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  1. DNA methylation is a well-known epigenetic mechanism involved in epigenetic gene regulation. Several genes were reported hypermethylated in CRC, althought no gene marker was proven to be individually of suffic...

    Authors: Jean-Pierre Roperch, Roberto Incitti, Solène Forbin, Floriane Bard, Hicham Mansour, Farida Mesli, Isabelle Baumgaertner, Francesco Brunetti and Iradj Sobhani
    Citation: BMC Cancer 2013 13:566
    Content type: Research article Published on:

  2. Genetic BRCA2 insufficiency is associated with breast cancer development; however, in sporadic breast cancer cases, high BRCA2 expression is paradoxically correlated with poor prognosis. Because DSS1, a mammal...

    Authors: Andri Rezano, Kazuhiko Kuwahara, Mutsuko Yamamoto-Ibusuki, Masahiro Kitabatake, Penpak Moolthiya, Suchada Phimsen, Taiji Suda, Shigenobu Tone, Yutaka Yamamoto, Hirotaka Iwase and Nobuo Sakaguchi
    Citation: BMC Cancer 2013 13:562
    Content type: Research article Published on:

  3. The aim of this study was to evaluate the role of family history of cancer and personal history of other medical conditions in the aetiology of the oral cavity cancer in France.

    Authors: Loredana Radoï, Sophie Paget-Bailly, Florence Guida, Diane Cyr, Gwenn Menvielle, Annie Schmaus, Matthieu Carton, Sylvie Cénée, Marie Sanchez, Anne-Valérie Guizard, Brigitte Trétarre, Isabelle Stücker and Danièle Luce
    Citation: BMC Cancer 2013 13:560
    Content type: Research article Published on:

  4. A diagnosis of prostate cancer leads to emotional distress and anxiety, prompting calls for rapid diagnostic pathways. Nevertheless, it remains unclear what impact time between diagnosis and surgery has upon p...

    Authors: Maria Theresa Redaniel, Richard M Martin, David Gillatt, Julia Wade and Mona Jeffreys
    Citation: BMC Cancer 2013 13:559
    Content type: Research article Published on:

  5. The St Gallen surrogate molecular subtype definitions classify the oestrogen (ER) positive breast cancer into the luminal A and luminal B subtypes according to proliferation rate and/or expression of human epi...

    Authors: Anna-Karin Falck, Mårten Fernö, Pär-Ola Bendahl and Lisa Rydén
    Citation: BMC Cancer 2013 13:558
    Content type: Research article Published on:

  6. WNT signaling pathways are significantly altered during cancer development. Vertebrates possess two classes of WNT signaling pathways: the “canonical” WNT/β-catenin signaling pathway, and the “non-canonical” p...

    Authors: Beatriz García-Castro, Monserrat Alvarez-Zavala, Alma R Riveros-Magaña, Pablo C Ortíz-Lazareno, Sarah Ratkovich-González, Georgina Hernández-Flores, Alejandro Bravo-Cuellar, Luis F Jave-Suarez and Adriana Aguilar-Lemarroy
    Citation: BMC Cancer 2013 13:557
    Content type: Research article Published on:

  7. We have previously shown that a functional polymorphism of the UGT2B15 gene (rs1902023) was associated with increased risk of prostate cancer (PC). Novel functional polymorphisms of the UGT2B17 and UGT2B15 genes ...

    Authors: Adriana C Vidal, Cocoa Tucker, Joellen M Schildkraut, Ricardo M Richardson, Megan McPhail, Stephen J Freedland, Cathrine Hoyo and Delores J Grant
    Citation: BMC Cancer 2013 13:556
    Content type: Research article Published on:

  8. Glutamate decarboxylase 1 (GAD1), a rate-limiting enzyme in the production of γ-aminobutyric acid (GABA), is found in the GABAergic neurons of the central nervous system. Little is known about the relevance of...

    Authors: Ryota Kimura, Atsushi Kasamatsu, Tomoyoshi Koyama, Chonji Fukumoto, Yukinao Kouzu, Morihiro Higo, Yosuke Endo-Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa and Katsuhiro Uzawa
    Citation: BMC Cancer 2013 13:555
    Content type: Research article Published on:

  9. Pancreatic cancer (PC) is an aggressive disease with an urgent need for biomarkers. Hallmarks of PC include increased collagen deposition (desmoplasia) and increased matrix metalloproteinase (MMP) activity. Th...

    Authors: Nicholas Willumsen, Cecilie L Bager, Diana J Leeming, Victoria Smith, Morten A Karsdal, David Dornan and Anne-Christine Bay-Jensen
    Citation: BMC Cancer 2013 13:554
    Content type: Research article Published on:

  10. Data on the current burden of adenocarcinoma (ADC) and histology-specific human papillomavirus (HPV) type distribution are relevant to predict the future impact of prophylactic HPV vaccines.

    Authors: Jeanne M Pimenta, Claudia Galindo, David Jenkins and Sylvia M Taylor
    Citation: BMC Cancer 2013 13:553
    Content type: Research article Published on:

  11. The tumor suppressor p53 is a sequence-specific transcription factor that regulates an extensive network of coding genes, long non-coding RNAs and microRNAs, that establish intricate gene regulatory circuits i...

    Authors: Alessandra Bisio, Veronica De Sanctis, Valerio Del Vescovo, Michela A Denti, Anil G Jegga, Alberto Inga and Yari Ciribilli
    Citation: BMC Cancer 2013 13:552
    Content type: Research article Published on:

  13. Heterogeneous echogenicity of the thyroid gland has been associated with diffuse thyroid disease and benign and malignant nodules can coexist with diffuse thyroid disease. Underlying heterogeneous echogenicity...

    Authors: Mina Park, So Hee Park, Eun-Kyung Kim, Jung Hyun Yoon, Hee Jung Moon, Hye Sun Lee and Jin Young Kwak
    Citation: BMC Cancer 2013 13:550
    Content type: Research article Published on:

  14. Resistance to platinum-based chemotherapy remains a major impediment in the treatment of serous epithelial ovarian cancer. The objective of this study was to use gene expression profiling to delineate major de...

    Authors: Madhuri Koti, Robert J Gooding, Paulo Nuin, Alexandria Haslehurst, Colleen Crane, Johanne Weberpals, Timothy Childs, Peter Bryson, Moyez Dharsee, Kenneth Evans, Harriet E Feilotter, Paul C Park and Jeremy A Squire
    Citation: BMC Cancer 2013 13:549
    Content type: Research article Published on:

  15. Replanning in intensity-modulated radiotherapy (IMRT) has been reported to improve quality of life and loco-regional control in patients with nasopharyngeal cancer (NPC). Determination of the criteria for repl...

    Authors: DanFang Yan, SenXiang Yan, QiDong Wang, XinBiao Liao, ZhongJie Lu and YiXiang Wang
    Citation: BMC Cancer 2013 13:548
    Content type: Research article Published on:

  16. Nivestim™ (filgrastim) is a follow-on biologic agent licensed in the EU for the treatment of neutropenia and febrile neutropenia induced by myelosuppressive chemotherapy. Nivestim™ has been studied in phase 2 ...

    Authors: Didier Kamioner, Stefan Fruehauf, Fréderic Maloisel, Laurent Cals, Stéphane Lepretre and Christian Berthou
    Citation: BMC Cancer 2013 13:547
    Content type: Study protocol Published on:

  17. The chemotherapy resistance of non-small cell lung cancer (NSCLC) remains a clinic challenge and is closely associated with several biomarkers including epidermal growth factor receptor (EGFR) ( Drugs 72(Suppl...

    Authors: Xiao-Yi Duan, Wen Wang, Jian-Sheng Wang, Jin Shang, Jun-Gang Gao and You-Min Guo
    Citation: BMC Cancer 2013 13:546
    Content type: Research article Published on:

  18. The present study focused on the prognostic roles of PIK3CA and PIK3R1 genes and additional PI3K pathway-associated genes in breast cancer.

    Authors: Magdalena Cizkova, Sophie Vacher, Didier Meseure, Martine Trassard, Aurélie Susini, Dana Mlcuchova, Celine Callens, Etienne Rouleau, Frederique Spyratos, Rosette Lidereau and Ivan Bièche
    Citation: BMC Cancer 2013 13:545
    Content type: Research article Published on:

  19. During cancer treatment children have reduced contact with their social network of friends, and have limited participation in education, sports, and leisure activities. During and following cancer treatment, c...

    Authors: Troels Thorsteinsson, Anne Sofie Helms, Lis Adamsen, Lars Bo Andersen, Karen Vitting Andersen, Karl Bang Christensen, Henrik Hasle, Carsten Heilmann, Nete Hejgaard, Christoffer Johansen, Marianne Madsen, Svend Aage Madsen, Venka Simovska, Birgit Strange, Lone Friis Thing, Peder Skov Wehner…
    Citation: BMC Cancer 2013 13:544
    Content type: Study protocol Published on:

  20. Nowadays, evaluation of colorectal cancer prognosis and decision-making for treatment continues to be based primarily on TNM tumour stage. Administration of adjuvant chemotherapy is especially challenging for ...

    Authors: Daniel Ayude, Francisco Javier Rodríguez-Berrocal, José Ayude, Sonia Blanco-Prieto, Lorena Vázquez-Iglesias, Marta Vázquez-Cedeira and María Páez de la Cadena
    Citation: BMC Cancer 2013 13:543
    Content type: Research article Published on:

  21. Systemic capillary leak syndrome is a rare disease with a high mortality rate. This syndrome is characterised by generalised edema, hypotension, hemoconcentration, and hypoproteinemia. The cause is the sudden ...

    Authors: Andrea Casadei Gardini, Michele Aquilina, Devil Oboldi, Alessandro Lucchesi, Silvia Carloni, Elena Tenti, Marco Angelo Burgio, Dino Amadori and Giovanni Luca Frassineti
    Citation: BMC Cancer 2013 13:542
    Content type: Case report Published on:

  22. The purpose of the present study was to retrospectively evaluate whether copy number changes of the genes encoding the ribonucleotide reductase subunit M1 (RRM1) and/or subunit M2B (RRM2B) predict sensitivity to ...

    Authors: Charlotte LT Jørgensen, Bent Ejlertsen, Karsten D Bjerre, Eva Balslev, Dorte L Nielsen and Kirsten V Nielsen
    Citation: BMC Cancer 2013 13:541
    Content type: Research article Published on:

  23. In a previously published report we characterized the expression of the metastasis-associated proteins S100A4, osteopontin (OPN) and ephrin-A1 in a prospectively collected panel of non-small cell lung cancer (...

    Authors: Ane Kongsgaard Rud, Kjetil Boye, Miriam Øijordsbakken, Marius Lund-Iversen, Ann Rita Halvorsen, Steinar K Solberg, Gisle Berge, Åslaug Helland, Odd Terje Brustugun and Gunhild M Mælandsmo
    Citation: BMC Cancer 2013 13:540
    Content type: Research article Published on:

  24. Esophageal cancer (EC) is a frequently occurring cancer with poor prognosis despite combined therapeutic strategies. Many biomarkers have been proposed as predictors of adverse events. We sought to assess the ...

    Authors: Meilan Chen, Jizheng Huang, Zhenli Zhu, Jun Zhang and Ke Li
    Citation: BMC Cancer 2013 13:539
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2014 14:892

  25. Molecular imaging of breast cancer is a promising emerging technology, potentially able to improve clinical care. Valid imaging targets for molecular imaging tracer development are membrane-bound hypoxia-relat...

    Authors: Arthur Adams, Aram SA van Brussel, Jeroen F Vermeulen, Willem PThM Mali, Elsken van der Wall, Paul J van Diest and Sjoerd G Elias
    Citation: BMC Cancer 2013 13:538
    Content type: Research article Published on:

  26. Triple Negative subset of (TN) Breast Cancers (BC), a close associate of the basal-like subtype (with limited discordance) is an aggressive form of the disease which convey unpredictable, and poor prognosis du...

    Authors: Nandini Dey, Benjamin G Barwick, Carlos S Moreno, Maja Ordanic-Kodani, Zhengjia Chen, Gabriella Oprea-Ilies, Weining Tang, Charles Catzavelos, Kimberly F Kerstann, George W Sledge Jr., Mark Abramovitz, Mark Bouzyk, Pradip De and Brian R Leyland-Jones
    Citation: BMC Cancer 2013 13:537
    Content type: Research article Published on:

  27. Gastric cancer (GC) is a threat to human health with increasing incidence and mortality worldwide. Down-regulation or absence of RAF kinase inhibitor protein (RKIP) was associated with the occurrence, differen...

    Authors: Huan Gu, Xianquan Zhan, Guiying Zhang, Lu Yan, William CS Cho, Maoyu Li, Ting Liu and Zhuchu Chen
    Citation: BMC Cancer 2013 13:536
    Content type: Research article Published on:

  28. Mesenchymal stromal cells (MSCs) represent heterogeneous cell population suitable for cell therapies in regenerative medicine. MSCs can also substantially affect tumor biology due to their ability to be recrui...

    Authors: Lucia Kucerova, Svetlana Skolekova, Miroslava Matuskova, Martin Bohac and Zuzana Kozovska
    Citation: BMC Cancer 2013 13:535
    Content type: Research article Published on:

  29. National organizations recommend screening for hepatitis B virus (HBV) before chemotherapy but differ regarding which patients should be screened. We aimed to determine contemporary screening rates at a cancer...

    Authors: Jessica P Hwang, Michael J Fisch, Anna S-F Lok, Hong Zhang, John M Vierling and Maria E Suarez-Almazor
    Citation: BMC Cancer 2013 13:534
    Content type: Research article Published on:

  30. Current evidence implicates aberrant microRNA expression patterns in human malignancies; measurement of microRNA expression may have diagnostic and prognostic applications. Roles for microRNAs in head and neck...

    Authors: Patricia Severino, Holger Brüggemann, Flavia Maziero Andreghetto, Carme Camps, Maria de Fatima Garrido Klingbeil, Welbert Oliveira de Pereira, Renata Machado Soares, Raquel Moyses, Victor Wünsch-Filho, Monica Beatriz Mathor, Fabio Daumas Nunes, Jiannis Ragoussis and Eloiza Helena Tajara
    Citation: BMC Cancer 2013 13:533
    Content type: Research article Published on:

  31. An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL ...

    Authors: Ronald Koschny, Sylvia Brost, Ulf Hinz, Jaromir Sykora, Emanuela M Batke, Stephan Singer, Kai Breuhahn, Wolfgang Stremmel, Henning Walczak, Peter Schemmer, Peter Schirmacher and Tom M Ganten
    Citation: BMC Cancer 2013 13:532
    Content type: Research article Published on:

  32. In contrast to sessile serrated adenomas and traditional serrated adenomas which are associated with a significant cancer risk, the role of hyperplastic polyps (HP) in colorectal carcinogenesis as well as the ...

    Authors: Catherine Do, Claudine Bertrand, Julien Palasse, Marie-Bernadette Delisle, Elizabeth Cohen-Jonathan-Moyal and Catherine Seva
    Citation: BMC Cancer 2013 13:531
    Content type: Research article Published on:

  33. The objective of this work was to assess the overall survival, cause-specific survival and biochemical failure-free survival of a contemporary cohort of patients with localized prostate cancer (PCa) treated wi...

    Authors: Tomás Merino, Ignacio F San Francisco, Pablo A Rojas, Piero Bettoli, Álvaro Zúñiga and Pelayo Besa
    Citation: BMC Cancer 2013 13:530
    Content type: Research article Published on:

  34. Small-cell lung cancer with epidermal growth factor receptor (EGFR) gene mutation typically manifests as a transformation occurring after EGFR tyrosine kinase inhibitor therapy for adenocarcinoma with EGFR mutati...

    Authors: Yusuke Takagi, Yoshiro Nakahara, Yukio Hosomi and Tsunekazu Hishima
    Citation: BMC Cancer 2013 13:529
    Content type: Case report Published on:

  35. A total of 2,514,346 metric tons (Mt) of asbestos were imported into Spain from 1906 until the ban on asbestos in 2002. Our objective was to study pleural cancer mortality trends as an indicator of mesotheliom...

    Authors: Gonzalo López-Abente, Montserrat García-Gómez, Alfredo Menéndez-Navarro, Pablo Fernández-Navarro, Rebeca Ramis, Javier García-Pérez, Marta Cervantes, Eva Ferreras, María Jiménez-Muñoz and Roberto Pastor-Barriuso
    Citation: BMC Cancer 2013 13:528
    Content type: Research article Published on:

  36. Recent studies have demonstrated that synthetic dsRNAs may produce therapeutic effects in a target-independent manner through stimulation of the toll-like receptor-3 (TLR3)/interferon pathway; as a result, ang...

    Authors: Yu-Yin Xu, Li Chen, Gui-Lan Wang, Jia-Ming Zhou, Yi-Xin Zhang, Yin-Ze Wei, Yuan-Yuan Zhu and Jing Qin
    Citation: BMC Cancer 2013 13:527
    Content type: Research article Published on:

  37. Colorectal cancer (CRC) is one of the most common and comprehensively studied malignancies. Hypoxic conditions during formation of CRC may support the development of more aggressive cancers. Hypoxia inducible ...

    Authors: Agnieszka A Rawluszko, Katarzyna E Bujnicka, Karolina Horbacka, Piotr Krokowicz and Paweł P Jagodziński
    Citation: BMC Cancer 2013 13:526
    Content type: Research article Published on:

  38. The purpose of this study was to evaluate whether early changes in 3′-deoxy-3′-3H-fluorothymidine (3H-FLT) uptake can reflect the antiproliferative effect of gefitinib in a human tumor xenograft, in comparison wi...

    Authors: Songji Zhao, Yuji Kuge, Yan Zhao, Satoshi Takeuchi, Kenji Hirata, Toshiki Takei, Tohru Shiga, Hirotoshi Dosaka-Akita and Nagara Tamaki
    Citation: BMC Cancer 2013 13:525
    Content type: Research article Published on:

  39. Clear cell carcinomas are aggressive tumors with a distinct biologic behaviour. In a genome-wide screening for genes involved in chemo-resistance, NAPA was over-expressed in cisplatin-resistant cells. The NAPA...

    Authors: Ingiridur Skirnisdottir, Kathrine Bjersand, Helena Åkerud and Tomas Seidal
    Citation: BMC Cancer 2013 13:524
    Content type: Research article Published on:

  40. Poly(adenosine diphosphate–ribose) polymerase 1 (PARP-1) and the balance between BRCA1 and 53BP1 play a key role in the DNA repair and cell stress response. PARP inhibitors show promising clinical activity in ...

    Authors: William Jacot, Simon Thezenas, Romain Senal, Cathy Viglianti, Anne-Claire Laberenne, Evelyne Lopez-Crapez, Frédéric Bibeau, Jean-Pierre Bleuse, Gilles Romieu and Pierre-Jean Lamy
    Citation: BMC Cancer 2013 13:523
    Content type: Research article Published on:

  41. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in China. This study investigated the effects of Annexin A7 (ANXA7) on the inhibition of HCC lymph node metastasis in a mouse model.

    Authors: Yanling Jin, Shaoqing Wang, Wenjing Chen, Jun Zhang, Bo Wang, Hongwei Guan and Jianwu Tang
    Citation: BMC Cancer 2013 13:522
    Content type: Research article Published on:

  42. There is growing evidence indicating the insulin-like growth factor 1 receptor (IGF-1R) plays a critical role in the progression of human colorectal carcinomas. IGF-1R is an attractive drug target for the trea...

    Authors: Quan Wang, Feng Wei, Guoyue Lv, Chunsheng Li, Tongjun Liu, Costas G Hadjipanayis, Guikai Zhang, Chunhai Hao and Anita C Bellail
    Citation: BMC Cancer 2013 13:521
    Content type: Research article Published on:

  43. Ezrin, a member of the ezrin/radixin/moesin (ERM) protein family, plays a pivotal role in tumor invasion and metastasis. This study is aimed to investigate the clinicopathological significance of upregulated e...

    Authors: Jienan Kong, Yan Li, Shuangping Liu, Haidan Jin, Yongjun Shang, Chengshi Quan, Yulin Li and Zhenhua Lin
    Citation: BMC Cancer 2013 13:520
    Content type: Research article Published on:

  44. Given their frequency of occurrence in the United States, cancer and heart disease often coexist. For patients requiring open-heart surgery, this raises concern that the use of cardiopulmonary bypass (CPB) may...

    Authors: Cathy Anne Pinto, Stephen Marcella, David A August, Bart Holland, John B Kostis and Kitaw Demissie
    Citation: BMC Cancer 2013 13:519
    Content type: Research article Published on:

  45. Colorectal cancer (CRC) is characterised by hypoxia, which activates gene transcription through hypoxia-inducible factors (HIF), as well as by expression of epidermal growth factor (EGF) and EGF receptors, tar...

    Authors: Tak L Khong, Ngayu Thairu, Helene Larsen, Peter M Dawson, Serafim Kiriakidis and Ewa M Paleolog
    Citation: BMC Cancer 2013 13:518
    Content type: Research article Published on:

  46. CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies.

    Authors: Pamela A Havre, Long H Dang, Kei Ohnuma, Satoshi Iwata, Chikao Morimoto and Nam H Dang
    Citation: BMC Cancer 2013 13:517
    Content type: Research article Published on:

  47. Nerve growth factor (NGF) is a neurotrophin and has been suggested to induce heme oxygenase-1 (HO1) expression. Although the role of HO1 in tumorigenesis remains controversial, recent evidence suggests NGF and...

    Authors: Sang Jae Noh, Jun Sang Bae, Urangoo Jamiyandorj, Ho Sung Park, Keun Sang Kwon, Sung Hoo Jung, Hyun Jo Youn, Ho Lee, Byung-Hyun Park, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang and Kyu Yun Jang
    Citation: BMC Cancer 2013 13:516
    Content type: Research article Published on:

  48. The purpose of the present study was to investigate the feasibility of using volumetric modulated arc therapy with SmartArc (VMAT-S) to achieve radiation delivery efficiency higher than that of intensity-modul...

    Authors: Ruijie Yang, Junjie Wang, Shouping Xu and Hua Li
    Citation: BMC Cancer 2013 13:515
    Content type: Research article Published on:

  49. Near-infrared optical imaging targeting the intrinsic contrast of tissue hemoglobin has emerged as a promising approach for visualization of vascularity in cancer research. We evaluated the usefulness of diffu...

    Authors: Shigeto Ueda, Noriko Nakamiya, Kazuo Matsuura, Takashi Shigekawa, Hiroshi Sano, Eiko Hirokawa, Hiroko Shimada, Hiroaki Suzuki, Motoki Oda, Yutaka Yamashita, Osamu Kishino, Ichiei Kuji, Akihiko Osaki and Toshiaki Saeki
    Citation: BMC Cancer 2013 13:514
    Content type: Research article Published on:

  50. Concurrent chemo-radiotherapy is demonstrately superior to sequential chemo-radiotherapy in the treatment of advanced Non-Small-Cell Lung Cancer not suitable for surgery. Docetaxel is considered to enhance the...

    Authors: Alessandra Bearz, Emilio Minatel, Imad Abu Rumeileh, Eugenio Borsatti, Renato Talamini, Giovanni Franchin, Carlo Gobitti, Alessandro Del Conte, Marco Trovò and Tanja Baresic
    Citation: BMC Cancer 2013 13:513
    Content type: Research article Published on:

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