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  1. Toll-like receptor 3 (TLR3) plays a key role in innate immunity. In the present study, we analyzed tissues of patients with human hepatocellular carcinoma (HCC) to determine the significance of the relationshi...

    Authors: Ming-Ming Yuan, Yu-Yin Xu, Li Chen, Xing-Yu Li, Jing Qin and Ying Shen
    Citation: BMC Cancer 2015 15:245
    Content type: Research article Published on:

  2. No information is available on the attitudes of General Practitioners (GPs) and Breast Surgeons (BSs) to their delivery of genetic, environmental and lifestyle risk factor information about breast cancer. The ...

    Authors: Claire Julian-Reynier, Anne-Deborah Bouhnik, D Gareth Evans, Hilary Harris, Christi J van Asperen, Aad Tibben, Joerg Schmidtke and Irmgard Nippert
    Citation: BMC Cancer 2015 15:243
    Content type: Research article Published on:

  3. To date, there have been no reports characterizing the genome-wide somatic DNA chromosomal copy-number alteration landscape in metastatic urothelial carcinoma. We sought to characterize the DNA copy-number pro...

    Authors: Richard M Bambury, Ami S Bhatt, Markus Riester, Chandra Sekhar Pedamallu, Fujiko Duke, Joaquim Bellmunt, Edward C Stack, Lillian Werner, Rachel Park, Gopa Iyer, Massimo Loda, Philip W Kantoff, Franziska Michor, Matthew Meyerson and Jonathan E Rosenberg
    Citation: BMC Cancer 2015 15:242
    Content type: Research article Published on:

  4. Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTO...

    Authors: Masaru Matsumoto, Masahiro Seike, Rintaro Noro, Chie Soeno, Teppei Sugano, Susumu Takeuchi, Akihiko Miyanaga, Kazuhiro Kitamura, Kaoru Kubota and Akihiko Gemma
    Citation: BMC Cancer 2015 15:241
    Content type: Research article Published on:

  5. Colorectal carcinoma is a common cause of cancer. Adjuvant treatments include: 5-fluorouracil administered together with folinic acid, or more recently, oral fluoropyrimidines such as capecitabine, in combinat...

    Authors: Silvina Grasso, Isabel Martínez-Lacaci, Víctor Manuel Barberá, Adela Castillejo, José Luis Soto, Javier Gallego-Plazas, Natividad López-Riquelme, Pilar García-Morales, Trinidad Mata-Balaguer, José Antonio Ferragut and Miguel Saceda
    Citation: BMC Cancer 2015 15:240
    Content type: Research article Published on:

  6. Resistance to antiestrogen therapy is a major clinical challenge in the treatment of estrogen receptor α (ER)-positive breast cancer. The aim of the study was to explore the growth promoting pathways of anties...

    Authors: Sarah L Larsen, Christina W Yde, Anne-Vibeke Laenkholm, Birgitte B Rasmussen, Anne Katrine Duun-Henriksen, Martin Bak, Anne E Lykkesfeldt and Tove Kirkegaard
    Citation: BMC Cancer 2015 15:239
    Content type: Research article Published on:

  7. MicroRNAs are known to inhibit gene expression by binding to the 3′UTR of the target transcript. Downregulation of miR-223 has been recently reported to have prognostic significance in CLL. However, there is n...

    Authors: Ana E Rodríguez-Vicente, Dalia Quwaider, Rocío Benito, Irena Misiewicz-Krzeminska, María Hernández-Sánchez, Alfonso García de Coca, Rosa Fisac, José-María Alonso, Carolina Zato, Juan Francisco de Paz, Juan Luis García, Ma Eugenia Sarasquete, José Ángel Hernández, Juan M Corchado, Marcos González, Norma C Gutiérrez…
    Citation: BMC Cancer 2015 15:238
    Content type: Research article Published on:

  8. Adenocarcinoma originating from the digestive system is a major contributor to cancer-related deaths worldwide. Tumor recurrence, advanced local growth and metastasis are key factors that frequently prevent th...

    Authors: Hanno Niess, Jobst C von Einem, Michael N Thomas, Marlies Michl, Martin K Angele, Ralf Huss, Christine Günther, Peter J Nelson, Christiane J Bruns and Volker Heinemann
    Citation: BMC Cancer 2015 15:237
    Content type: Study protocol Published on:

  9. Sorafenib is an orally administered multikinase inhibitor with antiangiogenic and antiproliferative properties. The results of large clinical trials demonstrate that sorafenib prolongs survival and the time to...

    Authors: Sae Hwan Lee, Il Han Song, Ran Noh, Ha Yan Kang, Suk Bae Kim, Soon Young Ko, Eoum Seok Lee, Seok Hyun Kim, Byung Seok Lee, An Na Kim, Hee Bok Chae, Hong Soo Kim, Tae Hee Lee, Young Woo Kang, Jae Dong Lee and Heon Young Lee
    Citation: BMC Cancer 2015 15:236
    Content type: Research article Published on:

  10. Patients suffering from cancer are often treated with a range of chemotherapeutic agents, but the treatment efficacy varies greatly between patients. Based on recent popularisation of regularised regression mo...

    Authors: Steffen Falgreen, Karen Dybkær, Ken H Young, Zijun Y Xu-Monette, Tarec C El-Galaly, Maria Bach Laursen, Julie S Bødker, Malene K Kjeldsen, Alexander Schmitz, Mette Nyegaard, Hans Erik Johnsen and Martin Bøgsted
    Citation: BMC Cancer 2015 15:235
    Content type: Research article Published on:

  11. Shb is a signaling protein downstream of vascular endothelial growth factor receptor-2 and Shb deficiency has been found to restrict tumor angiogenesis. The present study was performed in order to assess metastas...

    Authors: Guangxiang Zang, Karin Gustafsson, Maria Jamalpour, JongWook Hong, Guillem Genové and Michael Welsh
    Citation: BMC Cancer 2015 15:234
    Content type: Research article Published on:

  12. Effective prevention against cancers depends heavily on sustained individual efforts practicing protective behaviors and avoiding risk factors in a complex sociocultural context, which requires continuous and ...

    Authors: Jing Chai, Xingrong Shen, Rui Feng, Jing Cheng, Yeji Chen, Zhengqiu Zha, Shangchun Jia, Han Liang, Ting Zhao, Rui Sha, Yong Shi, Kaichun Li and Debin Wang
    Citation: BMC Cancer 2015 15:233
    Content type: Study protocol Published on:

  13. Liver transplantation is a treatment option for combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) but its prognostic significance remains unclear. The present study aimed to evaluate the therap...

    Authors: Di Wu, Zhong-Yang Shen, Ya-Min Zhang, Jian Wang, Hong Zheng, Yong-Lin Deng and Cheng Pan
    Citation: BMC Cancer 2015 15:232
    Content type: Research article Published on:

  14. Mapping of the motor cortex by navigated transcranial magnetic stimulation (nTMS) can be used for preoperative planning in brain tumor patients. Just recently, it has been proven to actually change outcomes by...

    Authors: Sandro M Krieg, Nico Sollmann, Thomas Obermueller, Jamil Sabih, Lucia Bulubas, Chiara Negwer, Tobias Moser, Doris Droese, Tobias Boeckh-Behrens, Florian Ringel and Bernhard Meyer
    Citation: BMC Cancer 2015 15:231
    Content type: Research article Published on:

  15. The high risk Human Papillomavirus (HPV) E6 oncoproteins play an essential role in the development of cervical malignancy. Important cellular targets of E6 include p53 and the PDZ domain containing substrates ...

    Authors: Takayuki Seiki, Kazunori Nagasaka, Christian Kranjec, Kei Kawana, Daichi Maeda, Hiroe Nakamura, Ayumi Taguchi, Yoko Matsumoto, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Shunsuke Nakagawa, Tetsu Yano, Masashi Fukayama, Lawrence Banks, Yutaka Osuga…
    Citation: BMC Cancer 2015 15:230
    Content type: Research article Published on:

  16. HNF1B (formerly known as TCF2) gene encodes for a transcription factor that regulates gene expression involved in normal mesodermal and endodermal developments. A close association between rs4430796 polymorphi...

    Authors: Vincenzo Dario Mandato, Enrico Farnetti, Federica Torricelli, Martino Abrate, Bruno Casali, Gino Ciarlini, Debora Pirillo, Maria Carolina Gelli, Davide Nicoli, Mario Grassi, Giovanni Battista LA Sala and Stefano Palomba
    Citation: BMC Cancer 2015 15:229
    Content type: Research article Published on:

  17. Cancer stem cells (CSCs) are considered the cell subpopulation responsible for breast cancer (BC) initiation, growth, and relapse. CSCs are identified as self-renewing and tumor-initiating cells, conferring re...

    Authors: Federica Barbieri, Stefano Thellung, Alessandra Ratto, Elisa Carra, Valeria Marini, Carmen Fucile, Adriana Bajetto, Alessandra Pattarozzi, Roberto Würth, Monica Gatti, Chiara Campanella, Guendalina Vito, Francesca Mattioli, Aldo Pagano, Antonio Daga, Angelo Ferrari…
    Citation: BMC Cancer 2015 15:228
    Content type: Research article Published on:

  18. Modification of splicing by chemotherapeutic drugs has usually been evaluated on a limited number of pre-mRNAs selected for their recognized or potential importance in cell proliferation or apoptosis. However,...

    Authors: Maude Gabriel, Yves Delforge, Adeline Deward, Yvette Habraken, Benoit Hennuy, Jacques Piette, Roscoe Klinck, Benoit Chabot, Alain Colige and Charles Lambert
    Citation: BMC Cancer 2015 15:227
    Content type: Research article Published on:

  19. Acute lymphoblastic leukemia (ALL) is a heterogeneous group of malignant disorders derived from B- or T-cell lymphoid progenitor cells. ALL often is refractory to or relapses after treatment; thus, novel targe...

    Authors: Yanli Jin, Qi Cao, Chun Chen, Xin Du, Bei Jin and Jingxuan Pan
    Citation: BMC Cancer 2015 15:226
    Content type: Research article Published on:

  20. Glioblastoma (GBM) is the most malignant primary brain tumor in adults, with a median survival time of one and a half years. Traditional treatments, including radiation, chemotherapy, and surgery, are not cura...

    Authors: Timothy T Bui, Ryan T Nitta, Suzana A Kahn, Seyed-Mostafa Razavi, Maya Agarwal, Parvir Aujla, Sharareh Gholamin, Lawrence Recht and Gordon Li
    Citation: BMC Cancer 2015 15:225
    Content type: Research article Published on:

  21. Acquired resistance to standard chemotherapy causes treatment failure in patients with metastatic bladder cancer. Overexpression of pro-survival Bcl-2 family proteins has been associated with a poor chemothera...

    Authors: Jens Mani, Stefan Vallo, Stefanie Rakel, Patrick Antonietti, Florian Gessler, Roman Blaheta, Georg Bartsch, Martin Michaelis, Jindrich Cinatl, Axel Haferkamp and Donat Kögel
    Citation: BMC Cancer 2015 15:224
    Content type: Research article Published on:

  22. Pancreatic ductal adenocarcinoma is a particularly challenging malignancy characterized by poor responsiveness to conventional chemotherapy. Although this tumor frequently overexpresses or possesses constituti...

    Authors: Nerea Urtasun, Anna Vidal-Pla, Sandra Pérez-Torras and Adela Mazo
    Citation: BMC Cancer 2015 15:223
    Content type: Research article Published on:

  23. COU-AA-301 trial has proved that abiraterone acetate (AA), a selective inhibitor of androgen biosynthesis, improved overall survival (OS) of patients with metastatic castration resistant prostate cancer (mCRPC...

    Authors: Nadine Houédé, Philippe Beuzeboc, Sophie Gourgou, Diego Tosi, Laura Moise, Gwenaëlle Gravis, Remy Delva, Aude Fléchon, Igor Latorzeff, Jean-Marc Ferrero, Stéphane Oudard, Sophie Tartas, Brigitte Laguerre, Delphine Topart, Guilhem Roubaud, Hanane Agherbi…
    Citation: BMC Cancer 2015 15:222
    Content type: Research article Published on:

  24. Treatment failure is a critical issue in breast cancer and identifying useful interventions that optimize current cancer therapies remains a critical unmet need. Expression and functional studies have identifi...

    Authors: Christina L Grek, Joshua Matthew Rhett, Jaclynn S Bruce, Melissa A Abt, Gautam S Ghatnekar and Elizabeth S Yeh
    Citation: BMC Cancer 2015 15:296
    Content type: Research article Published on:

  25. The molecular regulators that orchestrate stem cell renewal, proliferation and differentiation along the mammary epithelial hierarchy remain poorly understood. Here we have performed a large-scale pooled RNAi ...

    Authors: Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, François Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman and Jane E Visvader
    Citation: BMC Cancer 2015 15:221
    Content type: Research article Published on:

  26. Up to 50% of penile squamous cell carcinomas (pSCC) develop in the context of high-risk human papillomavirus (HR-HPV) infection. Most of these tumours have been reported to show basaloid differentiation and ov...

    Authors: Julie Steinestel, Andreas Al Ghazal, Annette Arndt, Thomas J Schnoeller, Andres J Schrader, Peter Moeller and Konrad Steinestel
    Citation: BMC Cancer 2015 15:220
    Content type: Research article Published on:

  27. BRCA1 is a key protein in cell network, involved in DNA repair pathways and cell cycle. Recently, the ENIGMA consortium has reported a high number of alternative splicing (AS) events at this locus in blood-derive...

    Authors: Atocha Romero, Francisco García-García, Irene López-Perolio, Gorka Ruiz de Garibay, José A García-Sáenz, Pilar Garre, Patricia Ayllón, Esperanza Benito, Joaquín Dopazo, Eduardo Díaz-Rubio, Trinidad Caldés and Miguel de la Hoya
    Citation: BMC Cancer 2015 15:219
    Content type: Research article Published on:

  28. The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 in the ...

    Authors: Silvia Antolín, Lourdes Calvo, Moisés Blanco-Calvo, María Paz Santiago, María José Lorenzo-Patiño, Mar Haz-Conde, Isabel Santamarina, Angélica Figueroa, Luis Miguel Antón-Aparicio and Manuel Valladares-Ayerbes
    Citation: BMC Cancer 2015 15:297
    Content type: Research article Published on:

  29. Improvement of the initial management of sarcomas after the dissemination of evidence-based guidelines depends on the primary sarcoma location: a population-based study.

    Authors: Karine Ligier, Carlos Maynou, Xavier Leroy, Yves-Marie Robin, Philippe Martin, Stéphanie Clisant, Florence Richard and Nicolas Penel
    Citation: BMC Cancer 2015 15:218
    Content type: Research article Published on:

  30. The proliferating activity of a single leukemia stem cell and the molecular mechanisms for their quiescent property remain unknown, and also their prognostic value remains a matter of debate. Therefore, this s...

    Authors: Eun Jeong Won, Hye-Ran Kim, Ra-Young Park, Seok-Yong Choi, Jong Hee Shin, Soon-Pal Suh, Dong-Wook Ryang, Michael Szardenings and Myung-Geun Shin
    Citation: BMC Cancer 2015 15:217
    Content type: Research article Published on:

  31. Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test r...

    Authors: Ditte Møller Ejegod, Matejka Rebolj and Jesper Bonde
    Citation: BMC Cancer 2015 15:216
    Content type: Research article Published on:

  32. Germline DNA mutations that increase the susceptibility of a patient to certain cancers have been identified in various genes, and patients can be screened for mutations in these genes to assess their level of...

    Authors: Thaddeus Judkins, Benoît Leclair, Karla Bowles, Natalia Gutin, Jeff Trost, James McCulloch, Satish Bhatnagar, Adam Murray, Jonathan Craft, Bryan Wardell, Mark Bastian, Jeffrey Mitchell, Jian Chen, Thanh Tran, Deborah Williams, Jennifer Potter…
    Citation: BMC Cancer 2015 15:215
    Content type: Technical advance Published on:

  33. Using a cross-database integrative approach, we performed an epidemiological analysis in a representative region of central Poland to evaluate the availability of radiotherapy (RTx) and overall survival of adu...

    Authors: Justyna Chalubinska-Fendler, Wojciech Fendler, Michal Spych, Jolanta Luniewska-Bury, Wojciech Mlynarski and Jacek Fijuth
    Citation: BMC Cancer 2015 15:214
    Content type: Research article Published on:

  34. Sentinel lymph node (SLN) mapping is the standard method for axillary lymph node staging in patients with breast cancer. Blue dye and radioisotopes are commonly used agents to localize SLNs, but both have seve...

    Authors: Chuanming Li, Shan Meng, Xinhua Yang, Daiquan Zhou, Jian Wang and Jiani Hu
    Citation: BMC Cancer 2015 15:213
    Content type: Research article Published on:

  36. Breast cancer outcomes are influenced by multiple factors including access to care, and payer status is a recognized barrier to treatment access. To further define the influence of payer status on outcome, the...

    Authors: Runhua Shi, Hannah Taylor, Jerry McLarty, Lihong Liu, Glenn Mills and Gary Burton
    Citation: BMC Cancer 2015 15:211
    Content type: Research article Published on:

  37. The incidence of non-alcoholic steatohepatitis (NASH) is increasing worldwide and a poorly defined subset of patients develops end-stage liver disease and hepatocellular carcinoma (HCC). Differences in the bio...

    Authors: Arndt Weinmann, Yvonne Alt, Sandra Koch, Carina Nelles, Christoph Düber, Hauke Lang, Gerd Otto, Tim Zimmermann, Jens U Marquardt, Peter R Galle, Marcus A Wörns and Jörn M Schattenberg
    Citation: BMC Cancer 2015 15:210
    Content type: Research article Published on:

  38. Carbonic anhydrases (CAs) have been implicated in the pathogenesis of human cancers. Carbonic anhydrase VII (CA7), a member of the CA gene family, was recently demonstrated to be expressed in several human tis...

    Authors: Guang-Zhen Yang, Liang Hu, Jian Cai, Hai-Yang Chen, Yu Zhang, Dan Feng, Chen-Ye Qi, Yan-Xia Zhai, Hui Gong, Hao Fu, Qing-Ping Cai and Chun-Fang Gao
    Citation: BMC Cancer 2015 15:209
    Content type: Research article Published on:

  39. Definitive chemoradiotherapy (dCRT) has recently become one of the most effective therapies for the treatment of esophageal squamous cell carcinoma (ESCC). However, it is also true this treatment has not been ...

    Authors: Hiroshi Okamoto, Fumiyoshi Fujishima, Takashi Kamei, Yasuhiro Nakamura, Yohei Ozawa, Go Miyata, Toru Nakano, Kazunori Katsura, Shigeo Abe, Yusuke Taniyama, Tadashi Sakurai, Jin Teshima, Makoto Hikage, Hironobu Sasano and Noriaki Ohuchi
    Citation: BMC Cancer 2015 15:208
    Content type: Research article Published on:

  40. High-level expression of NAD(P)H: quinoneoxidoreductase 1 (NQO1) has been correlated with many types of human cancers, suggesting that NQO1 plays important roles in tumor occurrence and progression. This study...

    Authors: Zhenling Li, Yue Zhang, Tiefeng Jin, Jiguang Men, Zhenhua Lin, Peng Qi, Yingshi Piao and Guanghai Yan
    Citation: BMC Cancer 2015 15:207
    Content type: Research article Published on:

  41. Circulating biomarkers are urgently needed in hepatocellular carcinoma (HCC). The aims of this study were to determine the feasibility of detecting and isolating circulating tumor cells (CTCs) in HCC patients ...

    Authors: Robin K Kelley, Mark Jesus M Magbanua, Timothy M Butler, Eric A Collisson, Jimmy Hwang, Nikoletta Sidiropoulos, Kimberley Evason, Ryan M McWhirter, Bilal Hameed, Elizabeth M Wayne, Francis Y Yao, Alan P Venook and John W Park
    Citation: BMC Cancer 2015 15:206
    Content type: Research article Published on:

  42. Smoking induces oncogenic TP53-mutations in head and neck squamous cell carcinomas (HNSCCs). Disruptive mutations of TP53-gene and expression of p16 protein [p16 (+)] in tumor tissue associate with worse and bett...

    Authors: Aki Mafune, Takanori Hama, Toshihito Suda, Yutaka Suzuki, Masahiro Ikegami, Chikako Sakanashi, Satoko Imai, Akio Nakashima, Takashi Yokoo, Kota Wada, Hiromi Kojima and Mitsuyoshi Urashima
    Citation: BMC Cancer 2015 15:205
    Content type: Research article Published on:

  43. Identifying cellular signaling pathways that become corrupted in the presence of androgens that increase the metastatic potential of organ-confined tumor cells is critical to devising strategies capable of att...

    Authors: Jordy J Hsiao, Brandon H Ng, Melinda M Smits, Jiahui Wang, Rohini J Jasavala, Harryl D Martinez, Jinhee Lee, Jhullian J Alston, Hiroaki Misonou, James S Trimmer and Michael E Wright
    Citation: BMC Cancer 2015 15:204
    Content type: Research article Published on:

  44. Microtubule-associated tumor suppressor gene (MTUS1) has been identified as tumor suppressor gene in many malignant tumors. In this study, we investigated the role of MTUS1 in the development of salivary adeno...

    Authors: Tingting Zhao, Xueqiang Ding, Boyang Chang, Xiaofeng Zhou and Anxun Wang
    Citation: BMC Cancer 2015 15:203
    Content type: Research article Published on:

  45. The prognostic value of circulating tumor cells (CTCs) detected with the CellSearch System in patients with colorectal cancer (CRC) is controversial. The aim of our meta-analysis was to evaluate whether the de...

    Authors: Xuanzhang Huang, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Junhua Zhao, Huimian Xu and Zhenning Wang
    Citation: BMC Cancer 2015 15:202
    Content type: Research article Published on:

  46. The prognoses of young breast cancer patients are poor. The purpose of this study is to evaluate the different characteristics and prognoses among different subtypes of young breast cancer patients.

    Authors: Li-Chen Tang, Xi Jin, Hai-Yuan Yang, Min He, Helena Chang, Zhi-Ming Shao and Gen-Hong Di
    Citation: BMC Cancer 2015 15:201
    Content type: Research article Published on:

  47. Cutaneous melanoma is the most lethal skin cancer and its incidence in developed countries has dramatically increased over the past decades. Localized tumors are easily treated by surgery, but advanced melanom...

    Authors: Laure Humbert, Mostafa Ghozlan, Lucie Canaff, Jun Tian and Jean-Jacques Lebrun
    Citation: BMC Cancer 2015 15:200
    Content type: Research article Published on:

  48. Mounting evidence demonstrates a causal role for S100 proteins in tumourigenesis and several S100 isoforms have shown utility as biomarkers of several types of cancer. The S100 family is comprised of 21 small ...

    Authors: Juan Martínez-Aguilar, Roderick Clifton-Bligh and Mark P Molloy
    Citation: BMC Cancer 2015 15:199
    Content type: Technical advance Published on:

  49. Our previous study suggested that the recurrent CHEK2 H371Y mutation is a novel pathogenic mutation that confers an increased risk of breast cancer. The purpose of this study was to investigate whether breast can...

    Authors: Yin Liu, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin and Yuntao Xie
    Citation: BMC Cancer 2015 15:194
    Content type: Research article Published on:

  50. The standard trimodal treatment concept in locally advanced and non-metastasized non-small-cell superior sulcus tumors consists of a preoperative chemoradiation followed by surgical resection. High linear ener...

    Authors: Henrik Hauswald, Stefan Rieken, Hendrik C Dienemann, Michael Thomas, Meinhard Kieser, Jürgen Debus and Klaus Herfarth
    Citation: BMC Cancer 2015 15:192
    Content type: Study protocol Published on:

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