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  1. Evidences have indicated that miR-26a-5p regulates the malignant properties of various tumor cells. However, the influences of miR-26a-5p on proliferation, apoptosis and invasion are still vague in the cervica...

    Authors: Ming Li, Yubo Xiao, Minqi Liu, Qian Ning, Ziye Xiang, Xiang Zheng, Shengsong Tang and Zhongcheng Mo
    Citation: BMC Cancer 2022 22:876
    Content type: Research Published on:

  2. We studied the prognosis and clinicopathological background of lung adenocarcinoma predominance among patients who underwent lobectomy using data from the Japanese Joint Committee of Lung Cancer Registry.

    Authors: Hiroyuki Ito, Hiroshi Date, Yasushi Shintani, Etsuo Miyaoka, Ryoichi Nakanishi, Mitsutaka Kadokura, Shunsuke Endo, Masayuki Chida, Ichiro Yoshino and Hidemi Suzuki
    Citation: BMC Cancer 2022 22:875
    Content type: Research Published on:

  3. Breast cancer, comprising of several sub-phenotypes, is a leading cause of female cancer-related mortality in the UK and accounts for 15% of all cancer cases. Chemoresistant sub phenotypes of breast cancer rem...

    Authors: Layla Alnoumas, Lisa van den Driest, Zoe Apczynski, Alison Lannigan, Caroline H. Johnson, Nicholas J. W. Rattray and Zahra Rattray
    Citation: BMC Cancer 2022 22:874
    Content type: Research Published on:

  4. EphrinA (EFNA) are Eph receptor ligands that regulate various disease processes. Nonetheless, the expression characteristics of EFNAs in pan-cancer, their relationship with tumor immune microenvironment, and p...

    Authors: Zonglin Jiao, Xiao Feng, Yuqing Cui, Lei Wang, Junqing Gan, Yanbin Zhao and Qingwei Meng
    Citation: BMC Cancer 2022 22:871
    Content type: Research Published on:

  5. Sodium selenite (SSE) has been reported to exert anti-tumor effects in several cancer cells. However, the underlying mechanisms in renal cancer are yet to be elucidated. The effects of SSE on the proliferation...

    Authors: Xiao Liu, Meng Jiang, Chenggang Pang, Jianning Wang and Lijuan Hu
    Citation: BMC Cancer 2022 22:870
    Content type: Research Published on:

  6. Aberrant fibroblast growth factor receptor (FGFR) signaling can substantially influence oncogenicity. Despite that FGFR gene abnormality is often detected by cancer genome profiling tests, there is no tumor-ag...

    Authors: Yohei Chiba, Kazuki Sudo, Yuki Kojima, Hitomi Okuma, Shinji Kohsaka, Ryunosuke Machida, Masahiko Ichimura, Kenta Anjo, Kazumi Kurishita, Natsuko Okita, Kenichi Nakamura, Ichiro Kinoshita, Masanobu Takahashi, Junichi Matsubara, Hitoshi Kusaba, Kan Yonemori…
    Citation: BMC Cancer 2022 22:869
    Content type: Study protocol Published on:

  7. Preoperative neoadjuvant chemoradiation (nCRT) has been the standard treatment for locally advanced rectal cancer. Serum biomarkers to stratify patients with respect to prognosis and response to nCRT are neede...

    Authors: Hanyang Wang, Dengbo Ji, Huifang Tian, Zhaoya Gao, Can Song, Jinying Jia, Xinxin Cui, Lijun Zhong, Jing Shen and Jin Gu
    Citation: BMC Cancer 2022 22:868
    Content type: Research Published on:

  8. LncRNA N6-methylandenosine (m6A) modification has been shown to be associated with the constitution of the tumor microenvironment (TME) and tumorigenesis. It’s essential to understand the mechanisms of lncRNA ...

    Authors: Bo Chen, Zhan Yang, Zhichao Lang, Qiqi Tao, Rongrong Zhang, Yating Zhan, Xuantong Xu, Kai Zhu, Jianjian Zheng, Zhengping Yu and Suhui Yu
    Citation: BMC Cancer 2022 22:867
    Content type: Research Published on:

  9. Lung squamous cell carcinoma (LUSC) is prone to metastasis and likely to develop resistance to chemotherapeutic drugs. DNA repair has been reported to be involved in the progression and chemoresistance of LUSC...

    Authors: Xinshu Wang, Zhiyuan Huang, Lei Li, Guangxue Wang, Lin Dong, Qinchuan Li, Jian Yuan and Yunhui Li
    Citation: BMC Cancer 2022 22:866
    Content type: Research Published on:

  10. The role of adjuvant radiation in pancreatic adenocarcinoma (PDAC) remains unclear. We aimed to investigate the efficacy of gemcitabine combined with stereotactic body radiation therapy (SBRT) as adjuvant ther...

    Authors: Tao Ma, Xueli Bai, Qichun Wei, Yongjie Shui, Mengyi Lao, Wen Chen, Bingfeng Huang, Risheng Que, Shunliang Gao, Yun Zhang, Wei Chen, Ji Wang and Tingbo Liang
    Citation: BMC Cancer 2022 22:865
    Content type: Research Published on:

  11. IFN-γ has been traditionally recognized as an inflammatory cytokine that involves in inflammation and autoimmune diseases. Previously we have shown that sustained IFN-γ induced malignant transformation of bovi...

    Authors: Li Li, Fengyang Li, Xiuhong Hu, Zengshuai Wu, Wenbo Ren, Tingting Wang, Zhengchao Ji, Na Li, Jingmin Gu, Changjiang Sun, Xin Feng, Wenyu Han, Jing Huang and Liancheng Lei
    Citation: BMC Cancer 2022 22:864
    Content type: Research Published on:

  12. There is no clear consensus on the benefits of adjuvant chemotherapy for tumor-node-metastasis (TNM) stage T1 (T1N0M0) breast cancer (BC). Our study investigated the effects of adjuvant chemotherapy on T1N0M0 ...

    Authors: Kaiwen Shen, Longdi Yao, Jingyuan Zhu, Ximing Gu, Jie Wang, Wei Qian, Zhijian Zheng, Deyuan Fu and Song Wu
    Citation: BMC Cancer 2022 22:863
    Content type: Research Published on:

  13. Cervical cancer is a preventable disease, but it is a major public health problem despite having a good prognosis when diagnosed early. Although the Pap smear has led to huge drops in rates of cervical cancer ...

    Authors: Neila Pierote Gaspar Nascimento, Thais Borges Gally, Grasiely Faccin Borges, Luciene Cristina Gastalho Campos and Carla Martins Kaneto
    Citation: BMC Cancer 2022 22:862
    Content type: Research Published on:

  14. Tumor budding is associated with lymph node (LN) metastasis in submucosal colorectal cancer (CRC). However, the rate of LN metastasis associated with the number of tumor buds is unknown. Here, we determined th...

    Authors: Jeong-ki Kim, Ye-Young Rhee, Jeong Mo Bae, Jung Ho Kim, Seong-Joon Koh, Hyun Jung Lee, Jong Pil Im, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park and Gyeong Hoon Kang
    Citation: BMC Cancer 2022 22:861
    Content type: Research Published on:

  15. The adjuvant treatment with Aromatase Inhibitor (AI) is considered standard of care for postmenopausal breast cancer (BC) women with hormone receptor-positive (HR +), however, it often causes adverse effects s...

    Authors: Isis Danyelle Dias Custódio, Fernanda Silva Mazzutti Nunes, Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Débora Santana Alves, Juliana Freitas Chiaretto, Paula Philbert Lajolo Canto, Carlos Eduardo Paiva and Yara Cristina de Paiva Maia
    Citation: BMC Cancer 2022 22:860
    Content type: Research Published on:

  16. The KMT2A gene, formerly named the MLL gene, is rearranged (KMT2Ar) in 70–75% of infants, 5–6% of children and 10–15% of adult patients with B cell acute lymphoblastic leukemia (B-ALL). The outcome after chemothe...

    Authors: Jinquan Wen, Min Zhou, Yali Shen, Yueting long, Yuxia Guo, Lin Song and Jianwen Xiao
    Citation: BMC Cancer 2022 22:859
    Content type: Research Published on:

  17. Inflammatory parameters and Epstein–Barr virus (EBV) DNA status have been confirmed to be associated with prognosis in nasopharyngeal carcinoma (NPC) patients. However, there are few in-depth studies on the pr...

    Authors: Xiaofei Yuan, Hua Yang, Fangfang Zeng, Shiyu Zhou, Shuting Wu, Yue Yuan, Linchong Cui, Huiru Feng, Danfan Lin, Zilu Chen, Xiong Liu, Jing Chen and Fan Wang
    Citation: BMC Cancer 2022 22:858
    Content type: Research Published on:

  18. Liver cirrhosis is a well-known risk factor for hepatocellular carcinoma (HCC). However, some HCC cases can also originate from non-cirrhotic livers. The aim of this study was to identify key circular RNAs (ci...

    Authors: Hongyu Li, Liangliang Xu, Pengsheng Yi, Lian Li, Tao Yan, Liang Xie and Zhijun Zhu
    Citation: BMC Cancer 2022 22:857
    Content type: Research Published on:

  19. Active surveillance (AS) is one of the treatment methods for patients with small renal masses (SRMs; < 4 cm), including renal cell carcinomas (RCCs). However, some small RCCs may exhibit aggressive neoplastic ...

    Authors: Masato Yanagi, Tomonari Kiriyama, Jun Akatsuka, Yuki Endo, Hayato Takeda, Akifumi Katsu, Yuichiro Honda, Kyota Suzuki, Yoshihiro Nishikawa, Shunsuke Ikuma, Hikaru Mikami, Yuka Toyama, Go Kimura and Yukihiro Kondo
    Citation: BMC Cancer 2022 22:856
    Content type: Research Published on:

  21. Persistent high-risk (hr) human papillomavirus (HPV) infection is a necessary cause of cervical cancer. Cervical cancer is a major public health problem in Sub-Saharan Africa including South Africa. This study...

    Authors: Teboho Amelia Tiiti, Selokela Gloria Selabe, Johannes Bogers and Ramokone Lisbeth Lebelo
    Citation: BMC Cancer 2022 22:854
    Content type: Research Published on:

  22. High-sensitivity C-reactive protein (hs-CRP) levels and metabolic syndrome (MetS) are known to be associated with an increased incidence of different cancers. We aimed to evaluate the effect of MetS combined w...

    Authors: Mengmeng Song, Tong Liu, Hai Liu, Qi Zhang, Qingsong Zhang, Yiming Wang, Xiangming Ma, Liying Cao and Hanping Shi
    Citation: BMC Cancer 2022 22:853
    Content type: Research Published on:

  23. Tumor acidosis, a common phenomenon in solid cancers such as breast cancer, is caused by the abnormal metabolism of cancer cells. The low pH affects cells surrounding the cancer, and tumor acidosis has been sh...

    Authors: Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon and Sang-Kyu Ye
    Citation: BMC Cancer 2022 22:852
    Content type: Research Published on:

  24. Trials investigating neoadjuvant treatment with immune checkpoint inhibitors (ICI) in patients with melanoma have shown high clinical and pathologic response rates. Treatment with talimogene laherparepvec (T-V...

    Authors: Maartje W. Rohaan, Emma H. A. Stahlie, Viola Franke, Lisanne P. Zijlker, Sofie Wilgenhof, Vincent van der Noort, Alexander C. J. van Akkooi and John B. A. G. Haanen
    Citation: BMC Cancer 2022 22:851
    Content type: Study protocol Published on:

  25. The pandemic disrupted society and health services through lockdowns and resource reallocation to care for COVID-19 patients. Reductions in numbers of cancer patients having surgery, being diagnosed pathologic...

    Authors: Helen Mitchell, Ben S. Alford, Simon O’Hare, Eamon O’Callaghan, Colin Fox and Anna T. Gavin
    Citation: BMC Cancer 2022 22:850
    Content type: Research Published on:

  26. Breast cancer is an umbrella term referring to a group of biologically and molecularly heterogeneous diseases originating from the breast. Globally, incidences of breast cancer has been increasing dramatically...

    Authors: Ping-Hung Liu, James Cheng-Chung Wei, Yu-Hsun Wang and Ming-Hsin Yeh
    Citation: BMC Cancer 2022 22:849
    Content type: Research Published on:

  28. While cancer outcomes have improved over time, in Northern Ireland they continue to lag behind those of many other developed economies. The role of comorbid conditions has been suggested as a potential contrib...

    Authors: Ciaran O’Neill, David W. Donnelly, Mark Harbinson, Therese Kearney, Colin R. Fox, Gerard Walls and Anna Gavin
    Citation: BMC Cancer 2022 22:847
    Content type: Research Published on:

  29. Whether hypokalemia can affect the short-term outcomes of CRC patients after radical surgery remains unclear. The purpose of this study was to investigate the impact of preoperative hypokalemia on the short-te...

    Authors: Bin Zhang, Xiao-Yu Liu, Bing Kang, Chao Yuan, Zi-Wei Li, Zheng-Qiang Wei and Dong Peng
    Citation: BMC Cancer 2022 22:846
    Content type: Research Published on:

  30. Although immune-checkpoint inhibitors (ICI) are overall promissory for cancer treatment, they entail, in some cases, an undesired side-effect called hyperprogressive-cancer disease (HPD) associated with accele...

    Authors: Daniela R. Montagna, Alejandra Duarte, Paula Chiarella, Bárbara Rearte, Oscar D. Bustuoabad, Mónica Vermeulen and Raúl A. Ruggiero
    Citation: BMC Cancer 2022 22:845
    Content type: Research Published on:

  31. Glioblastoma (GBM) is one of the deadliest cancers. Treatment options are limited, and median patient survival is only several months. Translation of new therapies is hindered by a lack of GBM models that full...

    Authors: Julia A. Schulz, Louis T. Rodgers, Richard J. Kryscio, Anika M.S. Hartz and Björn Bauer
    Citation: BMC Cancer 2022 22:844
    Content type: Research Published on:

  32. Glioblastoma (GB) is the most common and most aggressive malignant brain tumor. In understanding its resistance to conventional treatments, iron metabolism and related pathways may represent a novel avenue. As...

    Authors: Charlotte Roy, Sylvie Avril, Claire Legendre, Bénédicte Lelièvre, Honorine Vellenriter, Sébastien Boni, Jérôme Cayon, Catherine Guillet, Yannick Guilloux, Michel Chérel, François Hindré and Emmanuel Garcion
    Citation: BMC Cancer 2022 22:843
    Content type: Research Published on:

  34. Acute, catastrophic bleeding in patients with head and neck cancer (HNC) is challenging and also a burden for their families and frontline physicians. This study analyzed the risk factors for rebleeding and lo...

    Authors: Chih-Kai Wang, Che-Fang Ho, Kuang-Yu Niu, Chia-Chien Wu, Yun-Chen Chang, Chien-Han Hsiao and Chieh-Ching Yen
    Citation: BMC Cancer 2022 22:841
    Content type: Research Published on:

  36. Inflammatory indices and tumor-infiltrating lymphocytes (TILs) have prognostic value in many cancer types. This study aimed to assess the prognostic value of inflammatory indices and evaluate their correlation...

    Authors: Hiroki Kanno, Toru Hisaka, Jun Akiba, Kazuaki Hashimoto, Fumihiko Fujita and Yoshito Akagi
    Citation: BMC Cancer 2022 22:839
    Content type: Research Published on:

  37. Most recent laboratory studies have suggested a promising role of vitamin D and its analogs as novel chemotherapeutic agents for cancer treatment. However, epidemiological evidence, especially regarding the ef...

    Authors: Minh Thien Nguyen, Nhi Ngoc Yen Huynh, Dai Duc Nguyen, Nguyen Ha Ta, Tai Van Nguyen, Huy Thanh Dang and Ngoan Tran Le
    Citation: BMC Cancer 2022 22:838
    Content type: Research Published on:

  38. Despite benefits of endocrine therapy (ET) for patients with hormone-receptor (HR)-positive breast cancer, many patients do not initiate or discontinue ET against recommendations.

    Authors: Beomyoung Cho, Maria Pérez, Donna B. Jeffe, Matthew W. Kreuter, Julie A. Margenthaler, Graham A. Colditz and Ying Liu
    Citation: BMC Cancer 2022 22:837
    Content type: Research Published on:

  40. A deep understanding of potential molecular biomarkers and therapeutic targets related to the progression of colorectal cancer (CRC) from early stages to metastasis remain mostly undone. Moreover, the regulati...

    Authors: Pouria Samadi, Meysam Soleimani, Fatemeh Nouri, Fatemeh Rahbarizadeh, Rezvan Najafi and Akram Jalali
    Citation: BMC Cancer 2022 22:835
    Content type: Research Published on:

  41. Cancer-testis antigens (CTAs) have emerged as potential clinical biomarkers targeting immunotherapy. KK-LC-1 is a member of CTAs, which has been demonstrated in a variety of tumors tissues and been found to el...

    Authors: Yanli Kang, Yuhan Gan, Yingfeng Jiang, Jianbin You, Chen Huang, Qianshun Chen, Xunyu Xu, Falin Chen and Liangyuan Chen
    Citation: BMC Cancer 2022 22:834
    Content type: Research Published on:

  42. The amino acid transporter SLC6A14, which transports 18 of the 20 proteinogenic amino acids, is too low to be detected in healthy normal tissues but is significantly increased in some solid cancers. However, l...

    Authors: Ying Lu, Ziting Jiang, Kaijing Wang, Shanshan Yu, Chongbo Hao, Zuan Ma, Xuelian Fu, Ming Qing Qin, Zengguang Xu and Lieying Fan
    Citation: BMC Cancer 2022 22:833
    Content type: Research Published on:

  43. Enhanced recovery after surgery programs have reduced complications and shortened hospital stays after lung resection. This study aimed to determine whether video-assisted thoracoscopic surgery performed as a ...

    Authors: Guofei Zhang, Junqiang Fan, Zipu Yu, Ying Chai, Sai Zhang, Ming Wu and Gang Shen
    Citation: BMC Cancer 2022 22:832
    Content type: Research Published on:

  44. To evaluate the diagnostic value of adding human epididymis protein 4 (HE4), cancer antigen 125 (CA125) and risk of malignancy algorithm (ROMA) to ultrasound for detecting ovarian cancer in patients with a pel...

    Authors: Elena Ioana Braicu, Catherine Linn Krause, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Malgorzata Lanowska, Bodo Müller, Elisa Koch, Janine Boenneß-Zaloum, Kerstin Ames, Radoslav Chekerov, Kati Hasenbein, Mathias Zimmermann, Mandy Mangler, Frank Chen…
    Citation: BMC Cancer 2022 22:831
    Content type: Research Published on:

  45. Hepatocellular carcinoma (HCC) is one of the most lethal cancers, with a poor prognosis. Prognostic biomarkers for HCC patients are urgently needed. We aimed to establish a nomogram prediction system that comb...

    Authors: Renguo Guan, Jingwen Zou, Jie Mei, Min Deng and Rongping Guo
    Citation: BMC Cancer 2022 22:830
    Content type: Research Published on:

  46. Carboplatin is the backbone cytotoxic agent for many chemotherapy regimens for lung cancer. Dosing of carboplatin is complicated due to its relationship to renal function and narrow therapeutic index. Overesti...

    Authors: Seçkin Akgül, Bryan A. Chan and Peter M. Manders
    Citation: BMC Cancer 2022 22:829
    Content type: Research Published on:

  47. The efficacy of bevacizumab in non-small cell lung cancer (NSCLC) patients is unsatisfactory, and the selection of suitable patients is still challenging. Given the epigenetic modifications can contribute to a...

    Authors: Butuo Li, Chao Jiang, Yiyue Xu, Xinyu Fan, Linlin Yang, Bing Zou, Bingjie Fan and Linlin Wang
    Citation: BMC Cancer 2022 22:828
    Content type: Research Published on:

  48. The most frequently diagnosed primary brain tumor is glioblastoma (GBM). Nearly all patients experience tumor recurrence and up to 90% of which is local recurrence. Thus, increasing the therapeutic ratio of ra...

    Authors: Yun Guan, Mingyuan Pan, Jun Yang, Qiuxia Lu, Liangfu Han, Ying Liu, Jing Li, Huaguang Zhu, Xiu Gong, Guanghai Mei, Xiaoxia Liu, Li Pan, Jiazhong Dai, Yang Wang, Enmin Wang and Xin Wang
    Citation: BMC Cancer 2022 22:827
    Content type: Study protocol Published on:

  49. The difference in epidemiological characteristics of breast cancer (BC) across countries is valuable for BC management and prevention. The study evaluated the up-to-date burden, trends, and risk factors of BC ...

    Authors: Na Liu, Da-Wei Yang, Yan-Xia Wu, Wen-Qiong Xue, Dan-Hua Li, Jiang-Bo Zhang, Yong-Qiao He and Wei-Hua Jia
    Citation: BMC Cancer 2022 22:826
    Content type: Research Published on:

  50. Authors: Vijayasarathy Ketavarapu, Vishnubhotla Ravikanth, Mitnala Sasikala, G. V. Rao, Ch. Venkataramana Devi, Prabhakar Sripadi, Murali Satyanarayana Bethu, Ramars Amanchy, H. V. V. Murthy, Stephen J. Pandol and D. Nageshwar Reddy
    Citation: BMC Cancer 2022 22:825
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2022 22:792

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