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  1. Neovascularization and peritumoral edema are hallmarks of glioblastoma (GBM). Programmed cell death 10 (PDCD10) plays a pivotal role in regulating apoptosis, neoangiogenesis and vessel permeability and is impl...

    Authors: Nicole Lambertz, Nicolai El Hindy, Ilonka Kreitschmann-Andermahr, Klaus Peter Stein, Philipp Dammann, Neriman Oezkan, Oliver Mueller, Ulrich Sure and Yuan Zhu
    Citation: BMC Cancer 2015 15:759
    Content type: Research article Published on:

  2. Head and neck mucosal melanoma (HNMM) is a rare type of malignant tumor that frequently exhibits postoperative recurrence and distant metastasis. Many clinicians administer postoperative adjuvant radiotherapy ...

    Authors: Wei Li, Yalian Yu, Hailong Wang, Aihui Yan and Xuejun Jiang
    Citation: BMC Cancer 2015 15:758
    Content type: Research article Published on:

  3. Acute myeloid leukemia (AML) is the second-most common form of leukemia in children. Aberrant DNA methylation patterns are a characteristic feature of AML. GATA4 has been suggested to be a tumor suppressor gen...

    Authors: Yan-Fang Tao, Fang Fang, Shao-Yan Hu, Jun Lu, Lan Cao, Wen-Li Zhao, Pei-Fang Xiao, Zhi-Heng Li, Na-Na Wang, Li-Xiao Xu, Xiao-Juan Du, Li-Chao Sun, Yan-Hong Li, Yi-Ping Li, Yun-Yun Xu, Jian Ni…
    Citation: BMC Cancer 2015 15:756
    Content type: Research article Published on:

  4. The BRCA1 gene plays a key role in triple negative breast cancers (TNBCs), in which its expression can be lost by multiple mechanisms: germinal mutation followed by deletion of the second allele; negative regulat...

    Authors: Meriem Boukerroucha, Claire Josse, Sonia ElGuendi, Bouchra Boujemla, Pierre Frères, Raphaël Marée, Stephane Wenric, Karin Segers, Joelle Collignon, Guy Jerusalem and Vincent Bours
    Citation: BMC Cancer 2015 15:755
    Content type: Research article Published on:

  5. No screening programs are available for ovarian or endometrial cancer. One reason for this is the low incidence of the conditions, resulting in low positive predictive values for tests, which are not very spec...

    Authors: Stefanie Burghaus, Lothar Häberle, Michael G. Schrauder, Katharina Heusinger, Falk C. Thiel, Alexander Hein, David Wachter, Johanna Strehl, Arndt Hartmann, Arif B. Ekici, Stefan P. Renner, Matthias W. Beckmann and Peter A. Fasching
    Citation: BMC Cancer 2015 15:751
    Content type: Research article Published on:

  6. Excellent dosimetric characteristics were demonstrated for volumetric modulated arc therapy (VMAT) in preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). In a single-center retrospe...

    Authors: Leif Hendrik Dröge, Hanne Elisabeth Weber, Manuel Guhlich, Martin Leu, Lena-Christin Conradi, Jochen Gaedcke, Steffen Hennies, Markus Karl Herrmann, Margret Rave-Fränk and Hendrik Andreas Wolff
    Citation: BMC Cancer 2015 15:750
    Content type: Research article Published on:

  7. To evaluate whether apparent diffusion coefficient (ADC) value of gastric cancer obtained from diffusion weighted imaging (DWI) correlates with the HER2 status.

    Authors: Jian He, Hua Shi, Zhuping Zhou, Jun Chen, Wenxian Guan, Hao Wang, Haiping Yu, Song Liu, Zhengyang Zhou, Xiaofeng Yang and Tian Liu
    Citation: BMC Cancer 2015 15:749
    Content type: Research article Published on:

  8. MicroRNAs (miRNAs) are small noncoding RNAs that potentially play a critical role in tumorigenesis. Mounting evidence indicates that one specific miRNA: miR-320b is down regulated in numerous human cancers, in...

    Authors: Hantao Wang, Fuao Cao, Xu Li, Hua Miao, Jifu E, Junjie Xing and Chuan-gang Fu
    Citation: BMC Cancer 2015 15:748
    Content type: Research article Published on:

  9. More than half of the patients selected based on KRAS mutation status fail to respond to the treatment with cetuximab in metastatic colorectal cancer (mCRC). We designed a study to identify additional biomarkers ...

    Authors: Seung Tae Kim, Tae Jin Ahn, Eunjin Lee, In-Gu Do, Su Jin Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Suk Hyeong Kim, Jeeyun Lee and Hee Cheol Kim
    Citation: BMC Cancer 2015 15:747
    Content type: Research article Published on:

  10. Stomatin-like protein 2 (SLP-2, also known as STOML2) is a stomatin homologue of uncertain function. SLP-2 overexpression has been suggested to be associated with cancer progression, resulting in adverse clini...

    Authors: Fei Sun, Wen Ding, Jie-Hua He, Xiao-Jing Wang, Ze-Biao Ma and Yan-Fang Li
    Citation: BMC Cancer 2015 15:746
    Content type: Research article Published on:

  11. Clinical care of unstable spinal bone metastases in many centers often includes patient immobilization by means of an orthopedic corset in order to prevent pathological fractures. The aim of this retrospective...

    Authors: Harald Rief, Robert Förster, Stefan Rieken, Thomas Bruckner, Ingmar Schlampp, Tilman Bostel and Jürgen Debus
    Citation: BMC Cancer 2015 15:745
    Content type: Research article Published on:

  12. In 5–20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but ...

    Authors: Menghan Zhu, Yuan He, Jan PA Baak, Xianrong Zhou, Yuqing Qu, Long Sui, Weiwei Feng and Qing Wang
    Citation: BMC Cancer 2015 15:744
    Content type: Research article Published on:

  13. Neutrophil-lymphocyte ratio (NLR) has been shown to be associated with prognosis in various solid tumors. This study aimed to evaluate the prognostic role of NLR in patients with laryngeal squamous cell carcin...

    Authors: Xiu-Ping Tu, Qian-Hui Qiu, Liang-Si Chen, Xiao-Ning Luo, Zhong-Ming Lu, Si-Yi Zhang and Shao-Hua Chen
    Citation: BMC Cancer 2015 15:743
    Content type: Research article Published on:

  14. Heparan sulfate proteoglycans (HSPGs) are complex molecules involved in the growth, invasion and metastatic properties of cancerous cells. This study analyses the alterations in the expression patterns of thes...

    Authors: Iván Fernández-Vega, Olivia García-Suárez, Beatriz García, Ainara Crespo, Aurora Astudillo and Luis M. Quirós
    Citation: BMC Cancer 2015 15:742
    Content type: Research article Published on:

  16. Docetaxel monotherapy is one of the standard treatments for non-small-cell lung cancer in elderly patients. The addition of bevacizumab to docetaxel seems promising; however, the feasibility of this combinatio...

    Authors: Yusuke Takagi, Yukio Hosomi, Fumihiro Oshita, Hiroaki Okamoto, Nobuhiko Seki, Koichi Minato, Hiromi Aono, Kouzo Yamada, Yusuke Okuma, Naoya Hida, Takahiko Sakamoto, Yosuke Miura, Makiko Yomota, Akira Satoh, Hideo Kunitoh, Kentaro Sakamaki…
    Citation: BMC Cancer 2015 15:740
    Content type: Research article Published on:

  17. Neoadjuvant chemotherapy (NAC) using platinum and irinotecan (CPT-11) followed by radical excision has been shown to be a valid treatment for locally advanced squamous cervical cancer (SCC) patients. However, ...

    Authors: Naoki Horikawa, Tsukasa Baba, Noriomi Matsumura, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Masafumi Koshiyama, Yumiko Yoshioka and Ikuo Konishi
    Citation: BMC Cancer 2015 15:739
    Content type: Research article Published on:

  18. Novel synthesized analogs of Aplidin, PM01215 and PM02781, were tested for antiangiogenic effects on primary human endothelial cells in vitro and for inhibition of angiogenesis and tumor growth in vivo.

    Authors: Bojana Borjan, Normann Steiner, Silvia Karbon, Johann Kern, Andrés Francesch, Martin Hermann, Wolfgang Willenbacher, Eberhard Gunsilius and Gerold Untergasser
    Citation: BMC Cancer 2015 15:738
    Content type: Research article Published on:

  19. The human Sushi Domain-Containing Protein 4 (SUSD4) was recently shown to function as a novel inhibitor of the complement system, but its role in tumor progression is unknown.

    Authors: Emelie Englund, Bart Reitsma, Ben C. King, Astrid Escudero-Esparza, Sioned Owen, Akira Orimo, Marcin Okroj, Lola Anagnostaki, Wen G. Jiang, Karin Jirström and Anna M. Blom
    Citation: BMC Cancer 2015 15:737
    Content type: Research article Published on:

  20. Colorectal cancer (CRC) development is accompanied by changes in expression for several genes; but the details of the underlying regulatory procesess remain unknown. Our aims were to assess the role of epigene...

    Authors: Alexandra Kalmár, Bálint Péterfia, Péter Hollósi, Orsolya Galamb, Sándor Spisák, Barnabás Wichmann, András Bodor, Kinga Tóth, Árpád V. Patai, Gábor Valcz, Zsófia Brigitta Nagy, Vivien Kubák, Zsolt Tulassay, Ilona Kovalszky and Béla Molnár
    Citation: BMC Cancer 2015 15:736
    Content type: Research article Published on:

  21. The early age at retinoblastoma occurrence, the most common eye malignancy in childhood, suggests that perinatal factors may contribute to its etiology.

    Authors: Julia E. Heck, Negar Omidakhsh, Saeedeh Azary, Beate Ritz, Ondine S. von Ehrenstein, Greta R. Bunin and Arupa Ganguly
    Citation: BMC Cancer 2015 15:735
    Content type: Research article Published on:

  22. In German breast cancer care, the S1-guidelines of the 1990s were substituted by national S3-guidelines in 2003. The application of guidelines became mandatory for certified breast cancer centers. The aim of t...

    Authors: Christian O. Jacke, Ute S. Albert and Matthias Kalder
    Citation: BMC Cancer 2015 15:734
    Content type: Research article Published on:

  23. Several observational studies suggest that coffee consumption may be associated with an increased risk of gastric cancer, but the results are inconsistent. We conducted a meta-analysis to evaluate the relation...

    Authors: Liqing Li, Yong Gan, Chunmei Wu, Xianguo Qu, Gang Sun and Zuxun Lu
    Citation: BMC Cancer 2015 15:733
    Content type: Research article Published on:

  24. BRAF and MEK are component of the MAPK/ERK pathway and inhibitors of these proteins have significantly improved the outcome of metastatic melanoma. We report for the first time two sequential episodes of pneum...

    Authors: Violaine Giraud, Christine Longvert, Solène Houlle-Crepin, Claire Danel, Sylvie Labrune, Philippe Camus, Philippe Saiag and Thierry Chinet
    Citation: BMC Cancer 2015 15:732
    Content type: Case report Published on:

  25. Chemotherapy is an important therapeutic approach for non-small cell lung cancer (NSCLC). However, a successful long-term treatment can be prevented by the occurring of chemotherapy resistance frequently, and ...

    Authors: Jian Zhao, Wenfan Fu, Hongying Liao, Lu Dai, Zeyong Jiang, Youguang Pan, Haoda Huang, Yijun Mo, Siwen Li, Guangping Yang and Jun Yin
    Citation: BMC Cancer 2015 15:731
    Content type: Research article Published on:

  26. The side population (SP) of cancer cells is reportedly enriched with cancer stem cells (CSCs), however, the functional role and clinical relevance of CSC marker molecules upregulated in the SP of head and neck...

    Authors: Noboru Habu, Yorihisa Imanishi, Kaori Kameyama, Masayuki Shimoda, Yutaka Tokumaru, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Hiroyuki Ozawa, Toshiki Tomita, Masato Fujii and Kaoru Ogawa
    Citation: BMC Cancer 2015 15:730
    Content type: Research article Published on:

  27. The GABARAP family members (GABARAP, GABARAPL1/GEC1 and GABARAPL2 /GATE-16) are involved in the intracellular transport of receptors and the autophagy pathway. We previously reported that GABARAPL1 expression was...

    Authors: Eric Hervouet, Aurore Claude-Taupin, Thierry Gauthier, Valérie Perez, Annick Fraichard, Pascale Adami, Gilles Despouy, Franck Monnien, Marie-Paule Algros, Michèle Jouvenot, Régis Delage-Mourroux and Michaël Boyer-Guittaut
    Citation: BMC Cancer 2015 15:729
    Content type: Research article Published on:

  29. The prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (TILs) in patients with breast cancer remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopatho...

    Authors: Daqing Jiang, Zhaohua Gao, Zhengang Cai, Meixian Wang and Jianjun He
    Citation: BMC Cancer 2015 15:727
    Content type: Research article Published on:

  30. Although pancreatic ductal adenocarcinomas (PDAs) widely express HER2, the expression level is generally low. If HER2 expression in PDA cells could be enhanced by treatment with a given agent, then combination...

    Authors: Shin Kan, Shigeo Koido, Masato Okamoto, Kazumi Hayashi, Masaki Ito, Yuko Kamata, Hideo Komita, Eijiro Nagasaki and Sadamu Homma
    Citation: BMC Cancer 2015 15:726
    Content type: Research article Published on:

  31. Induction chemotherapy incorporating docetaxel, cisplatin and 5- fluorouracil before radiotherapy may improve the outcome of patients with advanced head and neck cancer. Nevertheless, the addition of docetaxel...

    Authors: Thomas Melchardt, Clemens Hufnagl, Teresa Magnes, Lukas Weiss, Georg Hutarew, Daniel Neureiter, Alexander Schlattau, Gerhard Moser, Alexander Gaggl, Wolfgang Tränkenschuh, Richard Greil and Alexander Egle
    Citation: BMC Cancer 2015 15:725
    Content type: Research article Published on:

  32. Although the occurrence of acute myeloid leukemia (AML) after chemotherapy for multiple myeloma (MM) is common in clinical settings, the simultaneous occurrence of these malignancies in patients without previo...

    Authors: Wang Lu-qun, Li Hao, Li Xiang-xin, Li Fang-lin, Wang Ling-ling, Chen Xue-liang and Hou Ming
    Citation: BMC Cancer 2015 15:724
    Content type: Case report Published on:

  33. “Vulnerable Elders Survey” (VES-13) is a questionnaire accurate in predicting functional decline and highly correlated with comprehensive geriatric assessment in identifying vulnerable elderly. The purpose of ...

    Authors: F. Carneiro, N. Sousa, LF Azevedo and D. Saliba
    Citation: BMC Cancer 2015 15:723
    Content type: Research article Published on:

  34. The p38 MAPK is constitutively activated in B-NHL cell lines and regulates chemoresistance. Accordingly, we hypothesized that activated p38 MAPK may be associated with the in vivo unresponsiveness to chemotherapy...

    Authors: Gabriel G. Vega, Alejandro Avilés-Salas, J. Ramón Chalapud, Melisa Martinez-Paniagua, Rosana Pelayo, Héctor Mayani, Rogelio Hernandez-Pando, Otoniel Martinez-Maza, Sara Huerta-Yepez, Benjamin Bonavida and Mario I. Vega
    Citation: BMC Cancer 2015 15:722
    Content type: Research article Published on:

  35. More knowledge about genetic and molecular features of cholangiocarcinoma is needed to develop effective therapeutic strategies. We investigated the clinical and pathological significance of ROS1 expression in...

    Authors: Kyung-Hun Lee, Kyoung-Bun Lee, Tae-Yong Kim, Sae-Won Han, Do-Youn Oh, Seock-Ah Im, Tae-You Kim, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Ja-June Jang and Yung-Jue Bang
    Citation: BMC Cancer 2015 15:721
    Content type: Research article Published on:

  36. The Metabolic syndrome (MetS) is an emerging condition worldwide, consistently associated with an increased risk of several cancers. Some information exists on urothelial carcinoma of the bladder (UCB) and Met...

    Authors: Maurizio Montella, Matteo Di Maso, Anna Crispo, Maria Grimaldi, Cristina Bosetti, Federica Turati, Aldo Giudice, Massimo Libra, Diego Serraino, Carlo La Vecchia, Rosa Tambaro, Ernesta Cavalcanti, Gennaro Ciliberto and Jerry Polesel
    Citation: BMC Cancer 2015 15:720
    Content type: Research article Published on:

  37. Use of metformin has been associated with a decreased cancer risk. We aimed to explore whether use of metformin or other antidiabetic drugs is associated with a decreased risk for thyroid cancer.

    Authors: Claudia Becker, Susan S. Jick, Christoph R. Meier and Michael Bodmer
    Citation: BMC Cancer 2015 15:719
    Content type: Research article Published on:

  38. Variability in drug response between individual patients is a serious concern in medicine. To identify single-nucleotide polymorphisms (SNPs) related to drug response variability, many genome-wide association ...

    Authors: Hiro Takahashi, Nahoko Kaniwa, Yoshiro Saito, Kimie Sai, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Yasuhiro Matsumura, Atsushi Ohtsu, Takayuki Yoshino, Toshihiko Doi, Anna Takahashi, Yoko Odaka, Misuzu Okuyama, Jun-ichi Sawada, Hiromi Sakamoto…
    Citation: BMC Cancer 2015 15:718
    Content type: Research article Published on:

  39. Recently, it is found that T-helper (Th) 22 cells are involved in different types of autoimmune and tumor diseases. But, till now, no study has been carried out to understand the involvement of these cells in ...

    Authors: Wenjing Zhang, Xinli Tian, Fidia Mumtahana, Jun Jiao, Teng Zhang, Kimiko Della Croce, Daoxin Ma, Beihua Kong and Baoxia Cui
    Citation: BMC Cancer 2015 15:717
    Content type: Research article Published on:

  40. Clinical trials have indicated that preclinical results obtained with human tumor xenografts in mouse models may overstate the potential of adenovirus (Ad)-mediated oncolytic therapies. We have previously demo...

    Authors: Pei-Hsin Cheng, Xiao-Mei Rao, Stephen L. Wechman, Xiao-Feng Li, Kelly M. McMasters and Heshan Sam Zhou
    Citation: BMC Cancer 2015 15:716
    Content type: Research article Published on:

  41. For patients with locally advanced non-small-cell lung cancer (LA-NSCLC), the role of consolidation chemotherapy (CCT) following concurrent chemoradiotherapy (CRT) is partially defined. The aim of this study w...

    Authors: Lipin Liu, Nan Bi, Zhe Ji, Junling Li, Jingbo Wang, Xiaozhen Wang, Zhouguang Hui, Jima Lv, Jun Liang, Zongmei Zhou, Yan Wang, Weibo Yin and Luhua Wang
    Citation: BMC Cancer 2015 15:715
    Content type: Research article Published on:

  42. To determine differentially expressed and spliced RNA transcripts in chronic lymphocytic leukemia specimens a high throughput RNA-sequencing (HTS RNA-seq) analysis was performed.

    Authors: Wei Liao, Gwen Jordaan, Phillipp Nham, Ryan T. Phan, Matteo Pelegrini and Sanjai Sharma
    Citation: BMC Cancer 2015 15:714
    Content type: Research article Published on:

  43. This retrospective study aims to investigate the activity of retreatment with anti-EGFR-based therapies in order to explore the concept of clonal evolution by evaluating the impact of prior activity and interv...

    Authors: X. Liu, G. C. George, A. M. Tsimberidou, A. Naing, J. J. Wheler, S. Kopetz, S. Fu, S. A. Piha-Paul, C. Eng, G. S. Falchook, F. Janku, C. Garrett, D. Karp, R. Kurzrock, R. Zinner, K. Raghav…
    Citation: BMC Cancer 2015 15:713
    Content type: Research article Published on:

  44. Neuroblastoma is the most common extracranial solid tumor of childhood. The heterogeneous microenvironment of solid tumors contains hypoxic regions associated with poor prognosis and chemoresistance. Hypoxia i...

    Authors: Joshua J. Glass, Phoebe A. Phillips, Peter W. Gunning and Justine R. Stehn
    Citation: BMC Cancer 2015 15:712
    Content type: Research article Published on:

  45. Prior studies have described a reduced risk of developing ovarian cancer with the use of oral contraceptives. In this context, we decided to examine if oral contraceptive use prior to a diagnosis of ovarian ca...

    Authors: Aminah Jatoi, Nathan R. Foster, Kimberly R. Kalli, Robert A. Vierkant, Zhiying Zhang, Melissa C. Larson, Brooke Fridley and Ellen L. Goode
    Citation: BMC Cancer 2015 15:711
    Content type: Research article Published on:

  47. CD26 is an ectoenzyme with dipeptidyl peptidase 4 (DPP4) activity expressed on a variety of cell types. Considering that serum CD26 levels have been previously associated with different cancers, we examined th...

    Authors: Virginia Boccardi, Luigi Marano, Rosaria Rita Amalia Rossetti, Maria Rosaria Rizzo, Natale di Martino and Giuseppe Paolisso
    Citation: BMC Cancer 2015 15:703
    Content type: Research article Published on:

  49. A capillary network is needed in cancer growth and metastasis. Induction of angiogenesis represents one of the major hallmarks of cancer. CDK11p58, a Ser/Thr kinase that belongs to the Cell Division Cycle 2-like ...

    Authors: Yayun Chi, Sheng Huang, Haojie Peng, Mengying Liu, Jun Zhao, Zhiming Shao and Jiong Wu
    Citation: BMC Cancer 2015 15:701
    Content type: Research article Published on:

  50. Advanced malignant solitary fibrous tumors (SFTs) are rare soft-tissue sarcomas with a poor prognosis. Several treatment options have been reported, but with uncertain rates of efficacy. Our aim is to describe...

    Authors: J. Khalifa, M. Ouali, L. Chaltiel, S. Le Guellec, A. Le Cesne, J-Y Blay, P. Cousin, L. Chaigneau, E. Bompas, S. Piperno-Neumann, B. Bui-Nguyen, M. Rios, J-P Delord, N. Penel and C. Chevreau
    Citation: BMC Cancer 2015 15:700
    Content type: Research article Published on:

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