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3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

Page 61 of 79

  1. Tumour phenotype is regulated in a complex fashion as a result of interactions between malignant cells and the tumour stroma. Fibroblasts are the most abundant and perhaps most active part of the tumour stroma...

    Authors: Charlotta J Olsen, José Moreira, Eugene M Lukanidin and Noona S Ambartsumian
    Citation: BMC Cancer 2010 10:444
    Content type: Research article Published on:

  2. Increasing evidence suggests that forkhead box A1 (FOXA1) is frequently dysregulated in many types of human cancers. However, the exact function and mechanism of FOXA1 in human endometrial cancer (EC) remains ...

    Authors: Meiting Qiu, Wei Bao, Jingyun Wang, Tingting Yang, Xiaoying He, Yun Liao and Xiaoping Wan
    Citation: BMC Cancer 2014 14:78
    Content type: Research article Published on:

  3. The relationship between whole brain radiotherapy (WBRT) dose with intracranial tumor control and overall survival (OS) in patients with non-small cell lung cancer (NSCLC) brain metastases (BM) is largely unkn...

    Authors: Zhensheng Li, Dongxing Shen, Jian Zhang, Jun Zhang, Fang Yang, Deyou Kong, Jie Kong and Andu Zhang
    Citation: BMC Cancer 2019 19:1104
    Content type: Research article Published on:

  4. Perioperative chemotherapy (ChT) and preoperative chemoradiation (CRT) are both the standard treatments for locally advanced gastric cancer (LAGC). CRT can achieve a higher pathological complete regression (pC...

    Authors: Menglong Zhou, Wang Yang, Yan Xuan, Wei Zou, Yaqi Wang, Zhiyuan Zhang, Jing Zhang, Miao Mo, Changming Zhou, Yuan Liu, Wenming Zhang, Zhaozhen Zhang, Yiping He, Weiwei Weng, Cong Tan, Lei Wang…
    Citation: BMC Cancer 2022 22:710
    Content type: Study protocol Published on:

  5. Proven cost-effectiveness contrasted by low uptake of cancer screening (CS) calls for new methodologies promoting the service. Contemporary interventions in this regard relies primarily on strategies targeting...

    Authors: Rui Feng, Xingrong Shen, Jing Chai, Penglai Chen, Jing Cheng, Han Liang, Ting Zhao, Rui Sha, Kaichun Li and Debin Wang
    Citation: BMC Cancer 2015 15:674
    Content type: Study protocol Published on:

  6. Liver function is routinely assessed in clinical practice as liver function tests provide sensitive indicators of hepatocellular injury. However, the prognostic value of enzymes that indicate hepatic injury ha...

    Authors: Ting-Xun Lu, Shuang Wu, Dong-Yan Cai, Ting-Ting Hong, Ying Zhang, Hua-Qiang Gao, Hai-Ying Hua and Xiao-Hong Wu
    Citation: BMC Cancer 2019 19:553
    Content type: Research article Published on:

  7. It has been reported that triple negative phenotype is characterized by aggressive clinical history in Western breast cancer patients, however its pattern of metastatic spread had never been reported in the Ch...

    Authors: Yanping Lin, Wenjin Yin, Tingting Yan, Liheng Zhou, Genhong Di, Jiong Wu, Zhenzhou Shen, Zhimin Shao and Jinsong Lu
    Citation: BMC Cancer 2009 9:342
    Content type: Research article Published on:

  8. Although pancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the skeleton, disseminated tumor cells have been detected in bone marrow samples from patients with this disease. The prognostic value of...

    Authors: Oddmund Nordgård, Morten Lapin, Kjersti Tjensvoll, Satu Oltedal, Karin Hestnes Edland, Nicolay Bore Neverdahl, Dmitrij Fostenes, Herish Garresori, Nils Glenjen, Rune Smaaland and Bjørnar Gilje
    Citation: BMC Cancer 2022 22:609
    Content type: Research Published on:

  9. Standard treatment for patients with disseminated germ cell tumors is combination chemotherapy with bleomycin, etoposide and cisplatin (BEP). This treatment is highly effective, but the majority of patients ex...

    Authors: Jesper F Christensen, Jesper L Andersen, Lis Adamsen, Birgitte Lindegaard, Abigail L Mackey, Rie H Nielsen, Mikael Rørth and Gedske Daugaard
    Citation: BMC Cancer 2011 11:326
    Content type: Study protocol Published on:

  10. Sarcomas are rare, heterogeneous tumours affecting patients of any age. Previous surveys describe that sarcoma patients report a significantly worse experience than those with common cancers. Consequently, Sar...

    Authors: Eugenie Younger, Olga Husson, Lindsey Bennister, Jeremy Whelan, Roger Wilson, Andy Roast, Robin L Jones and Winette TA van der Graaf
    Citation: BMC Cancer 2018 18:991
    Content type: Research article Published on:

  11. There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which ...

    Authors: Cengiz Karacin, Berna Oksuzoglu, AyÅŸe Demirci, Merve Keskinkılıç, Naziyet Köse Baytemür, Funda Yılmaz, OÄŸuzhan Selvi, Dilek Erdem, Esin AvÅŸar, Nail Paksoy, Necla Demir, Sema Sezgin Göksu, Sema Türker, ErtuÄŸrul Bayram, Abdüssamet Çelebi, Hatice Yılmaz…
    Citation: BMC Cancer 2023 23:136
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2023 23:192

  12. Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether...

    Authors: Kellie A. Charles, Benjamin D. W. Harris, Carol R. Haddad, Stephen J. Clarke, Alex Guminski, Mark Stevens, Tristan Dodds, Anthony J. Gill, Michael Back, David Veivers and Thomas Eade
    Citation: BMC Cancer 2016 16:124
    Content type: Research article Published on:

  13. Inflammatory cells in the tumour stroma has gained increasing interest recently. Thus, we aimed to study the frequency and prognostic impact of stromal mast cells and tumour infiltrating eosinophils in invasiv...

    Authors: Rose-Marie Amini, Kirsimari Aaltonen, Heli Nevanlinna, Ricardo Carvalho, Laura Salonen, Päivi Heikkilä and Carl Blomqvist
    Citation: BMC Cancer 2007 7:165
    Content type: Research article Published on:

  14. The aim of this study was to investigate the clinical, imaging and pathological features of extraskeletal osteosarcoma (EOS) and to improve the understanding of this disease and other similar lesions.

    Authors: Xiao-chun Wang, Ling Zhang, Jiong-bin Lin, Xiao-yao Huang, Jing-hong Liang, Jian-ping Zhong, Ji-dong Peng and Jun-yuan Zhong
    Citation: BMC Cancer 2024 24:11
    Content type: Research Published on:

  15. Patients ≥ 70 years with small, low-risk breast cancer who are operated but not irradiated how local relapse rates around 4% after 4 years. With adjuvant whole breast radiotherapy (WBRT) the local relapse rate...

    Authors: Christian Neumaier, Sperk Elena, Welzel Grit, Abo-Madyan Yasser, Kraus-Tiefenbacher Uta, Keller Anke, Gerhardt Axel, Sütterlin Marc and Wenz Frederik
    Citation: BMC Cancer 2012 12:171
    Content type: Study protocol Published on:

  16. Epitheliomesenchymal transition (EMT) is the process where cancer cells attain fibroblastic features and are thus able to invade neighboring tissues. Transcriptional factors zeb1, snai1 and twist regulate EMT.

    Authors: Ylermi Soini, Hanna Tuhkanen, Reijo Sironen, Ismo Virtanen, Vesa Kataja, Päivi Auvinen, Arto Mannermaa and Veli-Matti Kosma
    Citation: BMC Cancer 2011 11:73
    Content type: Research article Published on:

  17. Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome. They have important regulatory functions in chromatin remodeling and gene expression. Dysregulated lncRNAs have been studied in cancers...

    Authors: Yibin Hao, Wei Wu, Fachun Shi, Rodrigo JS Dalmolin, Ming Yan, Fu Tian, Xiaobing Chen, Guoyong Chen and Wei Cao
    Citation: BMC Cancer 2015 15:168
    Content type: Research article Published on:

  18. Changes in cellular metabolism are now recognized as potential drivers of cancer development, rather than as secondary consequences of disease. Here, we explore the mechanism by which metabolic changes depende...

    Authors: Diana Andrejeva, Jan-Michael Kugler, Hung Thanh Nguyen, Anders Malmendal, Mette Lind Holm, Birgitte Groenkaer Toft, Anand C. Loya and Stephen M. Cohen
    Citation: BMC Cancer 2018 18:1180
    Content type: Research article Published on:

  19. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies today with an urgent need for novel therapeutic strategies. Biomarker analysis helps to better understand tumor biology and might ...

    Authors: Felix C. Popp, Marie Christine Popp, Yue Zhao, Christopher Betzler, Siegfried Kropf, Benjamin Garlipp, Christoph Benckert, Thomas Kalinski, Hans Lippert and Christiane J. Bruns
    Citation: BMC Cancer 2017 17:229
    Content type: Study protocol Published on:

  20. Performance of urinary cytology is recommended as the part of a standard diagnostic workup and base surveillance regimens in upper tract urothelial carcinoma (UTUC). However, the effect of positive voided urin...

    Authors: Wen Liu, Zhankun Wang, Shuai Liu, Yu Yao, Yong Liu and Guiming Zhang
    Citation: BMC Cancer 2020 20:1113
    Content type: Research article Published on:

  21. Epithelial ovarian cancer exhibits extensive interpatient and intratumoral heterogeneity, which can hinder successful treatment strategies. Herein, we investigated the efficacy of an emerging oncolytic, Maraba...

    Authors: Jessica G. Tong, Yudith Ramos Valdes, Milani Sivapragasam, John W. Barrett, John C. Bell, David Stojdl, Gabriel E. DiMattia and Trevor G. Shepherd
    Citation: BMC Cancer 2017 17:594
    Content type: Research article Published on:

  22. Neuromedin U (NMU) is a neuropeptide belonging to the neuromedin family. Recently, significant associations between NMU and several cancers have been reported. However, no studies have examined the association...

    Authors: Qiao Li, Lingyu Han, Shengnan Ruan, Shunli Shen, Qinghua Cao, Xiuqin Cai, Yuan Yan, Baogang Peng and Yunpeng Hua
    Citation: BMC Cancer 2020 20:95
    Content type: Research article Published on:

  23. Mortality is high in patients with esophageal carcinoma as tumors are rarely detected before the disease has progressed to an advanced stage. Here, we sought to isolate cell-free DNA released into the plasma o...

    Authors: Immacolata Andolfo, Giuseppe Petrosino, Loredana Vecchione, Pasqualino De Antonellis, Mario Capasso, Donatella Montanaro, Marica Gemei, Giancarlo Troncone, Achille Iolascon, Michele Orditura, Fortunato Ciardiello, Fernando De Vita and Massimo Zollo
    Citation: BMC Cancer 2011 11:126
    Content type: Research article Published on:

  24. In hepatocellular carcinoma (HCC), pulmonary metastasis (PM) after hepatectomy is associated with poor clinical outcomes. The crucial phases of tumour cell proliferation, angiogenesis, and metastasis all entai...

    Authors: Wen-juan Huang, Guang-yu Wang, Zeng-yao Liu, Meng-lin Zhang, Wen Wang, Xin Zhang and Rui-tao Wang
    Citation: BMC Cancer 2022 22:683
    Content type: Research article Published on:

  25. This study aims to investigate the expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 in bulky cervical squamous carcinoma and its predictive role in cisplatin-based neoadjuvant chemotherapy.

    Authors: Haiyan Zhu, Xuejiao Tao, Lulu Zhou, Bo Sheng, Xuejie Zhu and Xueqiong Zhu
    Citation: BMC Cancer 2019 19:865
    Content type: Research article Published on:

  26. The immune system plays an important role in the multifactorial biologic system during the development of neoplasias. However, the involvement of the inflammatory response in the promotion/control of malignant...

    Authors: Alessandra Estrela-Lima, Márcio SS Araújo, João M Costa-Neto, Andréa Teixeira-Carvalho, Stella M Barrouin-Melo, Sergio V Cardoso, Olindo A Martins-Filho, Rogéria Serakides and Geovanni D Cassali
    Citation: BMC Cancer 2010 10:256
    Content type: Research article Published on:

  27. Endostatin is a potent endogenous anti-angiogenic agent which inhibits tumour growth. A non-synonymous coding polymorphism in the Endostatin gene is thought to affect Endostatin activity. We aimed to determine...

    Authors: Sabapathy P Balasubramanian, Simon S Cross, Jenny Globe, Angela Cox, Nicola J Brown and Malcolm W Reed
    Citation: BMC Cancer 2007 7:107
    Content type: Research article Published on:

  28. Invasive urothelial carcinoma (iUC) is a major cause of death in humans, and approximately 165,000 individuals succumb to this cancer annually worldwide. Comparative oncology using relevant animal models is ne...

    Authors: Shingo Maeda, Hirotaka Tomiyasu, Masaya Tsuboi, Akiko Inoue, Genki Ishihara, Takao Uchikai, James K. Chambers, Kazuyuki Uchida, Tomohiro Yonezawa and Naoaki Matsuki
    Citation: BMC Cancer 2018 18:472
    Content type: Research article Published on:

  29. In many tumour types serumlactate dehydrogenase (LDH) levels proved to represent an indirect marker of tumour hypoxia, neo-angiogenesis and worse prognosis. As we previously reported LDH is an important predic...

    Authors: Luca Faloppi, Mario Scartozzi, Maristella Bianconi, Gianluca Svegliati Baroni, Pierluigi Toniutto, Riccardo Giampieri, Michela Del Prete, Samuele De Minicis, Davide Bitetto, Cristian Loretelli, Marco D’Anzeo, Antonio Benedetti and Stefano Cascinu
    Citation: BMC Cancer 2014 14:110
    Content type: Research article Published on:

  30. Pulmonary sarcomatoid carcinoma (SC) consists of both carcinomatous and sarcomatous tumors with high degree of malignancy, rapid progression, and poor prognosis. However, little is known regarding how pulmonar...

    Authors: Jianjun Ge, Bin Yao, Jia Huang, Xue Wu, Hua Bao, Qiuxiang Ou, Yang W. Shao and Jun Chen
    Citation: BMC Cancer 2019 19:592
    Content type: Case report Published on:

  31. Danish cancer patients have lower survival rates than patients in many other western countries. Half of the patients present with non-alarm symptoms and thus have a long diagnostic pathway. Consequently, an ur...

    Authors: Esben Næser, Henrik Møller, Ulrich Fredberg, Jan Frystyk and Peter Vedsted
    Citation: BMC Cancer 2017 17:817
    Content type: Research article Published on:

  32. Attempts to reduce morbidity and mortality in breast cancer is based on efforts to identify novel biomarkers to support prognosis and therapeutic choices. The present study has focussed on S100 proteins as a p...

    Authors: Patrizia Cancemi, Gianluca Di Cara, Nadia Ninfa Albanese, Francesca Costantini, Maria Rita Marabeti, Rosa Musso, Carmelo Lupo, Elena Roz and Ida Pucci-Minafra
    Citation: BMC Cancer 2010 10:476
    Content type: Research article Published on:

  33. Our previous studies showed that SIRT1 was over-expressed in gastric cancer specimens and related with lymph node metastasis. However, the mechanism of SIRT1 up-regulation and its association with metastasis i...

    Authors: Lihua Zhang, Xueqing Wang and Pingsheng Chen
    Citation: BMC Cancer 2013 13:290
    Content type: Research article Published on:

  34. Long non-coding RNAs (lncRNAs) play important roles in many pathophysiological processes, including cancer progression. Namely, lncRNA Receptor-tyrosine-kinase-like orphan receptor-1 antisense 1 (ROR1-AS1) is ...

    Authors: Xueliang Li, Zhaowei Sun, Li Wang, Qinlei Wang, Maobing Wang, Jingyun Guo, Haoran Li, MenShou Chen, Guanghua Cao, Yanan Yu, Haochen Zhong, Hao Zou, Kai Ma, Bingyuan Zhang, Guolei Wang and Yujie Feng
    Citation: BMC Cancer 2023 23:912
    Content type: Research Published on:

  35. Overexpression of Twist1, one of the epithelial-mesenchymal transition-transcription factors (EMT-TFs), is associated with hepatocellular carcinoma (HCC) metastasis. Pelitinib is known to be an irreversible ep...

    Authors: Sewoong Lee, Eunjeong Kang, Unju Lee and Sayeon Cho
    Citation: BMC Cancer 2023 23:703
    Content type: Research Published on:

  36. Tumor genomic profiling (TGP) identifies targets for precision cancer treatments, but also secondary hereditary risks. Oncologists are poorly trained to communicate the results of TGP, especially among patient...

    Authors: Michael J. Hall, Paul A. D’Avanzo, Yana Chertock, Patrick J. A. Kelly, Jesse Brajuha, Katie Singley, Caseem C. Luck and Sarah B. Bass
    Citation: BMC Cancer 2024 24:412
    Content type: Research Published on:

  37. In patients with BRAFV600 mutated unresectable stage IIIc or metastatic melanoma, molecular targeted therapy with combined BRAF/MEK-inhibitor vemurafenib plus cobimetinib has shown a significantly improved pro...

    Authors: Bernies van der Hiel, John B.A.G. Haanen, Marcel P.M. Stokkel, Daniel S. Peeper, Connie R. Jimenez, Jos H. Beijnen, Bart A. van de Wiel, Ronald Boellaard and Alfons J.M. van den Eertwegh
    Citation: BMC Cancer 2017 17:649
    Content type: Study protocol Published on:

  38. Intravoxel incoherent motion (IVIM) MR imaging has been applied in researches of various diseases, however its potential in cervical cancer patients has not been fully explored. The purpose of this study was t...

    Authors: Li Zhu, Lijing Zhu, Hua Shi, Huanhuan Wang, Jing Yan, Baorui Liu, Weibo Chen, Jian He, Zhengyang Zhou, Xiaofeng Yang and Tian Liu
    Citation: BMC Cancer 2016 16:79
    Content type: Research article Published on:

  39. In Taiwan, there is a high incidence of breast cancer and a high prevalence of viral hepatitis. In this case-control study, we used a population-based insurance dataset to evaluate whether breast cancer in wom...

    Authors: Fu-Hsiung Su, Shih-Ni Chang, Pei-Chun Chen, Fung-Chang Sung, Chien-Tien Su and Chih-Ching Yeh
    Citation: BMC Cancer 2011 11:495
    Content type: Research article Published on:

  40. Despite standard treatments including chemoradiotherapy with temozolomide (TMZ) (STUPP protocol), the prognosis of glioblastoma patients remains poor. AGuIX nanoparticles have a high radiosensitizing potential...

    Authors: Emilie Thivat, Mélanie Casile, Juliette Moreau, Ioana Molnar, Sandrine Dufort, Khalide Seddik, Géraldine Le Duc, Olivier De Beaumont, Markus Loeffler, Xavier Durando and Julian Biau
    Citation: BMC Cancer 2023 23:344
    Content type: Study Protocol Published on:

  41. Immunotherapy has emerged as a robust clinical strategy for cancer treatment. PD1/PD-L1 inhibitors have been used as second-line therapy for urothelial carcinoma due to the high tumor mutational burden. Despit...

    Authors: Qing Zhang, Wenlong Zhang, Tingsheng Lin, Wenfeng Lu, Xin He, Yuanzhen Ding, Wei Chen, Wenli Diao, Meng Ding, Pingping Shen and Hongqian Guo
    Citation: BMC Cancer 2022 22:677
    Content type: Research Published on:

  42. Locally advanced rectal cancer (LARC) comprises heterogeneous tumours with predominant hypoxic components. The hypoxia-inducible metabolic shift causes microenvironmental acidification generated by carbonic an...

    Authors: Helga Helseth Hektoen, Kjersti Flatmark, Yvonne Andersson, Svein Dueland, Kathrine Røe Redalen and Anne Hansen Ree
    Citation: BMC Cancer 2015 15:543
    Content type: Research article Published on:

  43. Etoposide (E) at 100 mg/m2 combined with Cisplatin (P) at 20 mg/m2 represents an induction 2-day regimen embedded in our clinical practice for patients with advanced GCT or TN at high risk of early death. We eval...

    Authors: Charleen Chan Wah Hak, Christopher Coyle, Arwa Kocache, Dee Short, Naveed Sarwar, Michael J. Seckl and Michael A. Gonzalez
    Citation: BMC Cancer 2019 19:770
    Content type: Research article Published on:

  44. The Intratumoral Microvessel Density (IMVD) is commonly used to quantify tumoral vascularization and is usually assessed by pan-endothelial markers, such as CD31. Endoglin (CD105) is a protein predominantly ex...

    Authors: Virginia Di Paolo, Ida Russo, Renata Boldrini, Lucilla Ravà, Marco Pezzullo, Maria Chiara Benedetti, Angela Galardi, Marta Colletti, Rossella Rota, Domenico Orlando, Alessandro Crocoli, Hector Peinado, Giuseppe Maria Milano and Angela Di Giannatale
    Citation: BMC Cancer 2018 18:31
    Content type: Research article Published on:

  45. Pyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related to the terminal protein GSDMD. Hydrogen exerts a biphasic effect on cancer by...

    Authors: Ye Yang, Ping Yin Liu, Wei Bao, Song Jun Chen, Fang Su Wu and Ping Ya Zhu
    Citation: BMC Cancer 2020 20:28
    Content type: Research article Published on:

  46. Chemoradiotherapy is the standard of care for patients with oesophageal cancer unsuitable for surgery due to the presence of co-morbidity or extent of disease, and is a standard treatment option for patients w...

    Authors: Christopher N Hurt, Lisette S Nixon, Gareth O Griffiths, Ruby Al-Mokhtar, Simon Gollins, John N Staffurth, Ceri J Phillips, Jane M Blazeby and Tom D Crosby
    Citation: BMC Cancer 2011 11:466
    Content type: Study protocol Published on:

  47. PPP2R2A deletions were recently linked to a subgroup of luminal breast carcinoma (BC) that exhibits poor survival. This subgroup also exhibited amplification of a chromosome region containing the Cyclin D1 cod...

    Authors: Francisco Beca, Miguel Pereira, Jorge F Cameselle-Teijeiro, Diana Martins and Fernando Schmitt
    Citation: BMC Cancer 2015 15:285
    Content type: Research article Published on:

  48. This study aimed to identify the health-related quality of life (HRQOL) domains associated with prognosis by assessing longitudinal alterations in HRQOL in patients with advanced hepatocellular carcinoma recei...

    Authors: Masako Shomura, Tatehiro Kagawa, Haruka Okabe, Koichi Shiraishi, Shunji Hirose, Yoshitaka Arase, Kota Tsuruya, Sachiko Takahira and Tetsuya Mine
    Citation: BMC Cancer 2016 16:878
    Content type: Research article Published on:

  49. Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcin...

    Authors: Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-yu Xiong, Zi-yi Yang, Yun-xiao Zhu and Nathan Jeffreys
    Citation: BMC Cancer 2018 18:543
    Content type: Case report Published on:

  50. Cancer stem cells (CSCs) are thought to play important roles in carcinogenesis, recurrence, metastasis, and therapy-resistance. We have successfully induced cancer stem-like sphere cells (CSLCs) which possess ...

    Authors: Ryouichi Tsunedomi, Kiyoshi Yoshimura, Yuta Kimura, Mitsuo Nishiyama, Nobuyuki Fujiwara, Satoshi Matsukuma, Shinsuke Kanekiyo, Hiroto Matsui, Yoshitaro Shindo, Yusaku Watanabe, Yukio Tokumitsu, Shin Yoshida, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Tatsuya Ioka…
    Citation: BMC Cancer 2022 22:260
    Content type: Research Published on:

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