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336 result(s) for 'ctla 4' within BMC Cancer

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  1. Prostate, bladder and kidney cancers are common age-related genitourinary cancers. China's population is aging at an increasing rate, so predicting the morbidity and mortality of prostate, bladder, and kidney ...

    Authors: Qiao Huang, Hao Zi, Lisha Luo, Xuhui Li, Cong Zhu and Xiantao Zeng
    Citation: BMC Cancer 2022 22:1164
    Content type: Research Published on:

  2. Malignant pleural mesothelioma (MPM) is a rare, aggressive malignancy of the pleural cavity linked to asbestos exposure. The combination of pemetrexed and platinum is a standard first-line therapy for malignan...

    Authors: Barbara Ziółkowska, Bożena Cybulska-Stopa, Dimitrios Papantoniou and Rafał Suwiński
    Citation: BMC Cancer 2022 22:432
    Content type: Research Published on:

  3. Patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC) have a poor prognosis and limited therapeutic options. Immune checkpoint inhibitors (ICIs) are effective in patients with...

    Authors: Agathe Vienne, Laetitia Collet, Thomas Chevalier, Christian Borel, Magalie Tardy, Florence Huguet, Sandrine Richard, Sebastien Salas, Esma Saada-Bouzid, Jerome Fayette and Amaury Daste
    Citation: BMC Cancer 2023 23:663
    Content type: Research Published on:

  4. The safety and short-term outcomes of gastrectomy after preoperative chemotherapy plus immunotherapy (PCIT) versus preoperative chemotherapy (PCT) in patients with advanced gastric cancer (AGC) remain unclear....

    Authors: Yinkui Wang, Xiaokang Lei, Fei Shan, Shuangxi Li, Yongning Jia, Rulin Miao, Kan Xue, Zhemin Li, Jiafu Ji and Ziyu Li
    Citation: BMC Cancer 2022 22:1306
    Content type: Research Published on:

  5. There are limited and no standard therapies for recurrent glioblastoma. We herein report the antitumour activity and safety of sintilimab, bevacizumab and temozolomide (TMZ) in recurrent glioblastoma.

    Authors: Yinghao Lu, Limin Liao, Kunpeng Du, Jianhua Mo, Xia Zou, Junxian Liang, Jiahui Chen, Wenwen Tang, Liwei Su, Jieping Wu, Junde Zhang and Yujing Tan
    Citation: BMC Cancer 2024 24:133
    Content type: Research Published on:

  6. Identification of microsatellite instability high (MSI-H) colorectal cancer (CRC) is crucial for screening patients most likely to benefit from immunotherapy. We aim to investigate whether the metabolic charac...

    Authors: Jinling Song, Zhongwu Li, Lujing Yang, Maomao Wei, Zhi Yang and Xuejuan Wang
    Citation: BMC Cancer 2022 22:808
    Content type: Research Published on:

  7. Lynch syndrome (LS) is an autosomal dominant hereditary cancer syndrome responsible for 2–4% of hereditary colorectal cancers (CRC). Mismatch repair protein deficiency (dMMR) is a characteristic feature of LS....

    Authors: Alice Talbot, Emily O’Donovan, Eileen Berkley, Carmel Nolan, Roisin Clarke and David Gallagher
    Citation: BMC Cancer 2021 21:617
    Content type: Research Published on:

  8. The positive response and the clinical usefulness of 14 serum antibodies in patients with esophageal squamous cell carcinoma (ESCC) were examined in this study. The Cancer Genome Atlas (TCGA) was used to inves...

    Authors: Isamu Hoshino, Yoshihiro Nabeya, Nobuhiro Takiguchi, Hisashi Gunji, Fumitaka Ishige, Yosuke Iwatate, Akiko Kuwajima, Fumiaki Shiratori, Rei Okada and Hideaki Shimada
    Citation: BMC Cancer 2020 20:1007
    Content type: Research article Published on:

  9. This retrospective analysis of data from clinical trials in metastatic urothelial carcinoma (mUC) was conducted to determine baseline patient characteristics associated with long-term survival (LTS) following ...

    Authors: Marie Alt, Carlos Stecca, Yian Lin, Gbenga Kazeem, Erik T. Goluboff and Srikala S. Sridhar
    Citation: BMC Cancer 2023 23:919
    Content type: Research Published on:

  10. Lung adenocarcinoma (LUAD) is the most prevalent non-small cell lung cancer (NSCLC). Patients with LUAD have a poor 5-year survival rate. The use of immune checkpoint inhibitors (ICIs) for the treatment of LUA...

    Authors: Weishuang Ma, Jiaming Liang, Junjian Mo, Siyuan Zhang, Ningdong Hu, Dongbo Tian and Zisheng Chen
    Citation: BMC Cancer 2021 21:1096
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:1146

  11. Benzamide-based radioligands targeting melanin were first developed for imaging melanoma and then for therapeutic purpose with targeted radionuclide therapy (TRT).

    Authors: Emilie Thivat, Jacques Rouanet, Philippe Auzeloux, Nicolas Sas, Elodie Jouberton, Sophie Levesque, Tommy Billoux, Sandrine Mansard, Ioana Molnar, Marion Chanchou, Giovanna Fois, Lydia Maigne, Jean-Michel Chezal, Elisabeth Miot-Noirault, Michel D’Incan, Xavier Durando…
    Citation: BMC Cancer 2022 22:417
    Content type: Study protocol Published on:

  12. Nephrectomy, whether in the era of cytokine therapy or targeted therapy, has an important role in the treatment of metastatic renal cell carcinoma. With the advent of immunotherapy, immunotherapy combined with...

    Authors: Hanzhi Dong, Yuan Cao, Yan Jian, Jun Lei, Weimin Zhou, Xiaoling Yu, Xiquan Zhang, Zhiqiang Peng and Zhe Sun
    Citation: BMC Cancer 2023 23:943
    Content type: Research Published on:

  13. Sinonasal mucosal melanoma (SNMM) is a relatively rare malignant tumour with a poor prognosis. This study was designed to identify prognostic factors and establish a nomogram model to predict the overall survi...

    Authors: Zhenzhen Zhu, Weiqing Wang, Yang Zha, Xiaowei Wang, Surita Aodeng, Lei Wang, Yuzhuo Liu and Wei Lv
    Citation: BMC Cancer 2024 24:184
    Content type: Research Published on:

  14. Immune-related adverse events (irAEs) are a major toxicity of immune checkpoint inhibitors. Studies have reported that pre-existing autoimmunity increases the risk of irAEs, but it remains unknown which clinic...

    Authors: Aaron N. Holmes, Helen Swede, Wendy M. Feer, Donna Comins Pike, Xiaoyan Wang and Upendra P. Hegde
    Citation: BMC Cancer 2021 21:1300
    Content type: Research Published on:

  15. B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HL...

    Authors: Cheng-Shyong Chang, Julia H Chang, Nicholas C Hsu, Hsuan-Yu Lin and Chih-Yuan Chung
    Citation: BMC Cancer 2007 7:88
    Content type: Research article Published on:

  16. The standard treatment for patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC) is definitive chemoradiotherapy (CRT) using 5-FU plus cisplatin. However, complete response (CR)...

    Authors: Hideaki Bando, Daisuke Kotani, Takahiro Tsushima, Hiroki Hara, Shigenori Kadowaki, Ken Kato, Keisho Chin, Kensei Yamaguchi, Shun-ichiro Kageyama, Hidehiro Hojo, Masaki Nakamura, Hidenobu Tachibana, Masashi Wakabayashi, Miki Fukutani, Yosuke Togashi, Nozomu Fuse…
    Citation: BMC Cancer 2020 20:336
    Content type: Study protocol Published on:

  17. To assess the long-term prognosis for patients with iris melanomas and compare it with the prognosis for small choroidal melanomas.

    Authors: Shiva Sabazade, Christina Herrspiegel, Viktor Gill and Gustav Stålhammar
    Citation: BMC Cancer 2021 21:1270
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:32

  18. As part of the multi-country I-O Optimise research initiative, this population-based study evaluated real-world treatment patterns and overall survival (OS) in patients treated for advanced non-small cell lung...

    Authors: Robert Carroll, Margherita Bortolini, Alan Calleja, Robin Munro, Shiying Kong, Melinda J. Daumont, John R. Penrod, Khalid Lakhdari, Laure Lacoin and Winson Y. Cheung
    Citation: BMC Cancer 2022 22:255
    Content type: Research Published on:

  19. The goal of this study was to evaluate efficacy and safety of 90Y radioembolization for neuroendocrine liver metastases (NELM) in a multicenter registry.

    Authors: Thomas Y. Wong, Kevin S. Zhang, Ripal T. Gandhi, Zachary S. Collins, Ryan O’Hara, Eric A. Wang, Kirubahara Vaheesan, Lea Matsuoka, Daniel Y. Sze, Andrew S. Kennedy and Daniel B. Brown
    Citation: BMC Cancer 2022 22:224
    Content type: Research Published on:

  20. After neoadjuvant chemotherapy of breast cancer pathologic complete response (pCR) indicates a favorable prognosis. Among non-selected patients, pCR is, however, achieved in only 10–30%. Early evaluation of tu...

    Authors: Bernhard Tribukait
    Citation: BMC Cancer 2020 20:440
    Content type: Research article Published on:

  21. Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy, although newly developing targeted therapy and immunotherapy have been showing promising effects in clinical treatment, the effectiv...

    Authors: Ziwei Gui, Juan Du, Nan Wu, Ningning Shen, Zhiqing Yang, Huijun Yang, Xuzhi Wang, Na Zhao, Zixin Zeng, Rong Wei, Wenxia Ma and Chen Wang
    Citation: BMC Cancer 2023 23:649
    Content type: Research Published on:

  22. To compare the efficacy and safety of TACE combined with Donafenib and Toripalimab versus TACE combined with Sorafenib in the treatment of unresectable hepatocellular carcinoma (HCC), aiming to guide personali...

    Authors: Haohao Lu, Bin Liang, Xiangwen Xia and Chuansheng Zheng
    Citation: BMC Cancer 2023 23:1033
    Content type: Research Published on:

  23. The study aimed to compare efficacy and safety of various immune checkpoint inhibitors for patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC).

    Authors: Tian-Tian Gao, Jia-Hui Shan, Yu-Xian Yang, Ze-Wei Zhang, Shi-Liang Liu, Mian Xi, Meng-Zhong Liu and Lei Zhao
    Citation: BMC Cancer 2022 22:992
    Content type: Research Published on:

  25. Breast malignancies are now the most common and deadliest type of neoplasms among women worldwide. Novel therapeutic approaches are needed to combat advanced stages of breast cancer. In this study, we aimed to...

    Authors: Mohammadhossein Pournabee, Mahsa Keshavarz-Fathi, Pooyesh Esmaeili, Pouya Mahdavi Sharif, Fatemeh Nili and Behnaz Jahanbin
    Citation: BMC Cancer 2023 23:495
    Content type: Research Published on:

  26. Pancreatic cancer (PC) is a highly malignant tumor featured with high intra-tumoral heterogeneity and poor prognosis. Cell-in-cell (CIC) structures have been reported in multiple cancers, and their presence is...

    Authors: Jianlu Song, Rexiati Ruze, Yuan Chen, Ruiyuan Xu, Xinpeng Yin, Chengcheng Wang, Qiang Xu and Yupei Zhao
    Citation: BMC Cancer 2022 22:894
    Content type: Research Published on:

  27. Esophageal and gastric cancers are a significant public health problem worldwide, with most patients presenting with advanced-stage disease and, consequently, poor prognosis. Systemic oncological treatments (S...

    Authors: M. Santero, J. Pérez-Bracchiglione, R. Acosta-Dighero, A. G. Meade, A. Antequera, A. Auladell-Rispau, M. J. Quintana, C. Requeijo, G. Rodríguez-Grijalva, K. Salas-Gama, R. Dorantes-Romandia, J. Salazar, I. Solà, G. Urrútia and X. Bonfill Cosp
    Citation: BMC Cancer 2021 21:712
    Content type: Research Published on:

  28. Semaphorins have been found to play important roles in multiple malignancy-related processes. However, the role of Semaphorin 4B (SEMA4B) in lung cancer remains unclear. Here, we aimed to explore the biologica...

    Authors: Jun Jiang, Yuan Lu, Fang Zhang, Tao Pan, Zhipei Zhang, Yi Wan, Xinling Ren and Rui Zhang
    Citation: BMC Cancer 2022 22:632
    Content type: Research Published on:

  29. Basement membrane (BM) is an important component of the extracellular matrix, which plays an important role in the growth and metastasis of tumor cells. However, few biomarkers based on BM have been developed ...

    Authors: Xuezhou Zhang, Baoan Hong, Hongwei Li, Jiahui Zhao, Mingchuan Li, Dechao Wei, Yongxing Wang and Ning Zhang
    Citation: BMC Cancer 2024 24:746
    Content type: Research Published on:

  30. Viral infections are prevalent in human cancers and they have great diagnostic and theranostic values in clinical practice. Recently, their potential of shaping the tumor immune microenvironment (TIME) has bee...

    Authors: Siyuan Chen, Hongyan Lai, Jingjing Zhao, Bing Chen, Yan Li, Yuchen Li, Qin Li, Qiupeng Zheng, Shenglin Huang and Xiaodong Zhu
    Citation: BMC Cancer 2021 21:1183
    Content type: Research Published on:

  31. Skin cutaneous melanoma (SKCM) is one of most aggressive type of cancers worldwide. Serglycin (SRGN) is an intracellular proteoglycan that playing an important role in various tumors. However, its effect on im...

    Authors: Xiaofang Wang, Hui Xiong, Daning Liang, Zhenzhen Chen, Xiqing Li and Kun Zhang
    Citation: BMC Cancer 2020 20:378
    Content type: Research article Published on:

  32. Biliary tract cancer (BTC) is a relatively rare but highly aggressive malignancy. However, there is currently no satisfactory second-line regimen for patients without specific genetic mutations. Nanoparticle a...

    Authors: Nan Zhou, Xiaofen Li, Yu Yang, Sirui Tan, Shunyu Zhang, Qiyue Huang and Hongfeng Gou
    Citation: BMC Cancer 2023 23:729
    Content type: Study Protocol Published on:

  33. Leukemic cell metabolism plays significant roles in their proliferation and survival. These metabolic adaptations are under regulation by different factors. Programmed Death Ligand -1 (CD-274) is one of the im...

    Authors: Mojdeh Soltani, Mustafa Ghanadian, Behrooz Ghezelbash, Abolfazl Shokouhi, Andrey A. Zamyatnin Jr, Alexandr V. Bazhin and Mazdak Ganjalikhani-Hakemi
    Citation: BMC Cancer 2023 23:447
    Content type: Research article Published on:

  34. B7-H4, a co-inhibitory molecule of the B7 family, can restrain T cell proliferation, cytokine secretion and the development of cytotoxicity. B7-H4 is expressed in tumor tissues at a higher level than in normal...

    Authors: Jie Zhang, Mingyan Zhang, Wei Jiang, Lihong Wang, Zhenkun Fu, Dalin Li, Da Pang and Dianjun Li
    Citation: BMC Cancer 2009 9:394
    Content type: Research article Published on:

  36. Cancer diagnoses and deaths among the elderly (65 +) are expected to increase significantly over the next decade. Immune checkpoint inhibitors specifically target ICI genes and enhance immune system function. ...

    Authors: Mohammed Safi, Chenxing Jin, Abdullah Aldanakh, Ping Feng, Henan Qin, Mohammed Alradhi, Lizhi Zhang, Junying Zhang, Salah Adlat, Yi Zhao and Jiwei Liu
    Citation: BMC Cancer 2022 22:978
    Content type: Research Published on:

  37. Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated an...

    Authors: Kana Mizuta, Takuma Matsubara, Akino Goto, William N. Addison, Mitsushiro Nakatomi, Kou Matsuo, Yukiyo Tada-Shigeyama, Tatsuki Yaginuma, Hiromi Honda, Izumi Yoshioka and Shoichiro Kokabu
    Citation: BMC Cancer 2022 22:936
    Content type: Research Published on:

  38. Leukocyte immunoglobulin-like receptor subfamily B1 (LILRB1) is regarded as an inhibitory molecule. However, the importance of LILRB1 expression in glioma has not yet been determined. This investigation examin...

    Authors: Renheng Zou, Xunlong Zhong, Kairong Liang, Cheng Zhi, Danmin Chen, Zhichao Xu, Jingbai Zhang, Degui Liao, Miaoling Lai, Yuhao Weng, Huaidong Peng, Xiao Pang, Yunxiang Ji, Yanbin Ke, Hongri Zhang, Zhaotao Wang…
    Citation: BMC Cancer 2023 23:403
    Content type: Research Published on:

  39. COVID-19 particularly impacted patients with co-morbid conditions, including cancer. Patients with melanoma have not been specifically studied in large numbers. Here, we sought to identify factors that associa...

    Authors: Douglas B. Johnson, Michael B. Atkins, Cassandra Hennessy, Trisha Wise-Draper, Hannah Heilman, Joy Awosika, Ziad Bakouny, Chris Labaki, Renee Maria Saliby, Clara Hwang, Sunny R. K. Singh, Nino Balanchivadze, Christopher R. Friese, Leslie A. Fecher, James J. Yoon, Brandon Hayes-Lattin…
    Citation: BMC Cancer 2023 23:265
    Content type: Research Published on:

  40. Intrahepatic cholangiocarcinoma (CCA) is amongst the most common primary liver tumors worldwide. CCA carries a bad prognosis prompting research to establish new treatment modalities other than surgery and the ...

    Authors: Charbel Elias, Youssef H. Zeidan, Youssef Bouferraa, Deborah Mukherji, Sally Temraz, Maya Charafeddine, Monita Al Darazi and Ali Shamseddine
    Citation: BMC Cancer 2022 22:1296
    Content type: Study protocol Published on:

  41. Ferroptosis has important value in cancer treatment. It is significant to explore the new ferroptosis-related lncRNAs prediction model in Hepatocellular carcinoma (HCC) and the potential molecular mechanism of...

    Authors: Ke Zong, Caifeng Lin, Kai Luo, Yilei Deng, Hongfei Wang, Jianfei Hu, Shi Chen and Renfeng Li
    Citation: BMC Cancer 2024 24:496
    Content type: Research Published on:

  42. SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch repair (MMR) in neoplastic cells. However, it remains unclear whether SETD2 dysfunction is a comple...

    Authors: Xiaobin Zheng, Jing Lin, Jiani Xiong, Yanfang Guan, Bin Lan, Yi Li, Xuan Gao, Zhaodong Fei, Lisha Chen, Lizhu Chen, Ling Chen, Gang Chen, Zengqing Guo, Xin Yi, Weiguo Cao, Xinghao Ai…
    Citation: BMC Cancer 2023 23:686
    Content type: Research Published on:

  43. Patients with primary multifocal hepatocellular carcinoma (HCC) have a poor prognosis and often experience a high rate of treatment failure. Multifocal HCC is mainly caused by intrahepatic metastasis (IM), and...

    Authors: Weilong Zou, Zhanjie Fang, Yu Feng, Shangjin Gong, Ziqiang Li, Meng Li, Yong Sun, Xiuyan Ruan, Xiangdong Fang, Hongzhu Qu and Haiyang Li
    Citation: BMC Cancer 2024 24:672
    Content type: Research Published on:

  44. To date only a handful of drugs are available for the treatment of melanoma. Among them vemurafenib, a BrafV600E specific inhibitor, showed promising results in terms of response rate and increase in median survi...

    Authors: Madhuri Bhandaru, Gholamreza Safaee Ardekani, Guohong Zhang, Magdalena Martinka, Kevin J McElwee, Gang Li and Anand Rotte
    Citation: BMC Cancer 2014 14:398
    Content type: Research article Published on:

  45. Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma (CTCL) that transforms from mature, skin-homing T cells and progresses during the early stages in the skin. The role of the skin microenvironment i...

    Authors: Syed Jafar Mehdi, Andrea Moerman-Herzog and Henry K. Wong
    Citation: BMC Cancer 2021 21:492
    Content type: Research article Published on:

  46. Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tu...

    Authors: Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P. Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G. Williams…
    Citation: BMC Cancer 2021 21:846
    Content type: Research article Published on:

  47. The immune checkpoint HERV-H LTR-associating 2 (HHLA2) is expressed in kidney cancer and various other tumor types. Therapeutics targeting HHLA2 or its inhibitory receptor KIR3DL3 are being developed for solid...

    Authors: Tomonari Shigemura, Nahuel Perrot, Zimo Huang, Rupal S. Bhatt, Aseman Bagheri Sheshdeh, Nourhan El Ahmar, Fatme Ghandour, Sabina Signoretti, David F. McDermott, Gordon J. Freeman and Kathleen M. Mahoney
    Citation: BMC Cancer 2023 23:1039
    Content type: Research Published on:

  48. Endometrial carcinoma (EC) is a malignant tumor of the female reproductive tract that has been associated with increased morbidity and mortality. This study aimed to identify biomarkers and potential therapeut...

    Authors: Qirong Hao, Hongqin Wu, Erniao Liu and Lina Wang
    Citation: BMC Cancer 2023 23:995
    Content type: Research Published on:

  49. The tumour microenvironment (TME) not only plays a role during tumour progression and metastasis but also profoundly influences treatment efficacy. Environment-mediated drug resistance is a result of crosstalk...

    Authors: Xintong Lyu, Ping Wang, Qiao Qiao and Yuanjun Jiang
    Citation: BMC Cancer 2021 21:646
    Content type: Research article Published on:

  50. Findings from numerous studies have revealed that ferroptosis is closely related to tumorigenesis and immune cell infiltration. Long non-coding RNAs (lncRNAs) are reportedly involved in the progression of vari...

    Authors: Chunhui Liu, Yue Gao, Jiaxuan Ni, Saisai Chen, Qiang Hu, Can Wang, Mingjin Hu and Ming Chen
    Citation: BMC Cancer 2022 22:788
    Content type: Research Published on:

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