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3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

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  1. Over the past years, EGFR tyrosine kinase inhibitors (TKI) revolutionized treatment response. 1st-generation (reversible) EGFR TKI and later the 2nd –generation irreversible EGFR TKI Afatinib were aimed to imp...

    Authors: Svenja Wagener-Ryczek, Carina Heydt, Juliane Süptitz, Sebastian Michels, Markus Falk, Christina Alidousty, Jana Fassunke, Michaela Angelika Ihle, Markus Tiemann, Lukas Heukamp, Jürgen Wolf, Reinhard Büttner and Sabine Merkelbach-Bruse
    Citation: BMC Cancer 2020 20:408
    Content type: Research article Published on:

  2. The insulin-like growth factor (IGF) system plays an important role in the development and progression of cancer. However, little is known about the expression of the IGF system components and their clinicopat...

    Authors: Xinwei Feng, Jianhua Lin, Shan Xing, Wanli Liu and Ge Zhang
    Citation: BMC Cancer 2017 17:90
    Content type: Research article Published on:

  3. We have preliminarily reported MTA2 expression in gastric cancer and its biological functions by using knockdown cell models, while the molecular mechanisms of MTA2 in regulating malignant behaviors are still ...

    Authors: Chenfei Zhou, Jun Ji, Qu Cai, Min Shi, Xuehua Chen, Yingyan Yu, Zhenggang Zhu and Jun Zhang
    Citation: BMC Cancer 2015 15:343
    Content type: Research article Published on:

  4. It has been hypothesized that radiotherapy (RT) techniques delivering radiations to larger volumes (IMRT, VMAT) are potentially associated with a higher risk of second primary tumors. The aim of this study was...

    Authors: Milly BUWENGE, Erica SCIROCCO, Francesco DEODATO, Gabriella MACCHIA, Maria NTRETA, Silvia BISELLO, Giambattista SIEPE, Savino CILLA, Anna Rita ALITTO, Vincenzo VALENTINI, Lidia STRIGARI, Alessio G. MORGANTI and Silvia CAMMELLI
    Citation: BMC Cancer 2020 20:90
    Content type: Research article Published on:

  5. Nimotuzumab (NTZ) is an anti-EGFR monoclonal antibody. However,the effect of targeted drugs combined with induction therapy in locally advanced nasopharyngeal carcinoma remains unclear. The aim of this study i...

    Authors: Ying Lu, Dagui Chen, Jinhui Liang, Jianquan Gao, Zhanxiong Luo, Rensheng Wang, Wenqi Liu, Changjie Huang, Xuejian Ning, Meilian Liu and Haixin Huang
    Citation: BMC Cancer 2019 19:1262
    Content type: Research article Published on:

  6. Nasopharyngeal adenoid cystic carcinoma (NACC) is a rare malignancy with special biological features. Controversies exist regarding the treatment approach and prognostic factors in the IMRT era. This study aim...

    Authors: Wen-Bin Wu, Wu-Lin Cai, Ye-Hao Zou, Rui You, You-Ping Liu, Zhao-Di Yuan, Qiong Li, Wen-Chao Li, Zhi-Xuan Pi, Yu-Long Xie, Kai Wen, Ming-Yuan Chen and Rui Sun
    Citation: BMC Cancer 2024 24:576
    Content type: Research Published on:

  7. Outcomes in younger (<40 years) and elderly (≥70 years) patients with advanced biliary cancer (ABC) receiving palliative chemotherapy are unclear. This study assessed outcomes in those receiving monotherapy or...

    Authors: Mairéad Geraldine McNamara, John Bridgewater, Andre Lopes, Harpreet Wasan, David Malka, Lars Henrik Jensen, Takuji Okusaka, Jennifer J. Knox, Dorothea Wagner, David Cunningham, Jenny Shannon, David Goldstein, Markus Moehler, Tanios Bekaii-Saab and Juan W. Valle
    Citation: BMC Cancer 2017 17:262
    Content type: Research article Published on:

  8. Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a few clinically useful prognostic markers have bee...

    Authors: Maija Wolf, Miikka Korja, Ritva Karhu, Henrik Edgren, Sami Kilpinen, Kalle Ojala, Spyro Mousses, Anne Kallioniemi and Hannu Haapasalo
    Citation: BMC Cancer 2010 10:181
    Content type: Research article Published on:

  9. The incidence of cutaneous malignant melanoma (CMM) is increasing worldwide. In Sweden, over 4600 cases were diagnosed in 2018. The prognosis after radical surgery varies considerably with tumor stage. In rece...

    Authors: Ylva Naeser, Hildur Helgadottir, Yvonne Brandberg, Johan Hansson, Roger Olofsson Bagge, Nils O. Elander, Christian Ingvar, Karolin Isaksson, Petra Flygare, Cecilia Nilsson, Frida Jakobsson, Olga del Val Munoz, Antonis Valachis, Malin Jansson, Charlotte Sparring, Lars Ohlsson…
    Citation: BMC Cancer 2020 20:1197
    Content type: Study protocol Published on:

  10. Soft-tissue metastasis of carcinoma is rare. In the present study, we investigated the surgical indications and clinical features of patients with soft tissue metastases of carcinoma.

    Authors: Sei Morinaga, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Yuta Taniguchi, Yohei Asano, Takayuki Nojima and Hiroyuki Tsuchiya
    Citation: BMC Cancer 2024 24:577
    Content type: Research Published on:

  11. The aim of this study was to investigate the relationship between multiple metabolism parameters derived from FDG and tumor TNM stages as well as tumor metastasis-associated protein of GLUT-1 and MACC1 in colo...

    Authors: Mingyu Zhang, Jigang Yang, Hao Jiang, Huijie Jiang and Zhenchang Wang
    Citation: BMC Cancer 2021 21:258
    Content type: Research article Published on:

  12. Currently, there is clear evidence that apoptosis plays an important role in the development and progression of tumors. One of the best characterized apoptosis triggering systems is the CD95/Fas/APO-1 pathway;...

    Authors: Adriana Aguilar-Lemarroy, Jose E Romero-Ramos, Vicente Olimon-Andalon, Georgina Hernandez-Flores, Jose M Lerma-Diaz, Pablo C Ortiz-Lazareno, Gilberto Morgan-Villela, Susana del Toro-Arreola, Alejandro Bravo-Cuellar and Luis F Jave-Suarez
    Citation: BMC Cancer 2008 8:99
    Content type: Research article Published on:

  13. Leptomeningeal metastasis, which results from metastasis of tumors to the arachnoid and pia mater, can lead to the dissemination of tumor cells throughout the subarachnoid space via the cerebral spinal fluid, ...

    Authors: Zhenyu Pan, Guozi Yang, Tingting Yuan, Xiaochuan Pang, Yongxiang Wang, Limei Qu and Lihua Dong
    Citation: BMC Cancer 2014 14:399
    Content type: Case report Published on:

  14. IKKε is an oncogenic kinase that was found amplified and overexpressed in a substantial percentage of human breast cancer cell lines and primary tumors using genomic and gene expression analyses. Molecular stu...

    Authors: Virginie Williams, Andrée-Anne Grosset, Natalia Zamorano Cuervo, Yves St-Pierre, Marie-Pierre Sylvestre, Louis Gaboury and Nathalie Grandvaux
    Citation: BMC Cancer 2017 17:356
    Content type: Research article Published on:

  15. Hyaluronan accumulation correlates with the degree of malignancy in many solid tumor types, including malignant endometrial carcinomas. To elucidate the mechanism of hyaluronan accumulation, we examined the ex...

    Authors: Timo K Nykopp, Kirsi Rilla, Markku I Tammi, Raija H Tammi, Reijo Sironen, Kirsi Hämäläinen, Veli-Matti Kosma, Seppo Heinonen and Maarit Anttila
    Citation: BMC Cancer 2010 10:512
    Content type: Research article Published on:

  16. Several factors contribute to delayed presentation with ovarian cancer (OC) symptoms including poor symptom awareness and barriers to seeking help. This study explored the anticipated time to seek medical advi...

    Authors: Mohamedraed Elshami, Sondos Al-Madhoun, Mohammed Alser, Ibrahim Al-Slaibi, Areej Yaseen, Aya Tuffaha, Hadeel Jabr, Sara Ubaiat, Salma Khader, Reem Khraishi, Inas Jaber, Zeina Abu Arafeh, Aya Alqattaa, Asmaa Abd El Hadi, Ola Barhoush, Maysun Hijazy…
    Citation: BMC Cancer 2023 23:975
    Content type: Research Published on:

  17. Advanced pancreatic cancer, in addition to its high mortality, is characterized by one of the highest rates of venous thromboembolic events (VTE) as compared to other types of cancer. Enoxaparin, a low molecul...

    Authors: Hanno Riess, Uwe Pelzer, Andreas Hilbig, Jens Stieler, Bernhard Opitz, Theo Scholten, Dörte Kauschat-Brüning, Peter Bramlage, Bernd Dörken and Helmut Oettle
    Citation: BMC Cancer 2008 8:361
    Content type: Study protocol Published on:

  18. Identification of molecular markers for early detection or prediction of metastasis is crucial for both management of HCC patient postoperative treatment and identify new therapeutic targets to inhibit HCC pro...

    Authors: Lui Ng, Virginia Kwan, Ariel Chow, Thomas Chung-Cheung Yau, Ronnie Tung-Ping Poon, Roberta Pang and Wai-Lun Law
    Citation: BMC Cancer 2019 19:713
    Content type: Research article Published on:

  19. Circulating tumour cells (CTC) are an important indicator of metastasis and associated with a poor prognosis. Detection sensitivity and specificity of CTC in the peripheral blood of metastatic cancer patient r...

    Authors: Ranjana Mitra, Olivia Chao, Yasuyo Urasaki, Oscar B Goodman and Thuc T Le
    Citation: BMC Cancer 2012 12:540
    Content type: Research article Published on:

  20. Previous related studies have mainly focused on renal cell carcinoma (RCC) with venous tumor thrombus, specifically inferior vena cava tumor thrombus with renal vein tumor thrombus (RVTT). However, only a few ...

    Authors: Chuanzhen Cao, Xingang Bi, Jing Liang, Lin Li, Huijuan Zhang, Zhendong Xiao, Zejun Xiao, Jun Tian, Dong Wang, Kaopeng Guan, Changling Li, Jianhui Ma, Shan Zheng and Jianzhong Shou
    Citation: BMC Cancer 2019 19:144
    Content type: Research article Published on:

  21. Osteosarcoma is a primary malignant tumor originating from mesenchymal tissue, with a poor distant metastasis prognosis. The molecular mechanisms of osteosarcoma metastasis are extremely complicated.

    Authors: Mi Li, Xin Jin, Hao Li, Gang Wu, Shanshan Wang, Caihong Yang and Sisi Deng
    Citation: BMC Cancer 2020 20:65
    Content type: Research article Published on:

  22. Complement component(C7) gene has been shown to influence the prognosis in Hepatocellular carcinoma (HCC) patients. The association between C7 and HCC recurrence after orthotopic liver transplantation (OLT), h...

    Authors: Zhongyi Jiang, Qianwei Jiang, Xu Fang, Pusen Wang, Weitao Que, Hao Li, Yang Yu, Xueni Liu, Chunguang Wang and Lin Zhong
    Citation: BMC Cancer 2021 21:521
    Content type: Research Published on:

  23. Immunohistochemical detection of cold shock proteins is predictive for deleterious outcome in various malignant diseases. We recently described active secretion of a family member, denoted Y-box (YB) protein-1...

    Authors: Frank Tacke, Nicolas Kanig, Abdelaziz En-Nia, Thilo Kaehne, Christiane S Eberhardt, Victoria Shpacovitch, Christian Trautwein and Peter R Mertens
    Citation: BMC Cancer 2011 11:185
    Content type: Research article Published on:

  24. Flotillin-1 and flotillin-2 are two homologous and ubiquitously expressed proteins that are involved in signal transduction and membrane trafficking. Recent studies have reported that flotillins promote breast...

    Authors: Nina Kurrle, Wymke Ockenga, Melanie Meister, Frauke Völlner, Sina Kühne, Bincy A John, Antje Banning and Ritva Tikkanen
    Citation: BMC Cancer 2013 13:575
    Content type: Research article Published on:

  25. Circulating tumor cells (CTCs) have been considered great clinical significance in various cancers. However, it remains unknown that how is the role of CTCs in patients with nasopharyngeal carcinoma (NPC). We ...

    Authors: Jing Zhang, Huashan Shi, Tingting Jiang, Zhe Liu, Peter P. Lin and Nianyong Chen
    Citation: BMC Cancer 2018 18:1133
    Content type: Research article Published on:

  26. Thyroid cancer is the most common endocrine malignancy. Some advanced disease is, or becomes, resistant to radioactive iodine therapy (refractory disease); this holds poor prognosis of 10% 10-year overall surv...

    Authors: Sarah R. Brown, Andrew Hall, Hannah L. Buckley, Louise Flanagan, David Gonzalez de Castro, Kate Farnell, Laura Moss, Rebecca Gregory, Kate Newbold, Yong Du, Glenn Flux and Jonathan Wadsley
    Citation: BMC Cancer 2019 19:582
    Content type: Study protocol Published on:

  27. Hepatocellular carcinoma (HCC) is among the deadliest cancers due to its heterogeneity, contributing to chemoresistance and recurrence. Cancer stem-like cells (CSCs) are suggested to play an important role in ...

    Authors: Harshul Pandit, Yan Li, Xuanyi Li, Weizhong Zhang, Suping Li and Robert C. G. Martin
    Citation: BMC Cancer 2018 18:783
    Content type: Research article Published on:

  28. We aimed to investigate the prevalence and predictors of Complementary and Alternative Medicine (CAM) use among cancer patients and non-cancer volunteers, and to assess the knowledge of and attitudes toward CA...

    Authors: Kah Hoong Chang, Rachel Brodie, Mei Ann Choong, Karl J Sweeney and Michael J Kerin
    Citation: BMC Cancer 2011 11:196
    Content type: Research article Published on:

  30. Metastasis to the breast from nonmammary malignancies is rare, and mostly involves patients in a pre-terminal condition with systemic metastases outside the breast. Lymphoma and leukemia, melanoma, and lung ca...

    Authors: Masahiro Yokouchi, Satoshi Nagano, Yuko Kijima, Takako Yoshioka, Akihide Tanimoto, Shoji Natsugoe and Setsuro Komiya
    Citation: BMC Cancer 2014 14:482
    Content type: Case report Published on:

  31. Tyrosine-kinase inhibitors (TKIs) have become the cornerstone treatment of patients with non-small cell lung cancer that harbor oncogenic EGFR mutations. The counterpart of these drugs is the financial burden ...

    Authors: Oscar Arrieta, Rodrigo Catalán, Silvia Guzmán-Vazquez, Feliciano Barrón, Luis Lara-Mejía, Herman Soto-Molina, Maritza Ramos-Ramírez, Diana Flores-Estrada and Jaime de la Garza
    Citation: BMC Cancer 2020 20:829
    Content type: Research article Published on:

  32. Proteins overexpressed on the surface of tumor cells can be selectively targeted. Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) are among the most often targeted p...

    Authors: Li Shen, Yongjie Shui, Xiaojia Wang, Liming Sheng, Zhengyan Yang, Danfeng Xue and Qichun Wei
    Citation: BMC Cancer 2008 8:232
    Content type: Research article Published on:

  33. Docetaxel based therapy is one of the first line chemotherapeutic agents for the treatment of metastatic castrate-resistant prostate cancer. However, one of the major obstacles in the treatment of these patien...

    Authors: D. J. Lundon, A. Boland, M. Prencipe, G. Hurley, A O’Neill, E. Kay, S. T. Aherne, P. Doolan, S. F. Madden, M. Clynes, C. Morrissey, J. M. Fitzpatrick and R. W. Watson
    Citation: BMC Cancer 2017 17:163
    Content type: Research article Published on:

  34. Non-V600E BRAF mutated colorectal cancer (CRC) is a rare disease entity with specific clinical features. These tumors are less likely to have microsatellite instability than CRC with a V600E BRAF mutation and oft...

    Authors: Eduard Callebout, Suzane Moura Ribeiro, Stephanie Laurent, Marc De Man, Liesbeth Ferdinande, Kathleen B. M. Claes, Joni Van der Meulen and Karen P. Geboes
    Citation: BMC Cancer 2019 19:567
    Content type: Case report Published on:

  35. Patients with breast cancer who overexpress the human epidermal growth factor receptor 2 (HER2) and subsequently develop brain metastasis (BM) typically experience poor quality of life and low survival. We con...

    Authors: Michelle D. Hackshaw, Heather E. Danysh, Mackenzie Henderson, Eric Wang, Nora Tu, Zahidul Islam, Amy Ladner, Mary E. Ritchey and Maribel Salas
    Citation: BMC Cancer 2021 21:967
    Content type: Research article Published on:

  36. Transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and the regulation of cell growth. Recent studies have shown the elevated expression levels of TfR ...

    Authors: Megumi Kawamoto, Tomohisa Horibe, Masayuki Kohno and Koji Kawakami
    Citation: BMC Cancer 2011 11:359
    Content type: Research article Published on:

  37. Tumour metastasis remains the major cause of death in cancer patients and, to date, the mechanism and signalling pathways governing this process are not completely understood. The TGF-β pathway is the most com...

    Authors: Jo-Anne de la Mare, Tamarin Jurgens and Adrienne L. Edkins
    Citation: BMC Cancer 2017 17:202
    Content type: Research article Published on:

  39. Detection of the ROS1 rearrangement is mandatory in patients with advanced or metastatic non-small cell lung cancer (NSCLC) to allow targeted therapy with specific inhibitors. However, in Spanish clinical practic...

    Authors: Federico Rojo, Esther Conde, Héctor Torres, Luis Cabezón-Gutiérrez, Dolores Bautista, Inmaculada Ramos, David Carcedo, Natalia Arrabal, J. Francisco García, Raquel Galán and Ernest Nadal
    Citation: BMC Cancer 2022 22:292
    Content type: Research Published on:

  40. Speckle-type POZ protein(SPOP), a substrate adaptor of Cul3 ubiquitin ligase, plays crucial roles in solid neoplasms by promoting the ubiquitination and degradation of substrates. Limited studies have shown th...

    Authors: Zhi Chen, Zuan Li, Chunlin Li, Bingcai Li, Haojian Wang, Deyong Nong, Ximing Li, Guihai Huang, Junhao Lin and Wei Li
    Citation: BMC Cancer 2022 22:1277
    Content type: Research Published on:

  41. It is generally believed that patients with Hürthle cell thyroid carcinoma (HCTC) have a poor prognosis. Furthermore, distant metastases represent the most frequent cause of thyroid cancer-related death of pat...

    Authors: Nikola Besic, Andreja Schwarzbartl-Pevec, Barbara Vidergar-Kralj, Tea Crnic, Barbara Gazic and Maja Marolt Music
    Citation: BMC Cancer 2016 16:162
    Content type: Research article Published on:

  42. This is a randomized, controlled trial of preoperative chemotherapy in patients undergoing surgery for oesophageal squamous cell carcinoma (OSCC). Patients were allocated to chemotherapy, consisting of 2-4 cyc...

    Authors: Jurjen J Boonstra, Tjebbe C Kok, Bas PL Wijnhoven, Mark van Heijl, Mark I van Berge Henegouwen, Fiebo JW ten Kate, Peter D Siersema, Winand NM Dinjens, Jan JB van Lanschot, Hugo W Tilanus and Ate van der Gaast
    Citation: BMC Cancer 2011 11:181
    Content type: Research article Published on:

  43. Cervical carcinoma (CC) is one of the most common cancers among women worldwide and the first cause of death among the Mexican female population. CC progression shows a continuum of neoplastic transitions unti...

    Authors: Guelaguetza Vazquez-Ortiz, Patricia Pina-Sanchez, Karla Vazquez, Alfonso Duenas, Lucia Taja, Patricia Mendoza, José A Garcia and Mauricio Salcedo
    Citation: BMC Cancer 2005 5:68
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2005 5:164

  44. Cuproptosis is a regulated cell death form associated with tumor progression, clinical outcomes, and immune response. However, the role of cuproptosis in pancreatic adenocarcinoma (PAAD) remains unclear. This ...

    Authors: Xiaoling Zhang, Yuxin Zhou, Jiahe Hu, Xuefeng Yu, Haitao Xu, Zhichang Ba, Haoxin Zhang, Yanan Sun, Rongfang Wang, Xinlian Du, Ruishu Mou, Xuedong Li, Jiuxin Zhu and Rui Xie
    Citation: BMC Cancer 2023 23:560
    Content type: Research Published on:

  45. Colorectal cancer (CRC) is one of the leading causes of malignant death worldwide. Because young age of onset is often considered a poor prognostic factor for CRC, it is important to identify the poor outcomes...

    Authors: Chun-Chao Chang, Shung-Haur Yang, Chih-Cheng Chien, Shu-Hung Chen, Shiann Pan, Chia-Long Lee, Chih-Ming Lin, Hsiao-Lun Sun, Chi-Cheng Huang, Yih-Yiing Wu, Ruey-Neng Yang and Chi-Jung Huang
    Citation: BMC Cancer 2009 9:376
    Content type: Research article Published on:

  47. The anticancer immune response has been reported to correlate with cancer progression. Tumor-infiltrating lymphocytes (TILs), which are one of the indicators of host immunity, affect the tumor growth, metastas...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2018 18:371
    Content type: Research article Published on:

  48. Glioblastoma (GBM) is the most aggressive malignant central nervous system tumor with a poor prognosis.The malignant transformation of glioma cells via epithelial-mesenchymal transition (EMT) has been observed...

    Authors: Li Li, Siyu Xia, Zitong Zhao, Lili Deng, Hanbing Wang, Dongbo Yang, Yizhou Hu, Jingjing Ji, Dayong Huang and Tao Xin
    Citation: BMC Cancer 2024 24:89
    Content type: Research Published on:

  49. Especially in human tumor cells, the osteopontin (OPN) primary transcript is subject to alternative splicing, generating three isoforms termed OPNa, OPNb and OPNc. We previously demonstrated that the OPNc spli...

    Authors: Tatiana M Tilli, Akeila Bellahcène, Vincent Castronovo and Etel R P Gimba
    Citation: BMC Cancer 2014 14:433
    Content type: Research article Published on:

  50. Follicular thyroid carcinoma (FTC) is the second most common cancer of the thyroid and easily develops into distant metastasis. PD-L1 is known to be associated with the carcinogenesis and progression of thyroi...

    Authors: Jianguang Lin, Yanru Qiu, Xueqin Zheng, Yijun Dai and Tianwen Xu
    Citation: BMC Cancer 2022 22:756
    Content type: Research Published on:

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