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  1. Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, l...

    Authors: Linda E Kelemen, Elisa V Bandera, Kathryn L Terry, Mary Anne Rossing, Louise A Brinton, Jennifer A Doherty, Roberta B Ness, Susanne Krüger Kjær, Jenny Chang-Claude, Martin Köbel, Galina Lurie, Pamela J Thompson, Michael E Carney, Kirsten Moysich, Robert Edwards, Clare Bunker…
    Citation: BMC Cancer 2013 13:28
    Content type: Research article Published on:

  2. As dose-escalation in prostate cancer radiotherapy improves cure rates, a major concern is rectal toxicity. We prospectively assessed an innovative approach of hydrogel injection between prostate and rectum to...

    Authors: Franziska Eckert, Saladin Alloussi, Frank Paulsen, Michael Bamberg, Daniel Zips, Patrick Spillner, Cihan Gani, Ulrich Kramer, Daniela Thorwarth, David Schilling and Arndt-Christian Müller
    Citation: BMC Cancer 2013 13:27
    Content type: Research article Published on:

  3. Human papillomavirus (HPV)-related head and neck cancer has been associated with an improved prognosis in patients treated with radiotherapy (RT) +/− chemotherapy (CT); however, RT combined with epidermal grow...

    Authors: Bella Pajares, Jose M Trigo, Maria D Toledo, Martina Álvarez, Carlos González-Hermoso, Antonio Rueda, Jose A Medina, Vanessa de Luque, Jose M Jerez and Emilio Alba
    Citation: BMC Cancer 2013 13:26
    Content type: Research article Published on:

  4. Choriocarcinoma is a gestational trophoblastic tumor which causes high mortality if left untreated. MicroRNAs (miRNAs) are small non protein-coding RNAs which inhibit target gene expression. The role of miRNAs...

    Authors: Ronald TK Pang, Carmen ON Leung, Cheuk-Lun Lee, Kevin KW Lam, Tian-Min Ye, Philip CN Chiu and William SB Yeung
    Citation: BMC Cancer 2013 13:25
    Content type: Research article Published on:

  5. The expression of a specific set of genes controls the different structures of heparan sulfate proteoglycans (HSPGs), which are involved in the growth, invasion and metastatic properties of cancerous cells. Th...

    Authors: Iván Fernández-Vega, Olivia García, Ainara Crespo, Sonia Castañón, Primitiva Menéndez, Aurora Astudillo and Luis M Quirós
    Citation: BMC Cancer 2013 13:24
    Content type: Research article Published on:

  6. There is scant data regarding disease presentation and treatment response among black men living in Africa. In this study we evaluate disease presentation and early clinical outcomes among Ghanaian men with pr...

    Authors: Kosj Yamoah, Kwamena Beecham, Sarah E Hegarty, Terry Hyslop, Timothy Showalter and Joel Yarney
    Citation: BMC Cancer 2013 13:23
    Content type: Research article Published on:

  7. Malignant pleural mesothelioma is an aggressive tumor that has a poor prognosis and is resistant to unimodal approaches. Multimodal treatment has provided encouraging results.

    Authors: Rea Federico, Favaretto Adolfo, Marulli Giuseppe, Spaggiari Lorenzo, DePas Tommaso Martino, Ceribelli Anna, Paccagnella Adriano, Crivellari Gino, Russo Francesca, Ceccarelli Matteo, Kazeem Gbenga, Marchi Paolo and Facciolo Francesco
    Citation: BMC Cancer 2013 13:22
    Content type: Research article Published on:

  8. MiR-221 is over-expressed in human hepatocellular carcinoma (HCC), but its clinical significance and function in HCC remains uncertain. The aim of the study was to investigate the relationship between miR-221 ...

    Authors: Minhua Rong, Gang Chen and Yiwu Dang
    Citation: BMC Cancer 2013 13:21
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:221

  9. Humanized KS-interleukin-2 (huKS-IL2), an immunocytokine with specificity for epithelial cell adhesion molecule (EpCAM), has demonstrated favorable tolerability and immunologic activity as a single agent.

    Authors: Joseph P Connor, Mihaela C Cristea, Nancy L Lewis, Lionel D Lewis, Philip B Komarnitsky, Maria R Mattiacci, Mildred Felder, Sarah Stewart, Josephine Harter, Jean Henslee-Downey, Daniel Kramer, Roland Neugebauer and Roger Stupp
    Citation: BMC Cancer 2013 13:20
    Content type: Research article Published on:

  10. MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few ...

    Authors: Ting-Yan Shi, Xiao-Jun Chen, Mei-Ling Zhu, Meng-Yun Wang, Jing He, Ke-Da Yu, Zhi-Ming Shao, Meng-Hong Sun, Xiao-Yan Zhou, Xi Cheng, Xiaohua Wu and Qingyi Wei
    Citation: BMC Cancer 2013 13:19
    Content type: Research article Published on:

  11. Despite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia...

    Authors: Jovan Mihajlović, Petros Pechlivanoglou, Marica Miladinov-Mikov, Snežana Živković and Maarten J Postma
    Citation: BMC Cancer 2013 13:18
    Content type: Research article Published on:

  12. Conventional therapeutic agents are largely unsatisfactory into the treatment of malignant melanoma. Recently, an innovative approach based on inhibitors of the mutated BRAF gene (which represents the most pre...

    Authors: Giusy Gentilcore, Gabriele Madonna, Nicola Mozzillo, Antoni Ribas, Antonio Cossu, Giuseppe Palmieri and Paolo A Ascierto
    Citation: BMC Cancer 2013 13:17
    Content type: Correspondence Published on:

  13. Interleukin (IL)-11, a cytokine produced by breast cancer, has been implicated in breast cancer-induced osteolysis (bone destruction) but the mechanism(s) of action remain controversial. Some studies show that...

    Authors: Erin M McCoy, Huixian Hong, Hawley C Pruitt and Xu Feng
    Citation: BMC Cancer 2013 13:16
    Content type: Research article Published on:

  14. Stage shift is widely considered a major determinant of the survival benefit conferred by breast cancer screening. However, factors and mechanisms underlying such a prognostic advantage need further clarificat...

    Authors: Anna Crispo, Maddalena Barba, Giuseppe D’Aiuto, Michelino De Laurentiis, Maria Grimaldi, Massimo Rinaldo, Giuseppina Caolo, Massimiliano D’Aiuto, Immacolata Capasso, Emanuela Esposito, Alfonso Amore, Maurizio Di Bonito, Gerardo Botti and Maurizio Montella
    Citation: BMC Cancer 2013 13:15
    Content type: Research article Published on:

  15. One of the molecules regulated by the transcription factor, hypoxia inducible factor (HIF), is the hypoxia-responsive hematopoietic factor, erythropoietin (EPO). This may have relevance to the development of r...

    Authors: Christudas Morais, David W Johnson, David A Vesey and Glenda C Gobe
    Citation: BMC Cancer 2013 13:14
    Content type: Review Published on:

  16. The aim of this study was to determine the proportions and predictors of first-degree relatives (FDRs) of colorectal cancer (CRC) patients (i) ever receiving any CRC testing and (ii) receiving CRC screening in...

    Authors: Ryan J Courtney, Christine L Paul, Mariko L Carey, Robert W Sanson-Fisher, Finlay A Macrae, Catherine D’Este, David Hill, Daniel Barker and Jody Simmons
    Citation: BMC Cancer 2013 13:13
    Content type: Research article Published on:

  17. The APC tumor suppressor is mutated or downregulated in many tumor types, and is prominently localized to punctate clusters at protrusion tips in migratory cells, such as in astrocytes where it has been implic...

    Authors: Matthew A Odenwald, Jenifer R Prosperi and Kathleen H Goss
    Citation: BMC Cancer 2013 13:12
    Content type: Research article Published on:

  18. Myelosuppressive chemotherapy can lead to dose-limiting febrile neutropenia. Prophylactic use of recombinant human G-CSF such as daily filgrastim and once-per-cycle pegfilgrastim may reduce the incidence of fe...

    Authors: Arash Naeim, Henry J Henk, Laura Becker, Victoria Chia, Sejal Badre, Xiaoyan Li and Robert Deeter
    Citation: BMC Cancer 2013 13:11
    Content type: Research article Published on:

  19. HPV is related to a number of cancer types, causing a considerable burden in both genders in Europe. Female vaccination programs can substantially reduce the incidence of HPV-related diseases in women and, to ...

    Authors: Rémi Marty, Stéphane Roze, Xavier Bresse, Nathalie Largeron and Jayne Smith-Palmer
    Citation: BMC Cancer 2013 13:10
    Content type: Research article Published on:

  20. Faced with a life-threatening illness, such as cancer, many patients develop stress symptoms, i.e. avoidance behaviour, intrusive thoughts and worry. Stress management interventions have proven to be effective...

    Authors: Cecilia Arving, Inger Thormodsen, Guri Brekke, Olav Mella, Sveinung Berntsen and Karin Nordin
    Citation: BMC Cancer 2013 13:9
    Content type: Study protocol Published on:

  21. A subset of lung adenocarcinomas harboring an EML4-ALK fusion gene resulting in dominant oncogenic activity has emerged as a target for specific therapy. EML4-ALK fusion confers a characteristic histology and is ...

    Authors: Hironori Ninomiya, Motohiro Kato, Masashi Sanada, Kengo Takeuchi, Kentaro Inamura, Noriko Motoi, Hiroko Nagano, Kimie Nomura, Yukinori Sakao, Sakae Okumura, Hiroyuki Mano, Seishi Ogawa and Yuichi Ishikawa
    Citation: BMC Cancer 2013 13:8
    Content type: Research article Published on:

  22. Diabetic patients have a higher risk of bladder cancer and benign prostatic hyperplasia (BPH). Theoretically, BPH patients may have an increased risk of bladder cancer because residual urine in the bladder sur...

    Authors: Chin-Hsiao Tseng
    Citation: BMC Cancer 2013 13:7
    Content type: Research article Published on:

  23. Mortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood. One explanation may b...

    Authors: Janine K Cataldo, Steven Paul, Bruce Cooper, Helen Skerman, Kimberly Alexander, Bradley Aouizerat, Virginia Blackman, John Merriman, Laura Dunn, Christine Ritchie, Patsy Yates and Christine Miaskowski
    Citation: BMC Cancer 2013 13:6
    Content type: Research article Published on:

  24. Alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) have been used as diagnostic tools for hepatocellular carcinoma (HCC). However, prediction of outcome using AFP and DCP has not been elucidated. ...

    Authors: Yong Kang Lee, Seung Up Kim, Do Young Kim, Sang Hoon Ahn, Kwang Hun Lee, Do Yun Lee, Kwang-Hyub Han, Chae Yoon Chon and Jun Yong Park
    Citation: BMC Cancer 2013 13:5
    Content type: Research article Published on:

  25. Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet a...

    Authors: Luca Cegolon, Cristiano Salata, Elisabete Weiderpass, Paolo Vineis, Giorgio Palù and Giuseppe Mastrangelo
    Citation: BMC Cancer 2013 13:4
    Content type: Debate Published on:

  26. Sunitinib interacts with radiation therapy, leading to synergism of the toxicities of these treatments. Radiation recall pneumonitis is a rare but serious complication of targeted therapy with tyrosine kinase ...

    Authors: Takeshi Yuasa, Shinichi Kitsukawa, Gen Sukegawa, Shinya Yamamoto, Keita Kudo, Kazunari Miyazawa, Takuyo Kozuka, Sohei Harada and Junji Yonese
    Citation: BMC Cancer 2013 13:3
    Content type: Case report Published on:

  28. Breast cancer is a potentially fatal malignancy in females despite the improvement in therapeutic techniques. The identification of novel molecular signatures is needed for earlier detection, monitoring effect...

    Authors: Emman Shubbar, Anikó Kovács, Shahin Hajizadeh, Toshima Z Parris, Szilárd Nemes, Katrin Gunnarsdóttir, Zakaria Einbeigi, Per Karlsson and Khalil Helou
    Citation: BMC Cancer 2013 13:1
    Content type: Research article Published on:

  29. There is a critical need for improved diagnostic markers for high grade serous epithelial ovarian cancer (SEOC). MicroRNAs are stable in the circulation and may have utility as biomarkers of malignancy. We inv...

    Authors: Casina WS Kan, Michael A Hahn, Gregory B Gard, Jayne Maidens, Jung Yoon Huh, Deborah J Marsh and Viive M Howell
    Citation: BMC Cancer 2012 12:627
    Content type: Research article Published on:

  30. This study reports the reliability and validity of a questionnaire designed to measure the time from detection of a breast cancer to arrival at a cancer hospital, as well as the factors that are associated wit...

    Authors: Karla Unger-Saldaña, Ingris Peláez-Ballestas and Claudia Infante-Castañeda
    Citation: BMC Cancer 2012 12:626
    Content type: Research article Published on:

  31. The purpose of the present study was to evaluate the prognostic value of POSTN expression following prostatectomy.

    Authors: Pier Vitale Nuzzo, Alessandra Rubagotti, Linda Zinoli, Francesco Ricci, Sandra Salvi, Simona Boccardo and Francesco Boccardo
    Citation: BMC Cancer 2012 12:625
    Content type: Research article Published on:

  32. G-protein-coupled estrogen receptor (GPER/GPR30) was reported to bind 17β-estradiol (E2), tamoxifen, and ICI 182,780 (fulvestrant) and promotes activation of epidermal growth factor receptor (EGFR)-mediated signa...

    Authors: Venkatakrishna Rao Jala, Brandie N Radde, Bodduluri Haribabu and Carolyn M Klinge
    Citation: BMC Cancer 2012 12:624
    Content type: Research article Published on:

  33. High-grade gliomas including glioblastoma multiforme (GBM) are among the most malignant and aggressive of tumors, and have a very poor prognosis despite a temozolomide-based intensive treatment. Therefore, a n...

    Authors: Yasuto Akiyama, Chie Oshita, Akiko Kume, Akira Iizuka, Haruo Miyata, Masaru Komiyama, Tadashi Ashizawa, Mika Yagoto, Yoshiaki Abe, Koichi Mitsuya, Reiko Watanabe, Takashi Sugino, Ken Yamaguchi and Yoko Nakasu
    Citation: BMC Cancer 2012 12:623
    Content type: Research article Published on:

  34. The ubiquitin-proteasome system and macroautophagy (hereafter referred to autophagy) are two complementary pathways for protein degradation. Emerging evidence suggests that proteasome inhibition might be a pro...

    Authors: Chuan Liu, Xu Yan, Hua-Qin Wang, Yan-Yan Gao, Juanjuan Liu, Zhenhua Hu, Dawo Liu, Jian Gao and Bei Lin
    Citation: BMC Cancer 2012 12:622
    Content type: Research article Published on:

  35. The minor allele of SNP rs3803662 has been shown to correlate with increased breast cancer risk and with lower expression of TOX3. The SNP is closely located to TOX3 residing within an uncharacterised gene LOC643...

    Authors: Eydis Th Gudmundsdottir, Rosa B Barkardottir, Adalgeir Arason, Haukur Gunnarsson, Laufey Th Amundadottir, Bjarni A Agnarsson, Oskar Th Johannsson and Inga Reynisdottir
    Citation: BMC Cancer 2012 12:621
    Content type: Research article Published on:

  36. The abundance of circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPs), which serve as surrogate markers for angiogenesis, may be affected by chemotherapy. We studied their d...

    Authors: Yu-Hsuan Kuo, Ching-Hung Lin, Wen-Yi Shau, Te-Jung Chen, Shih-Hung Yang, Shu-Min Huang, Chun Hsu, Yen-Shen Lu and Ann-Lii Cheng
    Citation: BMC Cancer 2012 12:620
    Content type: Research article Published on:

  37. Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key regulator of mitosis and programmed cell death. YM155, a novel molecular targeted agent, suppresses survivin, which is ov...

    Authors: Yan-Fang Tao, Jun Lu, Xiao-Juan Du, Li-Chao Sun, Xuan Zhao, Liang Peng, Lan Cao, Pei-Fang Xiao, Li Pang, Dong Wu, Na Wang, Xing Feng, Yan-Hong Li, Jian Ni, Jian Wang and Jian Pan
    Citation: BMC Cancer 2012 12:619
    Content type: Research article Published on:

  38. The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The d...

    Authors: Anna Gillio-Tos, Maria da Graça Bicalho, Valentina Fiano, Chiara Grasso, Valentina Tarallo, Laura De Marco, Morena Trevisan, MarinaBarbaradeSousa Xavier, Renata Slowik, Newton S Carvalho, Carlos A Maestri, Hadriano M Lacerda, Daniela Zugna, Lorenzo Richiardi and Franco Merletti
    Citation: BMC Cancer 2012 12:618
    Content type: Research article Published on:

  39. The oxidative stress mechanism is of particular interest in the pathogenesis of glioma, given the high rate of oxygen metabolism in the brain. Potential links between polymorphisms of antioxidant genes and gli...

    Authors: Peng Zhao, Lin Zhao, Peng Zou, Ailin Lu, Ning Liu, Wei Yan, Chunsheng Kang, Zhen Fu, Yongping You and Tao Jiang
    Citation: BMC Cancer 2012 12:617
    Content type: Research article Published on:

  40. Presence of disseminated tumor cells (DTCs) in bone marrow (BM) after completion of systemic adjuvant treatment predicts reduced survival in breast cancer. The present study explores the use of DTCs to identif...

    Authors: Marit Synnestvedt, Elin Borgen, Erik Wist, Gro Wiedswang, Kjetil Weyde, Terje Risberg, Christian Kersten, Ingvil Mjaaland, Lise Vindi, Cecilie Schirmer, Jahn Martin Nesland and Bjørn Naume
    Citation: BMC Cancer 2012 12:616
    Content type: Research article Published on:

  41. Asbestos is the main cause of MPM in industrialized countries. Even since asbestos is banned in most developed countries, the peak wave of MPM incidence is anticipated for the next years due to the long latenc...

    Authors: Ulf Petrausch, Petra C Schuberth, Christian Hagedorn, Alex Soltermann, Sandra Tomaszek, Rolf Stahel, Walter Weder and Christoph Renner
    Citation: BMC Cancer 2012 12:615
    Content type: Study protocol Published on:

  42. Diagnosis of multiple endocrine neoplasia type 1 (MEN1) is commonly based on clinical criteria, and confirmed by genetic testing. In patients without known MEN1-related germline mutations, the possibility of a...

    Authors: Enrico Erdas, Nicola Aste, Luca Pilloni, Angelo Nicolosi, Sergio Licheri, Antonello Cappai, Marco Mastinu, Filomena Cetani, Elena Pardi, Stefano Mariotti and Mariano Pomata
    Citation: BMC Cancer 2012 12:614
    Content type: Case report Published on:

  43. In breast cancer, diabetes diagnosed prior to cancer (previously diagnosed) is associated with advanced cancer stage and increased mortality. However, in the general population, 40% of diabetes is undiagnosed ...

    Authors: Robert I Griffiths, Mark D Danese, Michelle L Gleeson and José M Valderas
    Citation: BMC Cancer 2012 12:613
    Content type: Research article Published on:

  45. HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in carcinogenesis, such as CCNA2 encoding cyclin A. No prior study attempted to evaluate the ...

    Authors: Peir-In Liang, Wei-Ming Li, Yu-Hui Wang, Ting-Feng Wu, Wen-Ren Wu, Alex C Liao, Kun-Hung Shen, Yu-Ching Wei, Chung-Hsi Hsing, Yow-Ling Shiue, Hsuan-Ying Huang, Han-Ping Hsu, Li-Tzon Chen, Ching-Yih Lin, Chein Tai, Chun-Mao Lin…
    Citation: BMC Cancer 2012 12:611
    Content type: Research article Published on:

  46. The goal of this study was to identify the clinicopathological factors of co-existing papillary thyroid cancer (PTC) in patients with Hashimoto’s thyroiditis (HT) and provide information to aid in the diagnosi...

    Authors: Ling Zhang, Hui Li, Qing-hai Ji, Yong-xue Zhu, Zhuo-ying Wang, Yu Wang, Cai-ping Huang, Qiang Shen, Duan-shu Li and Yi Wu
    Citation: BMC Cancer 2012 12:610
    Content type: Research article Published on:

  47. There is no consensus on the indication for salvage chemoradiotherapy (CRT) after failure of primary chemotherapy for locally advanced pancreatic cancer (LAPC). Here we report on the retrospective analysis of ...

    Authors: Hiroshi Mayahara, Yoshinori Ito, Chigusa Morizane, Hideki Ueno, Takuji Okusaka, Shunsuke Kondo, Naoya Murakami, Madoka Morota, Minako Sumi and Jun Itami
    Citation: BMC Cancer 2012 12:609
    Content type: Research article Published on:

  48. The malignant transformation of precancerous colorectal lesions involves progressive alterations at both the molecular and morphologic levels, the latter consisting of increases in size and in the degree of ce...

    Authors: Rosalia Maglietta, Vania Cosma Liuzzi, Elisa Cattaneo, Endre Laczko, Ada Piepoli, Anna Panza, Massimo Carella, Orazio Palumbo, Teresa Staiano, Federico Buffoli, Angelo Andriulli, Giancarlo Marra and Nicola Ancona
    Citation: BMC Cancer 2012 12:608
    Content type: Research article Published on:

  49. Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms...

    Authors: Renquan Lu, Chengsheng Wu, Lin Guo, Yingchao Liu, Wei Mo, Huijie Wang, Jianbo Ding, Eric T Wong and Min Yu
    Citation: BMC Cancer 2012 12:607
    Content type: Research article Published on:

  50. An n-6 essential fatty acid, arachidonic acid (ARA) is converted into prostaglandin E2, which is involved in tumour extension. However, it is unclear whether dietary ARA intake leads to cancer in humans. We thus ...

    Authors: Mai Sakai, Saki Kakutani, Chika Horikawa, Hisanori Tokuda, Hiroshi Kawashima, Hiroshi Shibata, Hitomi Okubo and Satoshi Sasaki
    Citation: BMC Cancer 2012 12:606
    Content type: Research article Published on:

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