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  1. microRNAs have recently succeeded in grabbing the center stage in cancer research for their potential to regulate vital cellular process like cell cycle, stem cell renewal and epithelial mesenchymal transition...

    Authors: Sushmita Bose Nandy, Ramadevi Subramani, Venkatesh Rajamanickam, Rebecca Lopez-Valdez, Arunkumar Arumugam, Thiyagarajan Boopalan and Rajkumar Lakshmanaswamy
    Citation: BMC Cancer 2014 14:644
    Content type: Research article Published on:

  2. Although several single-nucleotide polymorphisms in microRNA (miRNA) genes have been associated with primary hepatocellular carcinoma, published findings regarding this relationship are inconsistent and inconc...

    Authors: Jia-Hui Qi, Jin Wang, Jinyun Chen, Fan Shen, Jing-Tao Huang, Subrata Sen, Xin Zhou and Song-Mei Liu
    Citation: BMC Cancer 2014 14:643
    Content type: Research article Published on:

  3. O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is reported to be a prognostic and predictive factor of alkylating chemotherapy for glioblastoma patients. Methylation specific PCR (MSP) has bee...

    Authors: Manabu Kanemoto, Mitsuaki Shirahata, Akiyo Nakauma, Katsumi Nakanishi, Kazuya Taniguchi, Yoji Kukita, Yoshiki Arakawa, Susumu Miyamoto and Kikuya Kato
    Citation: BMC Cancer 2014 14:641
    Content type: Research article Published on:

  4. Hard consistency, developed under the influence of tumor cell factors, is a characteristic feature of a breast tumor. Activation of resident fibroblasts leading to a myofibroblast phenotype is the principal fe...

    Authors: Nicolás Tobar, Marcela Toyos, Carla Urra, Nicolás Méndez, Rodrigo Arancibia, Patricio C Smith and Jorge Martínez
    Citation: BMC Cancer 2014 14:640
    Content type: Research article Published on:

  5. The urokinase-type plasminogen activator receptor (uPAR) is an important regulator of ECM proteolysis, cell-ECM interactions and cell signaling. uPAR and heat shock proteins HSP70 and MRJ (DNAJB6) have been im...

    Authors: Yuli Lin, Nana Peng, Hongqin Zhuang, Di Zhang, Yao Wang and Zi-Chun Hua
    Citation: BMC Cancer 2014 14:639
    Content type: Research article Published on:

  6. The standard treatment for non-metastatic muscle-invasive bladder cancer (stages T2–T4a) is radical cystectomy with lymphadenectomy. However, patients undergoing cystectomy show metastatic spread in 25% of cas...

    Authors: Jens Reumert Laurberg, Jørgen Bjerggaard Jensen, Troels Schepeler, Michael Borre, Torben F Ørntoft and Lars Dyrskjøt
    Citation: BMC Cancer 2014 14:638
    Content type: Research article Published on:

  7. Incidence rates of various cancers are increasing in Arab countries and are expected to reach those of industrialized ones in few decades. This paper aimed to describe the incidence rates of most common cancer...

    Authors: Mokhtar Hamdi Cherif, Diego Serraino, Abbes Mahnane, Slimane Laouamri, Zoubida Zaidi, Hafida Boukharouba, Dahbia Cherka, Manel Rakeb, Lamia Kara, Asma Ayat, Silvia Birri, Saverio Virdone, Paolo De Paoli and Ettore Bidoli
    Citation: BMC Cancer 2014 14:637
    Content type: Research article Published on:

  8. Many countries have implemented standardised cancer patient pathways (CPPs) to ensure fast diagnosis of patients suspected of having cancer. Yet, studies are sparse on the impact of such CPPs, and few have dis...

    Authors: Henry Jensen, Marie Louise Tørring, Frede Olesen, Jens Overgaard and Peter Vedsted
    Citation: BMC Cancer 2014 14:636
    Content type: Research article Published on:

  9. Lymphoceles are a common complication after pelvic lymphadenectomy in women with gynecologic malignancies. Although typically asymptomatic, lymphoceles can superinfect requiring medical or surgical interventio...

    Authors: Christoph Grimm, Stephan Polterauer, Samir Helmy, David Cibula, Michal Zikan, Alexander Reinthaller and Clemens Tempfer
    Citation: BMC Cancer 2014 14:635
    Content type: Study protocol Published on:

  11. An increasing body of evidence indicates that miRNAs have a critical role in carcinogenesis and cancer progression; however, the role of miRNAs in the tumorigenesis of adencarcinoma of gastric esophageal junct...

    Authors: Xiaoshan Feng, Ying Wang, Zhikun Ma, Ruina Yang, Shuo Liang, Mengxi Zhang, Shiyuan Song, Shuoguo Li, Gang Liu, Daiming Fan and Shegan Gao
    Citation: BMC Cancer 2014 14:633
    Content type: Research article Published on:

  12. Aggressive fibromatosis (AF) is a rare fibroblastic proliferative disease with a locally aggressive behavior and no distant metastasis, characterized by driver mutations in CTNNB1 or the APC gene. When progressiv...

    Authors: Armelle Dufresne, Laurent Alberti, Mehdi Brahmi, Sarah Kabani, Héloïse Philippon, David Pérol and Jean Yves Blay
    Citation: BMC Cancer 2014 14:632
    Content type: Research article Published on:

  13. Glypican 3 (GPC3) is a member of the family of glypican heparan sulfate proteoglycans (HSPGs). The GPC3 gene may play a role in controlling cell migration, negatively regulating cell growth and inducing apoptosis...

    Authors: Marina Curado Valsechi, Ana Beatriz Bortolozo Oliveira, André Luis Giacometti Conceição, Bruna Stuqui, Natalia Maria Candido, Paola Jocelan Scarin Provazzi, Luiza Ferreira de Araújo, Wilson Araújo Silva Jr, Marilia de Freitas Calmon and Paula Rahal
    Citation: BMC Cancer 2014 14:631
    Content type: Research article Published on:

  14. Macrophage migration inhibitory factor (MIF) is a widely expressed cytokine involved in a variety of cellular processes including cell cycle regulation and the control of proliferation. Overexpression of MIF h...

    Authors: Camila S Oliveira, Charles E de Bock, Timothy J Molloy, Elham Sadeqzadeh, Xin Yan Geng, Peter Hersey, Xu Dong Zhang and Rick F Thorne
    Citation: BMC Cancer 2014 14:630
    Content type: Research article Published on:

  15. The 90-kDa heat shock protein HSP90AA1 is critical for the stability of several proteins that are important for tumor progression and thus, is a promising target for cancer therapy. Selenosemicarbazone metal c...

    Authors: Hongtao Shen, Haichuan Zhu, Mowei Song, Yonglu Tian, Yafei Huang, Hui Zheng, Ruiyuan Cao, Jian Lin, Zhenggang Bi and Wu Zhong
    Citation: BMC Cancer 2014 14:629
    Content type: Research article Published on:

  16. Notch signalling regulates cell fate in most tissues, promoting precursor cell proliferation in some, but differentiation in others. Accordingly, downregulation or overactivity variously contributes to cancer ...

    Authors: Annemarie Greife, Silvia Jankowiak, Jochen Steinbring, Parvaneh Nikpour, Günter Niegisch, Michèle J Hoffmann and Wolfgang A Schulz
    Citation: BMC Cancer 2014 14:628
    Content type: Research article Published on:

  17. Cancer metastasis is the main contributor to breast cancer fatalities as women with the metastatic disease have poorer survival outcomes than women with localised breast cancers. There is an urgent need to dev...

    Authors: Helen C Plant, Abhishek S Kashyap, Kerry J Manton, Brett G Hollier, Cameron P Hurst, Sandra R Stein, Glenn D Francis, Geoffrey F Beadle, Zee Upton and David I Leavesley
    Citation: BMC Cancer 2014 14:627
    Content type: Research article Published on:

  18. Colorectal cancer (CRC) is a disease that can be prevented through early detection. Through the use of effective educational tools, individuals can become better informed about CRC and understand the importanc...

    Authors: Janeth I Sanchez, Rebecca Palacios, Adrianna Cole and Mary A O’Connell
    Citation: BMC Cancer 2014 14:626
    Content type: Research article Published on:

  19. Dual anti-human epidermal growth factor receptor 2 (HER2) therapies have been shown to improve outcomes of HER2-positive breast cancer patients. We undertook a systematic review to compare treatment outcomes f...

    Authors: Xiao Zhang, Xin-Ji Zhang, Tian-Yi Zhang, Fei-Fei Yu, Xin Wei, Ye-Sheng Li and Jia He
    Citation: BMC Cancer 2014 14:625
    Content type: Research article Published on:

  20. The role of pERK, pAKT and p53 as biomarkers in patients with advanced pancreatic cancer has not yet been defined.

    Authors: Steffen Ormanns, Jens T Siveke, Volker Heinemann, Michael Haas, Bence Sipos, Anna Melissa Schlitter, Irene Esposito, Andreas Jung, Rüdiger P Laubender, Stephan Kruger, Ursula Vehling-Kaiser, Cornelia Winkelmann, Ludwig Fischer von Weikersthal, Michael R Clemens, Thomas C Gauler, Angela Märten…
    Citation: BMC Cancer 2014 14:624
    Content type: Research article Published on:

  21. The aim of the study was to assess the localization of Polysialic acid (polySia) and Neural cell adhesion molecule (NCAM) in grade I–IV astrocytomas by confocal microscopy, and also to clarify and compare thei...

    Authors: Katri Mäkelä, Kristiina Nordfors, Jukka Finne, Anne Jokilammi, Timo Paavonen, Hannu Haapasalo, Miikka Korja and Joonas Haapasalo
    Citation: BMC Cancer 2014 14:623
    Content type: Research article Published on:

  22. Patients with Ewing sarcoma family of tumors (ESFT) who are resistant even to salvage chemotherapy, have dismal prognoses and few therapeutic options. Because the docetaxel/irinotecan (DI) combination has not ...

    Authors: Jong Hyung Yoon, Mi Mi Kwon, Hyeon Jin Park, Seog Yun Park, Kun Young Lim, Jungnam Joo and Byung-Kiu Park
    Citation: BMC Cancer 2014 14:622
    Content type: Research article Published on:

  23. Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis....

    Authors: Jennifer A McAlpine, Hsin-Tze Lu, Katherine C Wu, Susan K Knowles and James A Thomson
    Citation: BMC Cancer 2014 14:621
    Content type: Research article Published on:

  24. Ovarian tumors create a dynamic microenvironment that promotes angiogenesis and reduces immune responses. Our research has revealed that threonyl-tRNA synthetase (TARS) has an extracellular angiogenic activity...

    Authors: Theresa L Wellman, Midori Eckenstein, Cheung Wong, Mercedes Rincon, Takamaru Ashikaga, Sharon L Mount, Christopher S Francklyn and Karen M Lounsbury
    Citation: BMC Cancer 2014 14:620
    Content type: Research article Published on:

  25. To assess the safety and efficacy of Stereotactic Ablative Radiotherapy (SABR) in oligometastatic patients from colorectal cancer.

    Authors: Tiziana Comito, Luca Cozzi, Elena Clerici, Maria Concetta Campisi, Rocco Luca Emanuele Liardo, Pierina Navarria, AnnaMaria Ascolese, Angelo Tozzi, Cristina Iftode, Fiorenza De Rose, Elisa Villa, Nicola Personeni, Lorenza Rimassa, Armando Santoro, Antonella Fogliata, Pietro Mancosu…
    Citation: BMC Cancer 2014 14:619
    Content type: Research article Published on:

  27. To report an unplanned interim analysis of a prospective, one-armed, single center phase I/II trial (NCT01566123).

    Authors: Falk Roeder, Alexis Ulrich, Gregor Habl, Matthias Uhl, Ladan Saleh-Ebrahimi, Peter E Huber, Daniela Schulz-Ertner, Anna V Nikoghosyan, Ingo Alldinger, Robert Krempien, Gunhild Mechtersheimer, Frank W Hensley, Juergen Debus and Marc Bischof
    Citation: BMC Cancer 2014 14:617
    Content type: Research article Published on:

  28. The aberrant expression of microRNAs has been demonstrated to play a crucial role in the initiation and progression of hepatocarcinoma. miR-1246 expression in High invasive ability cell line than significantly...

    Authors: Zhao Sun, Changting Meng, Shihua Wang, Na Zhou, Mei Guan, Chunmei Bai, Shan Lu, Qin Han and Robert Chunhua Zhao
    Citation: BMC Cancer 2014 14:616
    Content type: Research article Published on:

  29. Heat shock protein (Hsp) 90 and Hsp70 are indispensable for cell survival under conditions of stress. They bind to client proteins to assist in protein stabilization, translocation of polypeptides across the c...

    Authors: Tomohisa Horibe, Aya Torisawa, Masayuki Kohno and Koji Kawakami
    Citation: BMC Cancer 2014 14:615
    Content type: Research article Published on:

  30. Most cancer patients are treated with radiotherapy, but the treatment can also damage the surrounding normal tissue. Acute skin damage from cancer radiotherapy diminishes patients’ quality of life, yet effecti...

    Authors: Elina Korpela, Darren Yohan, Lee CL Chin, Anthony Kim, Xiaoyong Huang, Shachar Sade, Paul Van Slyke, Daniel J Dumont and Stanley K Liu
    Citation: BMC Cancer 2014 14:614
    Content type: Research article Published on:

  31. Pelvic lymph nodes removed during radical retropubic prostatectomy for prostatic cancer can be found on pathological examination to harbor various unexpected pathologies. Among these, hematologic neoplasms are...

    Authors: Antonio Di Meglio, Pier Vitale Nuzzo, Francesco Ricci, Bruno Spina and Francesco Boccardo
    Citation: BMC Cancer 2014 14:613
    Content type: Case report Published on:

  32. There is a lack of standardized definition for treatment-related mortality (TRM), which represents an important endpoint in cancer. Our objective was to describe TRM definitions used in studies of children, ad...

    Authors: Thai Hoa Tran, Michelle Lee, Sarah Alexander, Paul Gibson, Ute Bartels, Donna L Johnston, Carol Portwine, Marianna Silva, Jason D Pole and Lillian Sung
    Citation: BMC Cancer 2014 14:612
    Content type: Research article Published on:

  33. Although the incidence of glioma is relatively low, it is the most malignant tumor of the central nervous system. The prognosis of high-grade glioma patient is very poor due to the difficulties in complete res...

    Authors: Yan-chang Sun, Jing Wang, Cheng-cheng Guo, Ke Sai, Jian Wang, Fu-rong Chen, Qun-ying Yang, Yin-sheng Chen, Jie Wang, Tony Shing-shun To, Zong-ping Zhang, Yong-gao Mu and Zhong-ping Chen
    Citation: BMC Cancer 2014 14:611
    Content type: Research article Published on:

  34. The rapid aging of the population in Japan has been accompanied by an increased rate of surgery for lung cancer among elderly patients. It is thus an urgent priority to map out a treatment strategy for elderly...

    Authors: Teppei Nishii, Tomoyuki Yokose, Yohei Miyagi, Yataro Daigo, Hiroyuki Ito, Tetsuya Isaka, Kentaro Imai, Shuji Murakami, Tetsuro Kondo, Haruhiro Saito, Fumihiro Oshita, Kouzo Yamada, Shoichi Matsukuma, Masahiro Tsuboi, Haruhiko Nakayama and Munetaka Masuda
    Citation: BMC Cancer 2014 14:610
    Content type: Research article Published on:

  36. The role of postoperative adjuvant treatment for sinonasal malignant melanoma remains unclear. This study evaluates the impact of three different surgical and postoperative adjuvant treatment modalities: surge...

    Authors: Xin-Jun Meng, Hua-Fei Ao, Wei-Ting Huang, Fu Chen, Xi-Cai Sun, Jing-Jing Wang, Zhuo-Fu Liu, Wade W Han, Allison N Fry and De-Hui Wang
    Citation: BMC Cancer 2014 14:608
    Content type: Research article Published on:

  37. Both laparoscopic and fast-track surgery (FTS) have shown some advantages in colorectal surgery. However, the effectiveness of using both methods together is unclear. We performed this meta-analysis to compare...

    Authors: Jun-hua Zhao, Jing-xu Sun, Peng Gao, Xiao-wan Chen, Yong-xi Song, Xuan-zhang Huang, Hui-mian Xu and Zhen-ning Wang
    Citation: BMC Cancer 2014 14:607
    Content type: Research article Published on:

  38. The standard therapy regimen of conventional osteosarcoma includes neoadjuvant chemotherapy followed by surgical resection and postoperative chemotherapy. The percentage of necrotic tissue following induction ...

    Authors: Sébastien Salas, Carine Jiguet-Jiglaire, Loic Campion, Catherine Bartoli, Frédéric Frassineti, Jean-Laurent Deville, André Maues De Paula, Fabien Forest, Pascal Jézéquel, Jean-Claude Gentet and Corinne Bouvier
    Citation: BMC Cancer 2014 14:606
    Content type: Research article Published on:

  39. The VELOUR study demonstrated a survival benefit for FOLFIRI + aflibercept versus FOLFIRI + placebo in metastatic colorectal cancer (mCRC) patients who progressed on oxaliplatin-based chemotherapy. Continued d...

    Authors: Ian Chau, Florence Joulain, Sheikh Usman Iqbal and John Bridgewater
    Citation: BMC Cancer 2014 14:605
    Content type: Research article Published on:

  40. Breast cancer is a heterogeneous disease with a highly variable clinical outcome in which both genetic and epigenetic changes have critical roles. We investigated tumor expression levels of histone-modifying e...

    Authors: Remco S Derr, Anneke Q van Hoesel, Anne Benard, Inès J Goossens-Beumer, Anita Sajet, N Geeske Dekker-Ensink, Esther M de Kruijf, Esther Bastiaannet, Vincent THBM Smit, Cornelis JH van de Velde and Peter JK Kuppen
    Citation: BMC Cancer 2014 14:604
    Content type: Research article Published on:

  41. Hepatocellular carcinoma is the third cause of cancer related death for which new treatment strategies are needed. Targeting DNA repair pathways to sensitize tumor cells to chemo- or radiotherapy is under inve...

    Authors: Clément Guillot, Vincent Favaudon, Zdenko Herceg, Charlotte Sagne, Sylvie Sauvaigo, Philippe Merle, Janet Hall and Isabelle Chemin
    Citation: BMC Cancer 2014 14:603
    Content type: Research article Published on:

  42. We have previously reported overexpression of the immunoregulatory protein B7-H3 in colorectal cancer and that nuclear expression predicted poor outcome in colon cancer patients. The present study was performe...

    Authors: Vibeke A Ingebrigtsen, Kjetil Boye, Jahn M Nesland, Arild Nesbakken, Kjersti Flatmark and Øystein Fodstad
    Citation: BMC Cancer 2014 14:602
    Content type: Research article Published on:

  43. Patients with single hepatocellular carcinoma (HCC) usually undergo transarterial chemoembolization (TACE) if they are not candidates for curative surgical or ablative therapy. The primary aim of the study was...

    Authors: Eleonora Terzi, Fabio Piscaglia, Ludovica Forlani, Cristina Mosconi, Matteo Renzulli, Luigi Bolondi and Rita Golfieri
    Citation: BMC Cancer 2014 14:601
    Content type: Research article Published on:

  44. The crosstalk between Hedgehog (HH) signaling and other signal transduction cascades has been extensively studied in different cancers. In neuroblastoma, mTOR/S6K1 signaling is known to have a role in the deve...

    Authors: Yumei Diao, Mohammed Ferdous-Ur Rahman, Victoria E Villegas, Malin Wickström, John I Johnsen and Peter G Zaphiropoulos
    Citation: BMC Cancer 2014 14:600
    Content type: Research article Published on:

  45. The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway is activated in cells exposed to various stimuli, including those originating on the cell surface or in the nucleus....

    Authors: Temesgen Samuel, Khalda Fadlalla, Dominique N Gales, Balananda DK Putcha and Upender Manne
    Citation: BMC Cancer 2014 14:599
    Content type: Research article Published on:

  46. Despite advances in the treatment of primary breast tumors, the outcome of metastatic breast cancer remains dismal. Brain metastases present a particularly difficult therapeutic target due to the “sanctuary” s...

    Authors: Yuriy Shapovalov, Martha Zettel, Sara C Spielman, Stacy A Amico-Ruvio, Emily A Kelly, Grayson O Sipe, Ian M Dickerson, Ania K Majewska and Edward B Brown
    Citation: BMC Cancer 2014 14:598
    Content type: Research article Published on:

  47. Cancer is often described as the ‘number one’ health fear, but little is known about whether this affects quality of life by translating into high levels of worry or distress in everyday life, or which populat...

    Authors: Charlotte Vrinten, Cornelia H M van Jaarsveld, Jo Waller, Christian von Wagner and Jane Wardle
    Citation: BMC Cancer 2014 14:597
    Content type: Research article Published on:

  48. Treatment variation is an important issue in health care provision. An external peer review programme for multidisciplinary cancer care was introduced in 1994 in the Netherlands to improve the multidisciplinar...

    Authors: Melvin J Kilsdonk, Boukje AC van Dijk, Renee Otter, Wim H van Harten and Sabine Siesling
    Citation: BMC Cancer 2014 14:596
    Content type: Research article Published on:

  50. Regions within solid tumours often experience oxygen deprivation, which is associated with resistance to chemotherapy and irradiation. The aim of this study was to evaluate the radiosensitising effect of gemci...

    Authors: An Wouters, Bea Pauwels, Natalie Burrows, Marc Baay, Vanessa Deschoolmeester, Trung Nghia Vu, Kris Laukens, Paul Meijnders, Dirk Van Gestel, Kaye J Williams, Danielle Van den Weyngaert, Jan B Vermorken, Patrick Pauwels, Marc Peeters and Filip Lardon
    Citation: BMC Cancer 2014 14:594
    Content type: Research article Published on:

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