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  1. Preoperative neoadjuvant chemotherapy (NACT) has been widely used in developing countries for the treatment of patients with International Federation of Gynecology and Obstetrics (FIGO) stages IB3 and IIA2 cer...

    Authors: Yingjie Hu, Yingyan Han, Yuanming Shen, Jing Chen, Yaheng Chen, Yile Chen, Junying Tang, Min Xue, Li Hong, Wenjun Cheng, Danbo Wang, Zhiqing Liang, Yifeng Wang, Qinghua Zhang, Hui Xing, Yu Zhang…
    Citation: BMC Cancer 2022 22:1270
    Content type: Research Published on:

  3. Dealing with uncertainty is one of the critical topics in health technology assessment. The greater decision uncertainty in appraisals, the less clear the clinical- and cost-effectiveness of the health technol...

    Authors: Jiyeon Kang and John Cairns
    Citation: BMC Cancer 2022 22:1268
    Content type: Research Published on:

  4. Breast cancer (BC) is the most common malignant tumor among women worldwide. Tissue transglutaminase 2 (TG2) has been reported as a major player across several types of cancer. However, the effects of TG2 in brea...

    Authors: Dahai Xu, Ning Xu, Liang Sun, Zhaoying Yang, Miao He and Youjun Li
    Citation: BMC Cancer 2022 22:1267
    Content type: Research Published on:

  5. Cancer is a major public health problem with pharmacotherapy being the cornerstone of its management. Cancer patients receive multiple drugs concurrently risking Drug-Drug Interactions (DDIs). DDIs, though avo...

    Authors: Bonny Luzze, Barnabas Atwiine, Henry Mark Lugobe and Tadele Mekuriya Yadesa
    Citation: BMC Cancer 2022 22:1266
    Content type: Research Published on:

  6. MicroRNA (miR)-214-3p is emerging as an important tumor suppressor in esophageal cancer. In this study, we examined the interaction between miR-214-3p and RAB14, a membrane trafficking protein shown to exert o...

    Authors: Pornima Phatak, Whitney M. Burrows, Timothy Michael Creed, Mariam Youssef, Goo Lee and James M. Donahue
    Citation: BMC Cancer 2022 22:1265
    Content type: Research Published on:

  7. Risk stratified breast cancer screening is being considered as a means of improving the balance of benefits and harms of mammography. Stratified screening requires the communication of risk estimates. We aimed...

    Authors: Louise S. Gorman, Helen Ruane, Victoria G. Woof, Jake Southworth, Fiona Ulph, D. Gareth Evans and David P. French
    Citation: BMC Cancer 2022 22:1264
    Content type: Research Published on:

  8. This retrospective study was performed to determine the prognostic potential of smoking and its combination with pre-treatment plasma Epstein-Barr virus (EBV) DNA levels in patients with nasopharyngeal carcino...

    Authors: Wanxia Li, Chao Yang, Feipeng Zhao, Junzheng Li, Zonghua Li, Ping Ouyang, Xiaofei Yuan, Shuting Wu, Yue Yuan, Linchong Cui, Huiru Feng, Danfan Lin, Zilu Chen, Juan Lu, Xiaohong Peng and Jing Chen
    Citation: BMC Cancer 2022 22:1262
    Content type: Research article Published on:

  9. Women from Asian and western countries have vastly different ages of onset of breast cancer, with the disease tending to occur at an older age in the West. Through an investigation of the patterns of old-onset...

    Authors: Hyun-June Paik, Suk Jung Kim, Ku Sang Kim, Yongsuk Kim, Se Kyung Lee, Su Hwan Kang, Jeong Joon and Hyun Jo Youn
    Citation: BMC Cancer 2022 22:1261
    Content type: Research article Published on:

  10. Neuropathic pain is common in cancer survivorship and is one of the most distressing symptoms for patients previously treated for head and neck cancer. Persistent neuropathic pain, when it is ongoing and uncon...

    Authors: Antoine Boden, Amélie Lusque, Sabrina Lodin, Marie Bourgouin, Valérie Mauries, Christelle Moreau, Amandine Fabre, Muriel Mounier, Muriel Poublanc, Nathalie Caunes-Hilary and Thomas Filleron
    Citation: BMC Cancer 2022 22:1260
    Content type: Study protocol Published on:

  11. Radiobiological daily changes within tumors are considered to be quite different between stereotactic radiotherapy (SRT) (e.g., 50 Gy in 4 fractions) and conventional radiotherapy (e.g., 60 Gy in 30 fractions)...

    Authors: Natsuo Tomita, Hiromichi Ishiyama, Chiyoko Makita, Yukihiko Ohshima, Aiko Nagai, Fumiya Baba, Mayu Kuno, Shinya Otsuka, Takuhito Kondo, Chikao Sugie, Tatsuya Kawai, Taiki Takaoka, Dai Okazaki, Akira Torii, Masanari Niwa, Nozomi Kita…
    Citation: BMC Cancer 2022 22:1259
    Content type: Study protocol Published on:

  12. We evaluated a new chemoimmunotherapy combination based on the anti-PD1 monoclonal antibody pembrolizumab and the pyrimidine antimetabolite gemcitabine in HER2- advanced breast cancer (ABC) patients previously...

    Authors: L. de la Cruz-Merino, M. Gion, J. Cruz, JL. Alonso-Romero, V. Quiroga, F. Moreno, R. Andrés, M. Santisteban, M. Ramos, E. Holgado, J. Cortés, E. López-Miranda, A. Cortés, F. Henao, N. Palazón-Carrión, L. M. Rodriguez…
    Citation: BMC Cancer 2022 22:1258
    Content type: Research Published on:

  16. The integrated stress response (ISR) facilitates cellular adaptation to unfavorable conditions by reprogramming the cellular response. ISR activation was reported in neurological disorders and solid tumors; ho...

    Authors: Wioleta Dudka, Grazyna Hoser, Shamba S. Mondal, Laura Turos-Korgul, Julian Swatler, Monika Kusio-Kobialka, Magdalena Wołczyk, Agata Klejman, Marta Brewinska-Olchowik, Agata Kominek, Milena Wiech, Marcin M. Machnicki, Ilona Seferynska, Tomasz Stoklosa and Katarzyna Piwocka
    Citation: BMC Cancer 2022 22:1254
    Content type: Research Published on:

  17. Single nucleotide polymorphisms (SNPs) located in microRNA (miRNA) binding sites can affect the interactions between miRNAs and target genes, which is related to cancer susceptibility and tumorigenesis. Howeve...

    Authors: Yi Shen, Yi Shao, Xiaoli Ruan, Lingyan Zhu, Zhaoping Zang, Tong Wei, Rena Nakyeyune, Wenqiang Wei and Fen Liu
    Citation: BMC Cancer 2022 22:1253
    Content type: Research Published on:

  18. Reconstruction of mandibular defects following ablative surgery remains a challenge even for experienced surgeons. Virtual planning and guided surgery, including computer-aided design/computer-aided manufactur...

    Authors: Mohammed Esmail Al-Sabahi, Omer Mohammed Jamali, Mostafa Ibrahim Shindy, Basma Gamal Moussa, Ayman Abdel-Wahab Amin and Mohamed Hamdallah Zedan
    Citation: BMC Cancer 2022 22:1252
    Content type: Research Published on:

  19. Early detection of pancreatic ductal adenocarcinoma (PDAC) is essential for survival. Preliminary research demonstrated significant associations between structural alternation of mycobiota and PDAC. In this st...

    Authors: Ailin Wei, Huiling Zhao, Xue Cong, Linyao Wang, Yiyang Chen, Juxiang Gou, Ziyi Hu, Xiuying Hu, Yali Tian, Ka Li, Yufeng Deng, Haojiang Zuo and Mei Rosemary Fu
    Citation: BMC Cancer 2022 22:1251
    Content type: Research Published on:

  20. Improving the early prediction of neoadjuvant chemotherapy (NAC) efficacy in breast cancer can lead to an improved prediction of the final prognosis of patients, which would be useful for promoting individuali...

    Authors: Xinhong Liang, Xiaofeng Chen, Zhiqi Yang, Yuting Liao, Mengzhu Wang, Yulin Li, Weixiong Fan, Zhuozhi Dai and Yunuo Zhang
    Citation: BMC Cancer 2022 22:1250
    Content type: Research Published on:

  21. The modified systemic inflammation score (mSIS) system, which is constructed based on the neutrophil to lymphocyte ratio (NLR) and albumin (Alb), has not been applied to evaluate the prognosis of malignant bre...

    Authors: Cong Jiang, Yuting Xiu, Xiao Yu, Kun Qiao, Shiyuan Zhang and Yuanxi Huang
    Citation: BMC Cancer 2022 22:1249
    Content type: Research Published on:

  22. Dopamine receptors have been reported to play important roles in cancer progression. However, the role of dopamine receptor D3 (DRD3) in hepatocellular carcinoma (HCC) remains unclear.

    Authors: Yan Yan, Yonghua Chen, Jiahao Pan, Wei Xing, Qiang Li, Yan Wang, Liba Gei, Yunfei Yuan, Jingdun Xie, Weian Zeng and Dongtai Chen
    Citation: BMC Cancer 2022 22:1248
    Content type: Research Published on:

  23. Antihormonal treatment for hormone receptor (HR) positive breast cancer has highly beneficial effects on both recurrence rates and survival. We investigate adherence and persistence in this group of patients.

    Authors: Ida Dragvoll, Anna M. Bofin, Håvard Søiland, Gunnar Taraldsen and Monica Jernberg Engstrøm
    Citation: BMC Cancer 2022 22:1247
    Content type: Research Published on:

  24. Lateral neck is not recommended for dissection in patients with pN1a papillary thyroid cancer (PTC), but its recurrence risk has not been well stratified. We aimed to develop a risk stratification system for l...

    Authors: Siyuan Xu, Hui Huang, Ying Huang, Xiaolei Wang, Zhengang Xu, Shaoyan Liu and Jie Liu
    Citation: BMC Cancer 2022 22:1246
    Content type: Research Published on:

  25. The optimal surveillance period and frequency after curative resection for oesophageal squamous cell carcinoma (OSCC) remain unclear, and current guidelines are mainly based on traditional Kaplan–Meier analyse...

    Authors: Kyohei Kanematsu, Yozo Kudose, Daichi Utsunomiya, Kentaro Kubo, Yusuke Fujii, Daisuke Kurita, Koshiro Ishiyama, Junya Oguma and Hiroyuki Daiko
    Citation: BMC Cancer 2022 22:1245
    Content type: Research Published on:

  26. Acid phosphatase type 6 (ACP6) is a mitochondrial lipid phosphate phosphatase that played a role in regulating lipid metabolism and there is still blank in the clinico-pathological significance and functional ...

    Authors: Li Gao, Dan-Dan Xiong, Xia Yang, Jian-Di Li, Rong-Quan He, Zhi-Guang Huang, Ze-Feng Lai, Li-Min Liu, Jia-Yuan Luo, Xiu-Fang Du, Jiang-Hui Zeng, Ming-Fen Li, Sheng-Hua Li, Yi-Wu Dang and Gang Chen
    Citation: BMC Cancer 2022 22:1244
    Content type: Research Published on:

  27. Radiotherapy has been widely used to treat various cancers, but its efficacy depends on the individual involved. Traditional gene-based machine-learning models have been widely used to predict radiosensitivity...

    Authors: Zihang Zeng, Maoling Luo, Yangyi Li, Jiali Li, Zhengrong Huang, Yuxin Zeng, Yu Yuan, Mengqin Wang, Yuying Liu, Yan Gong and Conghua Xie
    Citation: BMC Cancer 2022 22:1243
    Content type: Research Published on:

  28. Conventional-transarterial chemoembolization (C-TACE) was proven to improve overall survival (OS) in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT), drug-eluting microsphere-TAC...

    Authors: Junwei Chen, Lisha Lai, Junyang Luo, Haofan Wang, Mingan Li and Mingsheng Huang
    Citation: BMC Cancer 2022 22:1242
    Content type: Research Published on:

  29. Immune checkpoint inhibitors (ICIs) represent an approved treatment for various cancers; however, only a small proportion of the population is responsive to such treatment. We aimed to develop and validate a p...

    Authors: Yang Yu, Yuping Bai, Peng Zheng, Na Wang, Xiaobo Deng, Huanhuan Ma, Rong Yu, Chenhui Ma, Peng Liu, Yijing Xie, Chen Wang and Hao Chen
    Citation: BMC Cancer 2022 22:1241
    Content type: Research Published on:

  30. Breast cancer is a major health burden for women, worldwide. Lifestyle-related risk factors, such as obesity and being overweight, have reached epidemic proportions and contributes to the development of breast...

    Authors: Megan Sedeman, Claudia Christowitz, Louis de Jager and Anna-Mart Engelbrecht
    Citation: BMC Cancer 2022 22:1240
    Content type: Research Published on:

  31. Sorafenib is a multi-kinase inhibitor that shows antitumor activity in advanced hepatocellular carcinoma. Sorafenib exerts a regulatory effect on immune cells, including T cells, natural killer cells and dendr...

    Authors: Xinning Zhang, Yong Xu, Guodong Zhao, Rong Liu and Haisheng Yu
    Citation: BMC Cancer 2022 22:1239
    Content type: Research article Published on:

  32. There is still uncertainty on whether ionizing radiation from CT scans can increase the risks of cancer. This study aimed to identify the association of cumulative ionizing radiation from CT scans with pertain...

    Authors: Chun-Feng Cao, Kun-Long Ma, Hua Shan, Tang-Fen Liu, Si-Qiao Zhao, Yi Wan, Jun-Zhang and Hai-Qiang Wang
    Citation: BMC Cancer 2022 22:1238
    Content type: Research article Published on:

  33. Preoperative prediction of pancreatic cystic neoplasm (PCN) differentiation has significant value for the implementation of personalized diagnosis and treatment plans. This study aimed to build radiomics deep ...

    Authors: Wenjie Liang, Wuwei Tian, Yifan Wang, Pan Wang, Yubizhuo Wang, Hongbin Zhang, Shijian Ruan, Jiayuan Shao, Xiuming Zhang, Danjiang Huang, Yong Ding and Xueli Bai
    Citation: BMC Cancer 2022 22:1237
    Content type: Research Published on:

  34. Health economic comparisons of various therapies are often based on health-related quality of life (HRQOL) using EQ-5D questionnaires within the framework of clinical trials. This real-world study prospectivel...

    Authors: Tanja Sprave, Eleni Gkika, Vivek Verma, Anca-Ligia Grosu and Raluca Stoian
    Citation: BMC Cancer 2022 22:1236
    Content type: Research Published on:

  35. Concurrent chemoradiotherapy (CCRT) is a standard treatment choice for locally advanced hypopharyngeal carcinoma. The aim of this study was to investigate whether induction chemotherapy (IC) followed by CCRT i...

    Authors: Xi Luo, Xiaodong Huang, Jingwei Luo, Jianping Xiao, Kai Wang, Yuan Qu, Xuesong Chen, Ye Zhang, Runye Wu, Jingbo Wang, Jianghu Zhang, Guozhen Xu, Li Gao, Shaoyan Liu, Xiaolei Wang, Xiaohui He…
    Citation: BMC Cancer 2022 22:1235
    Content type: Research Published on:

  37. Lung immune prognostic index (LIPI) is a prognostic marker of extensive-stage small cell lung cancer (ES-SCLC) patients received immunotherapy or chemotherapy. However, its ability in limited-stage SCLC (LS-SC...

    Authors: Bochen Sun, Qing Hou, Yu Liang, Shuqin Xue, Ningning Yao, Lijuan Wei, Xin Cao, Hongwei Li, Hongwei Si and Jianzhong Cao
    Citation: BMC Cancer 2022 22:1233
    Content type: Research Published on:

  38. While immune checkpoint inhibitors (ICIs) occasionally cause immune-related adverse events (irAEs) in various organs, the prevalence of irAEs and potential risk factors have not been clarified. We identified i...

    Authors: Yuki Yoshikawa, Michio Imamura, Masami Yamauchi, C. Nelson Hayes, Hiroshi Aikata, Wataru Okamoto, Yoshihiro Miyata, Morihito Okada, Noboru Hattori, Kazuhiko Sugiyama, Yukio Yoshioka, Shigeaki Toratani, Masaaki Takechi, Tatsuo Ichinohe, Tsutomu Ueda, Sachio Takeno…
    Citation: BMC Cancer 2022 22:1232
    Content type: Research Published on:

  39. We aimed to identify effective routinely collected laboratory biomarkers for predicting postoperative outcomes in surgically treated spinal metastases and attempted to establish an effective prediction model.

    Authors: Zhehuang Li, Lingling Huang, Bairu Guo, Peng Zhang, Jiaqiang Wang, Xin Wang and Weitao Yao
    Citation: BMC Cancer 2022 22:1231
    Content type: Research Published on:

  40. The aims of this study focusing on Locoregionally advanced nasopharyngeal carcinoma (LANPC) were mainly two-fold: on the one hand, to establish a cut-off value to differentiate early and late failure based on ...

    Authors: Xing-Li Yang, Lu-Lu Zhang, Jia Kou, Guan-Qun Zhou, Chen-Fei Wu, Ying Sun and Li Lin
    Citation: BMC Cancer 2022 22:1230
    Content type: Research Published on:

  41. Dysregulation of inhibitor of differentiation/DNA binding (ID) genes is linked to cancer growth, angiogenesis, invasiveness, metastasis and patient survival. Nevertheless, few investigations have systematically d...

    Authors: Qi Zhao, Yun Wang, Di Yu, Jia-Yan Leng, Yangjing Zhao, Mingqiang Chu, Zijun Xu, Hao Ding, Jingdong Zhou and Tingjuan Zhang
    Citation: BMC Cancer 2022 22:1229
    Content type: Research Published on:

  42. The optimal duration of anti-PD-1 for cancer therapy has not been tested, especially when using combination therapy. Epidermal growth factor receptor (EGFR) pathway blocker was the top compound that enhanced T...

    Authors: Hsiang-Fong Kao, Huai-Cheng Huang, Bin-Chi Liao and Ruey-Long Hong
    Citation: BMC Cancer 2022 22:1228
    Content type: Research Published on:

  43. HPV has been detected in approximately 50% of invasive penile cancers but with a large span between 24 and 89%, most likely due to different types of tumors and various methods for HPV analysis. Most studies o...

    Authors: Sinja Kristiansen, Carina Bjartling, Christian Torbrand, Diane Grelaud, Martin Lindström, Åke Svensson and Ola Forslund
    Citation: BMC Cancer 2022 22:1227
    Content type: Research Published on:

  44. Cervical cancer is one of the most common cancer types among women in developing countries. Women’s behavior in the early detection of the disease is influenced by sociocultural factors. Thus, the present stud...

    Authors: Niloofar Seyrafi, Atefeh Homayuni, Zahra Hosseini, Teamur Aghamolaei, Amin Ghanbarnejad and Ali Mouseli
    Citation: BMC Cancer 2022 22:1226
    Content type: Research Published on:

  46. Authors: C. Martínez-Laperche, L. Sanz-Villanueva, F. J. Díaz Crespo, P. Muñiz, R. Martín Rojas, D. Carbonell, M. Chicano, J. Suárez-González, J. Menárguez, M. Kwon, J. L. Diez Martín, I. Buño and M. Bastos Oreiro
    Citation: BMC Cancer 2022 22:1224
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2022 22:982

  47. Paclitaxel plus S-1(PTXS) has shown definite efficacy for advanced gastric cancer. However, the efficacy and safety of this regimen in neoadjuvant setting for locally advanced gastric cancer (LAGC) are unclear...

    Authors: Chenghai Zhang, Binghong Wu, Hong Yang, Zhendan Yao, Nan Zhang, Fei Tan, Maoxing Liu, Kai Xu, Lei Chen, Jiadi Xing, Ming Cui and Xiangqian Su
    Citation: BMC Cancer 2022 22:1223
    Content type: Research Published on:

  48. Clinicians increasingly perform laparoscopic surgery for intrahepatic cholangiocarcinoma (ICC). However, this surgery can be difficult in patients with advanced-stage ICC because of the complicated procedures ...

    Authors: Cheng-Yu Liao, Dan-Feng Wang, Bin-Hua Jiang, Long Huang, Tian-Sheng Lin, Fu-Nan Qiu, Song-Qiang Zhou, Yao-Dong Wang, Xiao-Chun Zheng, Yi-Feng Tian and Shi Chen
    Citation: BMC Cancer 2022 22:1222
    Content type: Research Published on:

  49. Molecular subgrouping of medulloblastoma has become important due to its impact on risk group stratification. Immunohistochemistry (IHC) has been widely used but it has innate limitations. The NanoString assay...

    Authors: Joo Whan Kim, Sung-Hye Park, Seung Ah Choi, Seung-Ki Kim, Eun Jung Koh, Jae-Kyung Won, Sun Mo Nam and Ji Hoon Phi
    Citation: BMC Cancer 2022 22:1221
    Content type: Research Published on:

  50. Ovarian cancer is one of the most lethal gynecologic malignancies with a dismal prognosis that poses a serious threat to human health, highlighting the need for more knowledge about what is required for identi...

    Authors: Sai Li, Sifu Yang and Yupeng Hong
    Citation: BMC Cancer 2022 22:1216
    Content type: Research Published on:

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