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  1. Epidemiological studies have shown that individuals who regularly consume NSAIDs have lower rates of mortality associated with colorectal cancer. Because COX-2 inhibitors prevent tumor growth through some mech...

    Authors: Hirotoshi Kobayashi, Hiroyuki Uetake, Tetsuro Higuchi, Masayuki Enomoto and Kenichi Sugihara
    Citation: BMC Cancer 2005 5:26
    Content type: Research article Published on:

  2. Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge...

    Authors: Vasilis Karavasilis, Vasiliki Malamou-Mitsi, Evangelos Briasoulis, Elena Tsanou, Evangelia Kitsou, Haralambos Kalofonos, George Fountzilas, Theodore Fotsis and Nicholas Pavlidis
    Citation: BMC Cancer 2005 5:25
    Content type: Research article Published on:

  3. To identify early symptoms of familial adenomatous polyposis with a view to improve early diagnosis and treatment. Diagnosis on the basis of genetic testing is usually limited to where there is a known family ...

    Authors: Roland S Croner, Wolfgang M Brueckl, Bertram Reingruber, Werner Hohenberger and Klaus Guenther
    Citation: BMC Cancer 2005 5:24
    Content type: Research article Published on:

  4. Upper urothelial cancer (UUC), i.e. transitional cell carcinomas of the renal pelvis and the ureter, occur at an increased frequency in patients with hereditary nonpolyposis colorectal cancer (HNPCC). Defectiv...

    Authors: Kajsa M Ericson, Anna P Isinger, Björn L Isfoss and Mef C Nilbert
    Citation: BMC Cancer 2005 5:23
    Content type: Research article Published on:

  5. Desmoid tumour is a benign, non metastasising neoplasm characterised by an elevated deposition of organic macromolecules in the extracellular matrix (ECM). The matrix metalloproteinases (MMPs) are a family of ...

    Authors: Chiara Balducci, Cinzia Lilli, Giordano Stabellini, Lorella Marinucci, Giammario Giustozzi, Alessio Becchetti, Lucio Cagini and Paola Locci
    Citation: BMC Cancer 2005 5:22
    Content type: Research article Published on:

  6. Patients with metastatic breast cancer (MBC) are frequently exposed to high cumulative doses of anthracyclines and are at risk of resistance and cardiotoxicity. This phase II trial evaluated the efficacy and t...

    Authors: Se Hoon Park, Eun Kyung Cho, Soo-Mee Bang, Dong Bok Shin, Jae Hoon Lee and Young Don Lee
    Citation: BMC Cancer 2005 5:21
    Content type: Research article Published on:

  7. Leukemia is a clonal disorder characterized by uncontrolled proliferation of haematopoietic cells, and represents the most common form of cancer in children. Advances in therapy for childhood leukemia have rel...

    Authors: Silvija Jarnjak-Jankovic, Rolf D Pettersen, Stein Sæbøe-Larssen, Finn Wesenberg and Gustav Gaudernack
    Citation: BMC Cancer 2005 5:20
    Content type: Research article Published on:

  8. p53 mutations are relatively uncommon in medulloblastoma, but abnormalities in this cell cycle pathway have been associated with anaplasia and worse clinical outcomes. We correlated p53 protein expression with...

    Authors: Charles G Eberhart, Aneeka Chaudhry, Richard W Daniel, Leila Khaki, Keerti V Shah and Patti E Gravitt
    Citation: BMC Cancer 2005 5:19
    Content type: Research article Published on:

  9. There is a growing awareness among providers of the symptom burden experienced by cancer patients. Systematic symptom screening is difficult. Our plan was to evaluate a technology-based symptom screening proce...

    Authors: Ma'n Abdullah, Dale E Theobald, Donna Butler, Kurt Kroenke, Anthony Perkins, Sara Edgerton and William M Dugan Jr
    Citation: BMC Cancer 2005 5:18
    Content type: Research article Published on:

  10. The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of t...

    Authors: Meghan Webb, Ethan D Emberley, Michael Lizardo, Salem Alowami, Gefei Qing, Abdullah Alfia'ar, Linda J Snell-Curtis, Yulian Niu, Alberto Civetta, Yvonne Myal, Robert Shiu, Leigh C Murphy and Peter H Watson
    Citation: BMC Cancer 2005 5:17
    Content type: Research article Published on:

  12. Serine-threonine kinases of the Raf family (A-Raf, B-Raf, C-Raf) are central players in cellular signal transduction, and thus often causally involved in the development of cancer when mutated or over-expresse...

    Authors: Ivaylo Gentschev, Joachim Fensterle, Andreas Schmidt, Tamara Potapenko, Jakob Troppmair, Werner Goebel and Ulf R Rapp
    Citation: BMC Cancer 2005 5:15
    Content type: Research article Published on:

  13. Modeling the complex development and growth of tumor angiogenesis using mathematics and biological data is a burgeoning area of cancer research. Architectural complexity is the main feature of every anatomical...

    Authors: Fabio Grizzi, Carlo Russo, Piergiuseppe Colombo, Barbara Franceschini, Eldo E Frezza, Everardo Cobos and Maurizio Chiriva-Internati
    Citation: BMC Cancer 2005 5:14
    Content type: Research article Published on:

  15. Recent studies relating to the association between DNA repair-gene polymorphisms and colorectal cancer risk would, to the best of our knowledge, appear to be very limited. This study was designed to examine th...

    Authors: Chih-Ching Yeh, Fung-Chang Sung, Reiping Tang, Chung Rong Chang-Chieh and Ling-Ling Hsieh
    Citation: BMC Cancer 2005 5:12
    Content type: Research article Published on:

  16. Suction drains are routinely used after modified radical mastectomy and are an important factor contributing to increased hospital stay as the patients are often discharged only after their removal. Amongst va...

    Authors: Chintamani, Vinay Singhal, JP Singh, Anju Bansal and Sunita Saxena
    Citation: BMC Cancer 2005 5:11
    Content type: Research article Published on:

  17. Both paclitaxel (P) and carboplatin (C) have significant activity in non-small cell lung cancer (NSCLC). The weekly administration of P is active, dose intense, and has a favorable toxicity profile. We retrosp...

    Authors: Perran F Yumuk, Nazim S Turhal, Mahmut Gumus, Nilgun F Hatabay, Orhan Turken, Alper Ozkan, Taflan Salepci, Mehmet Aliustaoglu and Rengin Ahiskali
    Citation: BMC Cancer 2005 5:10
    Content type: Research article Published on:

  18. Insulin-like growth factor binding protein (IGFBP)-3 functions as a carrier of insulin-like growth factors (IGFs) in circulation and a mediator of the growth suppression signal in cells. There are two reported...

    Authors: Tadashi Hanafusa, Toshiyuki Shinji, Hidenori Shiraha, Kazuhiro Nouso, Yoshiaki Iwasaki, Eichiro Yumoto, Toshiro Ono and Norio Koide
    Citation: BMC Cancer 2005 5:9
    Content type: Research article Published on:

  19. Molecular markers for localized colon tumours and for prognosis following therapy are needed. Proteomics research is currently producing numerous biomarker studies with clinical potential. We investigate the p...

    Authors: Jakob Albrethsen, Rikke Bøgebo, Steen Gammeltoft, Jesper Olsen, Benny Winther and Hans Raskov
    Citation: BMC Cancer 2005 5:8
    Content type: Research article Published on:

  20. Both Taxotere and Capecitabine have shown anti-cancer activity against various cancers including prostate cancer. In combination, Taxotere plus Capecitabine has demonstrated higher anti-cancer activity in adva...

    Authors: Yiwei Li, Maha Hussain, Sarah H Sarkar, James Eliason, Ran Li and Fazlul H Sarkar
    Citation: BMC Cancer 2005 5:7
    Content type: Research article Published on:

  21. We have previously demonstrated that NF-Y and Sp1 interact with the human telomerase RNA (hTR) promoter and play a central role in its regulation. We have also shown that pRB activates the hTR promoter, but th...

    Authors: Jiangqin Zhao, Alan Bilsland, Katrina Jackson and W Nicol Keith
    Citation: BMC Cancer 2005 5:6
    Content type: Research article Published on:

  22. TRAIL (tumor necrosis factor related apoptosis inducing ligand) is an apoptosis inducing ligand with high specificity for malignant cell systems. Combined treatment modalities using TRAIL and cytotoxic drugs reve...

    Authors: Patrizia Marini, Angelika Schmid, Verena Jendrossek, Heidrun Faltin, Peter T Daniel, Wilfried Budach and Claus Belka
    Citation: BMC Cancer 2005 5:5
    Content type: Research article Published on:

  23. Tumor development remains one of the major obstacles following organ transplantation. Immunosuppressive drugs such as cyclosporine and tacrolimus directly contribute to enhanced malignancy, whereas the influen...

    Authors: Tobias Engl, Jasmina Makarević, Borna Relja, Iyad Natsheh, Iris Müller, Wolf-Dietrich Beecken, Dietger Jonas and Roman A Blaheta
    Citation: BMC Cancer 2005 5:4
    Content type: Research article Published on:

  25. Prostate cancer is a significant health problem among American men. Treatment strategies for androgen-independent cancer are currently not available. Tumor necrosis factor-related apoptosis-inducing ligand (Ap...

    Authors: Ahmed El-Zawahry, John McKillop and Christina Voelkel-Johnson
    Citation: BMC Cancer 2005 5:2
    Content type: Research article Published on:

  27. Recently, several members of a vertebrate protein family containing a six trans-membrane (6TM) domain and involved in apoptosis and cancer (e.g. STEAP, STAMP1, TSAP6), have been identified in Golgi and cytopla...

    Authors: Luis Sanchez-Pulido, Ana M Rojas, Alfonso Valencia, Carlos Martinez-A and Miguel A Andrade
    Citation: BMC Cancer 2004 4:98
    Content type: Research article Published on:

  28. Colorectal cancer is a common malignancy of the gastrointestinal tract. It is the second cancer cause of death in females and third in males. Production of prolactin has been reported with several tumours. How...

    Authors: Ahmad Reza Soroush, Hosein Mahmood zadeh, Mehrnush Moemeni, Behnam Shakiba and Sara Elmi
    Citation: BMC Cancer 2004 4:97
    Content type: Research article Published on:

  29. Splenic metastases occur in rare cases with a few case reports of patients in the literature. Generally, splenic metastases mean late dissemination of a disease. Solitary splenic metastases from solid tumors a...

    Authors: Yang Seok Koh, Jung Chul Kim and Chol Kyoon Cho
    Citation: BMC Cancer 2004 4:96
    Content type: Case report Published on:

  30. We describe a patient who underwent transurethral resection of the prostate for urinary obstructive symptoms and had histological findings of adenocarcinoma of the prostate with prostatic localization of chron...

    Authors: Riccardo Ballario, Paolo Beltrami, Stefano Cavalleri, Lorenzo Ruggera, Maria Grazia Zorzi and Walter Artibani
    Citation: BMC Cancer 2004 4:95
    Content type: Case report Published on:

  31. Uncertainty regarding comorbid illness, and ability to tolerate aggressive therapy has led to minimal enrollment of elderly cancer patients into clinical trials and often substandard treatment. Increasingly, c...

    Authors: William H Hall, Ramanathan Ramachandran, Samir Narayan, Ashesh B Jani and Srinivasan Vijayakumar
    Citation: BMC Cancer 2004 4:94
    Content type: Software Published on:

  32. Previous research has indicated that at various organ sites there is a subset of adenocarcinomas that is regulated by beta-adrenergic and arachidonic acid-mediated signal transduction pathways. We wished to de...

    Authors: Howard K Plummer III, Qiang Yu, Yavuz Cakir and Hildegard M Schuller
    Citation: BMC Cancer 2004 4:93
    Content type: Research article Published on:

  33. Colon adenocarcinomas are refractory to a number of widely used anticancer agents. Multifactorial mechanisms have been implicated in this intrinsically resistant phenotype, including deregulation of cell death...

    Authors: Raffaella Ravizza, Marzia B Gariboldi, Laura Passarelli and Elena Monti
    Citation: BMC Cancer 2004 4:92
    Content type: Research article Published on:

  35. Almost one-third of all penile metastases are detected at the same time as a primary tumor, whereas the remaining two-thirds are detected a mean of 18 months after the discovery of the primary tumor. Cutaneous...

    Authors: Giorgio Pomara, Ilaria Pastina, Maurizio Simone, Paolo Casale, Gabriella Marchetti and Francesco Francesca
    Citation: BMC Cancer 2004 4:90
    Content type: Case report Published on:

  36. Hepatocellular carcinoma is a common malignancy for which chronic hepatitis B infection has been defined as the most common etiologic factor. The most frequent metastatic sites are the lung, bone, lymphatics, ...

    Authors: Şahin Çoban, Osman Yüksel, Seyfettin Köklü, Koray Ceyhan, Meltem Baykara and Abdulkadir Dökmeci
    Citation: BMC Cancer 2004 4:89
    Content type: Case report Published on:

  38. In vivo studies were conducted to quantify the effectiveness of low-level direct electric current for different amounts of electrical charge and the survival rate in fibrosarcoma Sa-37 and Ehrlich tumors, also t...

    Authors: HC Ciria, MS Quevedo, LB Cabrales, RP Bruzón, MF Salas, OG Pena, TR González, DS López and JM Flores
    Citation: BMC Cancer 2004 4:87
    Content type: Research article Published on:

  39. Bacillus Calmette Guérin (BCG)-immunotherapy has a well-documented and successful clinical history in the treatment of bladder cancer. However, regularly observed side effects, a certain degree of nonresponder...

    Authors: Christian Sänger, Andreas Busche, Gabriele Bentien, Ralf Spallek, Fatima Jonas, Andreas Böhle, Mahavir Singh and Sven Brandau
    Citation: BMC Cancer 2004 4:86
    Content type: Research article Published on:

  40. BAG-1 is a multifunctional co-chaperone of heat shock proteins (Hsc70/Hsp70) that is expressed in most cells. It interacts with Bcl-2 and Raf indicating that it might connect protein folding with other signali...

    Authors: Rudolf Götz, Boris W Kramer, Guadalupe Camarero and Ulf R Rapp
    Citation: BMC Cancer 2004 4:85
    Content type: Research article Published on:

  41. Smac/Diablo is a recently identified protein that is released from mitochondria after apoptotic stimuli. It binds IAPs, allowing caspase activation and cell death. In view of its activity it might participate ...

    Authors: Magali Espinosa, David Cantu, Carlos M Lopez, Jaime G De la Garza, Vilma A Maldonado and Jorge Melendez-Zajgla
    Citation: BMC Cancer 2004 4:84
    Content type: Research article Published on:

  42. Activation of the epidermal growth factor receptor (EGFR) triggers downstream signaling pathways that regulate many cellular processes involved in tumour survival and growth. Gefitinib ('Iressa') is an orally ...

    Authors: Louise A Knight, Federica Di Nicolantonio, Pauline Whitehouse, Stuart Mercer, Sanjay Sharma, Sharon Glaysher, Penny Johnson and Ian A Cree
    Citation: BMC Cancer 2004 4:83
    Content type: Research article Published on:

  43. The incidence of breast cancer in young women (age < 35) is low. The biology of the disease in this age group is poorly understood, and there are conflicting data regarding the prognosis for these women compar...

    Authors: Wonshik Han, Seok Won Kim, In Ae Park, Daehee Kang, Sung-Won Kim, Yeo-Kyu Youn, Seung Keun Oh, Kuk Jin Choe and Dong-Young Noh
    Citation: BMC Cancer 2004 4:82
    Content type: Research article Published on:

  44. Electroporation is currently receiving much attention as a way to increase drug and DNA delivery. Recent studies demonstrated the feasibility of electrogene therapy using a range of therapeutic genes for the t...

    Authors: Maja Cemazar, Ian Wilson, Gabi U Dachs, Gillian M Tozer and Gregor Sersa
    Citation: BMC Cancer 2004 4:81
    Content type: Research article Published on:

  45. Transcription factors are frequently involved in the process of cellular transformation, and many malignancies are characterized by a distinct genetic event affecting a specific transcription factor. This prob...

    Authors: Anna Lagergren, Christina Manetopoulos, HÃ¥kan Axelson and Mikael Sigvardsson
    Citation: BMC Cancer 2004 4:80
    Content type: Research article Published on:

  46. G-protein inwardly rectifying potassium channel 1 (GIRK1) is thought to play a role in cell proliferation in cancer, and GIRK1 gene expression level may define a more aggressive phenotype. We detected GIRK1 ex...

    Authors: Iwao Takanami, Yoshimasa Inoue and Masatoshi Gika
    Citation: BMC Cancer 2004 4:79
    Content type: Research article Published on:

  47. Tumor-associated antigens recognized by humoral effectors of the immune system are a very attractive target for human cancer diagnostics and therapy. Recent advances in molecular techniques have led to molecul...

    Authors: Emiliano Pavoni, Paola Vaccaro, Andrea Pucci, Giorgia Monteriù, Elisa Beghetto, Stefano Barca, Maria Luisa Dupuis, Adolfo De Pasquale Ceratti, Antonio Lugini, Maurizio Cianfriglia, Enrico Cortesi, Franco Felici and Olga Minenkova
    Citation: BMC Cancer 2004 4:78
    Content type: Research article Published on:

  48. Several reports indicated that non-thermal electromagnetic radiation such as from mobile phones and base stations may promote cancer. Therefore, it was investigated experimentally, whether 900 MHz electromagne...

    Authors: Angela M Sommer, Joachim Streckert, Andreas K Bitz, Volkert W Hansen and Alexander Lerchl
    Citation: BMC Cancer 2004 4:77
    Content type: Research article Published on:

  50. Human monoclonal antibodies (MAbs) are needed for colon cancer radioimmunotherapy (RIT) to allow for repeated injections. Carcinoembryonic antigen (CEA) being the reference antigen for immunotargeting of these...

    Authors: Véronique Garambois, Fabienne Glaussel, Elodie Foulquier, Marc Ychou, Martine Pugnière, Robin X Luo, Binyam Bezabeh and André Pèlegrin
    Citation: BMC Cancer 2004 4:75
    Content type: Research article Published on:

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