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  1. Some cancers such as sarcomas (bone and soft tissue sarcomas) and adenoid cystic carcinomas are considered as radioresistant to low linear energy transfer radiation (including photons and protons) and may ther...

    Authors: Jacques Balosso, Olivia Febvey-Combes, Annie Iung, Hélène Lozano, Abdoulkader Soumai Alloh, Catherine Cornu, Magali Hervé, Zohra Akkal, Michel Lièvre, Valérie Plattner, Francesca Valvo, Cristina Bono, Maria Rosaria Fiore, Viviana Vitolo, Barbara Vischioni, Stéphanie Patin…
    Citation: BMC Cancer 2022 22:575
    Content type: Study protocol Published on:

  2. Non-specific symptoms are  common and often sign of a non-serious disease. Because of this, patients with non-specific symptoms of cancer (NSSC) present a challenge for general practitioners (GP). Studies desc...

    Authors: Ellen Jensen, Jette Kolding Kristensen, Rikke Tveden Bjerglund, Søren Paaske Johnsen and Janus Laust Thomsen
    Citation: BMC Cancer 2022 22:574
    Content type: Research Published on:

  3. Extracellular vesicle (EV) biomarkers have promising diagnosis and screening capacity for several cancers, but the diagnostic value for pancreatic cancer (PC) is controversial. The aim of our study was to revi...

    Authors: Erna Jia, Na Ren, Xianquan Shi, Rongkui Zhang, Haixin Yu, Fan Yu, Shaoyou Qin and Jinru Xue
    Citation: BMC Cancer 2022 22:573
    Content type: Research Published on:

  4. Post-translational modification plays an important role in the occurrence and development of various tumors. However, few researches were focusing on the SUMOylation regulatory genes as tumor biomarkers to pre...

    Authors: Hongxu Sheng, Zhexue Hao, Linhai Zhu, Yuan Zeng and Jianxing He
    Citation: BMC Cancer 2022 22:572
    Content type: Research Published on:

  5. The addition of anti-angiogenesis drugs to epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) or chemotherapy in patients with EGFR-mutant non–small cell lung cancer (NSCLC) can improve di...

    Authors: Chieh-Lung Chen, Sing-Ting Wang, Wei-Chih Liao, Chia-Hung Chen, Chih-Yen Tu, Hung-Jen Chen, Te-Chun Hsia and Wen-Chien Cheng
    Citation: BMC Cancer 2022 22:571
    Content type: Research Published on:

  6. To develop and validate a nebulizer device for anti-cancer research on pressurized intraperitoneal aerosol supply in a preclinical peritoneal metastases (PM) rat model.

    Authors: Jonathan R. Buggisch, Daniel Göhler, Julien Sobilo, Stéphanie Lerondel, Günther A. Rezniczek, Michael Stintz, Andreas Rudolph, Nicolas Tabchouri, Sébastien Roger, Mehdi Ouaissi and Urs Giger-Pabst
    Citation: BMC Cancer 2022 22:570
    Content type: Research Published on:

  7. This report summarizes three phase I studies evaluating volasertib, a polo-like kinase inhibitor, plus azacitidine in adults with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myel...

    Authors: Uwe Platzbecker, Joerg Chromik, Jan Krönke, Hiroshi Handa, Stephen Strickland, Yasushi Miyazaki, Martin Wermke, Wataru Sakamoto, Yoshifumi Tachibana, Tillmann Taube and Ulrich Germing
    Citation: BMC Cancer 2022 22:569
    Content type: Research article Published on:

  8. Cadherin-23 (CDH23) plays an important role in intercellular adhesion and is involved in the progression of several types of cancer. However, the biological functions and effect of CDH23 expression on the prog...

    Authors: Jiao Yang, Fei Lu, Guangxin Ma, Yihua Pang, Yanan Zhao, Tao Sun, Daoxin Ma, Jingjing Ye and Chunyan Ji
    Citation: BMC Cancer 2022 22:568
    Content type: Research Published on:

  9. The uncontrolled proliferation of cancer cells determines hypoxic conditions within the neoplastic mass with consequent activation of specific molecular pathways that allow cells to survive despite oxygen depr...

    Authors: Chiara Zichittella, Maria Magdalena Barreca, Aurora Cordaro, Chiara Corrado, Riccardo Alessandro and Alice Conigliaro
    Citation: BMC Cancer 2022 22:567
    Content type: Research Published on:

  10. The role of Berberine (BBR) in colorectal cancer (CRC) and gut microbiota has begun to appreciate. However, there was no direct evidence confirm that the gut microbiota regulated by BBR could inhibit CRC. This...

    Authors: Haitao Chen, Chenxiao Ye, Biyu Cai, Fan Zhang, Xuanying Wang, Jin Zhang, Zewei Zhang, Yong Guo and Qinghua Yao
    Citation: BMC Cancer 2022 22:566
    Content type: Research Published on:

  11. Anti-programmed cell death receptor-1 (PD-1) monotherapy is the standard treatment for metastatic melanoma in current. Camrelizumab is a humanized IgG4 anti-PD-1 monoclonal antibody whose safety and efficacy h...

    Authors: Li Zhou, Xiaowen Wu, Zhihong Chi, Lu Si, Xinan Sheng, Yan Kong, Lili Mao, Bin Lian, Bixia Tang, Xieqiao Yan, Xuan Wang, Xue Bai, Siming Li, Xiaoting Wei, Juan Li, Qing Yang…
    Citation: BMC Cancer 2022 22:565
    Content type: Research Published on:

  12. Ribosomal protein S6 (S6), a downstream effect media of the AKT/mTOR pathway, not only is a part of 40S small subunit of eukaryotic ribosome, but also involves in protein synthesis and cell proliferation durin...

    Authors: Yaoxiang Tang, Jiadi Luo, Ying Zhou, Hongjing Zang, Yang Yang, Sile Liu, Hongmei Zheng, Jian Ma, Songqing Fan and Qiuyuan Wen
    Citation: BMC Cancer 2022 22:564
    Content type: Research Published on:

  13. Metastatic pancreatic cancer (mPC) and its treatments significantly impact health-related quality of life (HRQoL). POLO, a randomized, double-blind, placebo-controlled phase 3 trial evaluated the efficacy of o...

    Authors: Suvina Amin, Seongjung Joo, Sandra Nolte, Hyun Kyoo Yoo, Nikunj Patel, Hilary F. Byrnes, Sara Costa-Cabral and Colin D. Johnson
    Citation: BMC Cancer 2022 22:563
    Content type: Research Published on:

  15. Studies have shown that DAB2IP inhibits cancer progression, while HSP90AA1 promotes cancer progression. However, the specific regulatory mechanism of DAB2IP and HSP90AA1 in colorectal cancer (CRC) is not clear...

    Authors: Mengna Zhang, Yanan Peng, Zhenwei Yang, Hailin Zhang, Cong Xu, Lan Liu, Qiu Zhao, Jixiong Wu, Hongling Wang and Jing Liu
    Citation: BMC Cancer 2022 22:561
    Content type: Research Published on:

  16. Given the psychosocial burdens patients in advanced stages of cancer face, innovative care concepts are needed. At the same time, such vulnerable patient groups are difficult to reach for participation in inte...

    Authors: Johann Frick, Pimrapat Gebert, Ulrike Grittner, Anne Letsch, Daniel Schindel and Liane Schenk
    Citation: BMC Cancer 2022 22:560
    Content type: Research article Published on:

  18. Laminins are high-molecular weight (400 ~ 900 kDa) proteins in extracellular matrix, which serve as major component of the basal lamina, and play a crucial role in promoting tumor cell migration. This study ai...

    Authors: Nan Hao, Daming Yang, Tianpei Liu, Shucheng Liu, Xinsheng Lu and Libo Chen
    Citation: BMC Cancer 2022 22:558
    Content type: Research Published on:

  19. Chemokines are highly expressed in tumor microenvironment and play a critical role in all aspects of tumorigenesis, including the recruitment of tumor-promoting immune cells, activation of cancer-associated fi...

    Authors: Sarah Johnson, Yaroslava Karpova, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov and Alexei V. Tulin
    Citation: BMC Cancer 2022 22:557
    Content type: Research Published on:

  20. The bifunctional methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) has been reported to play an oncogenic role in various types of cancers. However, the...

    Authors: Lin Zhu, Xianhui Liu, Weiyu Zhang, Hao Hu, Qi Wang and Kexin Xu
    Citation: BMC Cancer 2022 22:556
    Content type: Research Published on:

  21. It is known that geographic location plays a role in developing lung cancer. The objectives of this study were to examine spatio-temporal patterns of lung cancer incidence in Pennsylvania, to identify geograph...

    Authors: Nuria Camiña, Tara L. McWilliams, Thomas P. McKeon, Trevor M. Penning and Wei-Ting Hwang
    Citation: BMC Cancer 2022 22:555
    Content type: Research Published on:

  22. While prostate cancer (PCa) cells most often metastasize to bone in men, species-specific differences between human and mouse bone marrow mean that this pattern is not faithfully replicated in mice. Herein we ...

    Authors: Bianca Nowlan, Elizabeth D. Williams and Michael Robert Doran
    Citation: BMC Cancer 2022 22:554
    Content type: Research Published on:

  23. Breast cancer survivors have a unique risk for negative health outcomes. Engaging in routine physical activity (PA) can reduce these risks. However, PA levels are low among this population. Narrative visualiza...

    Authors: Jason R. Bentley, Xiaoying Yu, Amol M. Karmarkar, Brian Downer, John Prochaska and Elizabeth J. Lyons
    Citation: BMC Cancer 2022 22:553
    Content type: Research Published on:

  25. Immune-mediated pneumonitis has a high mortality rate; however, information regarding the related risk factors remains limited. This study aimed to analyze risk factors for pneumonitis, including smoking and l...

    Authors: Yasuki Uchida, Daisuke Kinose, Yukihiro Nagatani, Sachiko Tanaka-Mizuno, Hiroaki Nakagawa, Kentaro Fukunaga, Masafumi Yamaguchi and Yasutaka Nakano
    Citation: BMC Cancer 2022 22:551
    Content type: Research Published on:

  26. Homologous recombination deficiency (HRD) is a molecular biomarker for administrating PARP inhibitor (PARPi) or platinum-based (Pt) chemotherapy. The most well-studied mechanism of causing HRD is pathogenic BRCA1...

    Authors: Hao Wen, Zheng Feng, Yutong Ma, Rui Liu, Qiuxiang Ou, Qinhao Guo, Yi Shen, Xue Wu, Yang Shao, Hua Bao and Xiaohua Wu
    Citation: BMC Cancer 2022 22:550
    Content type: Research article Published on:

  28. This study was conducted to evaluate the prognostic significance of different molecular typing methods and immune status based on RNA sequencing (RNA-seq) in hormone receptor (HR)-positive and human epidermal ...

    Authors: Xinyu Ren, Yu Song, Yanna zhang, Huanwen Wu, Longyun Chen, Junyi Pang, Liangrui Zhou, Songjie Shen and Zhiyong Liang
    Citation: BMC Cancer 2022 22:548
    Content type: Research Published on:

  29. During the cancer treatment path, cancer patients use numerous drugs, including anticancer, supportive, and other prescribed medications, along with herbs and certain products. This puts them at risk of signif...

    Authors: Amer A. Koni, Maisa A. Nazzal, Bushra A. Suwan, Samah S. Sobuh, Najiya T. Abuhazeem, Asil N. Salman, Husam T. Salameh, Riad Amer and Sa’ed H. Zyoud
    Citation: BMC Cancer 2022 22:547
    Content type: Research Published on:

  30. Body mass index (BMI) and cardiometabolic comorbidities such as cardiovascular disease and type 2 diabetes have been studied as negative prognostic factors in cancer survival, but possible dependencies in the ...

    Authors: Mirjam Kohls, Heinz Freisling, Hadrien Charvat, Isabelle Soerjomataram, Vivian Viallon, Veronica Davila-Batista, Rudolf Kaaks, Renée Turzanski-Fortner, Krasimira Aleksandrova, Matthias B. Schulze, Christina C. Dahm, Helene Tilma Vistisen, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Catalina Bonet, Maria-Jose Sánchez…
    Citation: BMC Cancer 2022 22:546
    Content type: Research Published on:

  31. Laryngeal squamous cell carcinoma (LSCC) is the most common squamous cell carcinoma. Though significant effort has been focused on molecular pathogenesis, development, and recurrence of LSCC, little is known ...

    Authors: Lvsheng Qian, Tingting Ni, Bing Fei, Hui Sun and Haosheng Ni
    Citation: BMC Cancer 2022 22:545
    Content type: Research Published on:

  33. The interaction between tumor microenvironment (TME) and tumors offers various targets in mounting anti-tumor immunotherapies. However, the prognostic biomarkers in endometrial carcinoma (EC) are still limited...

    Authors: Heng Ma, Peng-hui Feng, Shuang-ni Yu, Zhao-hui Lu, Qi Yu and Jie Chen
    Citation: BMC Cancer 2022 22:543
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:592

  34. To investigate pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) safety and efficacy in preventing hematological toxicity during concurrent chemoradiotherapy (CCRT) for small-cell...

    Authors: Cunliang Wang, Shouhui Zhu, Chuanwang Miao, Yu Wang, Jiazhen Chen, Shuanghu Yuan and Xudong Hu
    Citation: BMC Cancer 2022 22:542
    Content type: Research Published on:

  35. Pleural invasion (PL) has been regarded as an unfavorable prognostic factor for non-small cell lung cancer (NSCLC). But there was no agreement on the optimal surgical extent in NSCLC patients with PL. We aimed...

    Authors: Xue Song, Yangyang Xie, Yurou Zhu and Yafang Lou
    Citation: BMC Cancer 2022 22:541
    Content type: Research Published on:

  36. Several studies investigated the utility of inflammation and nutritional markers in predicting the prognosis in patients with gastric cancer; however, the markers with the best predictive ability remain unclea...

    Authors: Tomoyuki Matsunaga, Hiroaki Saito, Tomohiro Osaki, Sadamu Takahashi, Akemi Iwamoto, Kenji Fukuda, Kenjiro Taniguchi, Hirohiko Kuroda, Tsutomu Takeuchi, Kenji Sugamura, Kenichi Sumi, Kuniyuki Katano, Yuji Shishido, Kozo Miyatani and Yoshiyuki Fujiwara
    Citation: BMC Cancer 2022 22:540
    Content type: Research Published on:

  37. Bronchoscopy can be a distress for the patient. There have been few studies on the combination of sedatives and opioids. The aim of this study was to demonstrate the usefulness and safety of administration of ...

    Authors: Masahiro Katsurada, Motoko Tachihara, Naoko Katsurada, Naoya Takata, Hiroki Sato, Chihiro Mimura, Junya Yoshioka, Koichi Furukawa, Masako Yumura, Takehiro Otoshi, Yuichiro Yasuda, Tatsunori Kiriu, Daisuke Hazama, Tatsuya Nagano, Masatsugu Yamamoto, Yoshihiro Nishimura…
    Citation: BMC Cancer 2022 22:539
    Content type: Research Published on:

  38. The standard of care treatment for soft tissue sarcoma of the extremities is a wide resection in combination with pre- or postoperative radiotherapy with high local control rates, sparing patients the necessit...

    Authors: D. Brügemann, B. Lehner, M. Kieser, J. Krisam, A. Hommertgen, C. Jaekel, S. B. Harrabi, K. Herfarth, G. Mechtesheimer, O. Sedlaczek, G. Egerer, A. Geisbüsch, M. Uhl, J. Debus and K. Seidensaal
    Citation: BMC Cancer 2022 22:538
    Content type: Study protocol Published on:

  39. Perioperative chemotherapy and surgery are a standard of care for patients with resectable gastric or gastroesophageal junction (GEJ) adenocarcinoma. However, the prognosis remains poor for this population. Th...

    Authors: Mélanie Dos Santos, Justine Lequesne, Alexandra Leconte, Stéphane Corbinais, Aurélie Parzy, Jean-Marc Guilloit, Sharmini Varatharajah, Pierre-Emmanuel Brachet, Marine Dorbeau, Dominique Vaur, Louis-Bastien Weiswald, Laurent Poulain, Corentin Le Gallic, Marie Castera-Tellier, Marie-Pierre Galais and Bénédicte Clarisse
    Citation: BMC Cancer 2022 22:537
    Content type: Study protocol Published on:

  40. The French PRODIGE 7 trial, published on January 2021, has raised doubts about the specific survival benefit provided by HIPEC with oxaliplatin 460 mg/m2 (30 minutes) for the treatment of peritoneal metastases fr...

    Authors: Fernando Pereira, Angel Serrano, Israel Manzanedo, Estibalitz Pérez-Viejo, Santiago González-Moreno, Luis González-Bayón, Alvaro Arjona-Sánchez, Juan Torres, Isabel Ramos, Maria E. Barrios, Pedro Cascales, Rafael Morales, Enrique Boldó, Alfonso García-Fadrique, Xabier Arteaga, Alberto Gutierrez-Calvo…
    Citation: BMC Cancer 2022 22:536
    Content type: Study protocol Published on:

  41. As opposed to observation of the neck, elective neck dissection has a survival benefit for cN0 oropharyngeal squamous cell carcinoma (OPSCC). However, there are limited date on level IV neck dissection in huma...

    Authors: Zirong Huo, Shuiting Fu, Chunyue Ma and Surui Sheng
    Citation: BMC Cancer 2022 22:535
    Content type: Research article Published on:

  42. Several studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined effect of cardiovascular risk factors on the risk of breast cancer is stil...

    Authors: Xiaoqi Zeng, Shanshan Jiang, Simin Ruan, Lijun Zhu, Huining Lian, Minfeng Liu, Zhaoze Guo, Jingyun Guo, Changsheng Ye, Yunjiu Cheng and Jianyu Dong
    Citation: BMC Cancer 2022 22:534
    Content type: Research article Published on:

  43. As a metastasis-related protein, NEDD9 has been reported in breast cancer (BC) metastasis research. However, there are few studies on the upstream regulators of NEDD9, especially involving the potential role o...

    Authors: Jiamin Zhou, Xianglin Sun, Xinyu Zhang, Huan Yang, Zhenglin Jiang, Qianqian Luo, Yifei Liu and Guohua Wang
    Citation: BMC Cancer 2022 22:533
    Content type: Research article Published on:

  44. Access to cancer care is a problem that continues to plague refugees displaced from their home countries. The turbulent political crisis in Syria, which has led to millions of refugees seeking asylum in Turkey...

    Authors: Mutlay Sayan, Mehmet Fuat Eren, Sarah Sabrine Kilic, Ayse Kotek, Sedenay Oskeroglu Kaplan, Ozge Duran, Funda Cukurcayır, Ibrahim Babalıoglu, Ozlem Derinalp Or, Gul Aysen Ozturk, Celalettin Eroglu, Fatma Teke, Neslihan Kurtul, Tugce Kutuk, Beyhan Ceylaner Bicakci, Sukran Senyurek…
    Citation: BMC Cancer 2022 22:532
    Content type: Research article Published on:

  45. Racial and ethnic disparities in outcomes for Black and Hispanic children with acute leukemia have been well documented, however little is known about the determinants of diagnostic delays in pediatric leukemi...

    Authors: Lucky Ding, Julia E. Szymczak, Erica Evans, Emma Canepa, Ashley E. Martin, Farah Contractor, Richard Aplenc, Galen Joseph and Lena E. Winestone
    Citation: BMC Cancer 2022 22:531
    Content type: Research Published on:

  46. Salivary biomarkers hold huge potential for the non-invasive diagnosis of oral squamous cell carcinoma. Angiogenic factors and matrix-metalloproteinases (MMPs) are highly expressed in OSCC tissue, but their ex...

    Authors: Meijuan Cai, Zhichao Zheng, Zhibao Bai, Kexiong Ouyang, Qiuyu Wu, Shaofen Xu, Lihuan Huang, Yingtong Jiang, Lijing Wang, Jie Gao, Janak L. Pathak and Lihong Wu
    Citation: BMC Cancer 2022 22:530
    Content type: Research Published on:

  47. There is a paucity of data regarding the prognostic influence of peripheral blood CD4+ T lymphopenia in non-small cell lung cancer (NSCLC). Therefore, we investigated the prognostic value of T lymphopenia in N...

    Authors: Guillaume Eberst, Dewi Vernerey, Caroline Laheurte, Aurélia Meurisse, Vincent Kaulek, Laurie Cuche, Pascale Jacoulet, Hamadi Almotlak, Jean Lahourcade, Marie Gainet-Brun, Elizabeth Fabre, Françoise Le Pimpec-Barthes, Olivier Adotevi and Virginie Westeel
    Citation: BMC Cancer 2022 22:529
    Content type: Research Published on:

  48. Soft tissue sarcomas (STSs) are a heterogeneous group of cancers with over 100 described subtypes. While these cancers are infrequent, the prognosis is quite poor, particularly for those with stage IV metastat...

    Authors: Akira Kawai, Hiroyuki Narahara, Shunji Takahashi, Tomoki Nakamura, Hiroshi Kobayashi, Yasunori Megumi, Toshiyuki Matsuoka and Eisuke Kobayashi
    Citation: BMC Cancer 2022 22:528
    Content type: Research Published on:

  49. Cancer is the major cause of morbidity and mortality worldwide. The cancer burden varies within the regions of India posing great challenges in its prevention and control. The national burden assessment remain...

    Authors: Vaitheeswaran Kulothungan, Krishnan Sathishkumar, Sravya Leburu, Thilagavathi Ramamoorthy, Santhappan Stephen, Dharmappa Basavarajappa, Nifty Tomy, Rohith Mohan, Geetha R. Menon and Prashant Mathur
    Citation: BMC Cancer 2022 22:527
    Content type: Research Published on:

  50. A current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a distinctive trait of cancer cells is their addiction to hyperactivation of r...

    Authors: Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel…
    Citation: BMC Cancer 2022 22:526
    Content type: Research Published on:

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