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  1. Translationally controlled tumor protein (TCTP), alternatively called fortilin, is believed to be involved in the development of the chemoresistance of tumor cells against anticancer drugs such as etoposide, t...

    Authors: Jaehoon Jung, Hyo Young Kim, Jeehye Maeng, Moonhee Kim, Dong Hae Shin and Kyunglim Lee
    Citation: BMC Cancer 2014 14:165
  2. Cervical cancer is the first female cancer in Lao PDR, a low-income country with no national screening and prevention programs for this human papillomavirus (HPV) associated pathology. HIV-infected women have ...

    Authors: Chanvilay SICHANH, Fabrice QUET, Phetsavanh CHANTHAVILAY, Joeffroy DIENDERE, Vatthanaphone LATTHAPHASAVANG, Christophe LONGUET and Yves BUISSON
    Citation: BMC Cancer 2014 14:161
  3. Resistance to 5-fluorouracil (5-FU) in patients with colorectal cancer prevents effective treatment and leads to unnecessary and burdensome chemotherapy. Therefore, prediction of 5-FU resistance is imperative.

    Authors: Ji-Won Park, Seung Cheol Kim, Won Ki Kim, Jun Pyu Hong, Kyung-Hee Kim, Hyun Yang Yeo, Jae Yong Lee, M Sun Kim, Jong Heon Kim, Se Young Yang, Dae Yong Kim, Jae Hwan Oh, Jae Youl Cho and Byong Chul Yoo
    Citation: BMC Cancer 2014 14:160
  4. The molecular basis to overcome therapeutic resistance to treat glioblastoma remains unclear. The anti-apoptotic b cell lymphoma 2 (BCL2) gene is associated with treatment resistance, and is transactivated by the...

    Authors: Noelyn Hung, Yu-Jen Chen, Ahmad Taha, Magnus Olivecrona, Ronald Boet, Anna Wiles, Tracy Warr, Alisha Shaw, Ramona Eiholzer, Bruce C Baguley, Michael R Eccles, Antony W Braithwaite, Martin MacFarlane, Janice A Royds and Tania Slatter
    Citation: BMC Cancer 2014 14:159
  5. In the present study we determined the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The infla...

    Authors: Tal Leibovich-Rivkin, Yulia Liubomirski, Tsipi Meshel, Anastasia Abashidze, Daphna Brisker, Hilla Solomon, Varda Rotter, Miguel Weil and Adit Ben-Baruch
    Citation: BMC Cancer 2014 14:158
  6. Rectal and pararectal gastrointestinal stromal tumors (GISTs) are rare. The optimal management strategy for primary localized GISTs remains poorly defined.

    Authors: Thanh-Khoa Huynh, Pierre Meeus, Philippe Cassier, Olivier Bouché, Sophie Lardière-Deguelte, Antoine Adenis, Thierry André, Julien Mancini, Olivier Collard, Michael Montemurro, Emmanuelle Bompas, Maria Rios, Nicolas Isambert, Didier Cupissol, Jean-Yves Blay and Florence Duffaud
    Citation: BMC Cancer 2014 14:156
  7. This randomized Phase III trial will evaluate whether the methylene blue-assisted technique is efficient for harvesting lymph nodes after radical surgery for gastric cancer.

    Authors: Toru Aoyama, Takaki Yoshikawa, Satoshi Morita, Junya Shirai, Hirohito Fujikawa, Kenichi Iwasaki, Tsutomu Hayashi, Takashi Ogata, Haruhiko Cho, Norio Yukawa, Takashi Oshima, Yasushi Rino, Munetaka Masuda and Akira Tsuburaya
    Citation: BMC Cancer 2014 14:155
  8. Cancer cell adopts peculiar metabolic strategies aimed to sustain the continuous proliferation in an environment characterized by relevant fluctuations in oxygen and nutrient levels. Monocarboxylate transporte...

    Authors: Patrizia Sanità, Mattia Capulli, Anna Teti, Giuseppe Paradiso Galatioto, Carlo Vicentini, Paola Chiarugi, Mauro Bologna and Adriano Angelucci
    Citation: BMC Cancer 2014 14:154
  9. Ki-67 is a nuclear protein involved in cell proliferation regulation, and its expression has been widely used as an index to evaluate the proliferative activity of lymphoma. However, its prognostic value for l...

    Authors: Xin He, Zhigang Chen, Tao Fu, Xueli Jin, Teng Yu, Yun Liang, Xiaoying Zhao and Liansheng Huang
    Citation: BMC Cancer 2014 14:153
  10. Experimental and clinical data suggest that solid cancers contain treatment-resistant cancer stem cells that will impair treatment efficacy. The objective of this study was to investigate if head and neck squa...

    Authors: Chann Lagadec, Erina Vlashi, Sunita Bhuta, Chi Lai, Paul Mischel, Martin Werner, Michael Henke and Frank Pajonk
    Citation: BMC Cancer 2014 14:152
  11. Chemoresistance of glioblastoma multiforme (GBM) has been attributed to the presence within the tumor of cancer stem cells (GSCs). The standard therapy for GBM consists of surgery followed by radiotherapy and ...

    Authors: Lucio Tentori, Lucia Ricci-Vitiani, Alessia Muzi, Fabio Ciccarone, Federica Pelacchi, Roberta Calabrese, Daniele Runci, Roberto Pallini, Paola Caiafa and Grazia Graziani
    Citation: BMC Cancer 2014 14:151
  12. Breast cancer has been poorly studied in women with intellectual disability (ID), which makes designing a policy for screening the nearly 70 million women with ID in the world difficult. As no data is availabl...

    Authors: Daniel Satgé, Eric-André Sauleau, William Jacot, Fernand Raffi, Bernard Azéma, Jean-Claude Bouyat and Nicolas El Hage Assaf
    Citation: BMC Cancer 2014 14:150
  13. Chemokine receptor signaling pathways are implicated in the pathobiology of renal cell carcinoma (RCC). However, the clinical relevance of CXCR2 receptor, mediating the effects of all angiogenic chemokines, re...

    Authors: Anastasios Stofas, Georgia Levidou, Christina Piperi, Christos Adamopoulos, Georgia Dalagiorgou, Aristotelis Bamias, Alexandra Karadimou, George A Lainakis, Stefanos Papadoukakis, Konstantinos Stravodimos, Meletios-Athanasios Dimopoulos, Efstratios Patsouris, Hariklia Gakiopoulou and Penelope Korkolopoulou
    Citation: BMC Cancer 2014 14:149
  14. The peritoneum is one of the most frequent sites of recurrent gastric carcinoma after curative treatment, despite the administration of pre- and/or postoperative systemic chemotherapy. Indeed, the prognosis of...

    Authors: Diane Goéré, Nathalie Gras-Chaput, Anne Aupérin, Caroline Flament, Christophe Mariette, Olivier Glehen, Laurence Zitvogel and Dominique Elias
    Citation: BMC Cancer 2014 14:148
  15. Neuroendocrine carcinoma (NEC) of the breast is a rare type of carcinoma that has not been well studied or characterized. Of the limited number of studies reported in the literature, most are case reports. A f...

    Authors: Jun Wang, Bing Wei, Constance T Albarracin, Jianhua Hu, Susan C Abraham and Yun Wu
    Citation: BMC Cancer 2014 14:147
  16. Celastrol is a promising anti-tumor agent, yet it also elevates heat shock proteins (HSPs), especially HSP70, this effect believed to reduce its anti-tumor effects. Concurrent use of siRNA to increase celastro...

    Authors: Bin Peng, Xue Zhang, Fanfan Cao, Ying Wang, Limin Xu, Lu Cao, Chunxin Yang, Maoquan Li, Georges Uzan and Denghai Zhang
    Citation: BMC Cancer 2014 14:146
  17. There is extensive evidence for the role of aberrant cell survival signaling mechanisms in cancer progression and metastasis. Akt is a major component of cell survival-signaling mechanisms in several types of ...

    Authors: Ekta Agarwal, Anathbandhu Chaudhuri, Premila D Leiphrakpam, Katie L Haferbier, Michael G Brattain and Sanjib Chowdhury
    Citation: BMC Cancer 2014 14:145
  18. The aim of this study was to examine the association of non-random X chromosome inactivation (XCI) and loss of heterozygosity (LOH) at Xq25 with breast cancer development.

    Authors: Hui-Tzu Chen, Yao-Chung Wu, Shou-Tung Chen, Hsien-Chang Tsai and Yi-Chih Chien
    Citation: BMC Cancer 2014 14:144
  19. Significant bleeding may occur following endobronchial forceps biopsy or brushing of necrotic or hypervascular tumors in the airways. In some cases, methods such as endobronchial instillation of iced saline la...

    Authors: Adil Zamani
    Citation: BMC Cancer 2014 14:143
  20. Maspin, which is classified as a tumor suppressor protein, is downregulated in many types of cancer. Several studies have suggested potential anti-proliferative activity of maspin as well as sensitizing activi...

    Authors: Magdalena Machowska, Katarzyna Wachowicz, Mirosław Sopel and Ryszard Rzepecki
    Citation: BMC Cancer 2014 14:142
  21. The anticancer properties of aspirin are restricted by its gastrointestinal toxicity and its limited efficacy. Therefore, we synthesized phospho-aspirin (PA-2; MDC-22), a novel derivative of aspirin, and evalu...

    Authors: Liqun Huang, Chi C Wong, Gerardo G Mackenzie, Yu Sun, Ka Wing Cheng, Kvetoslava Vrankova, Ninche Alston, Nengtai Ouyang and Basil Rigas
    Citation: BMC Cancer 2014 14:141
  22. Small cell cervical carcinoma (SCCC) is a rare, aggressive tumor with a poor prognosis. However, information in relation to its treatment is scarce due to the limited numbers of patients. The aim of this study...

    Authors: Long Huang, Ling-Min Liao, An-Wen Liu, Jian-Bing Wu, Xiao-Ling Cheng, Jia-Xin Lin and Min Zheng
    Citation: BMC Cancer 2014 14:140
  23. Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma derived from myogenic precursors that is characterized by a good prognosis in patients with localized disease. Conversely, metastatic tumors ...

    Authors: Roberta Ciarapica, Elena Carcarino, Laura Adesso, Maria De Salvo, Giorgia Bracaglia, Pier Paolo Leoncini, Alessandra Dall’Agnese, Federica Verginelli, Giuseppe M Milano, Renata Boldrini, Alessandro Inserra, Stefano Stifani, Isabella Screpanti, Victor E Marquez, Sergio Valente, Antonello Mai…
    Citation: BMC Cancer 2014 14:139
  24. MicroRNA (miR)-182 is frequently upregulated in cancers, has generally been viewed as an oncogene and is possibly connected to angiogenesis. We aimed to explore what impact miR-182 has in non-small cell lung c...

    Authors: Helge Stenvold, Tom Donnem, Sigve Andersen, Samer Al-Saad, Lill-Tove Busund and Roy M Bremnes
    Citation: BMC Cancer 2014 14:138
  25. Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and...

    Authors: Clara Guerzoni, Stefano Amatori, Luca Giorgi, Maria Cristina Manara, Lorena Landuzzi, Pier-Luigi Lollini, Aurora Tassoni, Mauro Balducci, Marco Manfrini, Loredana Pratelli, Massimo Serra, Piero Picci, Mauro Magnani, Vieri Fusi, Mirco Fanelli and Katia Scotlandi
    Citation: BMC Cancer 2014 14:137
  26. To observe the primary tumor (PT) regression speed after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) and evaluate its prognostic significance.

    Authors: Ning Zhang, Shao-Bo Liang, Yan-Ming Deng, Rui-Liang Lu, Hai-Yang Chen, Hai Zhao, Zhi-Qian Lv, Shao-Qiang Liang, Lin Yang, Dong-Sheng Liu and Yong Chen
    Citation: BMC Cancer 2014 14:136
  27. Resistance to humanized monoclonal erbB2/HER2 antibody, trastuzumab (Herceptin), has become a pivotal obstacle for targeted therapy of HER2-positive breast cancers. The activation of alternative growth factor ...

    Authors: Xing-Ming Ye, Hua-Yu Zhu, Wen-Dong Bai, Ting Wang, Lei Wang, Ying Chen, An-Gang Yang and Lin-Tao Jia
    Citation: BMC Cancer 2014 14:134
  28. Deregulation of the MAPK genes signalling caused by somatic mutations have been implied in leukaemia pathogenesis, including RAS mutation (RAS mut) in acute myeloid leukaemia (AML), which has been associated with...

    Authors: Francianne Gomes Andrade, Juliana Montibeller Furtado-Silva, Bruno Alves de Aguiar Gonçalves, Luiz Claudio Santos Thuler, Thayana Conceição Barbosa, Mariana Emerenciano, André Siqueira and Maria S Pombo-de-Oliveira
    Citation: BMC Cancer 2014 14:133
  29. Among women, breast cancer (BC) is the leading cancer and the most common cause of cancer-related death between 30 and 69 years. Although lifestyle and diet are considered to have a role in global BC incidence...

    Authors: Catarina Rodrigues dos Santos, Isabel Fonseca, Sérgio Dias and JC Mendes de Almeida
    Citation: BMC Cancer 2014 14:132
  30. To evaluate the insulin receptor isoform mRNA expression status in non-small cell lung cancer (NSCLC) patients.

    Authors: Liyan Jiang, Wei Zhu, Katie Streicher, Chris Morehouse, Philip Brohawn, Xiaoxiao Ge, Zhengwei Dong, Xiaolu Yin, Guanshan Zhu, Yi Gu, Koustubh Ranade, Brandon W Higgs, Yihong Yao and Jiaqi Huang
    Citation: BMC Cancer 2014 14:131
  31. Quantification of molecular cell processes is important for prognostication and treatment individualization of head and neck cancer (HNC). However, individual tumor comparison can show discord in upregulation ...

    Authors: Bianca AW Hoeben, Maud HW Starmans, Ralph TH Leijenaar, Ludwig J Dubois, Albert J van der Kogel, Johannes HAM Kaanders, Paul C Boutros, Philippe Lambin and Johan Bussink
    Citation: BMC Cancer 2014 14:130
  32. Colorectal-cancer is a leading cause of cancer death in the United States, and Latinos have particularly low rates of screening. Strategies and Opportunities to STOP Colon Cancer in Priority Populations (STOP CRC...

    Authors: Gloria D Coronado, William M Vollmer, Amanda Petrik, Josue Aguirre, Tanya Kapka, Jennifer DeVoe, Jon Puro, Tran Miers, Jennifer Lembach, Ann Turner, Jennifer Sanchez, Sally Retecki, Christine Nelson and Beverly Green
    Citation: BMC Cancer 2014 14:55
  33. To reduce sampling error associated with cancer detection in prostate needle biopsies, we explored the possibility of using fluorescence in situ hybridisation (FISH) to detect chromosomal abnormalities in the ...

    Authors: Ying Zhang, Thomas Perez, Beth Blondin, Jing Du, Ping Liu, Diana Escarzaga, John S Coon, Larry E Morrison and Katerina Pestova
    Citation: BMC Cancer 2014 14:129
  34. Loss of phosphatase and tensin homologue (PTEN) function evaluated by loss of PTEN protein expression on immunohistochemistry (IHC) has been reported as both prognostic in metastatic colorectal cancer and pred...

    Authors: Christopher Hocking, Jennifer E Hardingham, Vy Broadbridge, Joe Wrin, Amanda R Townsend, Niall Tebbutt, John Cooper, Andrew Ruszkiewicz, Chee Lee and Timothy J Price
    Citation: BMC Cancer 2014 14:128
  35. Acute leukemia in early age (EAL) is characterized by acquired genetic alterations such as MLL rearrangements (MLL-r). The aim of this case-controlled study was to investigate whether single nucleotide polymorphi...

    Authors: Mariana Emerenciano, Thayana Conceição Barbosa, Bruno Almeida Lopes, Caroline Barbieri Blunck, Alessandra Faro, Camilla Andrade, Claus Meyer, Rolf Marschalek and Maria S Pombo-de-Oliveira
    Citation: BMC Cancer 2014 14:127
  36. Breast cancer is the second most lethal cancer in women. Understanding biological mechanisms that cause progression of this disease could yield new targets for prevention and treatment. Recent experimental stu...

    Authors: Qi Cao, Jerome Hersl, Hongloan La, Mark Smith, Jason Jenkins, Olga Goloubeva, Vasken Dilsizian, Katherine Tkaczuk, Wengen Chen and Laundette Jones
    Citation: BMC Cancer 2014 14:126
  37. The wnt/β-catenin signaling pathway is known to affect in cancer oncogenesis and progression by interacting with the tumor microenvironment. However, the roles of wnt3a and wnt5a in colorectal cancer (CRC) hav...

    Authors: Myung Ah Lee, Jin-Hee Park, Si Young Rhyu, Seong-Taek Oh, Won-Kyoung Kang and Hee-Na Kim
    Citation: BMC Cancer 2014 14:125
  38. Triple negative breast cancer (TNBC) has higher rates of recurrence and distant metastasis, and poorer outcome as compared to non-TNBC. Aberrant activation of WNT signaling has been detected in TNBC, which mig...

    Authors: Lixin Yang, Aldwin Apollo Perez, Sayuri Fujie, Charles Warden, Jie Li, Yafan Wang, Bryan Yung, Yun-Ru Chen, Xiyong Liu, Hang Zhang, Shu Zheng, Zheng Liu, David Ann and Yun Yen
    Citation: BMC Cancer 2014 14:124
  39. In Germany, about 20% of the total population have a migration background. Differences exist between migrants and non-migrants in terms of health care access and utilisation. Colorectal cancer is the second mo...

    Authors: Anne Dahlhaus, Corina Guethlin, Arthur Schall, Maja Taubenroth, Reyn van Ewijk, Hajo Zeeb, Zeycan Albay, Sylvia Schulz-Rothe, Martin Beyer, Ferdinand M Gerlach, Maria Blettner and Andrea Siebenhofer
    Citation: BMC Cancer 2014 14:123
  40. Bmi1 has been identified as an important regulator in breast cancer, but its relationship with other signaling molecules such as ERα and HER2 is undetermined.

    Authors: Huali Wang, Haijing Liu, Xin Li, Jing Zhao, Hong Zhang, Jingzhuo Mao, Yongxin Zou, Hong Zhang, Shuang Zhang, Wei Hou, Lin Hou, Michael A McNutt and Bo Zhang
    Citation: BMC Cancer 2014 14:122
  41. It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme ...

    Authors: Béatrice Orsetti, Janick Selves, Caroline Bascoul-Mollevi, Laurence Lasorsa, Karine Gordien, Frédéric Bibeau, Blandine Massemin, François Paraf, Isabelle Soubeyran, Isabelle Hostein, Valérie Dapremont, Rosine Guimbaud, Christophe Cazaux, Michel Longy and Charles Theillet
    Citation: BMC Cancer 2014 14:121
  42. Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from end...

    Authors: Kimberly C Wiegand, Bryan T Hennessy, Samuel Leung, Yemin Wang, Zhenlin Ju, Mollianne McGahren, Steve E Kalloger, Sarah Finlayson, Katherine Stemke-Hale, Yiling Lu, Fan Zhang, Michael S Anglesio, Blake Gilks, Gordon B Mills, David G Huntsman and Mark S Carey
    Citation: BMC Cancer 2014 14:120
  43. Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast canc...

    Authors: Sophie Lehn, Nicholas P Tobin, Andrew H Sims, Olle Stål, Karin Jirström, Håkan Axelson and Göran Landberg
    Citation: BMC Cancer 2014 14:119
  44. Chemokines have been implicated in tumor progression and metastasis. In melanoma, chemokine receptors have been implicated in organ selective metastasis by regulating processes such as chemoattraction, adhesio...

    Authors: Sandra Pinto, Alicia Martínez-Romero, José-Enrique O’Connor, Rosario Gil-Benso, Teresa San-Miguel, Liria Terrádez, Carlos Monteagudo and Robert C Callaghan
    Citation: BMC Cancer 2014 14:118
  45. Neutrophil-lymphocyte ratio (NLR) has recently been reported as a predictor of Hepatocellular carcinoma (HCC). However, its prognostic value in HCC still remains controversial. In this study, we aimed to evalu...

    Authors: Wei-Kai Xiao, Dong Chen, Shao-Qiang Li, Shun-Jun Fu, Bao-Gang Peng and Li-Jian Liang
    Citation: BMC Cancer 2014 14:117
  46. Cervical cancer ranks second among all cancers reported in Sri Lankan women. This study assessed the prevalence and type-distribution of human papillomavirus (HPV) among Sri Lankan women with invasive cervical...

    Authors: Kanishka Karunaratne, Himali Ihalagama, Saman Rohitha, Anco Molijn, Kusuma Gopala, Johannes E Schmidt, Jing Chen, Sanjoy Datta and Shailesh Mehta
    Citation: BMC Cancer 2014 14:116
  47. Adult brainstem gliomas are rare primary brain tumors (<2% of gliomas). The goal of this study was to analyze clinical, prognostic and therapeutic factors in a large series of histologically proven brainstem g...

    Authors: Thomas Reithmeier, Aanyo Kuzeawu, Bettina Hentschel, Markus Loeffler, Michael Trippel and Guido Nikkhah
    Citation: BMC Cancer 2014 14:115
  48. Hepatocellular carcinoma (HCC) is a primary liver tumor and is the most difficult human malignancy to treat. In this study, we sought to develop an integrative approach in which real-time tumor monitoring, gen...

    Authors: Jing Chen, Shu Zhu, Liangqian Tong, Jiansha Li, Fei Chen, Yunfeng Han, Ming Zhao and Wei Xiong
    Citation: BMC Cancer 2014 14:114

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