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  1. UCN-01 (7-hydroxystaurosporine), a protein kinase inhibitor, has attracted a great deal of attention as a potent antitumour agent. Several clinical trials of UCN-01 alone or in combination with other agents fo...

    Authors: Guoyi Wu, Linan Xu, Nan Lin and Bo Liu
    Citation: BMC Cancer 2013 13:167
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2014 14:216

  2. Differential diagnosis of high-grade dysplastic nodules (HGDN) and well-differentiated hepatocellular carcinoma (WDHCC) represents a challenge to experienced hepatic clinicians, radiologists and hepatopatholog...

    Authors: Guang-Zhi Jin, Hui Dong, Wen-Long Yu, Yan Li, Xin-Yuan Lu, Hua Yu, Zhi-Hong Xian, Wei Dong, Yin-Kun Liu, Wen-Ming Cong and Meng-Chao Wu
    Citation: BMC Cancer 2013 13:161
    Content type: Research article Published on:

  3. Few high penetrance genes are known in Malignant Melanoma (MM), however, the involvement of low-penetrance genes such as MC1R, OCA2, ASIP, SLC45A2 and TYR has been observed. Lately, genome-wide association studie...

    Authors: Maria Peña-Chilet, Maite Blanquer-Maceiras, Maider Ibarrola-Villava, Conrado Martinez-Cadenas, Manuel Martin-Gonzalez, Cristina Gomez-Fernandez, Matias Mayor, Juan Antonio Aviles, Ana Lluch and Gloria Ribas
    Citation: BMC Cancer 2013 13:160
    Content type: Research article Published on:

  5. Systemic inflammation has been linked with cancer development, cancer cachexia and poor outcome. Advanced lung cancer inflammation index (ALI) was developed to assess degree of systemic inflammation at the tim...

    Authors: Syed H Jafri, Runhua Shi and Glenn Mills
    Citation: BMC Cancer 2013 13:158
    Content type: Research article Published on:

  7. L1CAM was originally identified as an adhesion molecule involved in neural development. In many human carcinomas L1CAM is over-expressed and is associated with a bad prognosis. We previously reported that L1CA...

    Authors: Uwe Schirmer, Heidi Fiegl, Marco Pfeifer, Alain G Zeimet, Elisabeth Müller-Holzner, Peter K Bode, Verena Tischler and Peter Altevogt
    Citation: BMC Cancer 2013 13:156
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:1047

  8. 53BP1 binds to the tumor suppressor p53 and has a key role in DNA damage response and repair. Low 53BP1 expression has been associated with decreased survival in breast cancer and has been shown to interact wi...

    Authors: Natalie L Ausborn, Tong Wang, Sabrina C Wentz, Mary Kay Washington, Nipun B Merchant, Zhiguo Zhao, Yu Shyr, Anuradha Bapsi Chakravarthy and Fen Xia
    Citation: BMC Cancer 2013 13:155
    Content type: Research article Published on:

  9. Pancreatic cancer shows a highly aggressive and infiltrative growth pattern and is characterized by an abundant tumor stroma known to interact with the cancer cells, and to influence tumor growth and drug resi...

    Authors: Daniel Öhlund, Oskar Franklin, Erik Lundberg, Christina Lundin and Malin Sund
    Citation: BMC Cancer 2013 13:154
    Content type: Research article Published on:

  10. Besides conventional adjuvant therapies, many breast cancer survivors engage in various activities like exercise, diet and complementary and alternative medicine (CAM) in order to improve their prognosis. Litt...

    Authors: Arnoud J Templeton, Beat Thürlimann, Michael Baumann, Michael Mark, Sarah Stoll, Madeleine Schwizer, Daniel Dietrich and Thomas Ruhstaller
    Citation: BMC Cancer 2013 13:153
    Content type: Research article Published on:

  11. This phase I study investigated the maximum tolerated dose (MTD), safety, pharmacokinetics and antitumor activity of ganetespib in patients with solid malignancies.

    Authors: Jonathan W Goldman, Robert N Raju, Gregory A Gordon, Iman El-Hariry, Florentina Teofilivici, Vojo M Vukovic, Robert Bradley, Michael D Karol, Yu Chen, Wei Guo, Takayo Inoue and Lee S Rosen
    Citation: BMC Cancer 2013 13:152
    Content type: Research article Published on:

  12. To determine whether ceramide is responsible for the induction of p53-independent early or late apoptosis in response to high- and low-Linear-Energy-Transfer (LET) irradiation.

    Authors: Gersende Alphonse, Mira Maalouf, Priscillia Battiston-Montagne, Dominique Ardail, Michaël Beuve, Robert Rousson, Gisela Taucher-Scholz, Claudia Fournier and Claire Rodriguez-Lafrasse
    Citation: BMC Cancer 2013 13:151
    Content type: Research article Published on:

  13. The insulin-like growth factor-1 (IGF-1) plays an important role in growth of prostate cancer (PCa) cells and facilitating the development and progression of PCa. This study aimed to evaluate the association o...

    Authors: Norihiko Tsuchiya, Shintaro Narita, Takamitsu Inoue, Mitsuru Saito, Kazuyuki Numakura, Mingguo Huang, Shingo Hatakeyama, Shigeru Satoh, Seiichi Saito, Chikara Ohyama, Yoichi Arai, Osamu Ogawa and Tomonori Habuchi
    Citation: BMC Cancer 2013 13:150
    Content type: Research article Published on:

  14. Adjuvant chemotherapy for stage III colon cancer is internationally accepted as standard treatment with established efficacy. Several oral fluorouracil (5-FU) derivatives with different properties are availabl...

    Authors: Megumi Ishiguro, Kenjiro Kotake, Genichi Nishimura, Naohiro Tomita, Wataru Ichikawa, Keiichi Takahashi, Toshiaki Watanabe, Tomohisa Furuhata, Ken Kondo, Masaki Mori, Yoshihiro Kakeji, Akiyoshi Kanazawa, Michiya Kobayashi, Masazumi Okajima, Ichinosuke Hyodo, Keiko Miyakoda…
    Citation: BMC Cancer 2013 13:149
    Content type: Study protocol Published on:

  15. Aberrant chromatin structure in cancer cells results from altered proteins involved in its packaging. Heterochromatin protein 1 gamma (HP1γ) is a non-histone heterochromatic protein that functions to maintain ...

    Authors: Jon Slezak, Matthew Truong, Wei Huang and David Jarrard
    Citation: BMC Cancer 2013 13:148
    Content type: Research article Published on:

  16. Temozolomide (TMZ) is the most widely used drug to treat glioblastoma (GBM), which is the most common and aggressive primary tumor of the Central Nervous System and one of the hardest challenges in oncotherapy...

    Authors: Eduardo C Filippi-Chiela, Marcos Paulo Thomé, Mardja Manssur Bueno e Silva, Alessandra Luíza Pelegrini, Pitia Flores Ledur, Bernardo Garicochea, Lauren L Zamin and Guido Lenz
    Citation: BMC Cancer 2013 13:147
    Content type: Research article Published on:

  17. Ovarian carcinoma is a common, and often deadly, gynecological cancer. Mutations in BRCA1 and BRCA2 genes are present in at least a fifth of patients. Uncovering other genes that become mutated subsequent to BRCA...

    Authors: Jian Zhang, Yuhao Shi, Emilie Lalonde, Lili Li, Luca Cavallone, Alex Ferenczy, Walter H Gotlieb, William D Foulkes and Jacek Majewski
    Citation: BMC Cancer 2013 13:146
    Content type: Research article Published on:

  18. Snail1 is a transcription regulator of E-cadherin. The loss of E-cadherin seems to be a crucial step in the process of Epithelial-mesenchymal transition (EMT). EMT initiates invasion and proliferation in many ...

    Authors: Feride Kroepil, Georg Fluegen, Daniel Vallböhmer, Stephan E Baldus, Levent Dizdar, Andreas M Raffel, Dieter Hafner, Nikolas H Stoecklein and Wolfram T Knoefel
    Citation: BMC Cancer 2013 13:145
    Content type: Research article Published on:

  19. The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined to...

    Authors: Robert Kim, Prakash Kulkarni and Sridhar Hannenhalli
    Citation: BMC Cancer 2013 13:144
    Content type: Research article Published on:

  20. It is important to simultaneously induce strong cell death and antitumor immunity in cancer patients for successful cancer treatment. Here, we investigated the cytotoxic and phenotypic modulation effects of th...

    Authors: Yun Choi, Ho Won Lee, Jaetae Lee and Yong Hyun Jeon
    Citation: BMC Cancer 2013 13:143
    Content type: Research article Published on:

  21. The aberrant methylation of CpG islands in the promoter is associated with colorectal cancer (CRC) carcinogenesis. In our previous study, the promoter of alcohol dehydrogenase, iron containing, 1 (ADHFE1) was mos...

    Authors: Chung Hyun Tae, Kyung Ju Ryu, Seok-Hyung Kim, Hee Cheol Kim, Ho-Kyung Chun, Byung-Hoon Min, Dong Kyung Chang, Poong-Lyul Rhee, Jae J Kim, Jong Chul Rhee and Young-Ho Kim
    Citation: BMC Cancer 2013 13:142
    Content type: Research article Published on:

  22. Salivary gland cancer (SGC) is one of the common malignancies of the head and neck area. It develops in the minor and major salivary glands and sometimes metastasizes to other organs, particularly to the lungs...

    Authors: Tomoki Sumida, Ryuichi Murase, Akiko Onishi-Ishikawa, Sean D McAllister, Hiroyuki Hamakawa and Pierre-Yves Desprez
    Citation: BMC Cancer 2013 13:141
    Content type: Research article Published on:

  23. Malignant pleural mesothelioma (MPM) is an aggressive malignancy closely associated with asbestos exposure and extremely resistant to current treatments. It exhibits a steady increase in incidence, thus necess...

    Authors: Bao-Zhu Yuan, Joshua Chapman, Min Ding, Junzhi Wang, Binghua Jiang, Yon Rojanasakul and Steven H Reynolds
    Citation: BMC Cancer 2013 13:140
    Content type: Research article Published on:

  24. NR4A orphan nuclear receptors are involved in multiple biological processes which are important in tumorigenesis such as cell proliferation, apoptosis, differentiation, and glucose utilization. The significanc...

    Authors: Shawn Llopis, Brittany Singleton, Tamika Duplessis, Latonya Carrier, Brian Rowan and Christopher Williams
    Citation: BMC Cancer 2013 13:139
    Content type: Research article Published on:

  25. Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA

    Authors: Emer M Guinan, Juliette Hussey, Sarah A McGarrigle, Laura A Healy, Jacintha N O’Sullivan, Kathleen Bennett and Elizabeth M Connolly
    Citation: BMC Cancer 2013 13:138
    Content type: Study protocol Published on:

  26. We attempted to identify novel biomarkers and therapeutic targets for esophageal squamous cell carcinoma by gene expression profiling of frozen esophageal squamous carcinoma specimens and examined the function...

    Authors: Qing Wang, Chenming Ma and Wolfgang Kemmner
    Citation: BMC Cancer 2013 13:137
    Content type: Research article Published on:

  27. In China, there are currently no approved therapies for the treatment of metastatic renal cell carcinoma (mRCC) following progression with vascular endothelial growth factor (VEGF)-targeted agents. In the phas...

    Authors: Jun Guo, Yiran Huang, Xu Zhang, Fangjian Zhou, Yinghao Sun, Shukui Qin, Zhangqun Ye, Hui Wang, Annette Jappe, Patrick Straub, Nicoletta Pirotta and Sven Gogov
    Citation: BMC Cancer 2013 13:136
    Content type: Research article Published on:

  28. The measurement properties of instruments used to assess functional capacity, physical activity and muscle strength in participants with non-small cell lung cancer (NSCLC) have not been systematically reviewed.

    Authors: Catherine L Granger, Christine F McDonald, Selina M Parry, Cristino C Oliveira and Linda Denehy
    Citation: BMC Cancer 2013 13:135
    Content type: Research article Published on:

  29. The p53 protein is expressed as multiple isoforms that differ in their N- and C-terminus due to alternative splicing, promoter or codon initiation usage. Δ40p53 lacks the first 39 residues containing the main ...

    Authors: Hind Hafsi, Daniela Santos-Silva, Stéphanie Courtois-Cox and Pierre Hainaut
    Citation: BMC Cancer 2013 13:134
    Content type: Research article Published on:

  30. The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has markedly increased over the last three decades due to newly found associations with human papillomavirus (HPV) infection. Primary radiotherapy...

    Authors: Anthony C Nichols, John Yoo, J Alex Hammond, Kevin Fung, Eric Winquist, Nancy Read, Varagur Venkatesan, S Danielle MacNeil, D Scott Ernst, Sara Kuruvilla, Jeff Chen, Martin Corsten, Michael Odell, Libni Eapen, Julie Theurer, Philip C Doyle…
    Citation: BMC Cancer 2013 13:133
    Content type: Study protocol Published on:

  32. There is currently no consensus regarding the optimal timing for androgen suppression therapy in patients with prostate cancer that have undergone local therapy with curative intent but are proven to have node...

    Authors: Frank Kunath, Bastian Keck, Gerta Rücker, Edith Motschall, Bernd Wullich, Gerd Antes and Joerg J Meerpohl
    Citation: BMC Cancer 2013 13:131
    Content type: Research article Published on:

  33. Lung cancer diagnosis is usually achieved through a set of bronchoscopic techniques or computed tomography guided-transthoracic needle aspiration (CT-TTNA). However these procedures have a variable diagnostic ...

    Authors: Antonio Bugalho, Dalila Ferreira, Ralf Eberhardt, Sara S Dias, Paula A Videira, Felix J Herth and Luis Carreiro
    Citation: BMC Cancer 2013 13:130
    Content type: Research article Published on:

  35. αB-crystallin is able to modulate vascular endothelial growth factor (VEGF) secretion. In many solid tumors VEGF is associated with angiogenesis, metastasis formation and poor prognosis. We set out to assess w...

    Authors: Chantal van de Schootbrugge, Johan Bussink, Paul N Span, Fred CGJ Sweep, Reidar Grénman, Hanneke Stegeman, Ger JM Pruijn, Johannes HAM Kaanders and Wilbert C Boelens
    Citation: BMC Cancer 2013 13:128
    Content type: Research article Published on:

  36. A long-term prospective assessment of QoL in cervical cancer patients is still lacking. Here, we provide the first 2-years prospective, longitudinal study evaluating emotional distress and QoL in early stage (...

    Authors: Giovanna Mantegna, Marco Petrillo, Gilda Fuoco, Laura Venditti, Serena Terzano, Luigi Pedone Anchora, Giovanni Scambia and Gabriella Ferrandina
    Citation: BMC Cancer 2013 13:127
    Content type: Research article Published on:

  37. Studies on the association between MDM2 SNP309 (T > G) and gastric cancer have reported conflicting results. Thus, the aim of this study was to investigate whether MDM2 SNP309 is associated with susceptibility an...

    Authors: Xiaolin Pan, Yuqin Li, Jin Feng, Xiaoyong Wang, Bo Hao, Ruihua Shi and Guoxin Zhang
    Citation: BMC Cancer 2013 13:126
    Content type: Research article Published on:

  38. The malignant potential of tumour cells may be influenced by the molecular nature of KRAS mutations being codon 13 mutations less aggressive than codon 12 ones. Their metabolic profile is also different, with an ...

    Authors: Agnès Figueras, Maria Antonia Arbos, Maria Teresa Quiles, Francesc Viñals, Josep Ramón Germà and Gabriel Capellà
    Citation: BMC Cancer 2013 13:125
    Content type: Research article Published on:

  39. Increased histone H3 phosphorylation is an essential regulatory mechanism for neoplastic cell transformation. We aimed to explore the role of histone H3 phosphorylation at serine10 (p-H3Ser10) in Epstein-Barr ...

    Authors: Binbin Li, Guoliang Huang, Xiangning Zhang, Rong Li, Jian Wang, Ziming Dong and Zhiwei He
    Citation: BMC Cancer 2013 13:124
    Content type: Research article Published on:

  40. Whether the 7th edition of American Joint Committee on Cancer (AJCC) TNM staging system (AJCC-7) is a successful revision remains debatable. We aimed to compare the predictive capacity of the AJCC-7 for colore...

    Authors: Peng Gao, Yong-xi Song, Zhen-ning Wang, Ying-ying Xu, Lin-lin Tong, Jing-xu Sun, Miao Yu and Hui-mian Xu
    Citation: BMC Cancer 2013 13:123
    Content type: Research article Published on:

  41. Supporting health care sector decisions using time-dependent endpoints (TDEs) such as time to progression (TTP), progression-free survival (PFS), and event-free survival (EFS) remains controversial. This study...

    Authors: Jorge Félix, Filipa Aragão, João M Almeida, Frederico JM Calado, Diana Ferreira, António BS Parreira, Ricardo Rodrigues and João FR Rijo
    Citation: BMC Cancer 2013 13:122
    Content type: Research article Published on:

  42. The objective of this Phase I dose escalation study was to explore the safety and tolerability of eltrombopag, an oral, nonpeptide, thrombopoietin receptor agonist, in patients with advanced soft tissue sarcom...

    Authors: Sant P Chawla, Arthur Staddon, Andrew Hendifar, Conrad A Messam, Rita Patwardhan and Yasser Yasser Mostafa Kamel
    Citation: BMC Cancer 2013 13:121
    Content type: Research article Published on:

  43. The use of bevacizumab in combination with fluoropyrimidine-containing chemotherapy is a well-established first-line and second-line treatment for patients with metastatic colorectal cancer (mCRC). However, th...

    Authors: Stephen Clarke, Matt Burge, Cassandra Cordwell, Peter Gibbs, William Reece and Niall Tebbutt
    Citation: BMC Cancer 2013 13:120
    Content type: Study protocol Published on:

  44. Vitamin D transcriptional effects were linked to tumor growth control, however, the hormone targets were determined in cell cultures exposed to supra physiological concentrations of 1,25(OH)2D3 (50-100nM). Our ai...

    Authors: Cintia Milani, Maria Lucia Hirata Katayama, Eduardo Carneiro de Lyra, JoEllen Welsh, Laura Tojeiro Campos, M Mitzi Brentani, Maria do Socorro Maciel, Rosimeire Aparecida Roela, Paulo Roberto del Valle, João Carlos Guedes Sampaio Góes, Suely Nonogaki, Rodrigo Esaki Tamura and Maria Aparecida Azevedo Koike Folgueira
    Citation: BMC Cancer 2013 13:119
    Content type: Research article Published on:

  45. The purpose of this study is to evaluate the prognostic value of TFPI-2 expression in breast cancer patients through examining the correlation between TFPI-2 expression and breast cancer clinicopathologic feat...

    Authors: Cheng Xu, Huijun Wang, Hongyu He, Fengyun Zheng, Yating Chen, Jin Zhang, Xiaoyan Lin, Duan Ma and Hongwei Zhang
    Citation: BMC Cancer 2013 13:118
    Content type: Research article Published on:

  47. Cytogenetic and gene expression analyses in head and neck squamous cell carcinomas (HNSCC) have allowed identification of genomic aberrations that may contribute to cancer pathophysiology. Nevertheless, the mo...

    Authors: Sandra Bernaldo de Quirós, Anna Merlo, Pablo Secades, Iriana Zambrano, Ines Saenz de Santa María, Nerea Ugidos, Eloisa Jantus-Lewintre, Rafael Sirera, Carlos Suarez and María-Dolores Chiara
    Citation: BMC Cancer 2013 13:116
    Content type: Research article Published on:

  48. Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), a coregulator of the estrogen receptors (ERs) alpha and beta, is a potential proto-oncogene in hormone dependent gynecological malignancies. To bet...

    Authors: Stefanie Aust, Peter Horak, Dietmar Pils, Sophie Pils, Christoph Grimm, Reinhard Horvat, Dan Tong, Bernd Schmid, Paul Speiser, Alexander Reinthaller and Stephan Polterauer
    Citation: BMC Cancer 2013 13:115
    Content type: Research article Published on:

  49. The management of advanced stage non-small cell lung cancer is increasingly based on diagnostic and predictive analyses performed mostly on limited amounts of tumor tissue. The evaluation of Epidermal Growth F...

    Authors: Luisella Righi, Alessandra Cuccurullo, Simona Vatrano, Susanna Cappia, Daniela Giachino, Paolo De Giuli, Mara Ardine, Silvia Novello, Marco Volante, Giorgio V Scagliotti and Mauro Papotti
    Citation: BMC Cancer 2013 13:114
    Content type: Technical advance Published on:

  50. Despite the potential of improving the delivery of epigenetic drugs, the subsequent assessment of changes in their epigenetic activity is largely dependent on the availability of a suitable and rapid screening...

    Authors: Sue Ping Lim, Raman Kumar, Yamini Akkamsetty, Wen Wang, Kristen Ho, Paul M Neilsen, Diego J Walther, Rachel J Suetani, Clive Prestidge and David F Callen
    Citation: BMC Cancer 2013 13:113
    Content type: Technical advance Published on:

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