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  1. Numerous studies have demonstrated that the high-order features (HOFs) of blood test data can be used to predict the prognosis of patients with different types of cancer. Although the majority of blood HOFs ca...

    Authors: Liping Luo, Yubo Tan, Shixuan Zhao, Man Yang, Yurou Che, Kezhen Li, Jieke Liu, Huaichao Luo, Wenjun Jiang, Yongjie Li and Weidong Wang
    Citation: BMC Cancer 2023 23:496
    Content type: Research Published on:

  3. Metabolic reprogramming is one of hallmarks of cancer progression and is of great importance for the tumor microenvironment (TME). As an abundant metabolite, lactate has been found to play a critical role in c...

    Authors: Rui Shi, Haojia Li, Sitian Wei, Zhicheng Yu, Jun Zhang, Qi Zhang, Ting Zhou, Yuwei Yao, Qian Zhang, Tangansu Zhang and Hongbo Wang
    Citation: BMC Cancer 2023 23:491
    Content type: Research Published on:

  4. Thrombocytopenia is a common complication in cancer patients undergoing chemotherapy. Chemotherapy-induced thrombocytopenia (CIT) leads to dose reduction and treatment delays, lowering chemotherapy efficacy an...

    Authors: Jiwon Shin, Min-Jung Kim, Xingguo Quan, Ji Woong Kim, Sukmook Lee, SaeGwang Park, Jee-Yeong Jeong and Kyungmoo Yea
    Citation: BMC Cancer 2023 23:490
    Content type: Research Published on:

  6. Single-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages at a single-cell level. Classification of bulk tumors by their indivi...

    Authors: Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Robert W. Porter, Sandhya Krishnan, Jyothishmathi Swaminathan, Amber Gibson, Alexander J. Lazar, J. Andrew Livingston, Vidya Gopalakrishnan, Nancy Gordon, Najat C. Daw, Nicholas E. Navin, Richard Gorlick and Joseph A. Ludwig
    Citation: BMC Cancer 2023 23:488
    Content type: Research article Published on:

  7. Organoids are a three-dimensional (3D) culture system that simulate actual organs. Therefore, tumor organoids are expected to predict precise response to chemotherapy in patients. However, to date, few studies...

    Authors: Fumiya Ito, Katsuhiro Kato, Izumi Yanatori, Yuki Maeda, Toyoaki Murohara and Shinya Toyokuni
    Citation: BMC Cancer 2023 23:487
    Content type: Research Published on:

  8. Thermal therapy induces an immune response in patients with hepatocellular carcinoma (HCC), but the dynamic characteristics of the natural killer (NK) cell immune response post-thermal ablation remain unclear....

    Authors: Hai-Yan Wang, Xiong-Wei Cui, Yong-Hong Zhang, Yu Chen, Ning-Ning Lu, Li Bai and Zhong-Ping Duan
    Citation: BMC Cancer 2023 23:486
    Content type: Research Published on:

  9. Most traditional procedures can destroy tissue natural structure, and the information on spatial distribution and temporal distribution of immune milieu in situ would be lost. We aimed to explore the potential...

    Authors: Jiangchun Wu, Qinhao Guo, Jun Zhu, Yong Wu, Simin Wang, Siyuan Liang, Xingzhu Ju and Xiaohua Wu
    Citation: BMC Cancer 2023 23:485
    Content type: Research Published on:

  10. Altered cellular metabolism has long been recognized as a hallmark of cancer. Oncogenic signaling cascades induce metabolic rewiring that further supports tumorigenesis, therapy resistance and metastasis. In v...

    Authors: Marija Trajkovic-Arsic and Elavarasan Subramani
    Citation: BMC Cancer 2023 23:484
    Content type: Editorial Published on:

  11. The authors intend to compare the effects of each targeted therapy (TT) in the treatment of patients with metastatic renal cell carcinoma (mRCC) using big data based on the Korean National Health Insurance Sys...

    Authors: Dong Hyuk Kang, Joo Yong Lee, Yunhee Lee and U-Syn Ha
    Citation: BMC Cancer 2023 23:483
    Content type: Research Published on:

  12. We aimed to examine whether patients with de novo and relapsed/progressed stage IIIB–IV non-small cell lung cancer (NSCLC) without epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) mutat...

    Authors: Byeong-Chan Oh, Ae-Ryeo Cho, Jin Hyun Nam, So-Young Yang, Min Ji Kim, Sun-Hong Kwon and Eui-Kyung Lee
    Citation: BMC Cancer 2023 23:482
    Content type: Research Published on:

  13. This study aims to evaluate the clinical efficacy and side effects of setting up a high-risk clinical target volume (CTV-hr) alongside simultaneous integrated boost intensity-modulated radiotherapy (IMRT-SIB) ...

    Authors: Yuqi Jiang, Jing Wang, Peng Jiang, Xiang Wang, Lei Zhang and Yongchun Zhang
    Citation: BMC Cancer 2023 23:481
    Content type: Research Published on:

  14. The role of ATF2 in colon cancer (CC) is controversial. Recently, we reported that low ATF2 expression is characteristic of highly invasive tumors, suggesting that ATF2 might also be involved in therapy resist...

    Authors: Hao Yang, Kerstin Huebner, Chuanpit Hampel, Katharina Erlenbach-Wuensch, Selva Babu Selvamani, Vikas Shukla, Carol I. Geppert, Arndt Hartmann, Vijayalakshmi Mahadevan and Regine Schneider-Stock
    Citation: BMC Cancer 2023 23:480
    Content type: Research Published on:

  15. B-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which possess four conserved Bcl-2 homologies (BH) domains. Among the BH domains, the BH3 domain is considered as a potent ‘death doma...

    Authors: Yihua Lin, Yiling Zhao, Minggui Chen, Zishuo Li, Qiao Liu, Jian Chen, Yi Ding, Chunyong Ding, Ye Ding, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Jia Zhou, Lijing Wang and Qian-Qian Zhang
    Citation: BMC Cancer 2023 23:479
    Content type: Research Published on:

  16. ADP-ribosylation factor-like protein 4 C (ARL4C) is a member of the ARF small GTP-binding protein subfamily. The ARL4C gene is highly expressed in colorectal cancer (CRC). ARL4C protein promotes cell motility, in...

    Authors: Ryo Kanai, Takeshi Uehara, Takahiro Yoshizawa, Masato Kamakura, Tomoyuki Nakajima, Yasuhiro Kinugawa, Mai Iwaya, Shiho Asaka, Masato Kitazawa, Tadanobu Nagaya and Hiroyoshi Ota
    Citation: BMC Cancer 2023 23:478
    Content type: Research Published on:

  17. To investigate the value of CT radiomics features of meso-esophageal fat in the overall survival (OS) prediction of patients with locally advanced esophageal squamous cell carcinoma (ESCC).

    Authors: Shuo Yan, Fei-Ping Li, Lian Jian, Hai-Tao Zhu, Bo Zhao, Xiao-Ting Li, Yan-Jie Shi and Ying-Shi Sun
    Citation: BMC Cancer 2023 23:477
    Content type: Research Published on:

  19. Circulating tumor cells (CTCs) are important biological indicators of the lung cancer prognosis, and CTC counting and typing may provide helpful biological information for the diagnosis and treatment of lung c...

    Authors: Ying Xu, Xue Ren, Tong Jiang, Shuang Lv, Kuanke Gao, Yunen Liu and Ying Yan
    Citation: BMC Cancer 2023 23:475
    Content type: Research Published on:

  20. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death, worldwide. The predominant causative factor for HCC is hepatitis B virus (HBV) infection. We conducted a meta-analysis to esti...

    Authors: Danxue Huang, Liyuan Ke, Hongxia Cui and Su Li
    Citation: BMC Cancer 2023 23:474
    Content type: Research Published on:

  21. The contributive role of the microbiome in tumor progression has been reported in multiple studies, such as the Fusobacterium nucleatum (F. nucleatum) in breast cancer (BC). This study aimed to explore the role o...

    Authors: Guiqiu Li, Yan Sun, Yu Huang, Jie Lian, Shaoyuan Wu, Dixian Luo and Hui Gong
    Citation: BMC Cancer 2023 23:473
    Content type: Research Published on:

  22. Cervical cancer is the fourth most frequently diagnosed and found to be the leading cause of cancer death in women, especially in low and middle-income countries. Even though cervical cancer is a preventable d...

    Authors: Alemayehu Sayih Belay, Wondwossen Niguse Asmare and Aychew Kassie
    Citation: BMC Cancer 2023 23:472
    Content type: Research Published on:

  23. Aprepitant, as a neurokinin-1 receptor (NK-1R) antagonist, originally applied for curing chemotherapy-induced nausea and vomiting, has been reported to have significant antitumor effect on several malignant tu...

    Authors: Xueyan Cao, Yang Yang, Wei Zhou, Yue Wang, Xue Wang, Xianxiu Ge, Fei Wang, Fangfang Zhou, Xueting Deng and Lin Miao
    Citation: BMC Cancer 2023 23:471
    Content type: Research Published on:

  24. The prognosis of patients with advanced biliary tract cancer (BTC) who have progressed on gemcitabine plus cisplatin is dismal. Trifluridine/tipiracil (FTD/TPI) and irinotecan have proven efficacy in different...

    Authors: Linde Kehmann, Marie-Luise Berres, Maria Gonzalez-Carmona, Dominik P. Modest, Raphael Mohr, Alexander Wree, Marino Venerito, Christian Strassburg, Verena Keitel, Christian Trautwein, Tom Luedde and Christoph Roderburg
    Citation: BMC Cancer 2023 23:470
    Content type: Study protocol Published on:

  25. Delay in the diagnosis of childhood cancer is one of the major health problem that contribute to decreased survival rates of children particularly in developing nations. Despite advances in the field of pediat...

    Authors: Yimenu Gardie, Mulugeta Wassie, Seid Wodajo, Mastewal Giza, Mulugeta Ayalew, Yihenew Sewale, Zelalem Feleke and Melkamu Tilahun Dessie
    Citation: BMC Cancer 2023 23:469
    Content type: Research Published on:

  26. Breast cancer brain metastasis (BCBM) is a growing therapeutic challenge and clinical concern. Stromal cancer-associated fibroblasts (CAFs) are crucial factors in the modulation of tumorigeneses and metastases...

    Authors: Md Rashedunnabi Akanda, Eun-Jung Ahn, Yeong Jin Kim, S M Abdus Salam, Myung-Giun Noh, Tae-Kyu Lee, Sung Sun Kim, Kyung-Hwa Lee and Kyung-Sub Moon
    Citation: BMC Cancer 2023 23:468
    Content type: Research Published on:

  27. Neoadjuvant chemoradiotherapy (NCRT) and total mesorectal excision are standard treatment regimen for patients with locally advanced rectal cancer (LARC). This sphincter-saving treatment strategy may be accomp...

    Authors: Jie Shi, Yi-Kan Cheng, Fang He, Jian Zheng, Yun-Long Wang, Xiang-Bo Wan, Hong-Cheng Lin and Xin-Juan Fan
    Citation: BMC Cancer 2023 23:467
    Content type: Study Protocol Published on:

  28. This study presents the trends of age-standardised incidence and mortality rates of common cancers in Brunei Darussalam from 2011 to 2020. All cancer cases diagnosed among Brunei Darussalam citizens and perman...

    Authors: Elvynna Leong, Sok King Ong, Khairil Azhar Si-Ramlee and Lin Naing
    Citation: BMC Cancer 2023 23:466
    Content type: Research Published on:

  29. To understand the proportion of uHCC (unresectable hepatocellular carcinoma) patients who achieve successful conversion resection in a high-volume setting with state of the art treatment options.

    Authors: Bo Zhang, Xuetao Shi, Kai Cui, Zhongchao Li, Lei Li, Zhaogang Liu, Chengsheng Zhang, Pengfei Sun, Jingtao Zhong, Zhicheng Sun, Zhibin Chang, Zhao Ma, Alex Gordon-Weeks, Mingming Li and Lei Zhao
    Citation: BMC Cancer 2023 23:465
    Content type: Research Published on:

  31. Treatment options for pretreated triple-negative breast cancer (TNBC) are limited. This study aimed to evaluate the efficacy and safety of apatinib, an antiangiogenic agent, in combination of etoposide for pre...

    Authors: Mengru Cao, Hailing Lu, Shi Yan, Hui Pang, Lichun Sun, Chunhong Li, Xuesong Chen, Wei Liu, Jing Hu, Jian Huang, Ying Xing, Ningzhi Zhang, Yingqi Chen, Ting He, Danni Zhao, Yuanyuan Sun…
    Citation: BMC Cancer 2023 23:463
    Content type: Research Published on:

  34. Double reading (DR) in screening mammography increases cancer detection and lowers recall rates, but has sustainability challenges due to workforce shortages. Artificial intelligence (AI) as an independent rea...

    Authors: Nisha Sharma, Annie Y. Ng, Jonathan J. James, Galvin Khara, Éva Ambrózay, Christopher C. Austin, Gábor Forrai, Georgia Fox, Ben Glocker, Andreas Heindl, Edit Karpati, Tobias M. Rijken, Vignesh Venkataraman, Joseph E. Yearsley and Peter D. Kecskemethy
    Citation: BMC Cancer 2023 23:460
    Content type: Research Published on:

  35. Triple negative BCa (TNBC) is defined by a lack of expression of estrogen (ERα), progesterone (PgR) receptors and human epidermal growth factor receptor 2 (HER2) as assessed by protein expression and/or gene a...

    Authors: Elena A. Takano, Melissa M. Younes, Katie Meehan, Lisa Spalding, Max Yan, Prue Allan, Stephen B. Fox, Andy Redfern, David Clouston, Graham G. Giles, Elizabeth L. Christie, Robin L. Anderson, Magnus Zethoven, Kelly-Anne Phillips, Kylie Gorringe and Kara L. Britt
    Citation: BMC Cancer 2023 23:459
    Content type: Research Published on:

  36. Pembrolizumab has become an integral first line therapeutic agent for non-small cell lung cancer (NSCLC), but its potential predictive role in clinical and molecular characteristics remains to be clarified. Ac...

    Authors: Wenjie Liu, Gengwei Huo and Peng Chen
    Citation: BMC Cancer 2023 23:458
    Content type: Research Published on:

  37. Smoking, alcohol consumption, and human papillomavirus (HPV) infection are known risk factors for oral squamous cell carcinoma (OSCC) including SCC of oropharynx (SCCOP) and SCC of oral cavity (SCCOC). Researc...

    Authors: Zheng Yang, Peng Sun, Kristina R. Dahlstrom, Neil Gross and Guojun Li
    Citation: BMC Cancer 2023 23:457
    Content type: Research Published on:

  38. To evaluate the feasibility and quality of biliary-enteric reconstruction (BER) in laparoscopic radical resection of hilar cholangiocarcinoma (LsRRH) versus open surgery and propose technical recommendations.

    Authors: Wenzheng Liu, Fei Xiong, Guanhua Wu, Qi Wang, Bing Wang and Yongjun Chen
    Citation: BMC Cancer 2023 23:456
    Content type: Research Published on:

  39. PVT1, a previously uncharacterized lncRNA, was identified as a critical regulator involved in multiple functions in tumor, including cell proliferation, cell motility, angiogenesis and so on. However, the clin...

    Authors: Yusheng Chen, Fengjin Ma, Zhe Zhang, Yang Guo, Hanwei Shen and Hang Chen
    Citation: BMC Cancer 2023 23:455
    Content type: Research Published on:

  40. Histone lysine demethylases (KDMs) have been reported in various malignances, which affect transcriptional regulation of tumor suppressor or oncogenes. However, the relationship between KDMs and formation of tumo...

    Authors: Haichao Zhang, Haoran Wang, Li Ye, Suyun Bao, Ruijia Zhang, Ji Che, Wenqin Luo, Cheng Yu and Wei Wang
    Citation: BMC Cancer 2023 23:454
    Content type: Research Published on:

  41. The cancer burden is a global public health concern associated with high morbidities and mortalities. Low and middle-income countries are more affected including South Africa. Limited access to oncology servic...

    Authors: Lumkile Wilmot Jojo and Nonyaniso Trustina Nkutu
    Citation: BMC Cancer 2023 23:453
    Content type: Research Published on:

  42. Tumour perineural invasion (PNI) is a predictor of poor prognosis, but its effect on the prognosis of patients with colorectal cancer (CRC) has not yet been elucidated.

    Authors: Le Qin, Yixin Heng, Shenghe Deng, Junnan Gu, Fuwei Mao, Yifan Xue, Zhenxing Jiang, Jun Wang, Denglong Cheng, Ke Wu, Yinghao Cao and Kailin Cai
    Citation: BMC Cancer 2023 23:452
    Content type: Research Published on:

  43. Selenium metabolism has been implicated in human health. This study aimed to identify a selenium metabolism regulator-based prognostic signature for hepatocellular carcinoma (HCC) and validate the role of INMT...

    Authors: Huishan Sun, Junyu Long, Bangyou Zuo, Yiran Li, Yu Song, Minghang Yu, Ziyu Xun, Yanyu Wang, Xi Wang, Xinting Sang and Haitao Zhao
    Citation: BMC Cancer 2023 23:451
    Content type: Research Published on:

  44. Total neoadjuvant therapy (TNT) is a novel treatment strategy that is an alternative to preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). However, an optimal protocol for TNT has ...

    Authors: Shinya Abe, Kazushige Kawai, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Hiroyuki Matsuzaki, Yuzo Nagai, Yuichiro Yoshioka, Takahide Shinagawa, Hirofumi Sonoda, Yoko Yamamoto, Koji Oba and Soichiro Ishihara
    Citation: BMC Cancer 2023 23:450
    Content type: Study Protocol Published on:

  45. Up to 70% of breast cancer patients report symptoms of insomnia during and after treatment. Despite the ubiquity of insomnia symptoms, they are under-screened, under-diagnosed and poorly managed in breast canc...

    Authors: Chloé Drozd, Elsa Curtit, Quentin Jacquinot, Charlène Marquine, Laura Mansi, Loïc Chaigneau, Erion Dobi, Julien Viot, Guillaume Meynard, Marie-Justine Paillard, Morgan Goujon, Pauline Roux, Dewi Vernerey, Valérie Gillet, Hubert Bourdin, Silvio Galli…
    Citation: BMC Cancer 2023 23:449
    Content type: Study Protocol Published on:

  46. Suboptimal treatment upon progression may affect overall survival (OS) results in oncology randomized controlled trials (RCTs). We aim to assess the proportion of trials reporting post-progression treatment.

    Authors: Timothée Olivier, Alyson Haslam and Vinay Prasad
    Citation: BMC Cancer 2023 23:448
    Content type: Research Published on:

  47. Leukemic cell metabolism plays significant roles in their proliferation and survival. These metabolic adaptations are under regulation by different factors. Programmed Death Ligand -1 (CD-274) is one of the im...

    Authors: Mojdeh Soltani, Mustafa Ghanadian, Behrooz Ghezelbash, Abolfazl Shokouhi, Andrey A. Zamyatnin Jr, Alexandr V. Bazhin and Mazdak Ganjalikhani-Hakemi
    Citation: BMC Cancer 2023 23:447
    Content type: Research article Published on:

  48. Upfront high-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) remains a profitable strategy for newly diagnosed multiple myeloma (MM) patients in the context of novel agents. However,...

    Authors: Chi-Maw Lin, Lih-Chyun Chang, Wen-Yi Shau, Chi-Ling Chen, Chi-Yuan Yao and Feng-Ming Tien
    Citation: BMC Cancer 2023 23:446
    Content type: Research Published on:

  50. Cholangiocarcinoma (CHOL) is the second most common primary hepatic malignant tumor, following hepatocellular carcinoma (HCC). CHOL is highly aggressive and heterogeneous resulting in poor prognosis. The diagn...

    Authors: Shuochen Liu, Shilong Fan, Yirui Wang, Ruixiang Chen, Ziyi Wang, Yaodong Zhang, Wangjie Jiang, Yananlan Chen, Xiao Xu, Yue Yu, Changxian Li and Xiangcheng Li
    Citation: BMC Cancer 2023 23:444
    Content type: Research Published on:

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