Siegel R, Naishadham D, Jemal A. Cancer statistics. CA Cancer J Clin. 2012;62(1):10–29.
Article
PubMed
Google Scholar
Smolle E, Taucher V, Pichler M, Petru E, Lax S, Haybaeck J. Targeting signaling pathways in epithelial ovarian cancer. Int J Mol Sci. 2013;14:9536–55.
Article
PubMed
PubMed Central
Google Scholar
Marsden DE, Friedlander M, Hacker NF. Current management of epithelial ovarian carcinoma. Semin Surg Oncol. 2000;19:11–9.
Article
CAS
PubMed
Google Scholar
Ross D, Kepa JK, Winski SL, Beall HD, Anwar A, Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact. 2000;129:77–97.
Article
CAS
PubMed
Google Scholar
Siegel D, Yan C, Ross D. NAD (P) H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol. 2012;83(8):1033–40.
Article
CAS
PubMed
Google Scholar
Nioi P, Hayes JD. Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat Res. 2004;555:149–71.
Article
CAS
PubMed
Google Scholar
Prawan A, Buranrat B, Kukongviriyapan U, Sripa B, Kukongviriyapan V. Inflammatory cytokines suppress NAD(P)H:quinone oxidoreductase-1 and induce oxidative stress in cholangiocarcinoma cells. J Cancer Res Clin Oncol. 2009;135:515–22.
Article
CAS
PubMed
Google Scholar
Kolesar JM, Pritchard SC, Kerr KM, Kim K, Nicolson MC, McLeod H. Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue. Int J Oncol. 2002;21:1119–24.
CAS
PubMed
Google Scholar
Cresteil T, Jaiswal AK. High levels of expression of the NAD(P)H: quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origan. Biochem Pharmacol. 1991;42:1021–7.
Article
CAS
PubMed
Google Scholar
Ross D, Siegel D, Beall H, Prakash AS, Mulcahy RT. DTdiaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C. Cancer Metastasis Rev. 1993;12:83–101.
Article
CAS
PubMed
Google Scholar
Tedeschi G, Chen S, Massey V. DT-diaphorase. Redox potential, steadystate, and rapid reaction studies. J Biol Chem. 1995;270:1198–204.
Article
CAS
PubMed
Google Scholar
Smitskamp-Wilms E, Hendriks HR, Peters GJ. Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9. Gen Pharmacol. 1996;27:421–9.
Article
CAS
PubMed
Google Scholar
Ross D, Beall H, Traver RD, Siegel D, Phillips RM. Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies. Oncol Res. 1994;6:493–500.
CAS
PubMed
Google Scholar
Cadenas E. Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism. Biochem Pharmacol. 1995;49:127–40.
Article
CAS
PubMed
Google Scholar
Ross D, Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1, DTdiaphorase), functions and pharmacogenetics. Methods Enzymol. 2004;382:115–44.
Article
CAS
PubMed
Google Scholar
Ma Y, Kong J, Yan G, Ren S, Jin D, Jin T, et al. NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix. BMC Cancer. 2014;14:414.
Article
PubMed
PubMed Central
Google Scholar
Siegel D, Franklin WA, Ross D. Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors. Clin Cancer Res. 1998;4(9):2065–70.
CAS
PubMed
Google Scholar
Awadallah NS, Dehn D, Shah RJ, Russell Nash S, Chen YK, Ross D, et al. NQO1 expression in pancreatic cancer and its potential use as a biomarker. Appl Immunohistochem Mol Morphol. 2008;16(1):24–31.
CAS
PubMed
Google Scholar
Garate M, Wani AA, Li G. The NAD(P)H:Quinone Oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells. Free Radic Biol Med. 2010;48(12):1601–9.
Article
CAS
PubMed
Google Scholar
Lin L, Piao J, Gao W, Piao Y, Jin G, Ma Y, et al. DEK over expression as an independent biomarker for poor prognosis in colorectal cancer. BMC Cancer. 2013;13:366.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ernster L, Navazio F. Soluble diaphorase in animal tissues. Acta Chem Scand. 1958;12:595–602.
Article
CAS
Google Scholar
Winski SL, Koutalos Y, Bentley DL, Ross D. Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells. Cancer Res. 2002;62:1420–4.
CAS
PubMed
Google Scholar
Lee H, Oh ET, Choi BH, Park MT, Lee JK, Lee JS, et al. NQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation. Sci Rep. 2015;5:7769.
Article
CAS
PubMed
PubMed Central
Google Scholar
Girolami F, Abbadessa G, Racca S, Spaccamiglio A, Piccione F, Dacasto M, et al. Time-dependent acetylsalicylic acid effects on liver CYP1A and antioxidant enzymes in a rat model of 7,12-dimethylbenzanthracene(DMBA)-induced mammary carcinogenesis. Toxicol Lett. 2008;181:87–92.
Article
CAS
PubMed
Google Scholar
Iskander K, Gaikwad A, Paquet M, Long II DJ, Brayton C, Barrios R, et al. Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. Cancer Res. 2005;65:2054–8.
Article
CAS
PubMed
Google Scholar
Long DJ, Waikel RL, Wang XJ, Roop DR, Jaiswal AK. NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin. J Natl Cancer Inst. 2001;93:1166–70.
Article
CAS
PubMed
Google Scholar
Choi TY, Sohn KC, Kim JH, Kim SM, Kim CH, Hwang JS, et al. Impact of NAD(P)H:quinone oxidoreductase-1 on pigmentation. J Invest Dermatol. 2010;130(3):784–92.
Article
CAS
PubMed
Google Scholar
Reigan P, Colucci MA, Siegel D, Chilloux A, Moody CJ, Ross D. Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells. Biochemistry. 2007;46:5941–50.
Article
CAS
PubMed
Google Scholar
Nagata M, Kimura T, Suzumura T, Kira Y, Nakai T, Umekawa K, et al. C609T polymorphism of NADPH quinone oxidoreductase 1 correlates clinical hematological toxicities in lung cancer patients treated with amrubicin. Clin Med Insights Oncol. 2013;7:31–9.
CAS
PubMed
PubMed Central
Google Scholar
Malik MA, Zargar SA, Mittal B. Role of NQO1 609C > T and NQO2–3423G > A gene polymorphisms in esophageal cancer risk in Kashmir valley and meta analysis. Mol Biol Rep. 2012;39(9):9095–104.
Article
CAS
PubMed
Google Scholar
Lin L, Qin Y, Jin T, Liu S, Zhang S, Shen X, et al. Significance of NQO1 overexpression for prognostic evaluation of gastric adenocarcinoma. Exp Mol Pathol. 2014;96(2):200–5.
Article
CAS
PubMed
Google Scholar
Goode EL, White KL, Vierkant RA, Phelan CM, Cunningham JM, Schildkraut JM, et al. Xenobiotic-metabolizing gene polymorphisms and Ovarian cancer risk. Mol Carcinog. 2011;50(5):397–402.
Article
CAS
PubMed
Google Scholar
Siegel D, Ross D. Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues. Free Radic Biol Med. 2000;29:246–53.
Article
CAS
PubMed
Google Scholar
Yang Y, Zhang Y, Wu Q, Cui X, Lin Z, Liu S, et al. Clinical implications of high NQO1 expression in breast cancers. J Exp Clin Cancer Res. 2014;33:14.
Article
CAS
PubMed
PubMed Central
Google Scholar
Buranrat B, Chau-In S, Prawan A, Puapairoj A, Zeekpudsa P, Kukongviriyapan V. NQO1 Expression correlates with cholangiocarcinoma prognosis. Asian Pac J Cancer Prev. 2012;13(Suppl):131–6.
PubMed
Google Scholar
Workman P. Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase. Oncol Res. 1994;6:461–75.
CAS
PubMed
Google Scholar
Kung H, Weng T, Liu Y, Lu K, Chau Y. Sulindac compounds facilitate the cytotoxicity of β-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cells. PLoS One. 2014;9(2):e88122.
Article
PubMed
PubMed Central
Google Scholar
Hadley K, Hendricks D. Use of NQO1 status as a selective biomarker for oesophageal squamous cell carcinomas with greater sensitivity to 17-AAG. BMC Cancer. 2014;14:334.
Article
PubMed
PubMed Central
Google Scholar
Huang X, Dong Y, Bey E. An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis. Cancer Res. 2012;72:3038–47.
Article
CAS
PubMed
PubMed Central
Google Scholar