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3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

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  1. To determine the effect of Yttrium-90 (Y90) radioembolization on health-related quality of life (HRQOL) and its effect on overall survival advanced, unresectable infiltrative hepatocellular carcinoma (HCC) pat...

    Authors: Minzhi Xing, Nima Kokabi, Juan C. Camacho and Hyun S. Kim
    Citation: BMC Cancer 2018 18:75
    Content type: Research article Published on:

  2. Medical oncology outpatients are a group for whom advance care planning (ACP) activities are particularly relevant. Patient views can help prioritise areas for improving end of life communication. The study ai...

    Authors: Amy Waller, Heidi Turon, Jamie Bryant, Alison Zucca, Tiffany-Jane Evans and Rob Sanson-Fisher
    Citation: BMC Cancer 2019 19:63
    Content type: Research article Published on:

  4. Molecular biomarkers capable of predicting recurrence patterns and prognosis are helpful for risk stratification and providing appropriate treatment to patients with hepatocellular carcinoma (HCC). In this stu...

    Authors: Shinichi Umeda, Mitsuro Kanda, Hiroyuki Sugimoto, Haruyoshi Tanaka, Masamichi Hayashi, Suguru Yamada, Tsutomu Fujii, Hideki Takami, Yukiko Niwa, Naoki Iwata, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara and Yasuhiro Kodera
    Citation: BMC Cancer 2017 17:610
    Content type: Research article Published on:

  5. Tumor-associated macrophages (TAMs) are the most abundant types of immune cells in the tumor microenvironment (TME) of breast cancer (BC). TAMs usually exhibit an M2 phenotype and promote tumor progression by ...

    Authors: Chongru Zhao, Ning Zeng, Xiaomei Zhou, Yufang Tan, Yichen Wang, Jun Zhang, Yiping Wu and Qi Zhang
    Citation: BMC Cancer 2023 23:392
    Content type: Research Published on:

  6. Aminopeptidase N (APN/CD13), a 150-kDa metalloprotease, is a multifunctional cell surface aminopeptidase with ubiquitous expression. Recent studies have suggested that APN/CD13 plays an important role in tumor...

    Authors: Mikio Terauchi, Hiroaki Kajiyama, Kiyosumi Shibata, Kazuhiko Ino, Akihiro Nawa, Shigehiko Mizutani and Fumitaka Kikkawa
    Citation: BMC Cancer 2007 7:140
    Content type: Research article Published on:

  7. Aberrant regulation in the invasion of cancer cells is closely associated with their metastatic potentials. TrkB functions as a receptor tyrosine kinase and is considered to facilitate tumor metastasis. Pyk2 i...

    Authors: Siyang Zhang, Dawei Guo, Wenting Luo, Qingfu Zhang, Ying Zhang, Chunyan Li, Yao Lu, Zeshi Cui and Xueshan Qiu
    Citation: BMC Cancer 2010 10:43
    Content type: Research article Published on:

  8. A growing body of evidence suggests that microRNAs (miRNAs) play an important role in cancer diagnosis and therapy. MicroRNA-99a (miR-99a), a potential tumor suppressor, is downregulated in several human malig...

    Authors: Li Cui, Hua Zhou, Hu Zhao, Yaojun Zhou, Renfang Xu, Xianlin Xu, Lu Zheng, Zhong Xue, Wei Xia, Bo Zhang, Tao Ding, Yunjie Cao, Zinong Tian, Qianqian Shi and Xiaozhou He
    Citation: BMC Cancer 2012 12:546
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:103

  9. Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify n...

    Authors: Lionel Flamant, Edith Roegiers, Michael Pierre, Aurélie Hayez, Christiane Sterpin, Olivier De Backer, Thierry Arnould, Yves Poumay and Carine Michiels
    Citation: BMC Cancer 2012 12:391
    Content type: Research article Published on:

  10. Endometrial Cancer (EC) is one of the most prevalent malignancies that affect the female population globally. In the context of immunotherapy, Tumor Mutation Burden (TMB) in the DNA polymerase epsilon (POLE) s...

    Authors: Qing Tan, Qian Wang, Suoqin Jin, Fuling Zhou and Xiufen Zou
    Citation: BMC Cancer 2023 23:712
    Content type: Research Published on:

  11. Humans and dogs are affected by squamous cell carcinomas of the oral cavity (OSCC) in a considerably high frequency. The high mobility group A2 (HMGA2) protein was found to be highly expressed in human OSCC an...

    Authors: Katharina Anna Sterenczak, Andre Eckardt, Andreas Kampmann, Saskia Willenbrock, Nina Eberle, Florian Länger, Sven Kleinschmidt, Marion Hewicker-Trautwein, Hans Kreipe, Ingo Nolte, Hugo Murua Escobar and Nils Claudius Gellrich
    Citation: BMC Cancer 2014 14:694
    Content type: Research article Published on:

  12. Patients suffering from advanced stage hepatocellular carcinoma (HCC) often exhibit a poor prognosis or dismal clinical outcomes due to ineffective chemotherapy or a multi-drug resistance (MDR) process. Thus, ...

    Authors: Jun Hou, Zhixian Hong, Fan Feng, Yantao Chai, Yunkai Zhang, Qiyu Jiang, Yan Hu, Shunquan Wu, Yingsong Wu, Xunian Gao, Qiong Chen, Yong Wan, Jingfeng Bi and Zheng Zhang
    Citation: BMC Cancer 2017 17:729
    Content type: Research article Published on:

  13. Cuproptosis is a newly discovered programmed cell death dependent on mitochondrial respiratory disorder induced by copper overload. Pyruvate dehydrogenase E1 subunit beta (PDHB) is one of the cuproptosis genes...

    Authors: Hu Wang, Zhan Yang, Xingyu He, Fengran Guo, Hao Sun, Sen Xu, Chao Xu, Zhu Wang, Hongzhuang Wen, Zhihai Teng, Yaxuan Wang and Zhenwei Han
    Citation: BMC Cancer 2023 23:804
    Content type: Research Published on:

  14. Intrahepatic cholangiocarcinoma (ICC) is the second most common type of primary liver cancer. Only few studies have focused on palliative radiotherapy used for patients who weren't suitable for resection by su...

    Authors: Yi-Xing Chen, Zhao-Chong Zeng, Zhao-You Tang, Jia Fan, Jian Zhou, Wei Jiang, Meng-Su Zeng and Yun-Shan Tan
    Citation: BMC Cancer 2010 10:492
    Content type: Research article Published on:

  16. Programmed cell death 1 (PD1) inhibitors have recently shown promising anti-cancer effects in a number of solid tumor types. A predictive biomarker to this class of drugs has not been clearly identified; howev...

    Authors: Basile Tessier-Cloutier, Steve E. Kalloger, Mohammad Al-Kandari, Katy Milne, Dongxia Gao, Brad H. Nelson, Daniel J. Renouf, Brandon S. Sheffield and David F. Schaeffer
    Citation: BMC Cancer 2017 17:618
    Content type: Research article Published on:

  17. Over than one third (28–58%) of pregnancy-associated breast cancer (PABC) cases are characterized by positive epidermal growth factor receptor 2-positive (HER2) expression. Trastuzumab anti-HER2 monoclonal ant...

    Authors: Angeliki Andrikopoulou, Kleoniki Apostolidou, Spyridoula Chatzinikolaou, Garyfalia Bletsa, Eleni Zografos, Meletios-Athanasios Dimopoulos and Flora Zagouri
    Citation: BMC Cancer 2021 21:463
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:1340

  18. Keratin (K) 19-positive hepatocellular carcinoma (HCC) is well known to have a higher malignant potential than K19-negative HCC: However, the molecular mechanisms involved in K19-mediated progression of HCC re...

    Authors: Masato Takano, Keiji Shimada, Tomomi Fujii, Kohei Morita, Maiko Takeda, Yoshiyuki Nakajima, Akitaka Nonomura, Noboru Konishi and Chiho Obayashi
    Citation: BMC Cancer 2016 16:903
    Content type: Research article Published on:

  19. The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is...

    Authors: Jan Bieńkiewicz, Hanna Romanowicz, Bożena Szymańska, Daria Domańska-Senderowska, Miłosz Wilczyński, Anna Stepowicz, Andrzej Malinowski and Beata Smolarz
    Citation: BMC Cancer 2022 22:343
    Content type: Research Published on:

  20. Increasing evidence indicates that cetuximab (CET) combined with chemoradiotherapy may be effective for patients with esophageal cancer. However, the recent results are still contradictory and no consensus has...

    Authors: Ze-Hao Huang, Xiao-Wen Ma, Jing Zhang, Xiao Li, Na-Lin Lai and Sheng-Xiao Zhang
    Citation: BMC Cancer 2018 18:1170
    Content type: Research article Published on:

  21. Chemoresistance is a major obstacle in cancer treatment. Targeted therapies that enhance cancer cell sensitivity to chemotherapeutic agents have the potential to increase drug efficacy while reducing toxic eff...

    Authors: Erin B Dickerson, William H Blackburn, Michael H Smith, Laura B Kapa, L Andrew Lyon and John F McDonald
    Citation: BMC Cancer 2010 10:10
    Content type: Research article Published on:

  22. Thrombin activatable fibrinolysis inhibitor (TAFI) is a plasma zymogen, which can be converted to activated TAFI (TAFIa) through proteolytic cleavage by thrombin, plasmin, and most effectively thrombin in comp...

    Authors: Zainab A. Bazzi, Danielle Lanoue, Mouhanned El-Youssef, Rocco Romagnuolo, Janice Tubman, Dora Cavallo-Medved, Lisa A. Porter and Michael B. Boffa
    Citation: BMC Cancer 2016 16:328
    Content type: Research article Published on:

  24. Patients with highly mutated tumors, such as melanoma or smoking-related lung cancer, have higher rates of response to immune checkpoint blockade therapy, perhaps due to increased neoantigen expression. Many c...

    Authors: Timothy O’Donnell, Elizabeth L. Christie, Arun Ahuja, Jacqueline Buros, B. Arman Aksoy, David D. L. Bowtell, Alexandra Snyder and Jeff Hammerbacher
    Citation: BMC Cancer 2018 18:87
    Content type: Research article Published on:

  25. For breast cancer patients diagnosed with estrogen receptor (ER)-positive tumors, treatment with tamoxifen is the gold standard. A significant number of patients, however, develop resistance to tamoxifen, and ...

    Authors: Aamir Ahmad, Kevin R. Ginnebaugh, Shuping Yin, Aliccia Bollig-Fischer, Kaladhar B. Reddy and Fazlul H. Sarkar
    Citation: BMC Cancer 2015 15:540
    Content type: Research article Published on:

  26. Prostate cancer is the most common form of cancer in males and accounts for high cancer related deaths. Therapeutic advancement in prostate cancer has not been able to reduce the mortality burden of prostate c...

    Authors: Ankit Tiwari, Bratati Mukherjee, Md. Khurshidul Hassan, Niharika Pattanaik, Archita Mohanty Jaiswal and Manjusha Dixit
    Citation: BMC Cancer 2019 19:346
    Content type: Research article Published on:

  27. Current evidence implicates aberrant microRNA expression patterns in human malignancies; measurement of microRNA expression may have diagnostic and prognostic applications. Roles for microRNAs in head and neck...

    Authors: Patricia Severino, Holger Brüggemann, Flavia Maziero Andreghetto, Carme Camps, Maria de Fatima Garrido Klingbeil, Welbert Oliveira de Pereira, Renata Machado Soares, Raquel Moyses, Victor Wünsch-Filho, Monica Beatriz Mathor, Fabio Daumas Nunes, Jiannis Ragoussis and Eloiza Helena Tajara
    Citation: BMC Cancer 2013 13:533
    Content type: Research article Published on:

  28. The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated or hypermethylated in up to 70 % of sporadic breast cancers depending on subtype; however, the effects of APC mutation on tumorigenic properties re...

    Authors: Monica K. VanKlompenberg, Claire O. Bedalov, Katia Fernandez Soto and Jenifer R. Prosperi
    Citation: BMC Cancer 2015 15:457
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:921

  29. In different cancer entities, several studies have shown the adverse effects of cancer on mental health, psychological well-being and the increased risk of high emotional distress in cancer patients. This stud...

    Authors: V. Kunz, G. Wichmann, A. Lehmann-Laue, A. Mehnert-Theuerkauf, A. Dietz and S. Wiegand
    Citation: BMC Cancer 2021 21:478
    Content type: Research Published on:

  30. Chemotherapy-induced peripheral neuropathy (CIPN) is a painful, dose-limiting adverse effect of commonly used chemotherapeutic agents. The purpose of this exploratory study was to evaluate the efficacy and saf...

    Authors: Sonoko Misawa, Tadamichi Denda, Sho Kodama, Takuji Suzuki, Yoichi Naito, Takahiro Kogawa, Mamoru Takada, Tomoki Suichi, Kazuhito Shiosakai and Satoshi Kuwabara
    Citation: BMC Cancer 2023 23:1098
    Content type: Research Published on:

  31. While immune checkpoint inhibitors (ICIs) occasionally cause immune-related adverse events (irAEs) in various organs, the prevalence of irAEs and potential risk factors have not been clarified. We identified i...

    Authors: Yuki Yoshikawa, Michio Imamura, Masami Yamauchi, C. Nelson Hayes, Hiroshi Aikata, Wataru Okamoto, Yoshihiro Miyata, Morihito Okada, Noboru Hattori, Kazuhiko Sugiyama, Yukio Yoshioka, Shigeaki Toratani, Masaaki Takechi, Tatsuo Ichinohe, Tsutomu Ueda, Sachio Takeno…
    Citation: BMC Cancer 2022 22:1232
    Content type: Research Published on:

  32. Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been r...

    Authors: Seunghwan Lim, Byoung Kwon Yoo, Hae-Suk Kim, Hannah L Gilmore, Yonghun Lee, Hyun-pil Lee, Seong-Jin Kim, John Letterio and Hyoung-gon Lee
    Citation: BMC Cancer 2014 14:928
    Content type: Research article Published on:

  33. Poor prognosis in gallbladder cancer is due to late presentation of the disease, lack of reliable biomarkers for early diagnosis and limited targeted therapies. Early diagnostic markers and novel therapeutic t...

    Authors: Tejaswini Subbannayya, Pamela Leal-Rojas, Mustafa A. Barbhuiya, Remya Raja, Santosh Renuse, Gajanan Sathe, Sneha M. Pinto, Nazia Syed, Vishalakshi Nanjappa, Arun H. Patil, Patricia Garcia, Nandini A. Sahasrabuddhe, Bipin Nair, Rafael Guerrero-Preston, Sanjay Navani, Pramod K. Tiwari…
    Citation: BMC Cancer 2015 15:843
    Content type: Research article Published on:

  34. Sequential inhibition of the vascular endothelial growth factor (VEGF) pathway with sorafenib could be useful for patients with metastatic renal cell carcinoma (RCC). Our aim was to determine the activity and ...

    Authors: Ana Elena Martín-Aguilar, Haidé Núñez-López and Juan C. Ramirez-Sandoval
    Citation: BMC Cancer 2021 21:16
    Content type: Research article Published on:

  35. Endometrial carcinoma (EC) is one of the most commonly diagnosed gynecologic malignancy in China. However, the genetic profile of Chinese EC patients has not been well established yet.

    Authors: Jin Li, Xiaoqi Li, Chenlian Quan, Xiaoqiu Li, Chong Wan and Xiaohua Wu
    Citation: BMC Cancer 2023 23:888
    Content type: Research Published on:

  36. Since the beginning of the twentieth century, infection has emerged as a fundamental aspect of cancer causation with a growing number of pathogens recognized as oncogenic. Meanwhile, oncolytic viruses have als...

    Authors: Camille Jacqueline, Aurélie Tasiemski, Gabriele Sorci, Beata Ujvari, Fatima Maachi, Dorothée Missé, François Renaud, Paul Ewald, Frédéric Thomas and Benjamin Roche
    Citation: BMC Cancer 2017 17:257
    Content type: Debate Published on:

  37. Chemoradiation therapy (CRT) is one of the most useful treatments for esophageal squamous cell carcinoma (ESCC). However, because some patients respond well to CRT and others do not, it is important to be able...

    Authors: Kiyokazu Tamotsu, Hiroshi Okumura, Yasuto Uchikado, Yoshiaki Kita, Ken Sasaki, Itaru Omoto, Tetsuhiro Owaki, Takaaki Arigami, Yoshikazu Uenosono, Akihiro Nakajo, Yuko Kijima, Sumiya Ishigami and Shoji Natsugoe
    Citation: BMC Cancer 2015 15:323
    Content type: Research article Published on:

  38. Cancer cell aggregation is a key process involved in the formation of clusters of circulating tumor cells. We previously reported that cell-cell adhesion proteins, such as E-cadherin, and desmosomal proteins a...

    Authors: Fabien Gava, Lise Rigal, Odile Mondesert, Elise Pesce, Bernard Ducommun and Valérie Lobjois
    Citation: BMC Cancer 2018 18:221
    Content type: Research article Published on:

  39. HPV-associated HNSCCs have a distinct etiologic mechanism and better prognosis than those with non-HPV associated HNSCCs. However, even within the each group, there is heterogeneity in survival time. Here, we ...

    Authors: Shama Virani, Emily Bellile, Carol R. Bradford, Thomas E. Carey, Douglas B. Chepeha, Justin A. Colacino, Joseph I. Helman, Jonathan B. McHugh, Lisa A. Peterson, Maureen A. Sartor, Jeremy MG Taylor, Heather M. Walline, Greg T. Wolf and Laura S. Rozek
    Citation: BMC Cancer 2015 15:825
    Content type: Research article Published on:

  40. Skin cutaneous melanoma (SKCM) is one of most aggressive type of cancers worldwide. Serglycin (SRGN) is an intracellular proteoglycan that playing an important role in various tumors. However, its effect on im...

    Authors: Xiaofang Wang, Hui Xiong, Daning Liang, Zhenzhen Chen, Xiqing Li and Kun Zhang
    Citation: BMC Cancer 2020 20:378
    Content type: Research article Published on:

  41. Bile duct invasion is a relatively rare event and is not well characterised in hepatocellular carcinoma (HCC). It remains very difficult to diagnose HCC with bile duct tumour thrombus (BDTT) before surgery. In...

    Authors: Jun-Yi Wu, Ju-Xian Sun, Jia-Yi Wu, Xiao-Xiao Huang, Yan-Nan Bai, Yong-Yi Zeng, Zhi-Bo Zhang, Shu-Qun Cheng and Mao-Lin Yan
    Citation: BMC Cancer 2021 21:272
    Content type: Research article Published on:

  42. Cancer cachexia is a multifactorial syndrome that dramatically decreases survival. Loss of white adipose tissue (WAT) is one of the key characteristics of cachexia. WAT wasting is paralleled by microarchitectu...

    Authors: Michele Joana Alves, Raquel Galvão Figuerêdo, Flavia Figueiredo Azevedo, Diego Alexandre Cavallaro, Nelson Inácio Pinto Neto, Joanna Darck Carola Lima, Emidio Matos-Neto, Katrin Radloff, Daniela Mendes Riccardi, Rodolfo Gonzalez Camargo, Paulo Sérgio Martins De Alcântara, José Pinhata Otoch, Miguel Luiz Batista Junior and Marília Seelaender
    Citation: BMC Cancer 2017 17:190
    Content type: Research article Published on:

  43. Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinoge...

    Authors: Alexandra Naba, Karl R Clauser, Charles A Whittaker, Steven A Carr, Kenneth K Tanabe and Richard O Hynes
    Citation: BMC Cancer 2014 14:518
    Content type: Research article Published on:

  44. Inflammatory blood markers have been associated with oncological outcomes in several cancers, but evidence for head and neck squamous cell carcinoma (HNSCC) is scanty. Therefore, this study aims at investigati...

    Authors: Paolo Boscolo-Rizzo, Andrea D’Alessandro, Jerry Polesel, Daniele Borsetto, Margherita Tofanelli, Alberto Deganello, Michele Tomasoni, Piero Nicolai, Paolo Bossi, Giacomo Spinato, Anna Menegaldo, Andrea Ciorba, Stefano Pelucchi, Chiara Bianchini, Diego Cazzador, Giulia Ramaciotti…
    Citation: BMC Cancer 2022 22:243
    Content type: Research article Published on:

  46. The relationship between KRAS mutational status and timing of colorectal liver metastasis (CRLM) remains unclear. This study evaluated the relationship between KRAS mutational status and long-term survival in pat...

    Authors: Nozomu Sakai, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano and Masayuki Ohtsuka
    Citation: BMC Cancer 2021 21:412
    Content type: Research article Published on:

  47. Leiomyosarcoma occurring as a primary cardiac tumor has been known as an extremely rare condition. Previous studies of leiomyosarcoma with rhabdomyoblastic differentiation have conducted to those arisen from a...

    Authors: Yoichiro Okubo, Kazutoshi Shibuya, Atsushi Namiki, Kazuhisa Takamura, Noriaki Kameda, Tetsuo Nemoto, Aki Mitsuda, Megumi Wakayama, Minoru Shinozaki, Nobuyuki Hiruta, Kanako Kitahara, Takao Ishiwatari and Junichi Yamazaki
    Citation: BMC Cancer 2011 11:76
    Content type: Case report Published on:

  48. The human pancreatic cancer cell line A818–6 can be grown in vitro either as a highly malignant, undifferentiated monolayer (ML) or as three-dimensional (3D) single layer hollow spheres (HS) simulating a benig...

    Authors: Doaa Tawfik, Angela Zaccagnino, Alexander Bernt, Monika Szczepanowski, Wolfram Klapper, Albrecht Schwab, Holger Kalthoff and Anna Trauzold
    Citation: BMC Cancer 2020 20:264
    Content type: Research article Published on:

  49. The standard treatment for patients with advanced transitional cell carcinoma of the bladder is platin based chemotherapy. Only approximately 50% of the patients respond to chemotherapy. Therefore, molecular p...

    Authors: Iver Nordentoft, Lars Dyrskjøt, Julie S Bødker, Peter J Wild, Arndt Hartmann, Simone Bertz, Jan Lehmann, Torben F Ørntoft and Karin Birkenkamp-Demtroder
    Citation: BMC Cancer 2011 11:135
    Content type: Research article Published on:

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