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3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

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  1. Fascin is the main actin cross-linker protein that regulates adhesion dynamics and stabilizes cell protrusion, such as filopodia. In human cancer, fascin expression correlates with aggressive clinical features...

    Authors: Athanasios Tampakis, Ekaterini-Christina Tampaki, Afrodite Nonni, Ioannis D. Kostakis, Alberto Posabella, Konstantinos Kontzoglou, Markus von Flüe, Evangelos Felekouras, Gregory Kouraklis and Nikolaos Nikiteas
    Citation: BMC Cancer 2021 21:153
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:191

  2. The gap in treatment and health outcomes after diagnosis of pancreatic cancer is a major public health concern. We aimed to investigate the differences in the health outcomes and treatment of pancreatic cancer...

    Authors: Sung Hoon Jeong, Hyeon Ji Lee, Choa Yun, Il Yun, Yun Hwa Jung, Soo Young Kim, Hee Seung Lee and Sung-In Jang
    Citation: BMC Cancer 2022 22:925
    Content type: Research Published on:

  3. All cell types express long non-coding RNAs (lncRNAs), which have the potential to play a role in carcinogenesis by altering the levels of their expression. Squamous cell carcinoma of the esophagus (ESCC) is a...

    Authors: Zahra Roohinejad, Shabbou Bahramian, Fatemeh Tash Shamsabadi, Reza Sahebi, Abolfazl Amini, Davood Sabour and Mohammad Shafiee
    Citation: BMC Cancer 2023 23:34
    Content type: Research Published on:

  4. Long non-coding RNAs play an important role in tumorigenesis, hence, identification of cancer-associated lncRNAs and investigation of their biological functions and molecular mechanisms are important for under...

    Authors: Kai-hua Lu, Wei Li, Xiang-hua Liu, Ming Sun, Mei-ling Zhang, Wei-qin Wu, Wei-ping Xie and Ya-yi Hou
    Citation: BMC Cancer 2013 13:461
    Content type: Research article Published on:

  5. The incidence and mortality rate of rectal cancer are still high, the metastasis of rectal cancer are main causes of death. The control of the distant metastasis is one of the main concerns in the treatment of...

    Authors: Xue Ding, Danqi Sun, Qiuchen Guo, Yeting Li, Hao Chen, Xiaoxiao Dai, Guohua Fan, Yongyou Wu, Guangqiang Chen and Yonggang Li
    Citation: BMC Cancer 2022 22:920
    Content type: Research Published on:

  6. Ovarian cancer (OC) is a highly lethal gynecological malignancy. Extensive research has shown that OC cells undergo significant metabolic alterations during tumorigenesis. In this study, we aim to leverage the...

    Authors: Linfeng Chen, Qiming Tang, Keying Zhang, Qianyang Huang, Yun Ding, Bo Jin, Szumam Liu, KuoYuan Hwa, C. James Chou, Yani Zhang, Sheeno Thyparambil, Weili Liao, Zhi Han, Richard Mortensen, James Schilling, Zhen Li…
    Citation: BMC Cancer 2023 23:844
    Content type: Research article Published on:

  7. The treatment strategy for brain metastasis (BM) in patients with epidermal growth factor receptor (EGFR) -mutant lung adenocarcinoma (LAC) remains controversial. In the present study, we compared the efficacy...

    Authors: Yanxin Chen, Jianping Wei, Jing Cai and Anwen Liu
    Citation: BMC Cancer 2019 19:793
    Content type: Research article Published on:

  8. The role of glycolysis in tumorigenesis has received increasing attention and multiple glycolysis-related genes (GRGs) have been proven to be associated with tumor metastasis. Hence, we aimed to construct a pr...

    Authors: Qianwei Xing, Tengyue Zeng, Shouyong Liu, Hong Cheng, Limin Ma and Yi Wang
    Citation: BMC Cancer 2021 21:381
    Content type: Research article Published on:

  9. Tumor mutation burden (TMB) is an emerging prognostic biomarker of immunotherapy for bladder cancer (BLCA). We aim at investigating radiomic features’ value in predicting the TMB status of BLCA patients.

    Authors: Xin Tang, Wen-lei Qian, Wei-feng Yan, Tong Pang, You-ling Gong and Zhi-gang Yang
    Citation: BMC Cancer 2021 21:823
    Content type: Research Published on:

  10. Mucinous adenocarcinoma (MAC) represents 6-19 % of all colorectal carcinoma. It is associated with poorer response to chemotherapy and chemoradiotherapy.

    Authors: Karolina Vernmark, Maria Albertsson, Bergthor Björnsson, Thomas Gasslander, Per Sandström, Xiao-Feng Sun and Annika Holmqvist
    Citation: BMC Cancer 2015 15:884
    Content type: Case report Published on:

  12. The increasing incidence and poor outcome associated with malignant pleural effusion (MPE) requires finding an effective treatment for this disease. Inhibitory B7-H4 is expressed in many different human cancer...

    Authors: Cheng Chen, Qiu-Xia Qu, Fang Xie, Wei-Dong Zhu, Ye-Han Zhu and Jian-An Huang
    Citation: BMC Cancer 2017 17:652
    Content type: Research article Published on:

  13. The NTRK2 genetic locus encodes neurotrophin membrane receptors that play an important role in normal neural tissue plasticity, growth, and survival. One NTRK2-encoded protein is TrkB-FL, which can regulate mu...

    Authors: Yalu Zhou, Saurabh Sinha, Joel L. Schwartz and Guy R. Adami
    Citation: BMC Cancer 2019 19:607
    Content type: Research article Published on:

  14. While many studies investigated changes in working status in cancer survivors, most studies have been performed in survivors of breast cancer and few studies evaluated factors associated with changes in the wo...

    Authors: Danbee Kang, Ka Ryeong Bae, Ho Young Kim, Yeojin Ahn, Nayeon Kim, Youngmog Shim, Tae Sung Sohn, Woo Yong Lee, Ji Hyun Baek, Sun-Seog Kweon and Juhee Cho
    Citation: BMC Cancer 2022 22:917
    Content type: Research Published on:

  15. The mechanism of long non-coding RNA MIR137HG in human gastric cancer (GC) is currently unknown. In the present study, we aimed to explore the function and mechanism of MIR137HG in gastric cancer.

    Authors: Yantao Du, Yichen Chen, Tao Wu, Xiaodan Fan, Wei Lin and Zhouhua Jiang
    Citation: BMC Cancer 2022 22:689
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:1234

  16. Kallikrein-related peptidase 7 (KLK7) is a chymotrypsin-like serine protease which is essential for the desquamation of corneocytes and thus plays a pivotal role in maintaining skin homeostasis. In cancer, KLK...

    Authors: Simon Kind, Carolina Palacios Castillo, Ria Schlichter, Natalia Gorbokon, Maximilian Lennartz, Lisa S. Hornsteiner, Sebastian Dwertmann Rico, Viktor Reiswich, Florian Viehweger, Martina Kluth, Claudia Hube-Magg, Christian Bernreuther, Franziska Büscheck, Till S. Clauditz, Christoph Fraune, Andrea Hinsch…
    Citation: BMC Cancer 2024 24:794
    Content type: Research Published on:

  17. Male breast cancer (MBC) is rare, accounting for only around 1% of all breast cancers. Most MBCs are hormone-driven. Not only the estrogen receptor (ER), but also other steroid hormone receptors, including the...

    Authors: Haruko Takuwa, Wakako Tsuji, Masayuki Shintaku and Fumiaki Yotsumoto
    Citation: BMC Cancer 2018 18:1282
    Content type: Case report Published on:

  18. Cancer patients’ survival time has obviously improved, with the development of systemic treatment techniques. However, the probability of metastases to the vertebrae has also been increased which makes some ad...

    Authors: Xiong-gang Yang, Deng-xing Lun, Yong-cheng Hu, Yong-heng Liu, Feng Wang, Jiang-tao Feng, Kun-chi Hua, Li Yang, Hao Zhang, Ming-you Xu and Hao-ran Zhang
    Citation: BMC Cancer 2018 18:1248
    Content type: Research article Published on:

  19. Colorectal cancer (CRC) diagnosis and the ensuing treatments can have a substantial impact on the physical and psychological health of survivors. As the number of CRC survivors increases, so too does the need ...

    Authors: Rosalind R Spence, Kristiann C Heesch, Elizabeth G Eakin and Wendy J Brown
    Citation: BMC Cancer 2007 7:154
    Content type: Study protocol Published on:

  20. Metastasis of cancer causes more than 90% of cancer deaths and is severely damaging to human health. In recent years, several studies have linked sarcopenia to shorter survival in patients with metastatic canc...

    Authors: Lingli Luo, Xiangru Shen, Shuai Fang, Teng Wan, Pan Liu, Peiling Li, Haifeng Tan, Yong Fu, Weiming Guo and Xiaojun Tang
    Citation: BMC Cancer 2023 23:127
    Content type: Research Published on:

  21. We conducted this study to combine the mean standardized uptake value (SUVmean) and neutrophil to lymphocyte ratio (NLR) to establish a strong predictive model for patients with esophageal squamous cell carcin...

    Authors: Chunsheng Wang, Kewei Zhao, Shanliang Hu, Yong Huang, Li Ma, Yipeng Song and Minghuan Li
    Citation: BMC Cancer 2020 20:544
    Content type: Research article Published on:

  22. PN is a secreted cell adhesion protein critical for carcinogenesis. In breast cancer, it is overexpressed compared to normal breast, and a few reports suggest that it has a potential role as a prognostic marker.

    Authors: P. V. Nuzzo, A. Rubagotti, L. Zinoli, S. Salvi, S. Boccardo and F. Boccardo
    Citation: BMC Cancer 2016 16:95
    Content type: Research article Published on:

  23. The burden of cancer is likely to increase among the human immunodeficiency virus (HIV)-positive population as it ages due to successful antiretroviral therapy (ART). The purpose of this study was to determine...

    Authors: Chang-Hua Chen, Chih-Yuan Chung, Li-Hsuan Wang, Che Lin, Hsiu-Li Lin and Hsiu-Chen Lin
    Citation: BMC Cancer 2015 15:133
    Content type: Research article Published on:

  24. Skin cutaneous melanoma (SKCM) is an extremely malignant tumor and accounts for the majority of skin cancer deaths. Aspartate beta-hydroxylase domain containing 1 (ASPHD1) may participate in cancer progression...

    Authors: Shiquan Sun, Min Deng, Juan Wen, Xiaoyuan Chen, Jiaqi Xu, Yu Liu, Huanhuan Wan, Jin Wang, Leping Yan, Yong He and Yunsheng Xu
    Citation: BMC Cancer 2023 23:292
    Content type: Research Published on:

  26. NOSTRIN, abundantly expressed in colon, was reported to be anti-angiogenic, anti-invasive and anti-inflammatory. NOSTRIN expression was inversely related to survival of pancreatic ductal adeno-carcinoma patien...

    Authors: Madhurima Paul, Tamal Kanti Gope, Priyanka Das and Rupasri Ain
    Citation: BMC Cancer 2022 22:594
    Content type: Research article Published on:

  27. Lipid metabolism has a profound impact on gastric cancer (GC) progression and is a newly targetable vulnerability for cancer therapy. Given the importance of lipids in cancer cellular processes, in this study ...

    Authors: Yanyan Li, Jungang Zhao, Renpin Chen, Shengwei Chen, Yilun Xu and Weiyang Cai
    Citation: BMC Cancer 2022 22:955
    Content type: Research Published on:

  28. Overexpression of Bmi-1 has been observed in a variety of cancers, and it has been suggested to be an independent prognostic marker for the patients. The objective of this study was to determine the level of B...

    Authors: Wan-li Liu, Xian-zhi Guo, Lan-jun Zhang, Jun-ye Wang, Ge Zhang, Su Guan, Yu-min Chen, Qing-li Kong, Li-hua Xu, Man-zhi Li, Li-bing Song and Mu-sheng Zeng
    Citation: BMC Cancer 2010 10:467
    Content type: Research article Published on:

  29. Esophageal squamous cell carcinoma (ESCC) is a fatal disease with poor prognosis. The predominant reason for ESCC-related death is distal metastasis. A comprehensive understanding of the molecular mechanism un...

    Authors: Yanan Jiang, Jing Zhang, Jimin Zhao, Zhenzhen Li, Hanyong Chen, Yan Qiao, Xinhuan Chen, Kangdong Liu and Ziming Dong
    Citation: BMC Cancer 2019 19:1264
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:43

  30. Cervical cancer is the third most common cancer in women globally, and despite treatment, distant metastasis and nodal recurrence will still develop in approximately 30% of patients. The ability to predict whi...

    Authors: Christine How, Jeff Bruce, Jonathan So, Melania Pintilie, Benjamin Haibe-Kains, Angela Hui, Blaise A Clarke, David W Hedley, Richard P Hill, Michael Milosevic, Anthony Fyles and Fei-Fei Liu
    Citation: BMC Cancer 2015 15:361
    Content type: Research article Published on:

  31. Detection of circulating (CTC) or disseminated tumor cells (DTC) has been associated with negative prognosis and outcome in patients with colorectal cancer, though testing for these cells is not yet part of cl...

    Authors: Sebastian Hinz, Alexander Hendricks, Amke Wittig, Clemens Schafmayer, Jürgen Tepel, Holger Kalthoff, Thomas Becker and Christian Röder
    Citation: BMC Cancer 2017 17:53
    Content type: Research article Published on:

  32. To explore the potential role of signal transducer and activator of transcription 5A (STAT5A) in the metastasis of breast cancer, and its mechanism of regulation underlying.

    Authors: Min-Na Chen, Ze-Xuan Fang, Zheng Wu, Jing-Wen Bai, Rong-Hui Li, Xiao-Fen Wen, Guo-Jun Zhang and Jing Liu
    Citation: BMC Cancer 2023 23:1257
    Content type: Research Published on:

  33. Current prognostic markers cannot adequately predict the clinical outcome of breast cancer patients. Therefore, additional biomarkers need to be included in routine immune panels. FOXA1 was a significant predi...

    Authors: Shahin De Lara, Jenny Nyqvist, Elisabeth Werner Rönnerman, Khalil Helou, Elisabeth Kenne Sarenmalm, Zakaria Einbeigi, Per Karlsson, Toshima Z. Parris and Anikó Kovács
    Citation: BMC Cancer 2019 19:187
    Content type: Research article Published on:

  34. Chemokine (C-C motif) ligand 18 (CCL18) affects the malignant progression of varying cancers by activating chemokine receptors. Our previous work has shown that CCL18 promotes hyperplasia and invasiveness of o...

    Authors: Xiao Jiang, Zhijie Huang, Xiang Sun, Xianghuai Zheng, Jingpeng Liu, Jun Shen, Bo Jia, Haiyun Luo, Zhaoyi Mai, Guodong Chen and Jianjiang Zhao
    Citation: BMC Cancer 2020 20:632
    Content type: Research article Published on:

  35. Heme oxygenase-1 (HO-1) and its major product carbon monoxide (CO) are known to be involved in the development and progression of many tumors. The present study was to elucidate the expression and function of ...

    Authors: Hongzhuan Yin, Jun Fang, Long Liao, Hiroshi Maeda and Qi Su
    Citation: BMC Cancer 2014 14:436
    Content type: Research article Published on:

  36. We evaluated treatment decisions and outcomes in a cohort of predominately Caucasian patients with EGFR mutation-positive (EGFR Mut+) non-small-cell lung cancer (NSCLC).

    Authors: Wolfgang Schuette, Peter Schirmacher, Wilfried E. E. Eberhardt, Manfred Dietel, Ute Zirrgiebel, Lars Muehlenhoff and Michael Thomas
    Citation: BMC Cancer 2018 18:135
    Content type: Research article Published on:

  37. Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis...

    Authors: Lie-Jun Mei, Xiao-Jun Yang, Li Tang, Alaa Hammed al-shammaa Hassan, Yutaka Yonemura and Yan Li
    Citation: BMC Cancer 2010 10:124
    Content type: Research article Published on:

  38. Prognosis for patients recurred rapidly after resection of pancreatic ductal adenocarcinoma (PDAC) was extremely poor. We proposed the concept of postoperative hyper-progression disease (PO-HPD) to define recu...

    Authors: Siyi Zou, Xinjing Wang, Haoda Chen, Jiewei Lin, Chenlei Wen, Qian Zhan, Hao Chen, Xiongxiong Lu, Xiaxing Deng and Baiyong Shen
    Citation: BMC Cancer 2022 22:649
    Content type: Research article Published on:

  40. The prognosis of patients with perihilar cholangiocarcinoma have been unsatisfactory. We established new anatomical resectability classification for patients with localized perihilar cholangiocarcinoma and per...

    Authors: Naohisa Kuriyama, Masanobu Usui, Kazuaki Gyoten, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Hiroyuki Kato, Yasuhiro Murata, Akihiro Tanemura, Masashi Kishiwada, Hiroyuki Sakurai, Shugo Mizuno and Shuji Isaji
    Citation: BMC Cancer 2020 20:405
    Content type: Research article Published on:

  41. Due to the significant heterogeneity of renal cell carcinoma (RCC), immune checkpoints may express differently between primary and metastatic tumor. We aimed to evaluate the differential expression of TIM-3 be...

    Authors: Xingming Zhang, Xiaoxue Yin, Haoran Zhang, Guangxi Sun, Yaojing Yang, Junru Chen, Kunpeng Shu, Jinge Zhao, Peng Zhao, Ni Chen, Jia Wang, Pengfei Shen and Hao Zeng
    Citation: BMC Cancer 2019 19:49
    Content type: Research article Published on:

  42. In colorectal cancer (CRC), unresectable liver metastases are linked to poor prognosis. Systemic chemotherapy with regimens such as FOLFOX (combination of infusional 5-fluorouracil, leucovorin and oxaliplatin)...

    Authors: Peter Gibbs, Val Gebski, Mark Van Buskirk, Kenneth Thurston, David N Cade and Guy A Van Hazel
    Citation: BMC Cancer 2014 14:897
    Content type: Study protocol Published on:

  43. Breast cancer is a highly heterogeneous disease resulting in diverse clinical behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is commonly perturbed in cancers. The a...

    Authors: Bernardo P. de Almeida, Joana Dias Apolónio, Alexandra Binnie and Pedro Castelo-Branco
    Citation: BMC Cancer 2019 19:219
    Content type: Research article Published on:

  44. SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss an...

    Authors: Hira Javaid, Alessandro Barberis, Olga Chervova, Isar Nassiri, Vitaly Voloshin, Yusuke Sato, Seishi Ogawa, Benjamin Fairfax, Francesca Buffa and Timothy C. Humphrey
    Citation: BMC Cancer 2023 23:721
    Content type: Research Published on:

  45. Over half of colorectal cancers (CRCs) are hard-wired to RAS/RAF/MEK/ERK pathway oncogenic signaling. However, the promise of targeted therapeutic inhibitors, has been tempered by disappointing clinical activi...

    Authors: Mingli Yang, Thomas B. Davis, Lance Pflieger, Michael V. Nebozhyn, Andrey Loboda, Heiman Wang, Michael J. Schell, Ramya Thota, W. Jack Pledger and Timothy J. Yeatman
    Citation: BMC Cancer 2022 22:256
    Content type: Research Published on:

  46. Vinorelbine constitutes effective chemotherapy for metastatic breast cancer (MBC) and acts synergistically with trastuzumab in HER-2/neu positive disease. The present study was set out to evaluate the efficacy an...

    Authors: Christiane Thallinger, Istvan Lang, Cvetka Grasic Kuhar, Rupert Bartsch, Christian F. Singer, Lubos Petruzelka, Bohuslav Melichar, Regina Knittelfelder, Thomas Brodowicz and Christoph Zielinski
    Citation: BMC Cancer 2016 16:121
    Content type: Research article Published on:

  47. Lymph node (LN) metastasis is the earliest sign of metastatic spread and an established predictor of poor outcome in gallbladder cancer (GBC). Patients with LN positive GBC have a significantly worse survival ...

    Authors: Vaishali Jain, Javed Akhtar, Ratna Priya, Puja Sakhuja, Surbhi Goyal, Anil Kumar Agarwal, Vivek Ghose, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Fouzia Siraj and Poonam Gautam
    Citation: BMC Cancer 2023 23:402
    Content type: Research Published on:

  49. RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK...

    Authors: Zulipiyamu Tuoheti, Lili Han, Sulaiya Husaiyin, Xiaoxi Liu, Chunhua Ma and Mayinuer Niyazi
    Citation: BMC Cancer 2020 20:299
    Content type: Research article Published on:

  50. Class III β-tubulin (TUBB3) is a prognostic marker in various tumors, but the role of TUBB3 in advanced gastric cancer is not clearly defined. We analyzed the significance of TUBB3 expression, along with that ...

    Authors: Jun-Eul Hwang, Ji-Yun Hong, Karham Kim, Seung-Hun Kim, Won-Young Choi, Min-Jee Kim, Sung-Hoon Jung, Hyun-Jeong Shim, Woo-Kyun Bae, Eu-Chang Hwang, Kyung-Hwa Lee, Jae-Hyuk Lee, Sang-Hee Cho and Ik-Joo Chung
    Citation: BMC Cancer 2013 13:431
    Content type: Research article Published on:

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