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  1. Locally recurrent non-small cell lung cancer (NSCLC) poses a great challenge to physicians. This study aimed to explore the efficacy and safety of the combination of brachytherapy and docetaxel and cisplatin f...

    Authors: Xiaojuan Yu, Jin Li, Xiaoming Zhong and Jingdong He
    Citation: BMC Cancer 2015 15:656
    Content type: Research article Published on:

  2. Specific genes, such as BCAT1 and IKZF1, are methylated with high frequency in colorectal cancer (CRC) tissue compared to normal colon tissue specimens. Such DNA may leak into blood and be present as cell-free ci...

    Authors: Susanne K. Pedersen, Erin L. Symonds, Rohan T. Baker, David H. Murray, Aidan McEvoy, Sascha C. Van Doorn, Marco W. Mundt, Stephen R. Cole, Geetha Gopalsamy, Dileep Mangira, Lawrence C. LaPointe, Evelien Dekker and Graeme P. Young
    Citation: BMC Cancer 2015 15:654
    Content type: Research article Published on:

  3. Metastatic pancreatic adenocarcinoma (PAC) prognosis remains dismal and gemcitabine monotherapy has been the standard treatment over the last decade. Currently, two first-line regimens are used in this setting...

    Authors: Jean-Baptiste Bachet, Benoist Chibaudel, Franck Bonnetain, Pierre Validire, Pascal Hammel, Thierry André and Christophe Louvet
    Citation: BMC Cancer 2015 15:653
    Content type: Study protocol Published on:

  4. Preclinical evidence shows that short-term fasting (STF) protects healthy cells against side effects of chemotherapy and makes cancer cells more vulnerable to it. This pilot study examines the feasibility of S...

    Authors: Stefanie de Groot, Maaike PG Vreeswijk, Marij JP Welters, Gido Gravesteijn, Jan JWA Boei, Anouk Jochems, Daniel Houtsma, Hein Putter, Jacobus JM van der Hoeven, Johan WR Nortier, Hanno Pijl and Judith R Kroep
    Citation: BMC Cancer 2015 15:652
    Content type: Research article Published on:

  5. This analysis was undertaken to evaluate the practice patterns of Japanese physicians regarding curative-intent chemotherapy, especially in outpatient settings, and to define factors negatively affecting the m...

    Authors: Hitomi Sakai, Noriyuki Katsumata and Genmu Kadokura
    Citation: BMC Cancer 2015 15:651
    Content type: Research article Published on:

  6. It is difficult for the parotid gland neoplasms to make an accurate preoperative diagnosis due to the restriction of biopsy in the parotid gland neoplasms. The aim of this study is to apply the surface-enhance...

    Authors: Bing Yan, Bo Li, Zhining Wen, Xianyang Luo, Lili Xue and Longjiang Li
    Citation: BMC Cancer 2015 15:650
    Content type: Research article Published on:

  7. ATM and ATR are kinases implicated in a myriad of DNA-damage responses. ATM kinase inhibition radiosensitizes cells and selectively kills cells with Fanconi anemia (FA) gene mutations. ATR kinase inhibition se...

    Authors: Jan H. Beumer, Katherine Y. Fu, Bean N. Anyang, Jill M. Siegfried and Christopher J. Bakkenist
    Citation: BMC Cancer 2015 15:649
    Content type: Research article Published on:

  8. Inflammation can promote tumor growth, invasion, angiogenesis and even metastasis. Inflammatory markers have been identified as prognostic indicators in various malignances. This study compared the usefulness ...

    Authors: Yi Que, Haibo Qiu, Yuanfang Li, Yongming Chen, Wei Xiao, Zhiwei Zhou and Xing Zhang
    Citation: BMC Cancer 2015 15:648
    Content type: Research article Published on:

  9. Approximately 1 in 5 women diagnosed with breast cancer are considered to have in situ disease, most often termed ductal carcinoma in situ (DCIS). Though recognized as a risk factor for the development of more in...

    Authors: Whitney Barham, Lianyi Chen, Oleg Tikhomirov, Halina Onishko, Linda Gleaves, Thomas P. Stricker, Timothy S. Blackwell and Fiona E. Yull
    Citation: BMC Cancer 2015 15:647
    Content type: Research article Published on:

  10. Metastatic prostate cancer remains a common cause of death in Europe, and improvements in management of the disease are urgently needed. The advent of positron-emission tomography (PET) imaging enhanced with f...

    Authors: Stephane Supiot, Emmanuel Rio, Valérie Pacteau, Marie-Hélène Mauboussin, Loïc Campion and François Pein
    Citation: BMC Cancer 2015 15:646
    Content type: Study protocol Published on:

  11. Breast cancer stem cells (BCSCs) have been reported as the origin of breast cancer and the radical cause of drug resistance, relapse and metastasis in breast cancer. BCSCs could be derived from mutated mammary...

    Authors: Zhong-Ming Feng, Jun Qiu, Xie-Wan Chen, Rong-Xia Liao, Xing-Yun Liao, Lu-Ping Zhang, Xu Chen, Yan Li, Zheng-Tang Chen and Jian-Guo Sun
    Citation: BMC Cancer 2015 15:645
    Content type: Research article Published on:

  12. Low-level expression of O6 methylguanine-DNA-methyl transferase (MGMT) prolactinomas has been noted previously in case reports, although what modulates MGMT expression remains unclear. This study therefore aimed ...

    Authors: Xiao-Bing Jiang, Bin Hu, Dong-Sheng He, Zhi-Gang Mao, Xin Wang, Bing-Bing Song, Yong-Hong Zhu and Hai-Jun Wang
    Citation: BMC Cancer 2015 15:644
    Content type: Research article Published on:

  13. The development of targeted therapies has undoubtedly broadened therapeutic options for patients with colorectal cancer (CRC). The use of bevacizumab to reduce angiogenesis has been associated with improved cl...

    Authors: Tadeu Ferreira Paiva Jr., Victor Hugo Fonseca de Jesus, Raul Amorim Marques, Alexandre André Balieiro Anastácio da Costa, Mariana Petaccia de Macedo, Patricia Maria Peresi, Aline Damascena, Benedito Mauro Rossi, Maria Dirlei Begnami and Vladmir Cláudio Cordeiro de Lima
    Citation: BMC Cancer 2015 15:643
    Content type: Research article Published on:

  14. Results from clinical trials in the 1990s led to changes in the recommended treatment for the standard therapy for stage IIB-IVA cervical cancer from radiotherapy alone to chemo-radiotherapy. We conducted the ...

    Authors: Yoon-Jung Kang, Dianne L. O’Connell, Robert Lotocki, Erich V. Kliewer, David E. Goldsbury, Alain A. Demers and Karen Canfell
    Citation: BMC Cancer 2015 15:642
    Content type: Research article Published on:

  15. The Wnt signaling pathway is abnormally activated in many human cancers. Secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and play an important role in carcinogenesis. S...

    Authors: Junqin Liang, Xiaojing Kang, Yilinuer Halifu, Xuewen Zeng, Tianbo Jin, Mingxia Zhang, Dong Luo, Yuan Ding, Yunmin Zhou, Buwajier Yakeya, Dilinuer Abudu and Xiongming Pu
    Citation: BMC Cancer 2015 15:641
    Content type: Research article Published on:

  16. Oesophagectomy for cancer could be safe and worthwhile in selected older patients, but less is known about the effect of oesophagectomy on perceived quality of life of such delicate class of cancer patients. T...

    Authors: Francesco Cavallin, Eleonora Pinto, Luca M. Saadeh, Rita Alfieri, Matteo Cagol, Carlo Castoro and Marco Scarpa
    Citation: BMC Cancer 2015 15:640
    Content type: Research article Published on:

  17. DNA methylation is an important epigenetic mechanism of transcriptional control that plays an essential role in several cellular functions. Aberrant DNA methylation in cancer has been frequently associated wit...

    Authors: Giulia Brisotto, Alessandra di Gennaro, Valentina Damiano, Michela Armellin, Tiziana Perin, Roberta Maestro and Manuela Santarosa
    Citation: BMC Cancer 2015 15:639
    Content type: Technical advance Published on:

  18. Coronin proteins are known as regulators of actin-based cellular processes, and some of them are associated with the malignant progression of human cancer. Here, we show that expression of coronin 2A is up-reg...

    Authors: Raphael H. Rastetter, Margit Blömacher, Uta Drebber, Marija Marko, Juliane Behrens, Roxana Solga, Sarah Hojeili, Kurchi Bhattacharya, Claudia M. Wunderlich, F. Thomas Wunderlich, Margarete Odenthal, Anja Ziemann, Ludwig Eichinger and Christoph S. Clemen
    Citation: BMC Cancer 2015 15:638
    Content type: Research article Published on:

  19. Our previous proteomic analysis revealed that mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD-binding protein (MAWBP) were downregulated in gastric cancer (GC) tissues. These prote...

    Authors: Dongmei Li, Jun Zhang, Yu Xi, Lei Zhang, Wenmei Li, Jiantao Cui, Rui Xing, Yuanmin Pan, Zemin Pan, Feng Li and Youyong Lu
    Citation: BMC Cancer 2015 15:637
    Content type: Research article Published on:

  20. Ultraviolet (UV) radiation from sun, particularly its UVB component (290–320 nm), is considered the major etiological cause of skin cancer that impacts over 2 million lives in the United States alone. Recently...

    Authors: Rohan Palanki, Sumit Arora, Nikhil Tyagi, Lilia Rusu, Ajay P. Singh, Srinivas Palanki, James E. Carter and Seema Singh
    Citation: BMC Cancer 2015 15:636
    Content type: Research article Published on:

  21. Upper limb morbidity is a well-recognised consequence of treatment for breast cancer that can develop for up to 6 years after treatment. However, the capacity to fully integrate evidence-based rehabilitation p...

    Authors: Delva Shamley and Karen Robb
    Citation: BMC Cancer 2015 15:635
    Content type: Correspondence Published on:

  22. Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our a...

    Authors: Baek Kim, Sam L. Stephen, Andrew M. Hanby, Kieran Horgan, Sarah L. Perry, Julie Richardson, Elizabeth A. Roundhill, Elizabeth M. A. Valleley, Eldo T. Verghese, Bethany J. Williams, James L. Thorne and Thomas A. Hughes
    Citation: BMC Cancer 2015 15:634
    Content type: Research article Published on:

  23. PCA3 has been included in a nomogram outperforming previous clinical models for the prediction of any prostate cancer (PCa) and high grade PCa (HGPCa) at the initial prostate biopsy (IBx). Our objective is to ...

    Authors: Jose Rubio-Briones, Angel Borque, Luis M. Esteban, Juan Casanova, Antonio Fernandez-Serra, Luis Rubio, Irene Casanova-Salas, Gerardo Sanz, Jose Domínguez-Escrig, Argimiro Collado, Alvaro Gómez-Ferrer, Inmaculada Iborra, Miguel Ramírez-Backhaus, Francisco Martínez, Ana Calatrava and Jose A. Lopez-Guerrero
    Citation: BMC Cancer 2015 15:633
    Content type: Research article Published on:

  24. Although the actin cytoskeleton is vital for carcinogenesis and subsequent pathology, no microfilament-directed agent has been approved for cancer chemotherapy. One of the most studied classes of microfilament...

    Authors: Matthew Trendowski, Timothy D. Christen, Christopher Acquafondata and Thomas P. Fondy
    Citation: BMC Cancer 2015 15:632
    Content type: Research article Published on:

  25. Altered expression of S100A16 has been reported in human cancers, but its biological role in tumorigenesis is not fully understood. This study aimed to investigate the clinical significance and functional role...

    Authors: Dipak Sapkota, Ove Bruland, Himalaya Parajuli, Tarig A. Osman, Muy-Teck Teh, Anne C. Johannessen and Daniela Elena Costea
    Citation: BMC Cancer 2015 15:631
    Content type: Research article Published on:

  26. Deleted in Liver Cancer 1 (Dlc1) is a tumor suppressor gene, which maps to human chromosome 8p21-22 and is found frequently deleted in many cancers including breast cancer. The promoter of the remaining allele...

    Authors: Pratima Basak, Rachelle Dillon, Heather Leslie, Afshin Raouf and Michael R. A. Mowat
    Citation: BMC Cancer 2015 15:630
    Content type: Research article Published on:

  27. Information and discussion of sexual changes with a health professional is a high priority for many cancer patients in order to assist with sexual changes and ensure that sexual intimacy does not cease post-ca...

    Authors: Janette Perz and Jane M Ussher
    Citation: BMC Cancer 2015 15:629
    Content type: Research article Published on:

  28. Platinum compounds are the mainstay of chemotherapy for lung cancer. Unfortunately treatment failure remains a critical issue since about 60 % of all non-small cell lung cancer (NSCLC) patients display intrins...

    Authors: Hogir Salim, Dali Zong, Petra Hååg, Metka Novak, Birgitta Mörk, Rolf Lewensohn, Lovisa Lundholm and Kristina Viktorsson
    Citation: BMC Cancer 2015 15:628
    Content type: Research article Published on:

  29. Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovaria...

    Authors: Niamh M. Cooke, Cathy D. Spillane, Orla Sheils, John O’Leary and Dermot Kenny
    Citation: BMC Cancer 2015 15:627
    Content type: Research article Published on:

  30. Metastatic colorectal cancer carries a poor prognosis and cannot be cured by currently available therapy. Chemotherapy designed to prolong survival and improve the quality of life (QOL) of patients is the main...

    Authors: Yoshito Komatsu, Chikashi Ishioka, Ken Shimada, Yasuhide Yamada, Makio Gamoh, Atsushi Sato, Tatsuro Yamaguchi, Satoshi Yuki, Satoshi Morita, Shin Takahashi, Rei Goto and Minoru Kurihara
    Citation: BMC Cancer 2015 15:626
    Content type: Study protocol Published on:

  31. Poor initial response to tamoxifen due to CYP2D6 polymorphism and adverse side effects are two clinical challenges in tamoxifen therapy. We report the development and preclinical testing of a boronic prodrug t...

    Authors: Qiu Zhong, Changde Zhang, Qiang Zhang, Lucio Miele, Shilong Zheng and Guangdi Wang
    Citation: BMC Cancer 2015 15:625
    Content type: Research article Published on:

  32. Normalization of cortisol concentration by multikinase inhibitors have been reported in three patients with medullary thyroid cancer-related Cushing’s syndrome. Aortic dissection has been reported in three pat...

    Authors: Muhammad M. Hammami, Najla Duaiji, Ghazi Mutairi, Sabah Aklabi, Nasser Qattan, Mohei El-Din M. Abouzied and Mohamed W. Sous
    Citation: BMC Cancer 2015 15:624
    Content type: Case report Published on:

  33. Recent reports using metabolism regulating drugs showed that nutrient deprivation was an efficient tool to suppress cancer progression. In addition, autophagy control is emerging to prevent cancer cell surviva...

    Authors: Jeong Yong Jeon, Seung Won Kim, Ki Cheong Park and Mijin Yun
    Citation: BMC Cancer 2015 15:623
    Content type: Research article Published on:

  34. Neoadjuvant chemotherapy (NAC) with taxanes followed by fluorouracil, epirubicin, and cyclophosphamide (FEC), and concurrent trastuzumab is a potent regimen for HER2 over-expressing breast cancer. A high patho...

    Authors: Sasagu Kurozumi, Kenichi Inoue, Hiroyuki Takei, Hiroshi Matsumoto, Masafumi Kurosumi, Jun Horiguchi, Izumi Takeyoshi and Tetsunari Oyama
    Citation: BMC Cancer 2015 15:622
    Content type: Research article Published on:

  35. The identification of oncogenic driver mutations has largely relied on the assumption that genes that exhibit more mutations than expected by chance are more likely to play an active role in tumorigenesis. Maj...

    Authors: Jean-François Spinella, Pauline Cassart, Nicolas Garnier, Philippe Rousseau, Claire Drullion, Chantal Richer, Manon Ouimet, Virginie Saillour, Jasmine Healy, Chantal Autexier and Daniel Sinnett
    Citation: BMC Cancer 2015 15:621
    Content type: Research article Published on:

  36. Metastatic breast cancer is a major cause of death among women worldwide; therefore efficient therapeutic strategies are extremely needed. In this work we have developed a gene therapy- and bacteria-based comb...

    Authors: M. Gabriela Kramer, Martín Masner, Erkuden Casales, María Moreno, Cristian Smerdou and José A. Chabalgoity
    Citation: BMC Cancer 2015 15:620
    Content type: Research article Published on:

  37. Allogeneic stem cell transplantation (allo-HCT) is associated with high treatment-related mortality and innumerable physical and psychosocial complications and side-effects, such as high fatigue levels, loss o...

    Authors: Joachim Wiskemann, Rea Kuehl, Peter Dreger, Gerhard Huber, Nikolaus Kleindienst, Cornelia M. Ulrich and Martin Bohus
    Citation: BMC Cancer 2015 15:619
    Content type: Study protocol Published on:

  38. Inequalities in cancer research participation are thought to exist with certain groups under-represented in research populations; however, much of the evidence is based on small-scale studies. The aim of this ...

    Authors: Louise Mc Grath-Lone, Sophie Day, Claudia Schoenborn and Helen Ward
    Citation: BMC Cancer 2015 15:618
    Content type: Research article Published on:

  39. Markers of systemic inflammation are correlated with patient survival in various cancers. The prognostic value of neutrophil-to-lymphocyte ratio (NLR) was compared with that of platelet-to-lymphocyte ratio (PL...

    Authors: Sheng Han, Yang Liu, Qingchang Li, Zhonghua Li, Haipei Hou and Anhua Wu
    Citation: BMC Cancer 2015 15:617
    Content type: Research article Published on:

  40. Diencephalic Syndrome is a rare clinical condition of failure to thrive despite a normal caloric intake, hyperalertness, hyperkinesis, and euphoria usually associated with low-grade hypothalamic astrocytomas.

    Authors: Alessia Stival, Maurizio Lucchesi, Silvia Farina, Anna Maria Buccoliero, Francesca Castiglione, Lorenzo Genitori, Maurizio de Martino and Iacopo Sardi
    Citation: BMC Cancer 2015 15:616
    Content type: Case report Published on:

  43. Cancer incidence and mortality varies across region, sex and country’s economic status. While most studies focused on global trends, this study aimed to describe and analyse cancer incidence and mortality in A...

    Authors: Chirk Jenn Ng, Chin Hai Teo, Nurdiana Abdullah, Wei Phin Tan and Hui Meng Tan
    Citation: BMC Cancer 2015 15:613
    Content type: Research article Published on:

  44. Survivors of young adult malignancies are at risk of accumulated exposures to radiation from repetitive diagnostic imaging. We designed a population-based cohort study to describe patterns of diagnostic imagin...

    Authors: Corinne Daly, David R. Urbach, Thérèse A. Stukel, Paul C. Nathan, Wayne Deitel, Lawrence F. Paszat, Andrew S. Wilton and Nancy N. Baxter
    Citation: BMC Cancer 2015 15:612
    Content type: Research article Published on:

  45. Recently, we showed that Sulindac (SU; 320 ppm) reduces precancerous lesions in the colon of Pirc rats, mutated in the Apc gene. Surprisingly, previous data in Apc-mutated mice showed that SU, with reported effic...

    Authors: Angelo Pietro Femia, Paulo Victoria Soares, Cristina Luceri, Maura Lodovici, Augusto Giannini and Giovanna Caderni
    Citation: BMC Cancer 2015 15:611
    Content type: Research article Published on:

  46. Trials failed to demonstrate additional value of completion axillary lymph node dissection in case of limited sentinel lymph node metastases in breast cancer patients undergoing breast conserving therapy. It h...

    Authors: L. M. van Roozendaal, J. HW de Wilt, T. van Dalen, J. A. van der Hage, L. JA Strobbe, L. J. Boersma, S. C. Linn, M. BI Lobbes, P. MP Poortmans, V. CG Tjan-Heijnen, K. KBT Van de Vijver, J. de Vries, A. H. Westenberg, A. GH Kessels and M. L. Smidt
    Citation: BMC Cancer 2015 15:610
    Content type: Study protocol Published on:

  47. There is increasing evidence supporting the concept of cancer stem cells (CSCs), which are responsible for the initiation, growth and metastasis of tumors. CSCs are thus considered the target for future cancer...

    Authors: Wenyi Gu, Indira Prasadam, Meihua Yu, Fengxia Zhang, Patrick Ling, Yin Xiao and Chengzhong Yu
    Citation: BMC Cancer 2015 15:609
    Content type: Research article Published on:

  48. In invasive malignancies, Dll4/Notch signaling inhibition enhances non-functional vessel proliferation and limits tumor growth by reducing its blood perfusion.

    Authors: Dusan Djokovic, Alexandre Trindade, Joana Gigante, Mario Pinho, Adrian L. Harris and Antonio Duarte
    Citation: BMC Cancer 2015 15:608
    Content type: Research article Published on:

  50. Although the risk of developing colorectal cancer (CRC) is 2-4 times higher in case of a positive family history, risk-adapted screening programs for family members related to CRC- patients do not exist in the...

    Authors: Andrea Siebenhofer, Jasper Plath, Maja Taubenroth, Susanne Singer, Marlene Hechtner, Anne Dahlhaus, Sandra Rauck, Sylvia Schulz-Rothe, Insa Koné and Ferdinand M. Gerlach
    Citation: BMC Cancer 2015 15:605
    Content type: Study protocol Published on:

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