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  2. Over-expression of insulin-like growth factor 2 mRNA binding protein 3 (IMP3) is correlated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Previous studies examining other cancer types have im...

    Authors: Clarissa C Pasiliao, Che-Wei A Chang, Brent W Sutherland, Shannon M Valdez, David Schaeffer, Donald T Yapp and Sylvia S W Ng
    Citation: BMC Cancer 2015 15:266
    Content type: Research article Published on:

  3. Whether portal hypertension (PHT) is an appropriate contraindication for hepatic resection (HR) in hepatocellular carcinoma (HCC) patient is still under debate.

    Authors: Wei He, Qingli Zeng, Yun Zheng, Meixian Chen, Jingxian Shen, Jiliang Qiu, Miao Chen, Ruhai Zou, Yadi Liao, Qijiong Li, Xianqiu Wu, Binkui Li and Yunfei Yuan
    Citation: BMC Cancer 2015 15:263
    Content type: Research article Published on:

  4. Cyclin D1 and its kinase partners control cell cycle progression. Cyclin D1 is frequently deregulated in various cancers, including malignant hemopathies, and tumor cells display uncontrolled cell proliferatio...

    Authors: Sophie Bustany, Julie Cahu, Philippe Guardiola and Brigitte Sola
    Citation: BMC Cancer 2015 15:262
    Content type: Research article Published on:

  5. Cancer stem cell (CSC) research has highlighted the necessity of developing drugs targeting CSCs. We investigated a hepatocellular carcinoma (HCC) cell line that not only has CSC hierarchy but also shows pheno...

    Authors: Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shirota, Taro Yamashita, Ichinosuke Hyodo and Yukio Nakamura
    Citation: BMC Cancer 2015 15:260
    Content type: Research article Published on:

  6. The objective of this study was to discover and to validate novel noninvasive biomarkers that distinguish between benign prostate hyperplasia (BPH) and localized prostate cancer (PCa), thereby helping to solve...

    Authors: Andrej Jedinak, Adam Curatolo, David Zurakowski, Simon Dillon, Manoj K Bhasin, Towia A Libermann, Roopali Roy, Monisha Sachdev, Kevin R Loughlin and Marsha A Moses
    Citation: BMC Cancer 2015 15:259
    Content type: Research article Published on:

  7. The mutation in KRAS exon 2 is a validated biomarker of resistance to anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer (mCRC). Several reports have confirmed associations of ot...

    Authors: Akihito Kawazoe, Kohei Shitara, Shota Fukuoka, Yasutoshi Kuboki, Hideaki Bando, Wataru Okamoto, Takashi Kojima, Nozomu Fuse, Takeharu Yamanaka, Toshihiko Doi, Atsushi Ohtsu and Takayuki Yoshino
    Citation: BMC Cancer 2015 15:258
    Content type: Research article Published on:

  8. Comparison of tissue microarray results of 29 cervical cancer and 27 normal cervix tissue samples using immunohistochemistry revealed considerable reorganization of the fibrillar stroma of these tumors.

    Authors: Alexandra Fullár, József Dudás, Lászlóné Oláh, Péter Hollósi, Zoltán Papp, Gábor Sobel, Katalin Karászi, Sándor Paku, Kornélia Baghy and Ilona Kovalszky
    Citation: BMC Cancer 2015 15:256
    Content type: Research article Published on:

  9. The treatment of glioblastoma multiforme (GBM) is an unmet clinical need. The 5-year survival rate of patients with GBM is less than 3%. Temozolomide (TMZ) remains the standard first-line treatment regimen for...

    Authors: Dawn Q Chong, Xin Y Toh, Ivy AW Ho, Kian C Sia, Jennifer P Newman, Yulyana Yulyana, Wai-Hoe Ng, Siang H Lai, Mac MF Ho, Nivedh Dinesh, Chee K Tham and Paula YP Lam
    Citation: BMC Cancer 2015 15:255
    Content type: Research article Published on:

  11. Advanced breast cancer patients have a higher risk of postoperative recurrence than early-stage breast cancer patients. Recurrence is believed to be caused by the increase in micrometases, which were not eradi...

    Authors: Takashi Shigekawa, Akihiko Osaki, Hiroshi Sekine, Nobuaki Sato, Chizuko Kanbayashi, Hiroshi Sano, Hideki Takeuchi, Shigeto Ueda, Noriko Nakamiya, Ikuko Sugitani, Michiko Sugiyama, Hiroko Shimada, Eiko Hirokawa, Takao Takahashi and Toshiaki Saeki
    Citation: BMC Cancer 2015 15:253
    Content type: Research article Published on:

  12. Breast neoplasms include different histopathological entities, varying from benign tumors to highly aggressive cancers. Despite the key role of imaging, traditional histology is still required for a definitive...

    Authors: Giovanni D De Palma, Dario Esposito, Gaetano Luglio, Gennaro Limite, Antonello Accurso, Viviana Sollazzo, Francesco Maione, Gianluca Cassese, Saverio Siciliano, Nicola Gennarelli, Gennaro Ilardi, Mariano Paternoster, Mariano C Giglio and Pietro Forestieri
    Citation: BMC Cancer 2015 15:252
    Content type: Research article Published on:

  13. Ovarian granulosa cell tumors (GCTs) are the most frequent sex cord-stromal tumors. Several studies have shown that a somatic mutation leading to a C134W substitution in the transcription factor FOXL2 appears ...

    Authors: Sandrine Caburet, Mikko Anttonen, Anne-Laure Todeschini, Leila Unkila-Kallio, Denis Mestivier, Ralf Butzow and Reiner A Veitia
    Citation: BMC Cancer 2015 15:251
    Content type: Research article Published on:

  14. To overcome the limitations of animal-based experiments, 3D culture models mimicking the tumor microenvironment in vivo are gaining attention. Herein, we investigated an alginate-based 3D scaffold for screening o...

    Authors: Mehdi Shakibaei, Patricia Kraehe, Bastian Popper, Parviz Shayan, Ajay Goel and Constanze Buhrmann
    Citation: BMC Cancer 2015 15:250
    Content type: Research article Published on:

  15. The purpose of the present study was to examine 1) characteristics and attitudes of oncologists toward exercise and toward recommending exercise to their patients, 2) association among oncologists’ own physica...

    Authors: Ji-Hye Park, Minsuk Oh, Yong Jin Yoon, Chul Won Lee, Lee W Jones, Seung Il Kim, Nam Kyu Kim and Justin Y Jeon
    Citation: BMC Cancer 2015 15:249
    Content type: Research article Published on:

  16. Retinoic acid receptor alpha (RARα) plays an essential role in the regulation of many biological processes, such as hematopoietic cell differentiation, while abnormal RARα function contributes to the pathogene...

    Authors: Yang Cao, Wei Wei, Nan Zhang, Qing Yu, Wen-Bin Xu, Wen-Jun Yu, Guo-Qiang Chen, Ying-Li Wu and Hua Yan
    Citation: BMC Cancer 2015 15:248
    Content type: Research article Published on:

  17. Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes...

    Authors: Henrique Alexandrino, Domingos Oliveira, Maria Augusta Cipriano, Luís Ferreira, J Guilherme Tralhão and Francisco Castro e Sousa
    Citation: BMC Cancer 2015 15:247
    Content type: Case report Published on:

  18. Aberrant expression of serine threonine tyrosine kinase 1 (STYK1) has been reported in several human malignancies including colorectal cancer (CRC). However, the prognostic significance of STYK1 expression in ...

    Authors: Liang Hu, Hai-Yang Chen, Jian Cai, Yu Zhang, Chen-Ye Qi, Hui Gong, Yan-Xia Zhai, Hao Fu, Guang-Zhen Yang and Chun-Fang Gao
    Citation: BMC Cancer 2015 15:246
    Content type: Research article Published on:

  19. Toll-like receptor 3 (TLR3) plays a key role in innate immunity. In the present study, we analyzed tissues of patients with human hepatocellular carcinoma (HCC) to determine the significance of the relationshi...

    Authors: Ming-Ming Yuan, Yu-Yin Xu, Li Chen, Xing-Yu Li, Jing Qin and Ying Shen
    Citation: BMC Cancer 2015 15:245
    Content type: Research article Published on:

  20. NAD(P)H:quinone oxidoreductase (NQO1) is a flavoprotein that catalyzes two-electron reduction and detoxification of quinones and its derivatives. NQO1 catalyzes reactions that have a protective effect against ...

    Authors: Xuelian Cui, Lianhua Li, Guanghai Yan, Kai Meng, Zhenhua Lin, Yunze Nan, Guang Jin and Chunyu Li
    Citation: BMC Cancer 2015 15:244
    Content type: Research article Published on:

  21. No information is available on the attitudes of General Practitioners (GPs) and Breast Surgeons (BSs) to their delivery of genetic, environmental and lifestyle risk factor information about breast cancer. The ...

    Authors: Claire Julian-Reynier, Anne-Deborah Bouhnik, D Gareth Evans, Hilary Harris, Christi J van Asperen, Aad Tibben, Joerg Schmidtke and Irmgard Nippert
    Citation: BMC Cancer 2015 15:243
    Content type: Research article Published on:

  22. To date, there have been no reports characterizing the genome-wide somatic DNA chromosomal copy-number alteration landscape in metastatic urothelial carcinoma. We sought to characterize the DNA copy-number pro...

    Authors: Richard M Bambury, Ami S Bhatt, Markus Riester, Chandra Sekhar Pedamallu, Fujiko Duke, Joaquim Bellmunt, Edward C Stack, Lillian Werner, Rachel Park, Gopa Iyer, Massimo Loda, Philip W Kantoff, Franziska Michor, Matthew Meyerson and Jonathan E Rosenberg
    Citation: BMC Cancer 2015 15:242
    Content type: Research article Published on:

  23. Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTO...

    Authors: Masaru Matsumoto, Masahiro Seike, Rintaro Noro, Chie Soeno, Teppei Sugano, Susumu Takeuchi, Akihiko Miyanaga, Kazuhiro Kitamura, Kaoru Kubota and Akihiko Gemma
    Citation: BMC Cancer 2015 15:241
    Content type: Research article Published on:

  24. Colorectal carcinoma is a common cause of cancer. Adjuvant treatments include: 5-fluorouracil administered together with folinic acid, or more recently, oral fluoropyrimidines such as capecitabine, in combinat...

    Authors: Silvina Grasso, Isabel Martínez-Lacaci, Víctor Manuel Barberá, Adela Castillejo, José Luis Soto, Javier Gallego-Plazas, Natividad López-Riquelme, Pilar García-Morales, Trinidad Mata-Balaguer, José Antonio Ferragut and Miguel Saceda
    Citation: BMC Cancer 2015 15:240
    Content type: Research article Published on:

  25. Resistance to antiestrogen therapy is a major clinical challenge in the treatment of estrogen receptor α (ER)-positive breast cancer. The aim of the study was to explore the growth promoting pathways of anties...

    Authors: Sarah L Larsen, Christina W Yde, Anne-Vibeke Laenkholm, Birgitte B Rasmussen, Anne Katrine Duun-Henriksen, Martin Bak, Anne E Lykkesfeldt and Tove Kirkegaard
    Citation: BMC Cancer 2015 15:239
    Content type: Research article Published on:

  26. MicroRNAs are known to inhibit gene expression by binding to the 3′UTR of the target transcript. Downregulation of miR-223 has been recently reported to have prognostic significance in CLL. However, there is n...

    Authors: Ana E Rodríguez-Vicente, Dalia Quwaider, Rocío Benito, Irena Misiewicz-Krzeminska, María Hernández-Sánchez, Alfonso García de Coca, Rosa Fisac, José-María Alonso, Carolina Zato, Juan Francisco de Paz, Juan Luis García, Ma Eugenia Sarasquete, José Ángel Hernández, Juan M Corchado, Marcos González, Norma C Gutiérrez…
    Citation: BMC Cancer 2015 15:238
    Content type: Research article Published on:

  27. Adenocarcinoma originating from the digestive system is a major contributor to cancer-related deaths worldwide. Tumor recurrence, advanced local growth and metastasis are key factors that frequently prevent th...

    Authors: Hanno Niess, Jobst C von Einem, Michael N Thomas, Marlies Michl, Martin K Angele, Ralf Huss, Christine Günther, Peter J Nelson, Christiane J Bruns and Volker Heinemann
    Citation: BMC Cancer 2015 15:237
    Content type: Study protocol Published on:

  28. Sorafenib is an orally administered multikinase inhibitor with antiangiogenic and antiproliferative properties. The results of large clinical trials demonstrate that sorafenib prolongs survival and the time to...

    Authors: Sae Hwan Lee, Il Han Song, Ran Noh, Ha Yan Kang, Suk Bae Kim, Soon Young Ko, Eoum Seok Lee, Seok Hyun Kim, Byung Seok Lee, An Na Kim, Hee Bok Chae, Hong Soo Kim, Tae Hee Lee, Young Woo Kang, Jae Dong Lee and Heon Young Lee
    Citation: BMC Cancer 2015 15:236
    Content type: Research article Published on:

  29. Patients suffering from cancer are often treated with a range of chemotherapeutic agents, but the treatment efficacy varies greatly between patients. Based on recent popularisation of regularised regression mo...

    Authors: Steffen Falgreen, Karen Dybkær, Ken H Young, Zijun Y Xu-Monette, Tarec C El-Galaly, Maria Bach Laursen, Julie S Bødker, Malene K Kjeldsen, Alexander Schmitz, Mette Nyegaard, Hans Erik Johnsen and Martin Bøgsted
    Citation: BMC Cancer 2015 15:235
    Content type: Research article Published on:

  30. Shb is a signaling protein downstream of vascular endothelial growth factor receptor-2 and Shb deficiency has been found to restrict tumor angiogenesis. The present study was performed in order to assess metastas...

    Authors: Guangxiang Zang, Karin Gustafsson, Maria Jamalpour, JongWook Hong, Guillem Genové and Michael Welsh
    Citation: BMC Cancer 2015 15:234
    Content type: Research article Published on:

  31. Effective prevention against cancers depends heavily on sustained individual efforts practicing protective behaviors and avoiding risk factors in a complex sociocultural context, which requires continuous and ...

    Authors: Jing Chai, Xingrong Shen, Rui Feng, Jing Cheng, Yeji Chen, Zhengqiu Zha, Shangchun Jia, Han Liang, Ting Zhao, Rui Sha, Yong Shi, Kaichun Li and Debin Wang
    Citation: BMC Cancer 2015 15:233
    Content type: Study protocol Published on:

  32. Liver transplantation is a treatment option for combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) but its prognostic significance remains unclear. The present study aimed to evaluate the therap...

    Authors: Di Wu, Zhong-Yang Shen, Ya-Min Zhang, Jian Wang, Hong Zheng, Yong-Lin Deng and Cheng Pan
    Citation: BMC Cancer 2015 15:232
    Content type: Research article Published on:

  33. Mapping of the motor cortex by navigated transcranial magnetic stimulation (nTMS) can be used for preoperative planning in brain tumor patients. Just recently, it has been proven to actually change outcomes by...

    Authors: Sandro M Krieg, Nico Sollmann, Thomas Obermueller, Jamil Sabih, Lucia Bulubas, Chiara Negwer, Tobias Moser, Doris Droese, Tobias Boeckh-Behrens, Florian Ringel and Bernhard Meyer
    Citation: BMC Cancer 2015 15:231
    Content type: Research article Published on:

  34. The high risk Human Papillomavirus (HPV) E6 oncoproteins play an essential role in the development of cervical malignancy. Important cellular targets of E6 include p53 and the PDZ domain containing substrates ...

    Authors: Takayuki Seiki, Kazunori Nagasaka, Christian Kranjec, Kei Kawana, Daichi Maeda, Hiroe Nakamura, Ayumi Taguchi, Yoko Matsumoto, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Shunsuke Nakagawa, Tetsu Yano, Masashi Fukayama, Lawrence Banks, Yutaka Osuga…
    Citation: BMC Cancer 2015 15:230
    Content type: Research article Published on:

  35. HNF1B (formerly known as TCF2) gene encodes for a transcription factor that regulates gene expression involved in normal mesodermal and endodermal developments. A close association between rs4430796 polymorphi...

    Authors: Vincenzo Dario Mandato, Enrico Farnetti, Federica Torricelli, Martino Abrate, Bruno Casali, Gino Ciarlini, Debora Pirillo, Maria Carolina Gelli, Davide Nicoli, Mario Grassi, Giovanni Battista LA Sala and Stefano Palomba
    Citation: BMC Cancer 2015 15:229
    Content type: Research article Published on:

  36. Cancer stem cells (CSCs) are considered the cell subpopulation responsible for breast cancer (BC) initiation, growth, and relapse. CSCs are identified as self-renewing and tumor-initiating cells, conferring re...

    Authors: Federica Barbieri, Stefano Thellung, Alessandra Ratto, Elisa Carra, Valeria Marini, Carmen Fucile, Adriana Bajetto, Alessandra Pattarozzi, Roberto Würth, Monica Gatti, Chiara Campanella, Guendalina Vito, Francesca Mattioli, Aldo Pagano, Antonio Daga, Angelo Ferrari…
    Citation: BMC Cancer 2015 15:228
    Content type: Research article Published on:

  37. Modification of splicing by chemotherapeutic drugs has usually been evaluated on a limited number of pre-mRNAs selected for their recognized or potential importance in cell proliferation or apoptosis. However,...

    Authors: Maude Gabriel, Yves Delforge, Adeline Deward, Yvette Habraken, Benoit Hennuy, Jacques Piette, Roscoe Klinck, Benoit Chabot, Alain Colige and Charles Lambert
    Citation: BMC Cancer 2015 15:227
    Content type: Research article Published on:

  38. Acute lymphoblastic leukemia (ALL) is a heterogeneous group of malignant disorders derived from B- or T-cell lymphoid progenitor cells. ALL often is refractory to or relapses after treatment; thus, novel targe...

    Authors: Yanli Jin, Qi Cao, Chun Chen, Xin Du, Bei Jin and Jingxuan Pan
    Citation: BMC Cancer 2015 15:226
    Content type: Research article Published on:

  39. Glioblastoma (GBM) is the most malignant primary brain tumor in adults, with a median survival time of one and a half years. Traditional treatments, including radiation, chemotherapy, and surgery, are not cura...

    Authors: Timothy T Bui, Ryan T Nitta, Suzana A Kahn, Seyed-Mostafa Razavi, Maya Agarwal, Parvir Aujla, Sharareh Gholamin, Lawrence Recht and Gordon Li
    Citation: BMC Cancer 2015 15:225
    Content type: Research article Published on:

  40. Acquired resistance to standard chemotherapy causes treatment failure in patients with metastatic bladder cancer. Overexpression of pro-survival Bcl-2 family proteins has been associated with a poor chemothera...

    Authors: Jens Mani, Stefan Vallo, Stefanie Rakel, Patrick Antonietti, Florian Gessler, Roman Blaheta, Georg Bartsch, Martin Michaelis, Jindrich Cinatl, Axel Haferkamp and Donat Kögel
    Citation: BMC Cancer 2015 15:224
    Content type: Research article Published on:

  41. Pancreatic ductal adenocarcinoma is a particularly challenging malignancy characterized by poor responsiveness to conventional chemotherapy. Although this tumor frequently overexpresses or possesses constituti...

    Authors: Nerea Urtasun, Anna Vidal-Pla, Sandra Pérez-Torras and Adela Mazo
    Citation: BMC Cancer 2015 15:223
    Content type: Research article Published on:

  42. COU-AA-301 trial has proved that abiraterone acetate (AA), a selective inhibitor of androgen biosynthesis, improved overall survival (OS) of patients with metastatic castration resistant prostate cancer (mCRPC...

    Authors: Nadine Houédé, Philippe Beuzeboc, Sophie Gourgou, Diego Tosi, Laura Moise, Gwenaëlle Gravis, Remy Delva, Aude Fléchon, Igor Latorzeff, Jean-Marc Ferrero, Stéphane Oudard, Sophie Tartas, Brigitte Laguerre, Delphine Topart, Guilhem Roubaud, Hanane Agherbi…
    Citation: BMC Cancer 2015 15:222
    Content type: Research article Published on:

  43. Treatment failure is a critical issue in breast cancer and identifying useful interventions that optimize current cancer therapies remains a critical unmet need. Expression and functional studies have identifi...

    Authors: Christina L Grek, Joshua Matthew Rhett, Jaclynn S Bruce, Melissa A Abt, Gautam S Ghatnekar and Elizabeth S Yeh
    Citation: BMC Cancer 2015 15:296
    Content type: Research article Published on:

  44. The molecular regulators that orchestrate stem cell renewal, proliferation and differentiation along the mammary epithelial hierarchy remain poorly understood. Here we have performed a large-scale pooled RNAi ...

    Authors: Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, François Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman and Jane E Visvader
    Citation: BMC Cancer 2015 15:221
    Content type: Research article Published on:

  45. Up to 50% of penile squamous cell carcinomas (pSCC) develop in the context of high-risk human papillomavirus (HR-HPV) infection. Most of these tumours have been reported to show basaloid differentiation and ov...

    Authors: Julie Steinestel, Andreas Al Ghazal, Annette Arndt, Thomas J Schnoeller, Andres J Schrader, Peter Moeller and Konrad Steinestel
    Citation: BMC Cancer 2015 15:220
    Content type: Research article Published on:

  46. BRCA1 is a key protein in cell network, involved in DNA repair pathways and cell cycle. Recently, the ENIGMA consortium has reported a high number of alternative splicing (AS) events at this locus in blood-derive...

    Authors: Atocha Romero, Francisco García-García, Irene López-Perolio, Gorka Ruiz de Garibay, José A García-Sáenz, Pilar Garre, Patricia Ayllón, Esperanza Benito, Joaquín Dopazo, Eduardo Díaz-Rubio, Trinidad Caldés and Miguel de la Hoya
    Citation: BMC Cancer 2015 15:219
    Content type: Research article Published on:

  47. Improvement of the initial management of sarcomas after the dissemination of evidence-based guidelines depends on the primary sarcoma location: a population-based study.

    Authors: Karine Ligier, Carlos Maynou, Xavier Leroy, Yves-Marie Robin, Philippe Martin, Stéphanie Clisant, Florence Richard and Nicolas Penel
    Citation: BMC Cancer 2015 15:218
    Content type: Research article Published on:

  48. Germline DNA mutations that increase the susceptibility of a patient to certain cancers have been identified in various genes, and patients can be screened for mutations in these genes to assess their level of...

    Authors: Thaddeus Judkins, Benoît Leclair, Karla Bowles, Natalia Gutin, Jeff Trost, James McCulloch, Satish Bhatnagar, Adam Murray, Jonathan Craft, Bryan Wardell, Mark Bastian, Jeffrey Mitchell, Jian Chen, Thanh Tran, Deborah Williams, Jennifer Potter…
    Citation: BMC Cancer 2015 15:215
    Content type: Technical advance Published on:

  49. Sentinel lymph node (SLN) mapping is the standard method for axillary lymph node staging in patients with breast cancer. Blue dye and radioisotopes are commonly used agents to localize SLNs, but both have seve...

    Authors: Chuanming Li, Shan Meng, Xinhua Yang, Daiquan Zhou, Jian Wang and Jiani Hu
    Citation: BMC Cancer 2015 15:213
    Content type: Research article Published on:

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