LeBlanc HN, Ashkenazi A: Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ. 2003, 10: 66-75. 10.1038/sj.cdd.4401187.
Article
CAS
PubMed
Google Scholar
Almasan A, Ashkenazi A: Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. Cytokine Growth Factor Rev. 2003, 14: 337-348. 10.1016/S1359-6101(03)00029-7.
Article
CAS
PubMed
Google Scholar
Wajant H, Pfizenmaier K, Scheurich P: TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy. Apoptosis. 2002, 7: 449-459. 10.1023/A:1020039225764.
Article
CAS
PubMed
Google Scholar
Held J, Schulze-Osthoff K: Potential and caveats of TRAIL in cancer therapy. Drug Resist Updat. 2001, 4: 243-252. 10.1054/drup.2001.0208.
Article
CAS
PubMed
Google Scholar
Srivastava RK: TRAIL/Apo-2L: mechanisms and clinical applications in cancer. Neoplasia. 2001, 3: 535-546. 10.1038/sj.neo.7900203.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA, Blackie C, Chang L, McMurtrey AE, Hebert A, DeForge L, Koumenis IL, Lewis D, Harris L, Bussiere J, Koeppen H, Shahrokh Z, Schwall RH: Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest. 1999, 104: 155-162.
Article
CAS
PubMed
PubMed Central
Google Scholar
Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T, Smith C, Smolak P, Goodwin RG, Rauch CT, Schuh JC, Lynch DH: Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 1999, 5: 157-163. 10.1038/5517.
Article
CAS
PubMed
Google Scholar
Jo M, Kim TH, Seol DW, Esplen JE, Dorko K, Billiar TR, Strom SC: Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med. 2000, 6: 564-567. 10.1038/75045.
Article
CAS
PubMed
Google Scholar
Gores GJ, Kaufmann SH: Is TRAIL hepatotoxic?. Hepatology. 2001, 34: 3-6. 10.1053/jhep.2001.25173a.
Article
CAS
PubMed
Google Scholar
Lawrence D, Shahrokh Z, Marsters S, Achilles K, Shih D, Mounho B, Hillan K, Totpal K, DeForge L, Schow P, Hooley J, Sherwood S, Pai R, Leung S, Khan L, Gliniak B, Bussiere J, Smith CA, Strom SS, Kelley S, Fox JA, Thomas D, Ashkenazi A: Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat Med. 2001, 7: 383-385. 10.1038/86397.
Article
CAS
PubMed
Google Scholar
Tolcher AW, Mita M, Patnaik A, Rowinsky EK, Corey A, Fleming M, Fox NL, Weiner LM, Meropol NJ, Cohen R: A phase I and pharmacokinetic study of HGS-ETR1(TRM-1), a human monoclonal agonist-antibody to TRAIL R1, in patients with advanced solid tumors. ASCO Annual meeting: June, 6–8, 2004; New Orleans, USA. 2004
Google Scholar
Cretney E, Takeda K, Yagita H, Glaccum M, Peschon JJ, Smyth MJ: Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice. J Immunol. 2002, 168: 1356-1361.
Article
CAS
PubMed
Google Scholar
Takeda K, Smyth MJ, Cretney E, Hayakawa Y, Kayagaki N, Yagita H, Okumura K: Critical Role for Tumor Necrosis Factor-related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development. J Exp Med. 2002, 195: 161-169. 10.1084/jem.20011171.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM: The receptor for the cytotoxic ligand TRAIL. Science. 1997, 276: 111-113. 10.1126/science.276.5309.111.
Article
CAS
PubMed
Google Scholar
Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT: TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. Embo J. 1997, 16: 5386-5397. 10.1093/emboj/16.17.5386.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM: An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science. 1997, 277: 815-818. 10.1126/science.277.5327.815.
Article
CAS
PubMed
Google Scholar
MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES: Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem. 1997, 272: 25417-25420. 10.1074/jbc.272.41.25417.
Article
CAS
PubMed
Google Scholar
Screaton GR, Mongkolsapaya J, Xu XN, Cowper AE, McMichael AJ, Bell JI: TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. Curr Biol. 1997, 7: 693-696. 10.1016/S0960-9822(06)00297-1.
Article
CAS
PubMed
Google Scholar
Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, Ramakrishnan L, Gray CL, Baker K, Wood WI, Goddard AD, Godowski P, Ashkenazi A: Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science. 1997, 277: 818-821. 10.1126/science.277.5327.818.
Article
CAS
PubMed
Google Scholar
Degli-Esposti MA, Smolak PJ, Walczak H, Waugh J, Huang CP, DuBose RF, Goodwin RG, Smith CA: Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J Exp Med. 1997, 186: 1165-1170. 10.1084/jem.186.7.1165.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A: A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol. 1997, 7: 1003-1006. 10.1016/S0960-9822(06)00422-2.
Article
CAS
PubMed
Google Scholar
Pan G, Ni J, Yu G, Wei YF, Dixit VM: TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett. 1998, 424: 41-45. 10.1016/S0014-5793(98)00135-5.
Article
CAS
PubMed
Google Scholar
Degli-Esposti MA, Dougall WC, Smolak PJ, Waugh JY, Smith CA, Goodwin RG: The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity. 1997, 7: 813-820. 10.1016/S1074-7613(00)80399-4.
Article
CAS
PubMed
Google Scholar
Hu WH, Johnson H, Shu HB: Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. J Biol Chem. 1999, 274: 30603-30610. 10.1074/jbc.274.43.30603.
Article
CAS
PubMed
Google Scholar
Emery JG, McDonnell P, Burke MB, Deen KC, Lyn S, Silverman C, Dul E, Appelbaum ER, Eichman C, DiPrinzio R, Dodds RA, James IE, Rosenberg M, Lee JC, Young PR: Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem. 1998, 273: 14363-14367. 10.1074/jbc.273.23.14363.
Article
CAS
PubMed
Google Scholar
Truneh A, Sharma S, Silverman C, Khandekar S, Reddy MP, Deen KC, McLaughlin MM, Srinivasula SM, Livi GP, Marshall LA, Alnemri ES, Williams WV, Doyle ML: Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. J Biol Chem. 2000, 275: 23319-23325. 10.1074/jbc.M910438199.
Article
CAS
PubMed
Google Scholar
Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995, 81: 505-512. 10.1016/0092-8674(95)90071-3.
Article
CAS
PubMed
Google Scholar
Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death – inducing signaling complex. Cell. 1996, 85: 817-827. 10.1016/S0092-8674(00)81266-0.
Article
CAS
PubMed
Google Scholar
Stroh C, Schulze-Osthoff K: Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ. 1998, 5: 997-1000. 10.1038/sj.cdd.4400451.
Article
CAS
PubMed
Google Scholar
Bodmer JL, Holler N, Reynard S, Vinciguerra P, Schneider P, Juo P, Blenis J, Tschopp J: TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat Cell Biol. 2000, 2: 241-243. 10.1038/35008667.
Article
CAS
PubMed
Google Scholar
Belka C, Schmid B, Marini P, Durand E, Rudner J, Faltin H, Bamberg M, Schulze-Osthoff K, Budach W: Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL. Oncogene. 2001, 20: 2190-2196. 10.1038/sj.onc.1204318.
Article
CAS
PubMed
Google Scholar
Kischkel FC, Lawrence DA, Tinel A, LeBlanc H, Virmani A, Schow P, Gazdar A, Blenis J, Arnott D, Ashkenazi A: Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J Biol Chem. 2001, 276: 46639-46646. 10.1074/jbc.M105102200.
Article
CAS
PubMed
Google Scholar
Marini P, Jendrossek V, Durand E, Gruber C, Budach W, Belka C: Molecular requirements for the combined effects of TRAIL and ionising radiation. Radiother Oncol. 2003, 68: 189-198. 10.1016/S0167-8140(03)00186-5.
Article
CAS
PubMed
Google Scholar
Norbury CJ, Zhivotovsky B: DNA damage-induced apoptosis. Oncogene. 2004, 23: 2797-2808. 10.1038/sj.onc.1207532.
Article
CAS
PubMed
Google Scholar
Debatin KM, Poncet D, Kroemer G: Chemotherapy: targeting the mitochondrial cell death pathway. Oncogene. 2002, 21: 8786-8803. 10.1038/sj.onc.1206039.
Article
CAS
PubMed
Google Scholar
Daniel PT, Schulze-Osthoff K, Belka C, Guner D: Guardians of cell death: the Bcl-2 family proteins. Essays Biochem. 2003, 39: 73-88.
Article
CAS
PubMed
Google Scholar
Lowe SW, Ruley HE, Jacks T, Housman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 1993, 74: 957-967. 10.1016/0092-8674(93)90719-7.
Article
CAS
PubMed
Google Scholar
Hymowitz SG, O'Connell MP, Ultsch MH, Hurst A, Totpal K, Ashkenazi A, de Vos AM, Kelley RF: A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL. Biochemistry. 2000, 39: 633-640. 10.1021/bi992242l.
Article
CAS
PubMed
Google Scholar
Cecconi F: Apaf1 and the apoptotic machinery. Cell Death Differ. 1999, 6: 1087-1098. 10.1038/sj.cdd.4400602.
Article
CAS
PubMed
Google Scholar
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997, 91: 479-489. 10.1016/S0092-8674(00)80434-1.
Article
CAS
PubMed
Google Scholar
Jendrossek V, Handrick R, Belka C: Celecoxib activates a novel mitochondrial apoptosis signaling pathway. Faseb J. 2003, 17: 1547-1549.
CAS
PubMed
Google Scholar
Shimizu S, Konishi A, Kodama T, Tsujimoto Y: BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci U S A. 2000, 97: 3100-3105. 10.1073/pnas.97.7.3100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Minn AJ, Kettlun CS, Liang H, Kelekar A, Vander Heiden MG, Chang BS, Fesik SW, Fill M, Thompson CB: Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms. Embo J. 1999, 18: 632-643. 10.1093/emboj/18.3.632.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vander Heiden MG, Chandel NS, Schumacker PT, Thompson CB: Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol Cell. 1999, 3: 159-167. 10.1016/S1097-2765(00)80307-X.
Article
CAS
PubMed
Google Scholar
Luo X, Budihardjo I, Zou H, Slaughter C, Wang X: Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 1998, 94: 481-490. 10.1016/S0092-8674(00)81589-5.
Article
CAS
PubMed
Google Scholar
Li H, Zhu H, Xu CJ, Yuan J: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998, 94: 491-501. 10.1016/S0092-8674(00)81590-1.
Article
CAS
PubMed
Google Scholar
Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R, Wajant H, Janicke RU, Porter AG, Belka C, Gregor M, Schulze-Osthoff K, Wesselborg S: Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene. 2000, 19: 4563-4573. 10.1038/sj.onc.1203824.
Article
CAS
PubMed
Google Scholar
Wieder T, Essmann F, Prokop A, Schmelz K, Schulze-Osthoff K, Beyaert R, Dorken B, Daniel PT: Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3. Blood. 2001, 97: 1378-1387. 10.1182/blood.V97.5.1378.
Article
CAS
PubMed
Google Scholar
Belka C, Rudner J, Wesselborg S, Stepczynska A, Marini P, Lepple-Wienhues A, Faltin H, Bamberg M, Budach W, Schulze-Osthoff K: Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis. Oncogene. 2000, 19: 1181-1190. 10.1038/sj.onc.1203401.
Article
CAS
PubMed
Google Scholar
Cuello M, Ettenberg SA, Nau MM, Lipkowitz S: Synergistic induction of apoptosis by the combination of trail and chemotherapy in chemoresistant ovarian cancer cells. Gynecol Oncol. 2001, 81: 380-390. 10.1006/gyno.2001.6194.
Article
CAS
PubMed
Google Scholar
Nimmanapalli R, Perkins CL, Orlando M, O'Bryan E, Nguyen D, Bhalla KN: Pretreatment with paclitaxel enhances apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels. Cancer Res. 2001, 61: 759-763.
CAS
PubMed
Google Scholar
Munshi A, McDonnell TJ, Meyn RE: Chemotherapeutic agents enhance TRAIL-induced apoptosis in prostate cancer cells. Cancer Chemother Pharmacol. 2002, 50: 46-52. 10.1007/s00280-002-0465-z.
Article
CAS
PubMed
Google Scholar
Nagane M, Pan G, Weddle JJ, Dixit VM, Cavenee WK, Huang HJ: Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. Cancer Res. 2000, 60: 847-853.
CAS
PubMed
Google Scholar
Singh TR, Shankar S, Chen X, Asim M, Srivastava RK: Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo. Cancer Res. 2003, 63: 5390-5400.
CAS
PubMed
Google Scholar
Ballestrero A, Nencioni A, Boy D, Rocco I, Garuti A, Mela GS, Van Parijs L, Brossart P, Wesselborg S, Patrone F: Tumor necrosis factor-related apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells. Clin Cancer Res. 2004, 10: 1463-1470.
Article
CAS
PubMed
Google Scholar
Jazirehi AR, Ng CP, Gan XH, Schiller G, Bonavida B: Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis. Clin Cancer Res. 2001, 7: 3874-3883.
CAS
PubMed
Google Scholar
Evdokiou A, Bouralexis S, Atkins GJ, Chai F, Hay S, Clayer M, Findlay DM: Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. Int J Cancer. 2002, 99: 491-504. 10.1002/ijc.10376.
Article
CAS
PubMed
Google Scholar
Mitsiades N, Mitsiades CS, Poulaki V, Anderson KC, Treon SP: Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells. Blood. 2002, 99: 2162-2171. 10.1182/blood.V99.6.2162.
Article
CAS
PubMed
Google Scholar
Sun SY, Yue P, Hong WK, Lotan R: Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung cancer cells. Cancer Res. 2000, 60: 7149-7155.
CAS
PubMed
Google Scholar
Chinnaiyan AM, Prasad U, Shankar S, Hamstra DA, Shanaiah M, Chenevert TL, Ross BD, Rehemtulla A: Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc Natl Acad Sci U S A. 2000, 97: 1754-1759. 10.1073/pnas.030545097.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ramp U, Caliskan E, Mahotka C, Krieg A, Heikaus S, Gabbert HE, Gerharz CD: Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage. Br J Cancer. 2003, 88: 1800-1807. 10.1038/sj.bjc.6600984.
Article
CAS
PubMed
PubMed Central
Google Scholar
Di Pietro R, Secchiero P, Rana R, Gibellini D, Visani G, Bemis K, Zamai L, Miscia S, Zauli G: Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) – mediated cytotoxicity by selective up-regulation of TRAIL-R1. Blood. 2001, 97: 2596-2603. 10.1182/blood.V97.9.2596.
Article
CAS
PubMed
Google Scholar
Berenbaum MC: A method for testing for synergy with any number of agents. J Infect Dis. 1978, 137: 122-130.
Article
CAS
PubMed
Google Scholar
Sheikh MS, Burns TF, Huang Y, Wu GS, Amundson S, Brooks KS, Fornace AJ, el-Deiry WS: p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha. Cancer Res. 1998, 58: 1593-1598.
CAS
PubMed
Google Scholar
Ravi R, Bedi GC, Engstrom LW, Zeng Q, Mookerjee B, Gelinas C, Fuchs EJ, Bedi A: Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB. Nat Cell Biol. 2001, 3: 409-416. 10.1038/35070096.
Article
CAS
PubMed
Google Scholar
Rudner J, Jendrossek V, Lauber K, Daniel PT, Wesselborg S, Belka C: Type I and type II reactions in TRAIL-induced apoptosis – results from dose-response studies. Oncogene. 2004
Google Scholar
von Haefen C, Gillissen B, Hemmati PG, Wendt J, Güner D, Mrozek A, Belka C, Dörken B, Daniel PT: Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway. Oncogene. 2004, 23: 8320-8332. 10.1038/sj.onc.1207971.
Article
CAS
PubMed
Google Scholar
Shankar S, Chen X, Srivastava RK: Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo. Prostate. 2004
Google Scholar
Shankar S, Singh TR, Srivastava RK.: Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: Intracellular mechanisms. Prostate. 2004, 61: 35-49. 10.1002/pros.20069.
Article
CAS
PubMed
Google Scholar
Shankar S, Singh TR, Chen X, Thakkar H, Firnin J, Srivastava RK: The sequential treatment with ionizing radiation followed by TRAIL/Apo-2L reduces tumor growth and induces apoptosis of breast tumor xenografts in nude mice. Int J Oncol. 2004, 24: 1133-1140.
CAS
PubMed
Google Scholar
Chen X, Kandasamy K, Srivastava RK: Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappa B in tumor necrosis factor-related apoptosis-inducing ligand signalling. Cancer Res. 2003, 63: 1059-1066.
CAS
PubMed
Google Scholar