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  1. The goal of research was to investigate the possible relations between serum concentrations of IL-6 and TGF-β1, individual and clinical characteristics, and adverse effects of radiotherapy in patients with pro...

    Authors: Katarina Kopčalić, Ivana Z. Matić, Irina Besu, Vesna Stanković, Zoran Bukumirić, Tatjana P. Stanojković, Aleksandar Stepanović and Marina Nikitović
    Citation: BMC Cancer 2022 22:1167
    Content type: Research Published on:

  2. Intrahepatic cholangiocarcinoma (ICC), originating from the bile ducts, is the second most common primary liver malignancy, and its incidence has recently increased. H2A.Z, a highly conserved H2A variant, is e...

    Authors: Qi Wang, Yongqiang Qi, Fei Xiong, Da Wang, Bing Wang and Yongjun Chen
    Citation: BMC Cancer 2022 22:1166
    Content type: Research Published on:

  3. Oral cancer patients suffer severe chronic and mechanically-induced pain at the site of the cancer. Our clinical experience is that oral cancer patients report new sensitivity to spicy foods. We hypothesized t...

    Authors: Caroline M. Sawicki, Malvin N. Janal, Samuel J. Nicholson, Angie K. Wu, Brian L. Schmidt and Donna G. Albertson
    Citation: BMC Cancer 2022 22:1165
    Content type: Research Published on:

  4. Prostate, bladder and kidney cancers are common age-related genitourinary cancers. China's population is aging at an increasing rate, so predicting the morbidity and mortality of prostate, bladder, and kidney ...

    Authors: Qiao Huang, Hao Zi, Lisha Luo, Xuhui Li, Cong Zhu and Xiantao Zeng
    Citation: BMC Cancer 2022 22:1164
    Content type: Research Published on:

  5. Ureteral reconstruction is required after surgical resection of the tumor invading the urinary tract in ovarian cancer with low incidence. There are no currently reported surgical outcomes of ureteral reconstr...

    Authors: Ji Hyun Kim, Dong-eun Lee, Hyeong In Ha, Jae Young Jung, Sung Han Kim, Hyung Ho Lee, Ho Kyung Seo, Sang-Soo Seo, Sokbom Kang, Sang-Yoon Park and Myong Cheol Lim
    Citation: BMC Cancer 2022 22:1163
    Content type: Research Published on:

  6. MAPK8IP2 is one of the JNK-interacting proteins (JIPs) family members, and is involved in the regulation of the JNK and P38 MAPK signaling pathways. MAPK8IP2 has been reported to be closely associated with sev...

    Authors: Zhenhao Zeng, Wenrui He, Yi Jiang, Hao Jiang, Xiaofeng Cheng, Wen Deng, Xiaochen Zhou, Cheng Zhang and Gongxian Wang
    Citation: BMC Cancer 2022 22:1162
    Content type: Research Published on:

  8. In recent years, it has been proved that necroptosis plays an important role in the occurrence, development, invasion, metastasis and drug resistance of malignant tumors. Hence, further evaluation and targetin...

    Authors: Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu and Yang Sun
    Citation: BMC Cancer 2022 22:1160
    Content type: Research Published on:

  9. Adjuvant chemotherapy is necessary for radical resection of intrahepatic cholangiocarcinoma (ICC) with a high risk of recurrence (T2–4, N1). However, its use in the treatment of early-stage ICC remains controv...

    Authors: Xiao-hui Li, Chong-yu Zhao, En-liang Zhou and Xiao-jun Lin
    Citation: BMC Cancer 2022 22:1159
    Content type: Research Published on:

  10. Bladder cancer (BLCA) is the ninth most common cancer globally, as well as the fourth most common cancer in men, with an incidence of 7%. However, few effective prognostic biomarkers or models of BLCA are avai...

    Authors: Jiyuan Hu, Linhui Wang, Luanfeng Li, Yutao Wang and Jianbin Bi
    Citation: BMC Cancer 2022 22:1158
    Content type: Research Published on:

  11. This study was designed to investigate the frequency and clinicopathological characteristics of POLE-mutated/ultramutated (POLEmut) in endometrial carcinoma (EC) and assess the prognostic values of POLE status.

    Authors: Qing Wu, Nianhai Zhang and Xianhe Xie
    Citation: BMC Cancer 2022 22:1157
    Content type: Research Published on:

  12. We evaluated the prognostic role of deficient mismatch repair (dMMR) systems in stage II and stage III colon cancer patients during different postoperative periods. We also assessed whether patients aged ≥75 c...

    Authors: Chunze Zhang, Yixiang Zhan, Kemin Ni, Zhaoce Liu, Ran Xin, Qiurong Han, Guoxun Li, Hangyu Ping, Yaohong Liu, Xuanzhu Zhao, Wanting Wang, Suying Yan, Jing Sun, Qinghuai Zhang, Guihua Wang, Zili Zhang…
    Citation: BMC Cancer 2022 22:1156
    Content type: Research Published on:

  13. Early identification of axillary lymph node metastasis (ALNM) in breast cancer (BC) is still a clinical difficulty. There is still no good method to replace sentinel lymph node biopsy (SLNB). The purpose of ou...

    Authors: Jiajia Xiong, Wei Zuo, Yu Wu, Xiuhua Wang, Wenqu Li, Qiaodan Wang, Hui Zhou, Mingxing Xie and Xiaojuan Qin
    Citation: BMC Cancer 2022 22:1155
    Content type: Research Published on:

  14. The prognosis of patients with gastric cancer (GC) with gastric outlet obstruction (GOO) after gastrectomy is highly variable. In this study, we aimed to develop a nomogram to predict the prognosis of these pa...

    Authors: Chengzhi Wei, Changhua Li, Xiaojiang Chen, Guoming Chen, Runcong Nie, Chongyu Zhao, Zhiwei Zhou and Yongming Chen
    Citation: BMC Cancer 2022 22:1154
    Content type: Research Published on:

  15. The approved dose of nivolumab is 3 mg/kg or a flat dose of 240 mg for indications. There is no dose-response relationship for nivolumab; therefore, a low-dose regimen may be an option to reduce financial toxi...

    Authors: Yen-Hao Chen, Chih-Chi Wang, Yen-Yang Chen, Jing-Houng Wang, Chao-Hung Hung and Yuan-Hung Kuo
    Citation: BMC Cancer 2022 22:1153
    Content type: Research Published on:

  16. Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may c...

    Authors: Lin Jiang, Yi-Qian Sun, Ben Michael Brumpton, Arnulf Langhammer, Yue Chen and Xiao-Mei Mai
    Citation: BMC Cancer 2022 22:1152
    Content type: Research article Published on:

  17. miR-145-5P is generally considered as a tumor suppressor at early stage of colorectal cancer, but up-regulation occurs in the progressive and later stages which is associated with metastasis, indicating miR-14...

    Authors: Xianshuo Cheng, Tao Shen, Ping Liu, Shaojun Fang, Zhibin Yang, Yunfeng Li and Jian Dong
    Citation: BMC Cancer 2022 22:1151
    Content type: Research Published on:

  18. Rucaparib is a poly(ADP-ribose) polymerase inhibitor approved in Europe as maintenance therapy for recurrent platinum-sensitive (Pt-S) ovarian cancer (OC). The Rucaparib Access Programme (RAP) was designed to ...

    Authors: Alfonso Yubero, Aranzazu Barquín, Purificación Estévez, Bella Pajares, Luisa Sánchez, Piedad Reche, Jesús Alarcón, Julia Calzas, Lydia Gaba, José Fuentes, Ana Santaballa, Carmen Salvador, Luis Manso, Ana Herrero, Álvaro Taus, Raúl Márquez…
    Citation: BMC Cancer 2022 22:1150
    Content type: Research Published on:

  19. To quantify the dose-response relationship of changes in pelvic bone marrow (PBM) functional MR radiomic features (RF) during concurrent chemoradiotherapy (CCRT) for patients with cervical cancer and establish...

    Authors: Xiaohang Qin, Cong Wang, Guanzhong Gong, Lizhen Wang, Ya Su and Yong Yin
    Citation: BMC Cancer 2022 22:1149
    Content type: Research Published on:

  20. KRAS-mutated non-small cell lung cancer (NSCLC) accounts for 23–35% and 13–20% of all NSCLCs in white patients and East Asians, respectively, and is therefore regarded as a major therapeutic target. However, i...

    Authors: Koichi Sato, Hiroaki Akamatsu, Yasuhiro Koh, Koichi Ogawa, Shun-ichi Isa, Masahiko Ando, Akihiro Tamiya, Akihito Kubo, Chiyoe Kitagawa, Tomoya Kawaguchi and Nobuyuki Yamamoto
    Citation: BMC Cancer 2022 22:1148
    Content type: Research Published on:

  21. The incidence of breast cancer (BC) in Thailand has been rising at an alarming rate. The annual incidence of BC in Thailand has doubled over a span of 15 years. A retrospective study was conducted with the pri...

    Authors: Chagkrit Ditsatham, Patumrat Sripan, Benjaporn Chaiwun, Pitchayaponne Klunklin, Ekkasit Tharavichitkul, Somvilai Chakrabandhu, Pooriwat Muangwong and Imjai Chitapanarux
    Citation: BMC Cancer 2022 22:1147
    Content type: Research Published on:

  22. HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) are sensitive to chemo-radiation therapy and have favorable survival outcomes compared with HPV-negative cancers. These tumors are usually not relat...

    Authors: Yoshikuni Inokawa, Masamichi Hayashi, Shahnaz Begum, Maartje G. Noordhuis, Daivd Sidransky, Joseph Califano, Wayne Koch, Mariana Brait, William H. Westra and Mohammad O. Hoque
    Citation: BMC Cancer 2022 22:1146
    Content type: Research Published on:

  24. Lynch Syndrome (LS) is an inherited cancer predisposition syndrome defined by pathogenic variants in the mismatch repair (MMR) or EPCAM genes. In the United Kingdom, people with LS are advised to undergo biennial...

    Authors: Anne Lincoln, Sally Benton, Carolyn Piggott, Bernard V. North, Jane Rigney, Caroline Young, Philip Quirke, Peter Sasieni and Kevin J. Monahan
    Citation: BMC Cancer 2022 22:1144
    Content type: Study protocol Published on:

  25. To assess prognostic value of pre-operative ipsilateral split renal function (SRF) on disease-free survival (DFS) and its association with aggressive pathological features in renal cell carcinoma (RCC) patients. 

    Authors: Jang Hee Han, Seung-hwan Jeong, Sanghun Han, Hyeong Dong Yuk, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim and Chang Wook Jeong
    Citation: BMC Cancer 2022 22:1143
    Content type: Research Published on:

  26. Our review discuss (i) the findings from analyzed data that have examined KRAS, NRAS and BRAF mutations in patients with colorectal cancer (CRC) in North Africa and to compare its prevalence with that shown in ot...

    Authors: Meryem Jafari, Abdelilah Laraqui, Walid Baba, Soukaina Benmokhtar, Sara El Zaitouni, Abdelmounaim Ait Ali, Ahmed Bounaim, Mountassir Moujahid, Rachid Tanz, Tarik Mahfoud, Yassir Sbitti, Hicham El Annaz, Rachid Abi, Mohamed Rida Tagajdid, Safae El Kochri, Idriss Amine Lahlou…
    Citation: BMC Cancer 2022 22:1142
    Content type: Research Published on:

  27. Clear cell renal cell carcinoma is a common malignant tumor of the urinary system. The mechanism of its occurrence and development is unknown, and there is currently few effective comprehensive predictive mark...

    Authors: Dian Xia, Qi Liu, Wen Jiao, Longfei Peng, Qi Wang, ZhouTing Tuo and Liangkuan Bi
    Citation: BMC Cancer 2022 22:1141
    Content type: Research Published on:

  28. Our previous study reported that recombinant human epidermal growth factor (rhEGF)-triggered EGFR internalization promoted radioresistance. Here, we aimed to evaluate the effect of rhEGF on the skin protection...

    Authors: Shuai Liu, Yun-Long Wang, Shu-Ting Shi, Guang-Dong Zeng, Yi-Wen Song, Xiao-Dong Zhang, Jian Zheng, Xin-Juan Fan and Yan-Ping Liu
    Citation: BMC Cancer 2022 22:1140
    Content type: Research Published on:

  29. Triple negative breast cancer (TNBC) is clinically aggressive breast cancer with a poor prognosis. Approximately 20% of TNBC has been found to express programmed death ligand 1 (PD-L1), making it a potential t...

    Authors: K. Sharmni Vishnu, Thin Thin Win, Saint Nway Aye and Arun Kumar Basavaraj
    Citation: BMC Cancer 2022 22:1139
    Content type: Research Published on:

  30. Radical nephrectomy (RN) is the standard treatment for localized renal cell carcinoma. The decrease in nephrons from RN could lead to postoperative chronic kidney disease (CKD). In this study, we aim to invest...

    Authors: Shuai Wang, Zhenghong Liu, Dahong Zhang, Fei Xiang and Wei Zheng
    Citation: BMC Cancer 2022 22:1138
    Content type: Research Published on:

  31. Dermatofibrosarcoma protuberans (DFSP) is a rare, low to intermediate-grade sarcoma, which needs imaging examination. Small series of ultrasound findings in DFSP have been published; however, the usefulness of...

    Authors: Xia Gong, Jia Li, Angang Ding, Jun Chen, Xiaofeng Tao, Ping Xiong, Yamin Rao, Yang Liu and Qilin Sun
    Citation: BMC Cancer 2022 22:1137
    Content type: Research Published on:

  32. Immune checkpoint inhibitors (ICIs) has shown remarkable benefit in the treatment of a range of cancer types, although it may initiate immune related adverse events (irAEs) in patients. Some studies have shown...

    Authors: Xiaoyun Zhang, Shuo Xu, Jiaqi Wang, Yalei Lv, Na Wang, Ruixue Lai, Ziyue Sha, Qun Zhao and Zhanjun Guo
    Citation: BMC Cancer 2022 22:1136
    Content type: Research Published on:

  33. Small-cell lung cancer (SCLC) accounts for 12–15% of lung cancers and has a limited prognosis, with approximately one-third of SCLC patients having a poor performance status (PS). Patients with extensive-stage...

    Authors: Tetsuhiko Asao, Satoshi Watanabe, Takahiro Tanaka, Satoshi Morita and Kunihiko Kobayashi
    Citation: BMC Cancer 2022 22:1135
    Content type: Study protocol Published on:

  34. The distribution of tissue infiltrating lymphocytes has been shown to affect the prognosis of patients with pancreatic cancer in some previous studies. However, the role of peripheral lymphocytes in pancreatic...

    Authors: Katsuhito Teramatsu, Takamasa Oono, Koki Oyama, Nao Fujimori, Masatoshi Murakami, Sho Yasumori, Akihisa Ohno, Kazuhide Matsumoto, Ayumu Takeno, Kohei Nakata, Masafumi Nakamura and Yoshihiro Ogawa
    Citation: BMC Cancer 2022 22:1134
    Content type: Research Published on:

  35. The COVID-19 pandemic greatly impacted primary care and cancer care. We studied how primary care utilization in Ontario, Canada changed for patients who were newly diagnosed with cancer just prior to the COVID...

    Authors: Ying Ling, Matthew C. Cheung, Kelvin K.W. Chan, Aisha Lofters, Colleen Fox, Aditi Patrikar, Ning Liu and Simron Singh
    Citation: BMC Cancer 2022 22:1133
    Content type: Research Published on:

  36. N7-Methylguanosine (m7G) and long non-coding RNAs (lncRNAs) have been widely studied in cancer and have been found to be useful for assessing tumor progression. However, the role of m7G-related lncRNAs in lung...

    Authors: Junfan Pan, Zhidong Huang, Hancui Lin, Wenfang Cheng, Jinhuo Lai and Jiancheng Li
    Citation: BMC Cancer 2022 22:1132
    Content type: Research Published on:

  37. Cuproptosis, a new form of programmed cell death, has been recently reported to be closely related to tumor progression. However, the significance of cuproptosis-related genes (CRGs) in papillary thyroid carci...

    Authors: Lidong Wang, Baiyu Yao, Jiapeng Yang, Zhong Tian and Jingni He
    Citation: BMC Cancer 2022 22:1131
    Content type: Research Published on:

  38. The aim of this study was to estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study.

    Authors: Timo Carpén, Evelina Gille, Lalle Hammarstedt-Nordenvall, Johnni Hansen, Sanna Heikkinen, Elsebeth Lynge, Jenny Selander, Ingrid Sivesind Mehlum, Jóhanna Eyrún Torfadottir, Antti Mäkitie and Eero Pukkala
    Citation: BMC Cancer 2022 22:1130
    Content type: Research Published on:

  39. To analyze the clinical outcomes of patients with regional persistent/recurrent nasopharyngeal carcinoma (NPC) who received neck dissection, and to evaluate the clinical benefit of postoperative adjuvant thera...

    Authors: Sai-Lan Liu, Xiao-Yun Li, Xue-Song Sun, Jing-Yun Peng, Chao Lin, Jin-Jie Yan, Qiu-Yan Chen, Lin-Quan Tang, Shan-Shan Guo, Ling Guo, Li-Ting Liu and Hai-Qiang Mai
    Citation: BMC Cancer 2022 22:1129
    Content type: Research Published on:

  40. Nutritional status and inflammation are closely associated with poor outcome in malignant tumors. However, the prognostic impact of postoperative in these variables on breast cancer (BC) remains inconclusive. ...

    Authors: Tai Xu, Si-Ming Zhang, He-Ming Wu, Xiao-Min Wen, Dong-Qin Qiu, Yu-Yang Yang, Li-Zhen Wang, Wen-Biao Zhu, Li-Shan He and Jian-Juan Li
    Citation: BMC Cancer 2022 22:1128
    Content type: Research Published on:

  41. Acute myeloid leukemia (AML) is the main type of adult leukemia, and 60-day mortality is a vital clinical problem that doctors have to face at the begin with treatment. Studies on the association between serum...

    Authors: Zuomiao Xiao, Haibo Li, Dejun Xiao, Yulan Liu, Xianchun Chen, Shi Luo and Yanhong Ji
    Citation: BMC Cancer 2022 22:1127
    Content type: Research Published on:

  42. Although determining the recurrence of cutaneous squamous cell carcinoma (cSCC) is important, currently suggested systems and single biomarkers have limited power for predicting recurrence.

    Authors: Yeongjoo Oh, Zhenlong Zheng, Ki-Yeol Kim, Xiangshu Xu, Meiling Pei, Byungho Oh, Sang Kyem Kim, Kee Yang Chung and Mi Ryung Roh
    Citation: BMC Cancer 2022 22:1126
    Content type: Research Published on:

  43. Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit f...

    Authors: Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai…
    Citation: BMC Cancer 2022 22:1125
    Content type: Research Published on:

  44. Osteosarcoma (OS) mainly happens in children and youths. Surgery, radiotherapy and chemotherapy are the common therapies for osteosarcoma treatment but all their anti-tumor effects are limited. In recent years...

    Authors: Qian Zhang, Zhiqiang Zhang, Guodi Liu, Dehua Li, Zhangjie Gu, Linsong Zhang, Yingjiao Pan, Xingbing Cui, Lu Wang, Guoping Liu, Xiaoli Tian and Ziming Zhang
    Citation: BMC Cancer 2022 22:1124
    Content type: Research Published on:

  45. Breast cancer incidence is rising globally, while mortality rates show a geographical heterogenous pattern. Early detection and treatment have been proven to have a profound impact on breast cancer prognosis. ...

    Authors: Mikaela Roginski, Dimitra Sifaki-Pistolla, Andreas Stomby, Georgia Velivasaki, Tomas Faresjö, Christos Lionis and Åshild Faresjö
    Citation: BMC Cancer 2022 22:1123
    Content type: Research Published on:

  47. Colorectal cancer remains the second leading cause of cancer death in North America. Fluorouracil and oxaliplatin based adjuvant chemotherapy for resected colon cancer (CC) reduces cancer recurrence, but also ...

    Authors: Daniel Breadner, Jonathan M. Loree, Winson Y. Cheung, Meghan Gipson, Suganija Lakkunarajah, Karen E. Mulder, Jennifer L. Spartlin, Shiying Kong, Philip Q. Ding, Sharlene Gill and Stephen A. Welch
    Citation: BMC Cancer 2022 22:1119
    Content type: Research Published on:

  48. Solid pulmonary nodules are different from subsolid nodules and the diagnosis is much more challenging. We intended to evaluate the diagnostic and prognostic value of radiomics and deep learning technologies f...

    Authors: Rui Zhang, Ying Wei, Feng Shi, Jing Ren, Qing Zhou, Weimin Li and Bojiang Chen
    Citation: BMC Cancer 2022 22:1118
    Content type: Research Published on:

  49. The aim of this prospective study was to investigate the prognostic value of metabolic tumor volume (MTV) and apparent diffusion coefficient (ADC) from baseline FDG PET/MRI compared to established clinical ris...

    Authors: Trine Husby, Håkon Johansen, Trond Velde Bogsrud, Kari Vekseth Hustad, Birte Veslemøy Evensen, Ronald Boellaard, Guro F. Giskeødegård, Unn-Merete Fagerli and Live Eikenes
    Citation: BMC Cancer 2022 22:1117
    Content type: Research Published on:

  50. Women with breast cancer are at risk for the development of sarcopenia and occurrence of fractures. The initial and periodic screening of these conditions can prevent the risks of disability, poor quality of l...

    Authors: Rayne de Almeida Marques Bernabé, Mariana de Souza Vieira, Vanusa Felício de Souza, Luana Gomes Fontana, Ben-Hur Albergaria, José Luiz Marques-Rocha and Valdete Regina Guandalini
    Citation: BMC Cancer 2022 22:1115
    Content type: Research Published on:

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