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  1. BCD-021 is a bevacizumab biosimilar which was shown to be equivalent to reference bevacizumab in a wide panel of physicochemical studies as well as preclinical studies in vitro and in vivo. International multicen...

    Authors: Daniil L. Stroyakovskiy, Natalya V. Fadeeva, Marina P. Matrosova, Konstantin G. Shelepen, Grigoriy A. Adamchuk, Bodhisatta Roy, Rajnish Nagarkar, Mahesh Kalloli, Daria Zhuravleva, Georgiy D. Voevodin, Mariya S. Shustova and Fedor Kryukov
    Citation: BMC Cancer 2022 22:129
    Content type: Research Published on:

  2. Imatinib is the gold standard for the treatment of all phases of Philadelphia positive Chronic Myeloid Leukemia (CML). During treatment, patients may develop cytopenia. We aimed to study the baseline character...

    Authors: Angela McLigeyo, Jamilla Rajab, Peter Oyiro, Mohammed Ezzi, Yatich Bett, Matilda Ong’ondi, Andrew Odhiambo, Sitna Mwanzi and Nicholas Othieno-Abinya
    Citation: BMC Cancer 2022 22:128
    Content type: Research Published on:

  3. Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. It has been demonstrated that apolipoproteins A1(ApoA1) are associated with diseas...

    Authors: Cong Shi, Shengping Gong, An Wu, Shujun Yang, Duobing Zou, Yi Zhang, Ningning Wu, Chao Ma, Songqiu Shi, Ying Chen, Ying Wu, Xiaojiao Zheng, Zhenya Huang, Jianghua Ding, Guifang Ouyang and Qitian Mu
    Citation: BMC Cancer 2022 22:127
    Content type: Research Published on:

  4. The purpose was to examine the effect of negative lymph nodes (NLN) number on survival in stage III colon cancer. To reduce the interference of acute inflammation, we included patients with stage III colon can...

    Authors: Yi-Hung Kuo, Jeng-Fu You, Hsin-Yuan Hung, Chih-Chien Chin, Jy-Ming Chiang and Chia-Hao Chang
    Citation: BMC Cancer 2022 22:126
    Content type: Research article Published on:

  5. Drug-drug interaction (DDI), which can occur at the pharmacokinetics and/or the pharmacodynamics (PD) levels, can increase or decrease the therapeutic or adverse response of a drug itself or a combination of d...

    Authors: Christina Pfab, Anush Abgaryan, Barbara Danzer, Fatme Mourtada, Weaam Ali, André Gessner and Nahed El-Najjar
    Citation: BMC Cancer 2022 22:125
    Content type: Research article Published on:

  6. Ovarian cancer (OC) is a female malignant tumor with a high fatality rate. Long non-coding RNAs (lncRNAs) are deeply involved in OC progression. The aim of this study is to explore the specific mechanism of ln...

    Authors: Bing Li, Ge Lou, Jiahui Zhang, Ning Cao and Xi Yu
    Citation: BMC Cancer 2022 22:124
    Content type: Research article Published on:

  7. Gastric cancer remains a major cause of cancer-related death worldwide. C12orf48, also named PARP1 binding protein, is over-expressed in several cancers. However, the expression profile and potential roles of ...

    Authors: Lele Lin, Hongbo Li, Dike Shi, Zhiqiang Liu, Yunhai Wei, Wei Wang, Dan Wu, Baozhong Li and Qingqu Guo
    Citation: BMC Cancer 2022 22:123
    Content type: Research Published on:

  9. The relationship between insurance status and interhospital transfers has not been adequately researched among cancer patients. Hence this study aimed for understanding this relationship using a nationally rep...

    Authors: Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Sandeep Appunni, Subrina Sundil, Emir Veledar, Peter McGranaghan, Raees Tonse, Sergio Jose Torralbas Fitz, Michael D. Chuong, Yazmin Odia, Ritesh Kotecha, Minesh P. Mehta and Rupesh Kotecha
    Citation: BMC Cancer 2022 22:121
    Content type: Research Published on:

  10. Endoscopic treatment methods for early colorectal cancer (ECRC) mainly depend on the size and morphology. It is unclear whether different endoscopic resection methods could achieve curative resection for ECRC ...

    Authors: Qing-Wei Zhang, Zi-Hao Dai, Xiao-Yi Wang, Yun-Jie Gao, Zhi-Zheng Ge and Xiao-Bo Li
    Citation: BMC Cancer 2022 22:120
    Content type: Research article Published on:

  11. Borderline resectable pancreatic cancer (BRPC) is a category of pancreatic cancer that is anatomically widely spread, and curative resection is uncommon with upfront surgery. Intensity-modulated radiation ther...

    Authors: Toshihiko Masui, Kazuyuki Nagai, Takayuki Anazawa, Asahi Sato, Yuichiro Uchida, Kenzo Nakano, Akitada Yogo, Akihiro Kaneda, Naoto Nakamura, Michio Yoshimura, Takashi Mizowaki, Norimitsu Uza, Akihisa Fukuda, Shigemi Matsumoto, Masashi Kanai, Hiroyoshi Isoda…
    Citation: BMC Cancer 2022 22:119
    Content type: Research Published on:

  12. The postoperative survival effect of the number of examined lymph nodes on patients of R0-resected esophageal squamous cell carcinoma with pathological stage T1–3N0M0 is still unclear.

    Authors: Lei-Lei Wu, Jiu-Di Zhong, Jia-Li Zhu, Lu Kang, Yang-Yu Huang, Peng Lin, Hao Long, Lan-Jun Zhang, Qi-Long Ma, Li-Hong Qiu and Guo-Wei Ma
    Citation: BMC Cancer 2022 22:118
    Content type: Research Published on:

  13. Calcium-activated nucleotidase 1 (CANT1), functions as a calcium-dependent nucleotidase with a preference for UDP. However, the potential clinical value of CANT1 in lung adenocarcinoma (LA) has not been fully ...

    Authors: Qiwei Yao, Yilin Yu, Zhiping Wang, Mengyan Zhang, Jiayu Ma, Yahua Wu, Qunhao Zheng and Jiancheng Li
    Citation: BMC Cancer 2022 22:117
    Content type: Research Published on:

  14. Sodium glucose transporters (SGLTs) play vital roles in glucose uptake in many solid cancers, including pancreatic cancer (PC). However, their expression profile in pancreatic cancer and correlation with progn...

    Authors: Jiali Du, Jichun Gu, Junyuan Deng, Lei Kong, Yujie Guo, Chen Jin, Yun Bao, Deliang Fu and Ji Li
    Citation: BMC Cancer 2022 22:116
    Content type: Research Published on:

  15. To identify hub genes from the competing endogenous RNA (ceRNA) network of lung adenocarcinoma (LUAD) and to explore their potential functions on prognosis of patients from a single-cell perspective.

    Authors: Wenhan Chen, Zhifeng Guo, Jingyang Wu, Guofu Lin, Shaohua Chen, Qinhui Lin, Jiansheng Yang, Yuan Xu and Yiming Zeng
    Citation: BMC Cancer 2022 22:115
    Content type: Research article Published on:

  16. The aim of this study was to investigate the epidemiological characteristics and associated risk factors of recurrent lower-grade glioma [LGG] (WHO grades II and III) according to the 2016 updated WHO classifi...

    Authors: Ruolun Wei, Chao Zhao, Jianguo Li, Fengdong Yang, Yake Xue and Xinting Wei
    Citation: BMC Cancer 2022 22:114
    Content type: Research Published on:

  17. This retrospective study investigated biomarkers that can reflect coagulation, inflammation, and lipid abnormalities: platelet-to-albumin ratio (PAR), platelet-to lymphocyte ratio (PLR), low-density lipoprotei...

    Authors: Cong Ma, Ruizhen Li, Ronghui Yu, Jingjing Guo, Jianyun Xu, Xuhui Yuan and Jianfeng Guo
    Citation: BMC Cancer 2022 22:113
    Content type: Research Published on:

  19. To determine how much an augmented analysis approach could improve the efficiency of prostate-specific antigen (PSA) response analyses in clinical practice. PSA response rates are commonly used outcome measure...

    Authors: Michael J. Grayling, Martina McMenamin, Robert Chandler, Rakesh Heer and James M. S. Wason
    Citation: BMC Cancer 2022 22:111
    Content type: Research Published on:

  20. Idiopathic pulmonary fibrosis (IPF) is the most common type of interstitial pneumonia. Lung cancer, mainly non-small cell lung cancer (NSCLC), is a complication of idiopathic pulmonary fibrosis. IPF is also an...

    Authors: Wenxin Kou, Bo Li, Yeifei Shi, Yifan Zhao, Qing Yu, Jianhui Zhuang, Yawei Xu and Wenhui Peng
    Citation: BMC Cancer 2022 22:110
    Content type: Research Published on:

  21. Older cancer patients may search for health information online to prepare for their consultations. However, seeking information online can have negative effects, for instance increased anxiety due to finding i...

    Authors: Melanie de Looper, Ellen M. A. Smets, Barbara C. Schouten, Sifra Bolle, Eric H. J. Belgers, Eric H. Eddes, Jeroen W. A. Leijtens and Julia C. M. van Weert
    Citation: BMC Cancer 2022 22:109
    Content type: Research Published on:

  22. Osteosarcoma is an aggressive malignant bone sarcoma worldwide. A causal gene network with specific functions underlying both the development and progression of OS was still unclear. Here we firstly identified...

    Authors: Jiahua Li, Hui Shi, Zhanyuan Yuan, Zhiheng Wu, Haohao Li, Yuelong Liu, Ming Lu and Ming Lu
    Citation: BMC Cancer 2022 22:108
    Content type: Research Published on:

  23. The incidence rate of non-small cell lung cancer (NSCLC) has been increasing worldwide, and the correlation of circadian rhythm disruption with a raised risk of cancer and worse prognosis has been shown by acc...

    Authors: Haocheng Xian, Yuan Li, Boliang Zou, Yajuan Chen, Houqing Yin, Xuejun Li and Yan Pan
    Citation: BMC Cancer 2022 22:107
    Content type: Research Published on:

  24. Screening supports early detection and treatment of colorectal cancer (CRC). Provision of fecal immunochemical tests/fecal occult blood tests (FIT/FOBT) in primary care can increase CRC screening, particularly...

    Authors: Cynthia M. Mojica, Rose Gunn, Robyn Pham, Edward J. Miech, Ann Romer, Stephanie Renfro, Khaya D. Clark and Melinda M. Davis
    Citation: BMC Cancer 2022 22:106
    Content type: Research article Published on:

  25. Nutrient acquisition and metabolism pathways are altered in cancer cells to meet bioenergetic and biosynthetic demands. A major regulator of cellular metabolism and energy homeostasis, in normal and cancer cel...

    Authors: Mehrshad Sadria, Deokhwa Seo and Anita T. Layton
    Citation: BMC Cancer 2022 22:105
    Content type: Research Published on:

  26. Administration of single-agent docetaxel in a weekly schedule may offer similar efficacy, with a more favorable toxicity profile, compared to a three-weekly schedule in patients with metastatic breast cancer.

    Authors: Maarten van Eijk, Marit A. C. Vermunt, Erik van Werkhoven, Erica A. Wilthagen, Alwin D. R. Huitema and Jos H. Beijnen
    Citation: BMC Cancer 2022 22:104
    Content type: Research article Published on:

  27. The study aimed to assess the impact of size differences of multiple liver metastases on liver recurrence-free survival (RFS) in patients undergoing hepatic resection for colorectal liver metastases (CRLMs).

    Authors: Yana Zhai, Weijun Bai, Jin Zhou, Qian Dong and Jingdong Zhang
    Citation: BMC Cancer 2022 22:103
    Content type: Research article Published on:

  29. Treatment outcomes of advanced non-small cell lung cancer (NSCLC) have substantially improved with immune checkpoint inhibitors (ICI), although only approximately 19% of patients respond to immunotherapy alone...

    Authors: Andrew F. Nyein, Shahla Bari, Stephanie Hogue, Yayi Zhao, Bradley Maller, Sybil Sha, Maria F. Gomez, Dana E. Rollison and Lary A. Robinson
    Citation: BMC Cancer 2022 22:101
    Content type: Research Published on:

  30. Platinum chemoresistance results in high-grade serous ovarian cancer (HGSOC) disease recurrence. Recent treatment advances using checkpoint inhibitor immunotherapy has not benefited platinum-resistant HGSOC. I...

    Authors: Michelle W. Wong-Brown, Andre van der Westhuizen and Nikola A. Bowden
    Citation: BMC Cancer 2022 22:100
    Content type: Research Published on:

  31. The gut microbiome is implicated as a marker of response to  immune checkpoint inhibitors (ICI) based on preclinical mouse models and preliminary observations in limited patient series. Furthermore, early stud...

    Authors: Nicola A. Thompson, Grant D. Stewart, Sarah J. Welsh, Gary J. Doherty, Matthew J. Robinson, B. Anne Neville, Kevin Vervier, Simon R. Harris, David J. Adams, Katy Dalchau, David Bruce, Nikolaos Demiris, Trevor D. Lawley and Pippa G. Corrie
    Citation: BMC Cancer 2022 22:99
    Content type: Study protocol Published on:

  32. Recently, chimeric antigen receptor-modified (CAR) T cell therapy for hematological malignancies has shown clinical efficacy. Hundreds of clinical trials have been registered and lots of studies have shown hem...

    Authors: Wenjing Luo, Chenggong Li, Yinqiang Zhang, Mengyi Du, Haiming Kou, Cong Lu, Heng Mei and Yu Hu
    Citation: BMC Cancer 2022 22:98
    Content type: Research article Published on:

  33. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Salonee Shah, Kerri Beckmann, Mieke Van Hemelrijck, Ben Challacombe, Rick Popert, Prokar Dasgupta, Jonah Rusere, Grace Zisengwe, Oussama Elhage and Aida Santaolalla
    Citation: BMC Cancer 2022 22:97
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2021 21:573

  34. To explore the maximum tolerated dose (MTD) and evaluate the safety of dose escalation using hypofractionated simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) concurrent with chemother...

    Authors: Qin Zhang, Xu-Wei Cai, Wen Feng, Wen Yu and Xiao-Long Fu
    Citation: BMC Cancer 2022 22:96
    Content type: Research Published on:

  35. Dietary patterns and symptoms research among Chinese with esophageal squamous cell carcinoma (ESCC) and its precursor lesions is limited, especially as it relates to multiple food consumption and multiple co-o...

    Authors: Zhaoping Zang, Yong Liu, Jialin Wang, Yuqin Liu, Shaokai Zhang, Yongzhen Zhang, Liwei Zhang, Deli Zhao, Fugang Liu, Lina Chao, Xinzheng Wang, Chunli Zhang, Guohui Song, Zhiyi Zhang, Youpeng Li, Zheng Yan…
    Citation: BMC Cancer 2022 22:95
    Content type: Research Published on:

  36. Preoperative chemotherapy is widely applied to high-grade localized soft tissue sarcomas (STSs); however, the prognostic significance of histological response to chemotherapy remains controversial. This study ...

    Authors: Yoshinao Oda, Kazuhiro Tanaka, Takanori Hirose, Tadashi Hasegawa, Nobuyuki Hiruta, Masanori Hisaoka, Masato Yoshimoto, Hiroshi Otsuka, Hirofumi Bekki, Takeaki Ishii, Makoto Endo, Toshiyuki Kunisada, Toru Hiruma, Hiroyuki Tsuchiya, Hirohisa Katagiri, Yoshihiro Matsumoto…
    Citation: BMC Cancer 2022 22:94
    Content type: Research Published on:

  37. Serum cholinesterase (ChE) was found to be involved in cancer initiation and progression. However, the survival association between serum ChE and non-small cell lung cancer (NSCLC) has not been extensively dis...

    Authors: Hailiang Ran, Jie Ma, Le Cai, Hai Zhou, Zhongqin Yuan, Ying Chen, Wei Chang, Yunchao Huang and Yuanyuan Xiao
    Citation: BMC Cancer 2022 22:93
    Content type: Research Published on:

  39. Hepatocellular carcinoma (HCC) is the sixth most common form of cancer worldwide. Although surgical treatments have an acceptable cure rate, tumor recurrence is still a challenging issue. In this meta-analysis...

    Authors: Elias Khajeh, Arash Dooghaie Moghadam, Pegah Eslami, Sadeq Ali-Hasan-Al-Saegh, Ali Ramouz, Saeed Shafiei, Omid Ghamarnejad, Sepehr Abbasi Dezfouli, Christian Rupp, Christoph Springfeld, Carlos Carvalho, Pascal Probst, Seyed Mostafa Mousavizadeh and Arianeb Mehrabi
    Citation: BMC Cancer 2022 22:91
    Content type: Research Published on:

  40. Oral mucositis (OM) associated with cancer treatment not only impairs patients’ quality of life but also causes treatment delays or changes. This prospective exploratory study was conducted to evaluate the eff...

    Authors: Takao Ueno, Wakako Yatsuoka, Hiroto Ishiki, Kanako Miyano and Yasuhito Uezono
    Citation: BMC Cancer 2022 22:90
    Content type: Research Published on:

  42. Radiotherapy is a highly effective treatment for cervical cancer. Recent studies focused on the radiotherapy induced anti-tumor immunity. Whether tumor-derived extracellular vesicles (EVs) play roles in radiot...

    Authors: Junli Ren, Lili Li, Baofeng Yu, Enwei Xu, Naiping Sun, Xiaoning Li, Zihan Xing, Xiaodong Han, Yaqin Cui, Xiaoyan Wang, Xiaoxue Zhang and Guoliang Wang
    Citation: BMC Cancer 2022 22:88
    Content type: Research Published on:

  43. Uterine cervical cancer (UCC) was the fourth leading cause of cancer death among women worldwide. The conventional MRI hardly revealing the microstructure information. This study aimed to compare the value of ...

    Authors: Mengyan Hou, Kai Song, Jipeng Ren, Kaiyu Wang, Jinxia Guo, Yongchao Niu, Zhenyu Li and Dongming Han
    Citation: BMC Cancer 2022 22:87
    Content type: Research Published on:

  45. Circulating cell-free DNA (cfDNA) in the plasma of cancer patients contains cell-free tumour DNA (ctDNA) derived from tumour cells and it has been widely recognized as a non-invasive source of tumour DNA for d...

    Authors: Devika Ganesamoorthy, Alan James Robertson, Wenhan Chen, Michael B. Hall, Minh Duc Cao, Kaltin Ferguson, Sunil R. Lakhani, Katia Nones, Peter T. Simpson and Lachlan J. M. Coin
    Citation: BMC Cancer 2022 22:85
    Content type: Research article Published on:

  46. Activated Cdc42-associated kinase 1 (ACK1), a kind of tyrosine kinase, is considered to be an oncogene in many cancers, and it is likely to become a potential target for cancer treatment. We found that the exp...

    Authors: Defeng Kong, Guoliang Li, Zhenrong Yang, Shujun Cheng, Wen Zhang, Lin Feng and Kaitai Zhang
    Citation: BMC Cancer 2022 22:84
    Content type: Research Published on:

  47. Cancer cells prefer utilizing aerobic glycolysis in order to exacerbate tumor mass and maintain un-regulated proliferative rates. As a key glycolytic activator, phosphofructo-2-kinase/fructose-2,6-bisphosphata...

    Authors: Jun Li, Shiqiang Zhang, Dingzhun Liao, Qian Zhang, Chujie Chen, Xiangwei Yang, Donggen Jiang and Jun Pang
    Citation: BMC Cancer 2022 22:83
    Content type: Research Published on:

  48. Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority of patients with ESCC in Eastern Africa present with advanced disease at the time of...

    Authors: Geoffrey C. Buckle, Alita Mrema, Michael Mwachiro, Yona Ringo, Msiba Selekwa, Gift Mulima, Fatma F. Some, Blandina T. Mmbaga, Gita N. Mody, Li Zhang, Alan Paciorek, Larry Akoko, Paul Ayuo, Stephen Burgert, Elizabeth Bukusi, Anthony Charles…
    Citation: BMC Cancer 2022 22:82
    Content type: Study protocol Published on:

  49. Lung cancer (LC) is the most commonly diagnosed cancer and the leading cause of cancer-related death in both sexes worldwide. Although the principal risk factor in the western world is tobacco smoking, genetic...

    Authors: Ramón Antonio Tubío-Pérez, María Torres-Durán, María Esmeralda García-Rodríguez, Cristina Candal-Pedreira, Julia Rey-Brandariz, Mónica Pérez-Ríos, Juan Barros-Dios, Alberto Fernández-Villar and Alberto Ruano-Raviña
    Citation: BMC Cancer 2022 22:81
    Content type: Research Published on:

  50. It has been postulated that patient’s sex impacts response to immunotherapy. Sex modulation of immunotherapy benefit, however, has not yet been explored using patient-level data, where potential confounders, a...

    Authors: Stephanie Tuminello, Naomi Alpert, Rajwanth R. Veluswamy, Arvind Kumar, Jorge E. Gomez, Raja Flores and Emanuela Taioli
    Citation: BMC Cancer 2022 22:80
    Content type: Research Published on:

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