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Occupational risk variation of nasopharyngeal cancer in the Nordic countries

BMC Cancer volume 22, Article number: 1130 (2022) Cite this article

Abstract

Background

The aim of this study was to estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study.

Methods

This study is based on a cohort of almost 15 million persons from Denmark, Finland, Iceland, Norway and Sweden, with 2898 nasopharyngeal cancer cases diagnosed in 1961–2005. The data on occupations were gathered from population censuses and cancer data from the national cancer registries. Standardized incidence ratios (SIR) with 95% confidence intervals (CI) were estimated using the national NPC incidence rates as the reference.

Results

There were 1980 male and 918 female NPC patients. The highest SIRs of NPC were observed among male waiters (SIR 3.69, 95% CI 1.91–6.45) and cooks and stewards (SIR 2.24, 95% CI 1.16–3.91). Among women, launderers had the highest SIR of NPC (2.04, 95% CI 1.02–3.65). Significantly decreased SIRs were found among male farmers (SIR 0.79, 95% CI 0.68–0.92) and male textile workers (SIR 0.49, 95% CI 0.22–0.93).

Conclusions

This study suggests that NPC may be associated with several work-related exposure agents such as smoking, kitchen air pollution and solvents. In future, occupational exposure-risk relations should be studied to understand more about causality and to assess effective prevention strategies.

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Background

Close to 850,000 new head and neck squamous cell carcinoma (HNSCC) cases are diagnosed annually worldwide, and approximately 130,000 of these are nasopharyngeal carcinomas (NPC) [1]. The NPC incidence is much higher in South-Asia than in Europe and North America [1, 2]. The majority of NPC cases in endemic areas are non-keratinizing and predominantly associated with the Epstein-Barr virus (EBV) [3]. Another major risk factor for NPC is tobacco smoking [4,5,6].

Exposure to occupation-related agents such as formaldehyde and chlorophenol, wood and cotton dust, smokes, and combustion have been associated with the development of NPC [7,8,9,10,11,12]. Upper airways including the nasopharynx are directly affected by these often work-related exposures. For example, occupational exposures to formaldehyde and wood dust have been classified by the International Agency for Research on Cancer (IARC) as having sufficient evidence of causing NPC in humans [13]. Long-lasting wood dust exposure especially appears to increase the risk of NPC [14,15,16,17,18,19]. Cotton dust, which is common in the textile industry, is another exposure that has been linked with NPC, but evidence remains inconclusive [20, 21].

The aim of this study was to identify occupations linked to NPC in the five Nordic countries.

Methods

This study is based on NPC patients included in the Nordic Occupational Cancer (NOCCA) study cohort. The NOCCA cohort includes census participants covering a total of 14.9 million persons from Denmark, Finland, Iceland, Norway and Sweden followed up between 1961 and 2005 [22].

Subjects aged 30–64 years old and alive on January 1 of the year after the first available census were linked to their occupational data and cancer data with the help of the unique personal identity codes given to all residents of the Nordic countries [23]. The follow-up time of each individual started from the year following the first available census record of the person and ended at the date of emigration, death or at the end of the following years: Finland and Sweden 2005, Iceland 2004 and Norway and Denmark 2003 [24]. The present study used the occupational data that were originally coded according to Nordic Occupational Classification (NYK), International Standard of Classification of Occupations (ISCO) versions 58 and 68, or a special Danish classification were classified into 54 occupational categories. A detailed description of the NOCCA cohort and occupational data are presented in previous reports [23, 25]. For this study, all health care occupations were combined as the group of “health workers” because the number of cases in each category was low. Only occupational categories with ≥5 cases (Nordic total) are shown separately in the tables. The categories with less than 5 cases were added into the category “other economically active”.

Data on NPCs (International Classification of Diseases, 7th Revision, code 146) were obtained from the cancer registry of each country. During the follow-up period, all cancer registries received clinical notifications from hospitals and all except Denmark also from cancer laboratories in the public and private sectors [26].

The standardized incidence ratio (SIR) was used as the measure of relative risk of NPC. SIR is the ratio of the observed and expected numbers of cases. The expected number of cases in each country, gender, 5-year calendar period and 5-year age category was calculated by multiplying the number of person-years in the stratum by the respective national incidence rate of NPC. Exact 95% confidence intervals (CI) were determined by Poisson distribution, and the SIR was considered as statistically significant if its CI did not include 1.0. The study has permissions as required in each of the Nordic countries.

Results

Altogether, 2898 patients diagnosed with NPC were observed during the follow-up of the present study. There were 1980 male and 918 female NPC patients. The majority (n = 1524) of the patients were from Sweden, and only 18 patients were from Iceland.

The highest SIR of NPC was found among male waiters in the whole Nordic cohort (SIR 3.69, 95% CI 1.91–6.45) and separately in Norway (SIR 4.79, 95% CI 1.30–12.25) and Denmark (SIR 6.81, 95% CI 2.21–15.88) (Table 1). The SIR for female waiters was not significantly elevated (Table 2).

Table 1 Observed (Obs) and expected (Exp) numbers of cancer of the nasopharynx and standardised incidence ratios (SIR) among men, by country and occupation. Only occupational categories with ≥5 cases (Nordic total) are shown. Country-specific numbers for Iceland not shown
Full size table
Table 2 Observed (Obs) and expected (Exp) numbers of cancer of the nasopharynx and standardised incidence ratios (SIR) among women, by country and occupation. Only occupational categories with ≥5 cases (Nordic total) are shown. Country-specific numbers for Iceland not shown
Full size table

The SIR was significantly elevated among male cooks and stewards in the entire Nordic cohort (SIR 2.24, 95% CI 1.16–3.91) and in the Swedish cohort (SIR 2.68, 95% CI 1.08–5.53). The incidence of NPC was consistently elevated among male bricklayers in all countries. Finnish male administrators and sales agents had significantly elevated SIRs, but similar findings were not observed in other Nordic countries.

Among females, launderers had the highest and significantly elevated SIR in the entire cohort (SIR 2.04, 95% CI 1.02–3.65) and separately in the Norwegian cohort (SIR 5.38, 95% CI 1.47–13.79).

Significantly decreased incidence of NPC was found among Nordic male farmers (SIR 0.79, 95% CI 0.68–0.92) and male textile workers (SIR 0.49, 95% CI 0.22–0.93). The SIR for farmers was especially low in Finland and Denmark (SIR 0.58, 95% CI 0.36–0.88 and 0.65, 95% CI 0.42–0.95, respectively).

Male fishermen in Norway had a significantly elevated SIR (1.64, 95% CI 1.03–2.49, Table 1), and SIRs for both fishermen and seamen were consistently elevated in all countries except for Swedish fishermen, who had a low SIR.

Discussion

This study provides new evidence on occupational risk variation of NPC in the Nordic countries. Norwegian, Finnish and Swedish fishermen had elevated SIRs of NPC in the present study, which to our knowledge, is a new finding. In addition, the SIRs for seamen were consistently elevated. Salted fish is a confirmed risk factor for NPC and commonly used in Southern Asia [27], but we have no evidence whether fishermen in the three Nordic countries consume more salted fish than the reference population. Fishermen might have been exposed to off-gas from fermented fish, especially in former times when the storage tanks on fishing boards were emptied manually.

Cooks and stewards showed elevated SIRs in the present study. The elevated risk for lung cancer among cooks has been previously related to indoor air pollution, which may also be one link between cooks and NPC [28]. In addition, wood combustion has been found to be a potential risk factor for NPC and a potential exposure agent for cooks [29].

In some previous studies, frequent exposure to cotton dust has been associated with elevated risk of NPC [12, 21, 30]. We did not find an elevated SIR among female textile workers, and there was a statistically significant decreased SIR for male textile workers. Thus, this study does not support such evidence.

We found that female launderers had statistically significantly higher risk of NPC than the population on average. In drycleaning, tetrachloroethylene is the dominant solvent used throughout the world and in the Nordic countries [31].

The IARC classified formaldehyde and wood dust as occupational carcinogens in relation to NPC. In the present study, exposure to these agents is most likely among woodworkers, but we did not find elevated SIRs among them [32].

NPC incidence was significantly elevated among male waiters. Previously, Nordic waiters have been related to elevated incidence of lung cancer, oral cancer and pharyngeal cancer [33]. An increased risk of death from NPC was reported among waiters in China [34]. One explanation may be that waiters have been exposed to passive and active tobacco smoke, which has also been associated with NPC [4, 35]. Prior to smoking restrictions in bars and restaurants, waiters worked in a smoke-filled environment and had a higher proportion of active smokers than other workers [33]. Several studies have shown a modestly increased risk of NPC associated with tobacco smoking, and a meta-analysis indicated an approximately 60% increased risk for NPC among smokers [36, 37]. In Finland and Norway, smoke-free legislation in restaurants has shown effective results in the decrease of passive smoking exposure [35, 38] and improving lung function [39] among waiters. Therefore, it is expected that the excess incidence of NPC among restaurant staff will become smaller in the future.

Strengths of this study include the large cohorts with nationwide population-based data, long follow-up periods and high quality registry data [26]. A limitation of the present study was the missing stratification of NPCs by histological subtype, and the lack of information on factors not directly related to occupation. It has been demonstrated that the role of tobacco and alcohol use in the occupational risk variation in the risk for head neck cancer in the Nordic countries is large [40]. In addition, since the current data only reach to the end of the year 2005, they mainly reflect occupational exposures before the mid-1990s, considering the long latency in cancer process.

Conclusions

The present study suggests that certain work-related exposures such as passive smoking, kitchen air pollution and solvents may be associated with NPC. In future, exposure-risk relations should be studied to understand more about causality and to assess effective prevention strategies against NPC.

Availability of data and materials

The tabulated datasets generated and/or analysed during the current study are available in the NOCCA repository, https://astra.cancer.fi/NOCCA/.

Abbreviations

EBV:

Epstein-Barr virus

CI:

Confidence interval

HNSCC:

Head and neck squamous cell carcinoma

HPV:

Human papillomavirus

IARC:

International Agency for Research on Cancer

ISCO:

International Standard of Classification of Occupations

NOCCA:

Nordic Occupational Cancer Study

NPC:

Nasopharyngeal carcinoma

NYK:

Nordic Occupational Classification

SIR:

Standardized incidence ratio

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Acknowledgements

We thank the Nordic Cancer Union for the financial support and Jan Ivar Martinsen (Cancer Registry of Norway) for data management and statistical analyses of the data.

Funding

Funding was provided by Finska Läkareskällskapet and open access funding was provided by Karolinska Institute. The data collection for the NOCCA study was supported by the Nordic Cancer Union.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology – Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, FI-00029 HUS, Helsinki, Finland

    Timo Carpén & Antti Mäkitie

  2. Department of Pathology, University of Helsinki and Helsinki University Hospital, FI-00014, Helsinki, Finland

    Timo Carpén

  3. Research Program in Systems Oncology, Faculty of Medicine, FI-00014 University of Helsinki, Helsinki, Finland

    Timo Carpén & Antti Mäkitie

  4. Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, SE-17176, Stockholm, Sweden

    Evelina Gille, Lalle Hammarstedt-Nordenvall & Antti Mäkitie

  5. Danish Cancer Society Research Center, DK-2100, Copenhagen, Denmark

    Johnni Hansen

  6. Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, FI-00130, Helsinki, Finland

    Sanna Heikkinen & Eero Pukkala

  7. Nykøbing Falster Hospital, University of Copenhagen, DK-4800, Nykøbing Falster, Denmark

    Elsebeth Lynge

  8. Institute of Environmental Medicine – IMM Karolinska Institutet, S-17177, Stockholm, Sweden

    Jenny Selander

  9. National Institute of Occupational Health (STAMI), N- 0363, Oslo, Norway

    Ingrid Sivesind Mehlum

  10. Institute of Health and Society, University of Oslo, N-0450, Oslo, Norway

    Ingrid Sivesind Mehlum

  11. Icelandic Cancer Registry, IS-105, Reykjavik, Iceland

    Jóhanna Eyrún Torfadottir

  12. Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, IS-102, Reykjavik, Iceland

    Jóhanna Eyrún Torfadottir

  13. Health Sciences Unit, Faculty of Social Sciences, FI-33014 Tampere University, Tampere, Finland

    Eero Pukkala

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  1. Timo Carpén
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Contributions

Timo Carpén, Evelina Gille, Lalle Hammastedt-Nordenvall and Antti Mäkitie; interpretation of results and writing of the manuscript; Elsebeth Lynge and Johnni Hansen: responsible for the data accuracy and SIR estimates of Denmark; Sanna Heikkinen current principal investigator in NOCCA study in Finland and leader of the NOCCA network; Jenny Selander: current principal investigator in NOCCA study in Sweden; Ingrid Sivesind Mehlum: current principal investigator in NOCCA study in Norway; Jóhanna Eyrún Torfadottir: current principal investigator in NOCCA study in Iceland; Eero Pukkala: design of the study, data analysis, interpretation of results, and writing the manuscript. All authors have commented the manuscript and read and approved the final version.

Corresponding authors

Correspondence to Timo Carpén or Antti Mäkitie.

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Ethics approval and consent to participate

The current study was based on data from existing registries and did not include any human intervention. The NOCCA study had ethics approvals and permissions as required in each of the participating countries at the time of data collection. The data were anonymized before using them in the analyses. Study participants were not contacted during the execution of the study. All methods were carried out in accordance with relevant guidelines and regulations.

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Carpén, T., Gille, E., Hammarstedt-Nordenvall, L. et al. Occupational risk variation of nasopharyngeal cancer in the Nordic countries. BMC Cancer 22, 1130 (2022). https://doi.org/10.1186/s12885-022-10209-y

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