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  1. The aim of the study was to explore the serum levels of eight angiogenesis biomarkers in patients with benign, borderline or malignant epithelial ovarian neoplasms and to compare them to those of healthy contr...

    Authors: Hanna Sallinen, Tommi Heikura, Jonna Koponen, Veli-Matti Kosma, Seppo Heinonen, Seppo Ylä-Herttuala and Maarit Anttila
    Citation: BMC Cancer 2014 14:696
    Content type: Research article Published on:

  2. Radiotherapy is an important treatment strategy for head and neck cancers. Tumor hypoxia and repopulation adversely affect the radiotherapy outcome. Accordingly, fractionated radiotherapy with dose escalation ...

    Authors: Chowdhury Nusrat Fatema, Songji Zhao, Yan Zhao, Wenwen Yu, Ken-ichi Nishijima, Koichi Yasuda, Yoshimasa Kitagawa, Nagara Tamaki and Yuji Kuge
    Citation: BMC Cancer 2014 14:692
    Content type: Research article Published on:

  3. Paraneoplastic neurological syndromes (PNS) have frequently been described in patients with lung or breast cancer. However, some reports also described a correlation to carcinoid tumors, probably triggered via...

    Authors: Michael Boch, Anja Rinke, Peter Rexin, Maria Seipelt, Dörte Brödje, Marvin Schober, Thomas M Gress, Patrick Michl and Sebastian Krug
    Citation: BMC Cancer 2014 14:691
    Content type: Case report Published on:

  4. Metastatic breast cancer has consistently been viewed as a non-curable disease. Specific palliative treatments such as chemotherapy and hormone therapy have resulted in a mean overall survival of approximately...

    Authors: Erika Viel, Flavie Arbion, Catherine Barbe and Philippe Bougnoux
    Citation: BMC Cancer 2014 14:690
    Content type: Case report Published on:

  5. Hypericum japonicum Thunb. ex Murray is widely used as an herbal medicine for the treatment of hepatitis and tumours in China. However, the molecular mechanisms of its effects are unclear. Our previous research s...

    Authors: Shoude Zhang, Jun Yin, Xia Li, Jigang Zhang, Rongcai Yue, Yanyan Diao, Honglin Li, Hui Wang, Lei Shan and Weidong Zhang
    Citation: BMC Cancer 2014 14:689
    Content type: Research article Published on:

  6. Ovarian cancer (OVCA) is the leading cause of death from gynecological cancer, with poorer survival for African American (AA) women compared to whites. However, little is known about risk factors for OVCA in A...

    Authors: Joellen M Schildkraut, Anthony J Alberg, Elisa V Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michelle L Cote, Ellen Funkhouser, Edward Peters, Ann G Schwartz, Paul Terry, Kristin Wallace, Lucy Akushevich, Frances Wang, Sydnee Crankshaw and Patricia G Moorman
    Citation: BMC Cancer 2014 14:688
    Content type: Research article Published on:

  7. Cancer stem cells (CSCs) have been reported to play an important role in chemoradiation resistance. Although the association of CSC markers with clinicopathological outcomes after neoadjuvant chemoradiotherapy...

    Authors: Tatsuzo Mizukami, Hirofumi Kamachi, Tomoko Mitsuhashi, Yosuke Tsuruga, Yutaka Hatanaka, Toshiya Kamiyama, Yoshihiro Matsuno and Akinobu Taketomi
    Citation: BMC Cancer 2014 14:687
    Content type: Research article Published on:

  8. Pancreatic cancer is a leading cause of cancer-related deaths in the world with a 5-year survival rate of less than 6%. Currently, there is no successful therapeutic strategy for advanced pancreatic cancer, an...

    Authors: Jiangbo Liu, Jiguang Ma, Zheng Wu, Wei Li, Dong Zhang, Liang Han, Fengfei Wang, Katie M Reindl, Erxi Wu and Qingyong Ma
    Citation: BMC Cancer 2014 14:686
    Content type: Research article Published on:

  9. About 10-15% of adult gastrointestinal stromal tumors (GIST) and the vast majority of pediatric GIST do not harbour KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutations (J Clin Oncol 22:3813–38...

    Authors: Margherita Nannini, Annalisa Astolfi, Milena Urbini, Valentina Indio, Donatella Santini, Michael C Heinrich, Christopher L Corless, Claudio Ceccarelli, Maristella Saponara, Anna Mandrioli, Cristian Lolli, Giorgio Ercolani, Giovanni Brandi, Guido Biasco and Maria A Pantaleo
    Citation: BMC Cancer 2014 14:685
    Content type: Research article Published on:

  10. Recent advances have shown that histology and genetic biomarkers are important in patient selection, which have led to significantly better outcomes for lung cancer patients. However, most new treatments only ...

    Authors: Jin-Ji Yang, Cheng Huang, Gong-Yan Chen, Yong Song, Ying Cheng, Hong-Hong Yan, Qing Zhou and Yi-Long Wu
    Citation: BMC Cancer 2014 14:684
    Content type: Study protocol Published on:

  11. Crizotinib was granted accelerated approval by the Food and Drug Administration in 2011 for the treatment of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). To evaluate the effica...

    Authors: Haili Qian, Feng Gao, Haijuan Wang and Fei Ma
    Citation: BMC Cancer 2014 14:683
    Content type: Research article Published on:

  12. Cancer-specific survival estimates rely on precise and correct data on the cause of death; however, these data can be difficult to acquire, particularly in elderly patients where comorbidity is common. Further...

    Authors: Katja Maretty-Nielsen, Ninna Aggerholm-Pedersen, Johnny Keller, Akmal Safwat, Steen Baerentzen and Alma B Pedersen
    Citation: BMC Cancer 2014 14:682
    Content type: Research article Published on:

  13. Reversing multidrug resistance (MDR) has been an important goal for clinical and investigational oncologists. In the last few decades, significant effort has been made to search for inhibitors to reverse MDR b...

    Authors: Zhenfeng Duan, Jianming Zhang, Shunan Ye, Jacson Shen, Edwin Choy, Gregory Cote, David Harmon, Henry Mankin, Yingqi Hua, Yu Zhang, Nathanael S Gray and Francis J Hornicek
    Citation: BMC Cancer 2014 14:681
    Content type: Research article Published on:

  14. Increasing evidence suggests that alterations in mitochondrial DNA (mtDNA) content may be implicated in the tumorigenesis of several malignancies. However, the association between mtDNA content in peripheral b...

    Authors: Jie Zhang, Deyang Li, Falin Qu, Yibing Chen, Gang Li, Hequn Jiang, Xiaojun Huang, Hushan Yang and Jinliang Xing
    Citation: BMC Cancer 2014 14:680
    Content type: Research article Published on:

  15. Oral tongue squamous cell carcinomas (TSCC) are a unique subset of head and neck cancers with a distinct demographic profile, where up to half of the cases are never smokers. A small proportion of patients wit...

    Authors: Daniel SW Tan, Weining Wang, Hui Sun Leong, Pui Hoon Sew, Dawn P Lau, Fui Teen Chong, Sai Sakktee Krisna, Tony KH Lim and N Gopalakrishna Iyer
    Citation: BMC Cancer 2014 14:679
    Content type: Research article Published on:

  16. miRNA-27a has been confirmed as an important regulator in carcinogenesis and other pathological processes. Whether and how it plays a role in the laryngeal carcinoma is unknown.

    Authors: Yuan Tian, Shuang Fu, Guang-Bin Qiu, Zhen-Ming Xu, Ning Liu, Xiao-Wen Zhang, Sheng Chen, Ye Wang, Kai-Lai Sun and Wei-Neng Fu
    Citation: BMC Cancer 2014 14:678
    Content type: Research article Published on:

  17. Bladder cancer is one of the most common cancers worldwide. Fibulin-1, a multi-functional extracellular matrix protein, has been demonstrated to be involved in many kinds of cancers, while its function in blad...

    Authors: Wei Xiao, Ji Wang, Heng Li, Ding Xia, Gan Yu, Weimin Yao, Yang Yang, Haibing Xiao, Bin Lang, Xin Ma, Xiaolin Guo, Wei Guan, Hua Xu, Jihong Liu, Xu Zhang and Zhangqun Ye
    Citation: BMC Cancer 2014 14:677
    Content type: Research article Published on:

  18. Lymphovascular invasion (LBVI) including lymphatic (LVI) and blood (BVI) vessel invasion is a critical step in cancer metastasis. In breast cancer, the optimal detection method of LBVI remains unclear. This re...

    Authors: Fadia J A Gujam, James J Going, Zahra M A Mohammed, Clare Orange, Joanne Edwards and Donald C McMillan
    Citation: BMC Cancer 2014 14:676
    Content type: Research article Published on:

  19. Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodr...

    Authors: Christopher A McGoldrick, Yu-Lin Jiang, Marianne Brannon, Koyamangalath Krishnan and William L Stone
    Citation: BMC Cancer 2014 14:675
    Content type: Research article Published on:

  20. Malignant mesothelioma (MM) carries a poor prognosis and response rates to palliative chemotherapy remain low. Identifying patients with MM that are unlikely to respond to chemotherapy could prevent futile tre...

    Authors: Mark Linch, Spyridon Gennatas, Stanislav Kazikin, Jhangir Iqbal, Ranga Gunapala, Kathryn Priest, Joanne Severn, Alison Norton, Bee Ayite, Jaishree Bhosle, Mary O’Brien and Sanjay Popat
    Citation: BMC Cancer 2014 14:674
    Content type: Research article Published on:

  21. Most biomarkers in prostate cancer have only been evaluated in surgical cohorts. The value of these biomarkers in a different therapy context remains unclear. Our objective was to test a panel of surgical biom...

    Authors: Naveen Kachroo, Anne Y Warren and Vincent J Gnanapragasam
    Citation: BMC Cancer 2014 14:673
    Content type: Research article Published on:

  22. The Prognostic value of microvessel density in cancer remains unclear. Recent studies have suggested that the uneven distribution of microvessels in tumours caused the variation in sample selection which led t...

    Authors: Jianyi Li, Yang Zhang, Wenhai Zhang, Yang Gao, Shi Jia and Jiao Guo
    Citation: BMC Cancer 2014 14:672
    Content type: Research article Published on:

  23. Metastases-directed therapy (MDT) with surgery or stereotactic body radiotherapy (SBRT) is emerging as a new treatment option for prostate cancer (PCa) patients with a limited number of metastases (≤3) at recu...

    Authors: Karel Decaestecker, Gert De Meerleer, Filip Ameye, Valerie Fonteyne, Bieke Lambert, Steven Joniau, Louke Delrue, Ignace Billiet, Wim Duthoy, Sarah Junius, Wouter Huysse, Nicolaas Lumen and Piet Ost
    Citation: BMC Cancer 2014 14:671
    Content type: Study protocol Published on:

  25. Previously we have suggested that cancer cells develop a mechanism(s) which allows for either: silencing of the wild-type TP53 transcription, degradation of the wild-type TP53 mRNA, or selective overproduction of...

    Authors: Marta Winiecka-Klimek, Malgorzata Szybka, Piotr Rieske, Sylwester Piaskowski, Michal Bienkowski, Maciej Walczak, Marcin Pacholczyk, Michal Rostkowski, Jolanta Zieba, Mateusz Banaszczyk, Krystyna Hulas-Bigoszewska, Joanna Peciak, Rafal Pawliczak and Ewelina Stoczynska-Fidelus
    Citation: BMC Cancer 2014 14:669
    Content type: Research article Published on:

  26. Acetylcholinesterase (AChE) mainly functions as an efficient terminator for acetylcholine signaling transmission. Here, we reported the effect of AChE on gastric cancer therapy.

    Authors: Haineng Xu, Zhengxuan Shen, Jing Xiao, Yu Yang, Weidan Huang, Zhiming Zhou, Jiani Shen, Yizhun Zhu, Xin-Yuan Liu and Liang Chu
    Citation: BMC Cancer 2014 14:668
    Content type: Research article Published on:

  27. Intraoperative in situ identification of 18F-FDG-avid tissue sites during radioguided oncologic surgery remains a significant challenge for surgeons. The purpose of our study was to evaluate the 1.5-to-1 ratiomet...

    Authors: Gregg J Chapman, Stephen P Povoski, Nathan C Hall, Douglas A Murrey Jr, Robert Lee and Edward W Martin Jr
    Citation: BMC Cancer 2014 14:667
    Content type: Research article Published on:

  28. Metastasis is the most crucial prognostic factor in osteosarcoma. The goal of this study was to develop a new nomogram to predict the probability of metastasis in Enneking stage IIB extremity osteosarcoma afte...

    Authors: Seung Hyun Kim, Kyoo-Ho Shin, Ha Yan Kim, Yong Jin Cho, Jae Kyoung Noh, Jin-Suck Suh and Woo-Ick Yang
    Citation: BMC Cancer 2014 14:666
    Content type: Research article Published on:

  29. For nearly two decades now, various studies have reported detecting the Epstein-Barr virus (EBV) in breast cancer (BC) cases. Yet the results are unconvincing, and their interpretation has remained a matter of...

    Authors: Gina Marrão, Mohammed Habib, Artur Paiva, Dominique Bicout, Catherine Fallecker, Sofia Franco, Samira Fafi-Kremer, Teresa Simões da Silva, Patrice Morand, Carlos Freire de Oliveira and Emmanuel Drouet
    Citation: BMC Cancer 2014 14:665
    Content type: Research article Published on:

  30. Ribonucleotide reductase (RR) is an essential enzyme involved in DNA synthesis. We hypothesized that RR subunit M2 (RRM2) might be a novel prognostic and predictive biomarker for estrogen receptor (ER)-negative b...

    Authors: Hang Zhang, Xiyong Liu, Charles D Warden, Yasheng Huang, Sofia Loera, Lijun Xue, Suzhan Zhang, Peiguo Chu, Shu Zheng and Yun Yen
    Citation: BMC Cancer 2014 14:664
    Content type: Research article Published on:

  32. Few studies have systematically reported the relationship between the risk of breast cancer and family history of other cancers. This study was designed to systematically determine the relationship between bre...

    Authors: Wenbin Zhou, Qiang Ding, Hong Pan, Naping Wu, Mengdi Liang, Yaoyu Huang, Lin Chen, Xiaoming Zha, Xiaoan Liu and Shui Wang
    Citation: BMC Cancer 2014 14:662
    Content type: Research article Published on:

  33. Hamartomatous polyposis syndromes (HPS) are inherited conditions associated with high cancer risk. They include the Peutz-Jeghers and the PTEN hamartoma tumor syndromes, which are caused by mutations in the LKB1 ...

    Authors: Giovanna Forte, Valentina Grossi, Valentina Celestini, Giuseppe Lucisano, Marco Scardapane, Dora Varvara, Margherita Patruno, Rosanna Bagnulo, Daria Loconte, Laura Giunti, Antonio Petracca, Sabrina Giglio, Maurizio Genuardi, Fabio Pellegrini, Nicoletta Resta and Cristiano Simone
    Citation: BMC Cancer 2014 14:661
    Content type: Research article Published on:

  34. The nonreceptor tyrosine kinase Src regulates multiple pathways critical to tumor proliferation, chemoresistance, and epithelial-to-mesenchymal transition. It is robustly activated after acute oxaliplatin expo...

    Authors: Scott Kopetz, Van K Morris, Nila Parikh, Michael J Overman, Zhi-Qin Jiang, Dipen Maru, Paul Elvin and Gary Gallick
    Citation: BMC Cancer 2014 14:660
    Content type: Research article Published on:

  35. A large body of genetic research has focused on the potential role that mitochondrial DNA (mtDNA) variants might play on the predisposition to common and complex (multi-factorial) diseases. It has been argued ...

    Authors: Antonio Salas, Manuel García-Magariños, Ian Logan and Hans-Jürgen Bandelt
    Citation: BMC Cancer 2014 14:659
    Content type: Research article Published on:

  36. Despite recently implemented access to care programs, Mexican breast cancer (BC) mortality rates remain substantially above those in the US. We conducted a survey among Mexican Oncologists to determine whether...

    Authors: Yanin Chavarri-Guerra, Jessica St Louis, Pedro ER Liedke, Heather Symecko, Cynthia Villarreal-Garza, Alejandro Mohar, Dianne M Finkelstein and Paul E Goss
    Citation: BMC Cancer 2014 14:658
    Content type: Research article Published on:

  38. MicroRNAs (miRNAs) are involved in numerous biological and pathological processes including colorectal cancer (CRC). The aim of our study was to evaluate the ability of miRNA expression patterns to predict che...

    Authors: Sonia Molina-Pinelo, Amancio Carnero, Fernando Rivera, Purificacion Estevez-Garcia, Juan Manuel Bozada, Maria Luisa Limon, Marta Benavent, Javier Gomez, Maria Dolores Pastor, Manuel Chaves, Rocio Suarez, Luis Paz-Ares, Fernando de la Portilla, Andres Carranza-Carranza, Isabel Sevilla, Luis Vicioso…
    Citation: BMC Cancer 2014 14:656
    Content type: Research article Published on:

  39. Prostate cancer has a variable clinical behaviour with frequently unpredictable outcome. DNA methylation plays an important role in determining the biology of cancer but prognostic information is scanty. We as...

    Authors: Nataša Vasiljević, Amar S Ahmad, Mangesh A Thorat, Gabrielle Fisher, Daniel M Berney, Henrik Møller, Christopher S Foster, Jack Cuzick and Attila T Lorincz
    Citation: BMC Cancer 2014 14:655
    Content type: Research article Published on:

  41. The aim of this study was to investigate the prognostic significance and various classifications for anatomic masticator space involvement (MSI) in patients with nasopharyngeal carcinoma (NPC).

    Authors: Dong-Hua Luo, Jing Yang, Hui-Zhi Qiu, Ting Shen, Qiu-Yan Chen, Pei-Yu Huang, Rui Sun, Chao-Nan Qian, Hai-Qiang Mai, Xiang Guo and Hao-Yuan Mo
    Citation: BMC Cancer 2014 14:653
    Content type: Research article Published on:

  42. Preoperative jaundice is frequent in gallbladder cancer (GBC) and indicates advanced disease. Resection is rarely recommended to treat advanced GBC. An aggressive surgical approach for advanced GBC remains lac...

    Authors: Xin-wei Yang, Jian-mao Yuan, Jun-yi Chen, Jue Yang, Quan-gen Gao, Xing-zhou Yan, Bao-hua Zhang, Shen Feng and Meng-chao Wu
    Citation: BMC Cancer 2014 14:652
    Content type: Research article Published on:

  43. The detection of circulating tumor cells (CTCs) in peripheral blood (PB) of patients with breast cancer predicts poor clinical outcome. Cancer cells with stemness and epithelial-to-mesenchymal transition (EMT)...

    Authors: Maria A Papadaki, Galatea Kallergi, Zafeiris Zafeiriou, Lefteris Manouras, Panayiotis A Theodoropoulos, Dimitris Mavroudis, Vassilis Georgoulias and Sofia Agelaki
    Citation: BMC Cancer 2014 14:651
    Content type: Research article Published on:

  44. P21-activated protein kinase 1 (PAK1), a main downstream effector of small Rho GTPases, is overexpressed in many malignancies. PAK1 overexpression is associated with poor prognosis in some tumor types, includi...

    Authors: Juan Han, Feng Wang, Shu-qiang Yuan, Ying Guo, Zhao-lei Zeng, Li-ren Li, Jing Yang, De-sen Wang, Mei-yuan Liu, Han Zhao, Kai-yan Liu, Jian-wei Liao, Qing-feng Zou and Rui-hua Xu
    Citation: BMC Cancer 2014 14:650
    Content type: Research article Published on:

  45. The Wnt inhibitor Dickkopf-1 (DKK-1) has been linked to the progression of malignant bone disease by impairing osteoblast activity. In addition, there is increasing data to suggest direct tumor promoting effec...

    Authors: Tilman D Rachner, Stefanie Thiele, Andy Göbel, Andrew Browne, Susanne Fuessel, Kati Erdmann, Manfred P Wirth, Michael Fröhner, Tilman Todenhöfer, Michael H Muders, Matthias Kieslinger, Martina Rauner and Lorenz C Hofbauer
    Citation: BMC Cancer 2014 14:649
    Content type: Research article Published on:

  46. Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this co...

    Authors: Gustaf Lindgren, Lars Ekblad, Johan Vallon-Christersson, Elisabeth Kjellén, Maria Gebre-Medhin and Johan Wennerberg
    Citation: BMC Cancer 2014 14:648
    Content type: Research article Published on:

  47. Along with de novo resistance, continued exposure to trastuzumab, an anti-human epidermal growth factor receptor 2 (HER2/neu) antibody, can lead to acquired resistance. In this study, we characterize a new ant...

    Authors: Hyunkeun Song, Tae Oh Kim, Sun Young Ma, Jin-Hee Park, Jae-Hyug Choi, Jin-Ho Kim, Mi Seon Kang, Sang Kyun Bae, Ki Hyaung Kim, Tae Hyun Kim, Su-Kil Seo, Il Whan Choi, Geun Am Song, Eric D Mortenson, Yang-Xin Fu and SaeGwang Park
    Citation: BMC Cancer 2014 14:647
    Content type: Research article Published on:

  48. The existence of two distinct groups of tumors with different clinical characteristic is a remarkable feature of transitional cell carcinomas (TCCs) of the bladder. More than 70% are low-grade (LG) non-infiltr...

    Authors: Donatella Conconi, Elena Panzeri, Serena Redaelli, Giorgio Bovo, Paolo Viganò, Guido Strada, Leda Dalprà and Angela Bentivegna
    Citation: BMC Cancer 2014 14:646
    Content type: Research article Published on:

  49. Large genomic rearrangements (LGRs) in the BRCA1/2 genes are frequently observed in breast cancer patients who are negative for BRCA1/2 small mutations. Here, we examined 221 familial breast cancer patients from ...

    Authors: Moon-Woo Seong, Sung Im Cho, Kyu Hyung Kim, Il Yong Chung, Eunyoung Kang, Jong Won Lee, Sue K Park, Min Hyuk Lee, Doo Ho Choi, Cha Kyong Yom, Woo-Chul Noh, Myung Chul Chang, Sung Sup Park and Sung-Won Kim
    Citation: BMC Cancer 2014 14:645
    Content type: Research article Published on:

  50. Colorectal cancer survival in the UK is lower than in other developed countries, but the association of time interval between diagnosis and treatment on excess mortality remains unclear.

    Authors: Maria Theresa Redaniel, Richard M Martin, Jane M Blazeby, Julia Wade and Mona Jeffreys
    Citation: BMC Cancer 2014 14:642
    Content type: Research article Published on:

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