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  1. The immune system is a key player in fighting cancer. Thus, we sought to identify a molecular ‘immune response signature’ indicating the presence of epithelial ovarian cancer (EOC) and to combine this with a s...

    Authors: Dietmar Pils, Dan Tong, Gudrun Hager, Eva Obermayr, Stefanie Aust, Georg Heinze, Maria Kohl, Eva Schuster, Andrea Wolf, Jalid Sehouli, Ioana Braicu, Ignace Vergote, Toon Van Gorp, Sven Mahner, Nicole Concin, Paul Speiser…
    Citation: BMC Cancer 2013 13:178
    Content type: Research article Published on:

  2. Leukocytes play an important role in cancer development. However, the impact of chemotherapy-associated neutropenia/lymphopenia on the prognosis of adjuvant chemotherapy is unknown. Here, we aimed to explore t...

    Authors: Hong Chu-Yuan, Peng Jing, Wei Yi-Sheng, Peng He-Ping, Yang Hui, Zhao Chu-Xiong, Liang Guo-Jian and Wang Guo-Qiang
    Citation: BMC Cancer 2013 13:177
    Content type: Research article Published on:

  3. Chemotherapeutic treatment of hepatocellular carcinoma often leads to chemoresistance during therapy or upon relapse of tumors. For the development of better treatments a better understanding of biochemical ch...

    Authors: Christian Marfels, Miriam Hoehn, Ernst Wagner and Michael Günther
    Citation: BMC Cancer 2013 13:176
    Content type: Research article Published on:

  4. Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as ...

    Authors: Patrick C O´Leary, Sarah A Penny, Roisin T Dolan, Catherine M Kelly, Stephen F Madden, Elton Rexhepaj, Donal J Brennan, Amanda H McCann, Fredrik Pontén, Mathias Uhlén, Radoslaw Zagozdzon, Michael J Duffy, Malcolm R Kell, Karin Jirström and William M Gallagher
    Citation: BMC Cancer 2013 13:175
    Content type: Research article Published on:

  5. Acquired resistance to Tamoxifen remains a critical problem in breast cancer patient treatment, yet the underlying causes of resistance have not been fully elucidated. Abberations in the Wnt signalling pathway...

    Authors: Yan Ni Loh, Ellen L Hedditch, Laura A Baker, Eve Jary, Robyn L Ward and Caroline E Ford
    Citation: BMC Cancer 2013 13:174
    Content type: Research article Published on:

  6. We evaluated BCR-ABL1 kinetics in patients treated with nilotinib and analyzed whether a dynamic model of changes in BCR-ABL1 levels over time could be used to predict long-term responses.

    Authors: Andrew M Stein, Giovanni Martinelli, Timothy P Hughes, Martin C Müller, Lan Beppu, Enrico Gottardi, Susan Branford, Simona Soverini, Richard C Woodman, Andreas Hochhaus, Dong-Wook Kim, Giuseppe Saglio and Jerald P Radich
    Citation: BMC Cancer 2013 13:173
    Content type: Research article Published on:

  7. Lipids A, the lipophilic partial structure of lipopolysaccharides, induce regression of several tumor types in animal models. Rather than exerting direct cytotoxic effect, these compounds trigger the immune sy...

    Authors: Nicolas Isambert, Pierre Fumoleau, Catherine Paul, Christophe Ferrand, Sylvie Zanetta, Jacques Bauer, Kevin Ragot, Gérard Lizard, Jean-François Jeannin and Marc Bardou
    Citation: BMC Cancer 2013 13:172
    Content type: Research article Published on:

  8. Tissue invasion and metastasis are acquired abilities of cancer and related to the death in oral squamous cell carcinoma (OSCC). Emerging observations indicate that the epithelial-to-mesenchymal transition (EM...

    Authors: Cong-Chong Yang, Li-Fang Zhu, Xiao-Hui Xu, Tian-Yun Ning, Jin-Hai Ye and Lai-Kui Liu
    Citation: BMC Cancer 2013 13:171
    Content type: Research article Published on:

  9. Advanced or metastatic renal cell carcinoma (RCC) has a poor prognosis, because it is relatively resistant to conventional chemotherapy or radiotherapy. Treatments with human interferon-α2b alone or in combina...

    Authors: Thomas M Cardillo, Preeti Trisal, Roberto Arrojo, David M Goldenberg and Chien-Hsing Chang
    Citation: BMC Cancer 2013 13:170
    Content type: Research article Published on:

  10. KRAS is an EGFR effector in the RAS/RAF/ERK cascade that is mutated in about 40% of metastatic colorectal cancer (mCRC). Activating mutations in codons 12 and 13 of the KRAS gene are the only established negative...

    Authors: Joana G Guedes, Isabel Veiga, Patrícia Rocha, Pedro Pinto, Carla Pinto, Manuela Pinheiro, Ana Peixoto, Maria Fragoso, Ana Raimundo, Paula Ferreira, Manuela Machado, Nuno Sousa, Paula Lopes, António Araújo, Joana Macedo, Fernando Alves…
    Citation: BMC Cancer 2013 13:169
    Content type: Research article Published on:

  11. Belinostat is a histone deacetylase inhibitor with anti-tumor effect in several pre-clinical tumor models and clinical trials. The aim of the study was to evaluate changes in cell proliferation and glucose upt...

    Authors: Mette Munk Jensen, Kamille Dumong Erichsen, Camilla Bardram Johnbeck, Fredrik Björkling, Jacob Madsen, Peter Buhl Jensen, Maxwell Sehested, Liselotte Højgaard and Andreas Kjær
    Citation: BMC Cancer 2013 13:168
    Content type: Research article Published on:

  12. UCN-01 (7-hydroxystaurosporine), a protein kinase inhibitor, has attracted a great deal of attention as a potent antitumour agent. Several clinical trials of UCN-01 alone or in combination with other agents fo...

    Authors: Guoyi Wu, Linan Xu, Nan Lin and Bo Liu
    Citation: BMC Cancer 2013 13:167
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2014 14:216

  13. Cancer stem cells (CSCs) are notorious for their capacity of tumor progression, metastasis or resistance to chemo-radiotherapy. However, the undisputed role of cancer stem marker, CD133, in colorectal cancers ...

    Authors: Khalilullah Mia-Jan, So Young Jung, Ik-Yong Kim, Sung Soo Oh, EunHee Choi, Sei Jin Chang, Tae Young Kang and Mee-Yon Cho
    Citation: BMC Cancer 2013 13:166
    Content type: Research article Published on:

  14. Clinical interpretation of health related quality of life (HRQOL) scores is challenging. The purpose of this analysis was to interpret score changes and identify minimal clinically important differences (MCID)...

    Authors: Fanxing Hong, Jaclyn L F Bosco, Nigel Bush and Donna L Berry
    Citation: BMC Cancer 2013 13:165
    Content type: Research article Published on:

  15. This open-label study compared docetaxel/gemcitabine vs. paclitaxel/gemcitabine and a weekly (W) vs. 3-weekly (3 W) schedule in metastatic breast cancer (MBC).

    Authors: Lucia Del Mastro, Alessandra Fabi, Mauro Mansutti, Michele De Laurentiis, Antonio Durando, Domenico Franco Merlo, Paolo Bruzzi, Ignazia La Torre, Matteo Ceccarelli, Gbenga Kazeem, Paolo Marchi, Davide Boy, Marco Venturini, Sabino De Placido and Francesco Cognetti
    Citation: BMC Cancer 2013 13:164
    Content type: Research article Published on:

  16. The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has be...

    Authors: George Fountzilas, Urania Dafni, Mattheos Bobos, Vassiliki Kotoula, Anna Batistatou, Ioannis Xanthakis, Christos Papadimitriou, Ioannis Kostopoulos, Triantafillia Koletsa, Eleftheria Tsolaki, Despina Televantou, Eleni Timotheadou, Angelos Koutras, George Klouvas, Epaminontas Samantas, Nikolaos Pisanidis…
    Citation: BMC Cancer 2013 13:163
    Content type: Research article Published on:

  17. Cancer-related fatigue (CRF) is one of the most common and distressing side effects of cancer and its treatment. During and after radiotherapy breast cancer patients often suffer from CRF which frequently impa...

    Authors: Karin Potthoff, Martina E Schmidt, Joachim Wiskemann, Holger Hof, Oliver Klassen, Nina Habermann, Philipp Beckhove, Juergen Debus, Cornelia M Ulrich and Karen Steindorf
    Citation: BMC Cancer 2013 13:162
    Content type: Study protocol Published on:

  18. Differential diagnosis of high-grade dysplastic nodules (HGDN) and well-differentiated hepatocellular carcinoma (WDHCC) represents a challenge to experienced hepatic clinicians, radiologists and hepatopatholog...

    Authors: Guang-Zhi Jin, Hui Dong, Wen-Long Yu, Yan Li, Xin-Yuan Lu, Hua Yu, Zhi-Hong Xian, Wei Dong, Yin-Kun Liu, Wen-Ming Cong and Meng-Chao Wu
    Citation: BMC Cancer 2013 13:161
    Content type: Research article Published on:

  19. Few high penetrance genes are known in Malignant Melanoma (MM), however, the involvement of low-penetrance genes such as MC1R, OCA2, ASIP, SLC45A2 and TYR has been observed. Lately, genome-wide association studie...

    Authors: Maria Peña-Chilet, Maite Blanquer-Maceiras, Maider Ibarrola-Villava, Conrado Martinez-Cadenas, Manuel Martin-Gonzalez, Cristina Gomez-Fernandez, Matias Mayor, Juan Antonio Aviles, Ana Lluch and Gloria Ribas
    Citation: BMC Cancer 2013 13:160
    Content type: Research article Published on:

  21. Systemic inflammation has been linked with cancer development, cancer cachexia and poor outcome. Advanced lung cancer inflammation index (ALI) was developed to assess degree of systemic inflammation at the tim...

    Authors: Syed H Jafri, Runhua Shi and Glenn Mills
    Citation: BMC Cancer 2013 13:158
    Content type: Research article Published on:

  22. Colorectal cancer (CRC) is the second leading cause of death from cancer in the United States. Colorectal cancers have a prolonged latency following initiation that may span decades providing ample time for im...

    Authors: Baktiar O Karim, Ki-Jong Rhee, Guosheng Liu, Dongfeng Zheng and David L Huso
    Citation: BMC Cancer 2013 13:157
    Content type: Research article Published on:

  23. L1CAM was originally identified as an adhesion molecule involved in neural development. In many human carcinomas L1CAM is over-expressed and is associated with a bad prognosis. We previously reported that L1CA...

    Authors: Uwe Schirmer, Heidi Fiegl, Marco Pfeifer, Alain G Zeimet, Elisabeth Müller-Holzner, Peter K Bode, Verena Tischler and Peter Altevogt
    Citation: BMC Cancer 2013 13:156
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:1047

  24. 53BP1 binds to the tumor suppressor p53 and has a key role in DNA damage response and repair. Low 53BP1 expression has been associated with decreased survival in breast cancer and has been shown to interact wi...

    Authors: Natalie L Ausborn, Tong Wang, Sabrina C Wentz, Mary Kay Washington, Nipun B Merchant, Zhiguo Zhao, Yu Shyr, Anuradha Bapsi Chakravarthy and Fen Xia
    Citation: BMC Cancer 2013 13:155
    Content type: Research article Published on:

  25. Pancreatic cancer shows a highly aggressive and infiltrative growth pattern and is characterized by an abundant tumor stroma known to interact with the cancer cells, and to influence tumor growth and drug resi...

    Authors: Daniel Öhlund, Oskar Franklin, Erik Lundberg, Christina Lundin and Malin Sund
    Citation: BMC Cancer 2013 13:154
    Content type: Research article Published on:

  26. Besides conventional adjuvant therapies, many breast cancer survivors engage in various activities like exercise, diet and complementary and alternative medicine (CAM) in order to improve their prognosis. Litt...

    Authors: Arnoud J Templeton, Beat Thürlimann, Michael Baumann, Michael Mark, Sarah Stoll, Madeleine Schwizer, Daniel Dietrich and Thomas Ruhstaller
    Citation: BMC Cancer 2013 13:153
    Content type: Research article Published on:

  27. This phase I study investigated the maximum tolerated dose (MTD), safety, pharmacokinetics and antitumor activity of ganetespib in patients with solid malignancies.

    Authors: Jonathan W Goldman, Robert N Raju, Gregory A Gordon, Iman El-Hariry, Florentina Teofilivici, Vojo M Vukovic, Robert Bradley, Michael D Karol, Yu Chen, Wei Guo, Takayo Inoue and Lee S Rosen
    Citation: BMC Cancer 2013 13:152
    Content type: Research article Published on:

  28. To determine whether ceramide is responsible for the induction of p53-independent early or late apoptosis in response to high- and low-Linear-Energy-Transfer (LET) irradiation.

    Authors: Gersende Alphonse, Mira Maalouf, Priscillia Battiston-Montagne, Dominique Ardail, Michaël Beuve, Robert Rousson, Gisela Taucher-Scholz, Claudia Fournier and Claire Rodriguez-Lafrasse
    Citation: BMC Cancer 2013 13:151
    Content type: Research article Published on:

  29. The insulin-like growth factor-1 (IGF-1) plays an important role in growth of prostate cancer (PCa) cells and facilitating the development and progression of PCa. This study aimed to evaluate the association o...

    Authors: Norihiko Tsuchiya, Shintaro Narita, Takamitsu Inoue, Mitsuru Saito, Kazuyuki Numakura, Mingguo Huang, Shingo Hatakeyama, Shigeru Satoh, Seiichi Saito, Chikara Ohyama, Yoichi Arai, Osamu Ogawa and Tomonori Habuchi
    Citation: BMC Cancer 2013 13:150
    Content type: Research article Published on:

  30. Adjuvant chemotherapy for stage III colon cancer is internationally accepted as standard treatment with established efficacy. Several oral fluorouracil (5-FU) derivatives with different properties are availabl...

    Authors: Megumi Ishiguro, Kenjiro Kotake, Genichi Nishimura, Naohiro Tomita, Wataru Ichikawa, Keiichi Takahashi, Toshiaki Watanabe, Tomohisa Furuhata, Ken Kondo, Masaki Mori, Yoshihiro Kakeji, Akiyoshi Kanazawa, Michiya Kobayashi, Masazumi Okajima, Ichinosuke Hyodo, Keiko Miyakoda…
    Citation: BMC Cancer 2013 13:149
    Content type: Study protocol Published on:

  31. Aberrant chromatin structure in cancer cells results from altered proteins involved in its packaging. Heterochromatin protein 1 gamma (HP1γ) is a non-histone heterochromatic protein that functions to maintain ...

    Authors: Jon Slezak, Matthew Truong, Wei Huang and David Jarrard
    Citation: BMC Cancer 2013 13:148
    Content type: Research article Published on:

  32. Temozolomide (TMZ) is the most widely used drug to treat glioblastoma (GBM), which is the most common and aggressive primary tumor of the Central Nervous System and one of the hardest challenges in oncotherapy...

    Authors: Eduardo C Filippi-Chiela, Marcos Paulo Thomé, Mardja Manssur Bueno e Silva, Alessandra Luíza Pelegrini, Pitia Flores Ledur, Bernardo Garicochea, Lauren L Zamin and Guido Lenz
    Citation: BMC Cancer 2013 13:147
    Content type: Research article Published on:

  33. Ovarian carcinoma is a common, and often deadly, gynecological cancer. Mutations in BRCA1 and BRCA2 genes are present in at least a fifth of patients. Uncovering other genes that become mutated subsequent to BRCA...

    Authors: Jian Zhang, Yuhao Shi, Emilie Lalonde, Lili Li, Luca Cavallone, Alex Ferenczy, Walter H Gotlieb, William D Foulkes and Jacek Majewski
    Citation: BMC Cancer 2013 13:146
    Content type: Research article Published on:

  34. Snail1 is a transcription regulator of E-cadherin. The loss of E-cadherin seems to be a crucial step in the process of Epithelial-mesenchymal transition (EMT). EMT initiates invasion and proliferation in many ...

    Authors: Feride Kroepil, Georg Fluegen, Daniel Vallböhmer, Stephan E Baldus, Levent Dizdar, Andreas M Raffel, Dieter Hafner, Nikolas H Stoecklein and Wolfram T Knoefel
    Citation: BMC Cancer 2013 13:145
    Content type: Research article Published on:

  35. The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined to...

    Authors: Robert Kim, Prakash Kulkarni and Sridhar Hannenhalli
    Citation: BMC Cancer 2013 13:144
    Content type: Research article Published on:

  36. It is important to simultaneously induce strong cell death and antitumor immunity in cancer patients for successful cancer treatment. Here, we investigated the cytotoxic and phenotypic modulation effects of th...

    Authors: Yun Choi, Ho Won Lee, Jaetae Lee and Yong Hyun Jeon
    Citation: BMC Cancer 2013 13:143
    Content type: Research article Published on:

  37. The aberrant methylation of CpG islands in the promoter is associated with colorectal cancer (CRC) carcinogenesis. In our previous study, the promoter of alcohol dehydrogenase, iron containing, 1 (ADHFE1) was mos...

    Authors: Chung Hyun Tae, Kyung Ju Ryu, Seok-Hyung Kim, Hee Cheol Kim, Ho-Kyung Chun, Byung-Hoon Min, Dong Kyung Chang, Poong-Lyul Rhee, Jae J Kim, Jong Chul Rhee and Young-Ho Kim
    Citation: BMC Cancer 2013 13:142
    Content type: Research article Published on:

  38. Salivary gland cancer (SGC) is one of the common malignancies of the head and neck area. It develops in the minor and major salivary glands and sometimes metastasizes to other organs, particularly to the lungs...

    Authors: Tomoki Sumida, Ryuichi Murase, Akiko Onishi-Ishikawa, Sean D McAllister, Hiroyuki Hamakawa and Pierre-Yves Desprez
    Citation: BMC Cancer 2013 13:141
    Content type: Research article Published on:

  39. Malignant pleural mesothelioma (MPM) is an aggressive malignancy closely associated with asbestos exposure and extremely resistant to current treatments. It exhibits a steady increase in incidence, thus necess...

    Authors: Bao-Zhu Yuan, Joshua Chapman, Min Ding, Junzhi Wang, Binghua Jiang, Yon Rojanasakul and Steven H Reynolds
    Citation: BMC Cancer 2013 13:140
    Content type: Research article Published on:

  40. NR4A orphan nuclear receptors are involved in multiple biological processes which are important in tumorigenesis such as cell proliferation, apoptosis, differentiation, and glucose utilization. The significanc...

    Authors: Shawn Llopis, Brittany Singleton, Tamika Duplessis, Latonya Carrier, Brian Rowan and Christopher Williams
    Citation: BMC Cancer 2013 13:139
    Content type: Research article Published on:

  41. Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA

    Authors: Emer M Guinan, Juliette Hussey, Sarah A McGarrigle, Laura A Healy, Jacintha N O’Sullivan, Kathleen Bennett and Elizabeth M Connolly
    Citation: BMC Cancer 2013 13:138
    Content type: Study protocol Published on:

  42. We attempted to identify novel biomarkers and therapeutic targets for esophageal squamous cell carcinoma by gene expression profiling of frozen esophageal squamous carcinoma specimens and examined the function...

    Authors: Qing Wang, Chenming Ma and Wolfgang Kemmner
    Citation: BMC Cancer 2013 13:137
    Content type: Research article Published on:

  43. In China, there are currently no approved therapies for the treatment of metastatic renal cell carcinoma (mRCC) following progression with vascular endothelial growth factor (VEGF)-targeted agents. In the phas...

    Authors: Jun Guo, Yiran Huang, Xu Zhang, Fangjian Zhou, Yinghao Sun, Shukui Qin, Zhangqun Ye, Hui Wang, Annette Jappe, Patrick Straub, Nicoletta Pirotta and Sven Gogov
    Citation: BMC Cancer 2013 13:136
    Content type: Research article Published on:

  44. The measurement properties of instruments used to assess functional capacity, physical activity and muscle strength in participants with non-small cell lung cancer (NSCLC) have not been systematically reviewed.

    Authors: Catherine L Granger, Christine F McDonald, Selina M Parry, Cristino C Oliveira and Linda Denehy
    Citation: BMC Cancer 2013 13:135
    Content type: Research article Published on:

  45. The p53 protein is expressed as multiple isoforms that differ in their N- and C-terminus due to alternative splicing, promoter or codon initiation usage. Δ40p53 lacks the first 39 residues containing the main ...

    Authors: Hind Hafsi, Daniela Santos-Silva, Stéphanie Courtois-Cox and Pierre Hainaut
    Citation: BMC Cancer 2013 13:134
    Content type: Research article Published on:

  46. The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has markedly increased over the last three decades due to newly found associations with human papillomavirus (HPV) infection. Primary radiotherapy...

    Authors: Anthony C Nichols, John Yoo, J Alex Hammond, Kevin Fung, Eric Winquist, Nancy Read, Varagur Venkatesan, S Danielle MacNeil, D Scott Ernst, Sara Kuruvilla, Jeff Chen, Martin Corsten, Michael Odell, Libni Eapen, Julie Theurer, Philip C Doyle…
    Citation: BMC Cancer 2013 13:133
    Content type: Study protocol Published on:

  48. There is currently no consensus regarding the optimal timing for androgen suppression therapy in patients with prostate cancer that have undergone local therapy with curative intent but are proven to have node...

    Authors: Frank Kunath, Bastian Keck, Gerta Rücker, Edith Motschall, Bernd Wullich, Gerd Antes and Joerg J Meerpohl
    Citation: BMC Cancer 2013 13:131
    Content type: Research article Published on:

  49. Lung cancer diagnosis is usually achieved through a set of bronchoscopic techniques or computed tomography guided-transthoracic needle aspiration (CT-TTNA). However these procedures have a variable diagnostic ...

    Authors: Antonio Bugalho, Dalila Ferreira, Ralf Eberhardt, Sara S Dias, Paula A Videira, Felix J Herth and Luis Carreiro
    Citation: BMC Cancer 2013 13:130
    Content type: Research article Published on:

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