuda, Yoshiro Saikawa, Hirofumi Kawakubo, Norihito Wada, Tsunehiro Takahashi, Rieko Nakamura, Kazumasa Fukuda, Tai Omori and Yuko Kitagawa
    Citation: BMC Cancer 2014 14:291
    Content type: Research article Published on:

  17. Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the...

    Authors: Hilde Ytre-Hauge Smeland, Ning Lu, Tine V. Karlsen, Gerd Salvesen, Rolf K. Reed and Linda Stuhr
    Citation: BMC Cancer 2019 19:234
    Content type: Research article Published on:

  18. Tumor-associated macrophages (TAMs) are known to promote cancer progression and metastasis through the release of a variety of cytokines. Phosphatase of regenerating liver (PRL-3) has been considered as a mark...

    Authors: Heyang Xu, Wei Lai, Yang Zhang, Lu Liu, Xingxi Luo, Yujie Zeng, Heng Wu, Qiusheng Lan and Zhonghua Chu
    Citation: BMC Cancer 2014 14:330
    Content type: Research article Published on:

  20. Cholangiocarcinoma (CCA) is an extremely aggressive cancer that is usually fatal. Although globally morbidity and mortality are increasing, knowledge of the disease remains limited. The Mekong region of Southe...

    Authors: Narong Khuntikeo, Nittaya Chamadol, Puangrat Yongvanit, Watcharin Loilome, Nisana Namwat, Paiboon Sithithaworn, Ross H. Andrews, Trevor N. Petney, Supannee Promthet, Kavin Thinkhamrop, Chaiwat Tawarungruang and Bandit Thinkhamrop
    Citation: BMC Cancer 2015 15:459
    Content type: Study protocol Published on:

  21. Dendritic cells (DCs) isolated from tumor bearing animals or from individuals with solid tumors display functional abnormalities and the DC impairment has emerged as one mechanism for tumor evasion from the co...

    Authors: Vegard Tjomsland, Per Sandström, Anna Spångeus, Davorka Messmer, Johan Emilsson, Ursula Falkmer, Sture Falkmer, Karl-Eric Magnusson, Kurt Borch and Marie Larsson
    Citation: BMC Cancer 2010 10:87
    Content type: Research article Published on:

  22. Hepatocellular carcinoma (HCC) usually has a dismal prognosis because of its limited response to current pharmacotherapy and high metastatic rate. Sulfated oligosaccharide has been confirmed as having potent a...

    Authors: Chun-Li Xiao, Zhong-Hua Tao, Lin Guo, Wei-Wei Li, Jin-Liang Wan, Hui-Chuan Sun, Lu Wang, Zhao-You Tang, Jia Fan and Wei-Zhong Wu
    Citation: BMC Cancer 2011 11:150
    Content type: Research article Published on:

  23. More than twenty years after its discovery, the role of the importin beta superfamily member Ran GTP-binding protein (RanBP) 17 is still ill defined. Previously, we observed notable RanBP17 RNA expression levels ...

    Authors: Robert Mandic, André Marquardt, Philip Terhorst, Uzma Ali, Annette Nowak-Rossmann, Chengzhong Cai, Fiona R. Rodepeter, Thorsten Stiewe, Bernadette Wezorke, Michael Wanzel, Andreas Neff, Boris A. Stuck and Michael Bette
    Citation: BMC Cancer 2022 22:785
    Content type: Research Published on:

  24. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors with a broad range of local and systemic treatment options. Still a lack of data regarding treatment sequences exists...

    Authors: Rahel Stiefel, Kuno Lehmann, Thomas Winder and Alexander R. Siebenhüner
    Citation: BMC Cancer 2023 23:148
    Content type: Research Published on:

  25. High-grade spindle cell sarcomas are a subtype of rare, undifferentiated pleomorphic sarcomas (UPSs) for which diagnosis is difficult and no specific treatment strategies have been established. The limited pub...

    Authors: Ning Zhou, Reinhold Schäfer, Tao Li, Meiyu Fang and Luying Liu
    Citation: BMC Cancer 2018 18:842
    Content type: Case report Published on:

  26. Hepatocellular carcinoma (HCC) is the most common type of tumor and is associated with high morbidity and mortality rates. Patients with HCC routinely undergo surgery followed by adjuvant radiation therapy and...

    Authors: Xuening Ji, Shi Jin, Xiaotong Qu, Kejun Li, Hongjiang Wang, Hui He, Fuchao Guo and Lei Dong
    Citation: BMC Cancer 2015 15:801
    Content type: Research article Published on:

  27. Pathologic complete response (pCR) following preoperative systemic therapy is associated with improved outcomes after subsequent liver transplant/resection in hepatocellular carcinoma (HCC). However, the relat...

    Authors: Cheng Huang, Xiao-Dong Zhu, Ying-Hao Shen, Bin Xu, Dong Wu, Yuan Ji, Ling-Li Chen, Tian-Qiang Song, Wei Zhang, Zhi-Ming Zeng, Hua-Sheng Huang, Kui Wang, Lan-Qing Huang, Yong-Jun Chen, Yu-Chen Yang, Le-Du Zhou…
    Citation: BMC Cancer 2023 23:416
    Content type: Research Published on:

  28. The optimal treatment strategy for resectable BRAF V600E mutant colorectal oligometastases (CRM) has not been established due to the rarity and rapid progression of the disease. Since the unresectable recurrence ...

    Authors: Shin Kobayashi, Hideaki Bando, Akinobu Taketomi, Takeshi Takamoto, Eiji Shinozaki, Manabu Shiozawa, Hiroki Hara, Kentaro Yamazaki, Koji Komori, Nobuhisa Matsuhashi, Takeshi Kato, Yoshinori Kagawa, Mitsuru Yokota, Eiji Oki, Keigo Komine, Shinichiro Takahashi…
    Citation: BMC Cancer 2023 23:779
    Content type: Study Protocol Published on:

  29. Cholangiocarcinoma, or bile duct cancer, is a gastrointestinal cancer with limited therapeutic options and a poor outcome. Studies have revealed that some major driver genes are associated with cholangiocarcin...

    Authors: Haibo Mou, Lanfang Yu, Qin Liao, Xuehua Hou, Yinfang Wu, Qiang Cui, Na Yan, Ruobing Ma, Lingjian Wang, Ming Yao and Kai Wang
    Citation: BMC Cancer 2018 18:1105
    Content type: Case report Published on:

  30. Glioma recurrence, subsequent to maximal safe resection, remains a pivotal challenge. This study aimed to identify key clinical predictors influencing recurrence and develop predictive models to enhance neurol...

    Authors: Wanyu Qiao, Yi Wang, Chen Luo, Jinsong Wu, Guoyou Qin, Jie Zhang and Ye Yao
    Citation: BMC Cancer 2024 24:274
    Content type: Research Published on:

  31. NUT midline carcinoma (NMC) is a rare and highly aggressive malignancy. Although more information on NMC has been recently accumulating in the literature, most oncologists and pathologists remain unfamiliar wi...

    Authors: Yohei Harada, Takafumi Koyama, Kengo Takeuchi, Kazufusa Shoji, Kazuei Hoshi and Yu Oyama
    Citation: BMC Cancer 2016 16:895
    Content type: Case report Published on:

  32. MEIS1 (Myeloid ecotropic viral integration site 1) as a homeobox (HOX) transcription factor plays regulatory roles in a variety of cellular processes including development, differentiation, survival, apoptosis...

    Authors: Selma Zargari, Shabnam Negahban Khameneh, Abolfazl Rad and Mohammad Mahdi Forghanifard
    Citation: BMC Cancer 2020 20:789
    Content type: Research article Published on:

  33. Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O

    Authors: Jeon Hwang-Bo, Mun Gyeong Bae, Jong-Hwa Park and In Sik Chung
    Citation: BMC Cancer 2018 18:714
    Content type: Research article Published on:

  34. 14-3-3 sigma (σ) promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3σ, which has been demonstrated in various carcinomas, may contribute to malignant ...

    Authors: Zhihui Wang, Claes G Tropè, Zhenhe Suo, Gunhild Trøen, Guanrui Yang, Jahn M Nesland and Ruth Holm
    Citation: BMC Cancer 2008 8:308
    Content type: Research article Published on:

  35. Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a...

    Authors: Harry H Yoon, Paul J Catalano, Kathleen M Murphy, Todd C Skaar, Santosh Philips, Mark Powell, Elizabeth A Montgomery, Michael J Hafez, Steven M Offer, Geoffrey Liu, Stephen J Meltzer, Xifeng Wu, Arlene A Forastiere, Al B Benson, Lawrence R Kleinberg and Michael K Gibson
    Citation: BMC Cancer 2011 11:176
    Content type: Research article Published on:

  36. Chemotherapy is the mainstay of non-Hodgkin lymphoma (NHL) treatment. Based on expert opinion, the use of radiotherapy (RT) is currently preferred in some institutions as consolidative treatment for patients w...

    Authors: Lucas Vieira dos Santos, JoãoPaulodaSilveiraNogueira Lima, Carmens Sílvia Passos Lima, Emma Chen Sasse and André Deeke Sasse
    Citation: BMC Cancer 2012 12:288
    Content type: Research article Published on:

  37. Head and neck squamous cell carcinoma (HNSCC) represents a common and heterogeneous malignancy of the oral cavity, pharynx and larynx. Surgery and radio(chemo)therapy are the standard treatment options and als...

    Authors: Christian Idel, Jonas Fleckner, Kirstin Plötze-Martin, Lotte Werner, Dirk Rades, Marie-Nicole Theodoraki, Linda Hofmann, Diana Huber, Anke Leichtle, Thomas K. Hoffmann, Karl-Ludwig Bruchhage and Ralph Pries
    Citation: BMC Cancer 2024 24:459
    Content type: Research Published on:

  38. Modified docetaxel, cisplatin, and 5-fluorouracil (mDCF) regimen has become a new standard for the treatment of metastatic or unresectable locally advanced recurrent squamous cell carcinoma of the anus (SCCA) ...

    Authors: Stefano Kim, Bruno Buecher, Thierry André, Marine Jary, François-Clément Bidard, François Ghiringhelli, Éric François, Julien Taieb, Denis Smith, Christelle de la Fouchardière, Jérôme Desramé, Emmanuelle Samalin, Aurélie Parzy, Nabil Baba-Hamed, Olivier Bouché, David Tougeron…
    Citation: BMC Cancer 2020 20:352
    Content type: Study protocol Published on:

  39. Primary malignant melanoma of the vagina is extremely rare, with a poorer prognosis than cutaneous malignant melanoma. Previous studies have explored the repurposing of itraconazole, a common oral anti-fungal ...

    Authors: Kayo Inoue, Hiroshi Tsubamoto, Roze Isono-Nakata, Kazuko Sakata and Nami Nakagomi
    Citation: BMC Cancer 2018 18:630
    Content type: Case report Published on:

  40. The Wnt signaling pathway is abnormally activated in many human cancers. Secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and play an important role in carcinogenesis. S...

    Authors: Junqin Liang, Xiaojing Kang, Yilinuer Halifu, Xuewen Zeng, Tianbo Jin, Mingxia Zhang, Dong Luo, Yuan Ding, Yunmin Zhou, Buwajier Yakeya, Dilinuer Abudu and Xiongming Pu
    Citation: BMC Cancer 2015 15:641
    Content type: Research article Published on:

  41. Increasing evidence indicates that Epithelial–mesenchymal transition (EMT) can be regulated by microRNAs (miRNAs). MiR-449a is a liver abundant miRNA. However, the role of miR-449a in the metastasis of hepatoc...

    Authors: Shu-peng Chen, Bao-xin Liu, Jie Xu, Xiao-feng Pei, Yi-ji Liao, Feng Yuan and Fang Zheng
    Citation: BMC Cancer 2015 15:706
    Content type: Research article Published on:

  42. The local and systemic activation and regulation of the immune system by malignant cells during carcinogenesis is highly complex with involvement of the innate and acquired immune system. Despite the fact that...

    Authors: Martin Grimm, Martin Gasser, Marco Bueter, Johanna Strehl, Johann Wang, Ekaterina Nichiporuk, Detlef Meyer, Christoph T Germer, Ana M Waaga-Gasser and Andreas Thalheimer
    Citation: BMC Cancer 2010 10:82
    Content type: Research article Published on:

  43. Clusterin (CLU) is a ubiquitous multifunctional factor involved in neoplastic transformation. The CLU transcript variants and protein forms play a crucial role in balancing cells proliferation and death.

    Authors: Paolo Fuzio, Anna Napoli, Anna Ciampolillo, Serafina Lattarulo, Angela Pezzolla, Nicoletta Nuzziello, Sabino Liuni, Francesco Giorgino, Eugenio Maiorano and Elda Perlino
    Citation: BMC Cancer 2015 15:349
    Content type: Research article Published on:

  44. Although the standard therapy for advanced-stage hepatocellular carcinoma (HCC) is systemic chemotherapy, the combination of atezolizumab and bevacizumab (atezo + bev) with a high objective response rate may l...

    Authors: Masayuki Okuno, Takamichi Ishii, Akihiko Ichida, Akihiko Soyama, Nobuyuki Takemura, Seiko Hirono, Susumu Eguchi, Kiyoshi Hasegawa, Yasuharu Sasaki, Kohei Uemura, Norihiro Kokudo and Etsuro Hatano
    Citation: BMC Cancer 2023 23:780
    Content type: Study Protocol Published on:

  45. Pancreatic ductal adenocarcinoma is a lethal disease with a 5-year survival rate of 4% and typically presents in an advanced stage. In this setting, prognostic markers identifying the more agrressive tumors co...

    Authors: David F Schaeffer, Daniel R Owen, Howard J Lim, Andrew K Buczkowski, Stephen W Chung, Charles H Scudamore, David G Huntsman, Sylvia SW Ng and David A Owen
    Citation: BMC Cancer 2010 10:59
    Content type: Research article Published on:

  46. Programmed cell death receptor 1 ligand 1 (PD-L1) expression in various tumors, including hematologic malignancies, has recently become a research topic of great interest. We performed a meta-analysis to evalu...

    Authors: Liping Qiu, Hanlu Zheng and Xiaoying Zhao
    Citation: BMC Cancer 2019 19:273
    Content type: Research article Published on:

  48. Colorectal cancer is a malignant gastrointestinal cancer, in which some advanced patients would develop cancer cachexia (CAC). CAC is defined as a multi-factorial syndrome characterized by weight loss and musc...

    Authors: Lingbi Jiang, Mingming Yang, Shihui He, Zhengyang Li, Haobin Li, Ting Niu, Dehuan Xie, Yan Mei, Xiaodong He, Lili Wei, Pinzhu Huang, Mingzhe Huang, Rongxin Zhang, Lijing Wang and Jiangchao Li
    Citation: BMC Cancer 2021 21:1297
    Content type: Research article Published on:

  49. Cancers of Unknown Primary (CUP) are the 3-4th most common causes of cancer death and recent clinical guidelines recommend that patients should be directed to a team dedicated to their care. Our aim was to inform...

    Authors: William Jones, Gwen Allardice, Iona Scott, Karin Oien, David Brewster and David S. Morrison
    Citation: BMC Cancer 2017 17:85
    Content type: Research article Published on:

  50. In patients with cancers of the pancreatic and biliary tract quality of life (QOL) improvement is the main treatment goal, since survival can be prolonged only marginally. Up to date, knowledge on QOL impairme...

    Authors: August Zabernigg, Johannes M Giesinger, Georg Pall, Eva-Maria Gamper, Klaus Gattringer, Lisa M Wintner, Monika J Sztankay and Bernhard Holzner
    Citation: BMC Cancer 2012 12:390
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Follow

BMC Cancer

ISSN: 1471-2407

Contact us