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  1. Pancreatic cancer remains one of the most difficult cancers to treat with the poorest prognosis. The key to improving survival rates in this disease is early detection and monitoring of disseminated and residu...

    Authors: Julie Earl, Sandra Garcia-Nieto, Jose Carlos Martinez-Avila, José Montans, Alfonso Sanjuanbenito, Mercedes Rodríguez-Garrote, Eduardo Lisa, Elena Mendía, Eduardo Lobo, Núria Malats, Alfredo Carrato and Carmen Guillen-Ponce
    Citation: BMC Cancer 2015 15:797
    Content type: Research article Published on:

  2. The anticancer TS-1® combination capsules of tegafur, gimeracil, and oteracil potassium (Taiho Pharmaceutical Co. Ltd, Japan) causes side effects, i. e., corneal epithelial disorder and dacryostenosis. However, i...

    Authors: Shin Mizoguchi, Yuka Okada, Masahide Kokado and Shizuya Saika
    Citation: BMC Cancer 2015 15:796
    Content type: Case report Published on:

  3. Although some molecularly targeted drugs for colorectal cancer are used clinically and contribute to a better prognosis, the current median survival of advanced colorectal cancer patients is not sufficient. Au...

    Authors: Kosuke Sakitani, Yoshihiro Hirata, Yohko Hikiba, Yoku Hayakawa, Sozaburo Ihara, Hirobumi Suzuki, Nobumi Suzuki, Takako Serizawa, Hiroto Kinoshita, Kei Sakamoto, Hayato Nakagawa, Keisuke Tateishi, Shin Maeda, Tsuneo Ikenoue, Shoji Kawazu and Kazuhiko Koike
    Citation: BMC Cancer 2015 15:795
    Content type: Research article Published on:

  4. The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal...

    Authors: Hidenori Takahashi, Toshiaki Ishikawa, Megumi Ishiguro, Satoshi Okazaki, Kaoru Mogushi, Hirotoshi Kobayashi, Satoru Iida, Hiroshi Mizushima, Hiroshi Tanaka, Hiroyuki Uetake and Kenichi Sugihara
    Citation: BMC Cancer 2015 15:794
    Content type: Research article Published on:

  5. Emerging evidence indicates that inappropriate cell-cell fusion might contribute to cancer progression. Similarly, mesenchymal stem cells (MSCs) can also fuse with other cells spontaneously and capable of adop...

    Authors: Jianguo Xue, Yuan Zhu, Zixuan Sun, Runbi Ji, Xu Zhang, Wenrong Xu, Xiao Yuan, Bin Zhang, Yongmin Yan, Lei Yin, Huijuan Xu, Leilei Zhang, Wei Zhu and Hui Qian
    Citation: BMC Cancer 2015 15:793
    Content type: Research article Published on:

  6. Carcinogenesis affects not only humans but almost all metazoan species. Understanding the rules driving the occurrence of cancers in the wild is currently expected to provide crucial insights into identifying ...

    Authors: Hugo Ducasse, Beata Ujvari, Eric Solary, Marion Vittecoq, Audrey Arnal, Florence Bernex, Nelly Pirot, Dorothée Misse, François Bonhomme, François Renaud, Frédéric Thomas and Benjamin Roche
    Citation: BMC Cancer 2015 15:792
    Content type: Debate Published on:

  7. In breast cancer, progesterone receptor (PR) positivity or abundance is positively associated with survival and treatment response. It was initially believed that PR was a useful diagnostic marker of estrogen ...

    Authors: Eleanor F. Need, Luke A. Selth, Andrew P. Trotta, Damien A. Leach, Lauren Giorgio, Melissa A. O’Loughlin, Eric Smith, Peter G. Gill, Wendy V. Ingman, J. Dinny Graham and Grant Buchanan
    Citation: BMC Cancer 2015 15:791
    Content type: Research article Published on:

  8. Tumor-associated macrophages (TAMs) promote tumor progression and have an effect on survival in human cancer. However, little is known regarding their influence on tumor progression and prognosis in human hila...

    Authors: Georgi Atanasov, Hans-Michael Hau, Corinna Dietel, Christian Benzing, Felix Krenzien, Andreas Brandl, Georg Wiltberger, Ivan Matia, Isabel Prager, Katrin Schierle, Simon C. Robson, Anja Reutzel-Selke, Johann Pratschke, Moritz Schmelzle and Sven Jonas
    Citation: BMC Cancer 2015 15:790
    Content type: Research article Published on:

  9. Methylation of HIN-1 is associated with poor outcomes in patients with ovarian clear cell carcinoma (OCCC), which is regarded to be an aggressive, chemo-resistant histological subtype. This study aimed to eval...

    Authors: Chih-Ming Ho, Chi-Jung Huang, Shih-Hung Huang, Shwu-Fen Chang and Wen-Fang Cheng
    Citation: BMC Cancer 2015 15:789
    Content type: Research article Published on:

  10. Hypercalcemia is the most common oncologic metabolic emergency but very rarely observed in patients with gastrointestinal stromal tumour, which is a rare mesenchymal malignancy of the gastrointestinal tract. W...

    Authors: Katrine Hygum, Christian Nielsen Wulff, Torben Harsløf, Anders Kindberg Boysen, Philip Blach Rossen, Bente Lomholt Langdahl and Akmal Ahmed Safwat
    Citation: BMC Cancer 2015 15:788
    Content type: Case report Published on:

  11. Healthcare resource utilization in breast cancer varies by disease characteristics and treatment choices. However, lack of clarity in guidelines can result in varied interpretation and heterogeneous treatment ...

    Authors: Guy Jerusalem, Patrick Neven, Nina Marinsek, Jie Zhang, Ravi Degun, Giancarlo Benelli, Stephen Saletan, Jean-François Ricci and Fabrice Andre
    Citation: BMC Cancer 2015 15:787
    Content type: Research article Published on:

  12. Although number of elderly patients with metastatic colorectal cancer (mCRC) is rapidly increasing, this population is often underrepresented in clinical trials. Recently, a phase II trial demonstrated that ca...

    Authors: Yoshinori Munemoto, Mitsuro Kanda, Keiichiro Ishibashi, Taishi Hata, Michiya Kobayashi, Junichi Hasegawa, Mutsumi Fukunaga, Akinori Takagane, Toshio Otsuji, Yasuhiro Miyake, Michitaka Nagase, Junichi Sakamoto, Masaki Matsuoka, Koji Oba and Hideyuki Mishima
    Citation: BMC Cancer 2015 15:786
    Content type: Research article Published on:

  13. The aim of this study was to elucidate the value of putative cancer stem cell markers Musashi-1, ALDH1, Sox2, and CD49f in predicting the prognosis in cervical squamous cell carcinoma (CSCC).

    Authors: Teng Hou, Weijing Zhang, Chongjie Tong, Gallina Kazobinka, Xin Huang, Yongwen Huang and Yanna Zhang
    Citation: BMC Cancer 2015 15:785
    Content type: Research article Published on:

  14. Cyclin A1 is essential for male gametopoiesis. In acute myeloid leukemia, it acts as a leukemia-associated antigen. Cyclin A1 expression has been reported in several epithelial malignancies, including testicul...

    Authors: Ruza Arsenic, Elena Ilona Braicu, Anne Letsch, Manfred Dietel, Jalid Sehouli, Ulrich Keilholz and Sebastian Ochsenreither
    Citation: BMC Cancer 2015 15:784
    Content type: Research article Published on:

  15. The tumor microenvironment impacts pancreatic cancer (PC) development, progression and metastasis. How intratumoral inflammatory mediators modulate this biology remains poorly understood. We hypothesized that ...

    Authors: Daniel Delitto, Brian S. Black, Heather L. Sorenson, Andrea E. Knowlton, Ryan M. Thomas, George A. Sarosi, Lyle L. Moldawer, Kevin E. Behrns, Chen Liu, Thomas J. George, Jose G. Trevino, Shannon M. Wallet and Steven J. Hughes
    Citation: BMC Cancer 2015 15:783
    Content type: Research article Published on:

  16. Cancer survivorship has emerged as an important aspect of oncology due to the possibility of physical and psychosocial complications. The purpose of this study was to assess the feasibility of the Ambulatory M...

    Authors: Gisèle Compaci, Manuela Rueter, Sébastien Lamy, Lucie Oberic, Christian Recher, Maryse Lapeyre-Mestre, Guy Laurent and Fabien Despas
    Citation: BMC Cancer 2015 15:781
    Content type: Research article Published on:

  17. Tumor genotype plays a crucial role in clinical management of GIST. Whether genetic polymorphism of KIT may influence GIST patient outcome is unclear.

    Authors: Mehdi Brahmi, Laurent Alberti, Armelle Dufresne, Isabelle Ray-Coquard, Philippe Cassier, Pierre Meeus, Anne-Valérie Decouvelaere, Dominique Ranchère-Vince and Jean-Yves Blay
    Citation: BMC Cancer 2015 15:780
    Content type: Research article Published on:

  18. Selective BRAF inhibitors, vemurafenib and dabrafenib, and the MEK inhibitor, trametinib, have been approved for treatment of metastatic melanomas with a BRAF p.V600E mutation. The clinical significance of non-co...

    Authors: Gang Zheng, Li-Hui Tseng, Guoli Chen, Lisa Haley, Peter Illei, Christopher D. Gocke, James R. Eshleman and Ming-Tseh Lin
    Citation: BMC Cancer 2015 15:779
    Content type: Research article Published on:

  19. Pilocytic astrocytoma is the most common type of brain tumor in the pediatric population, with a generally favorable prognosis, although recurrences or leptomeningeal dissemination are sometimes also observed....

    Authors: Krzysztof Zakrzewski, Michał Jarząb, Aleksandra Pfeifer, Małgorzata Oczko-Wojciechowska, Barbara Jarząb, Paweł P. Liberski and Magdalena Zakrzewska
    Citation: BMC Cancer 2015 15:778
    Content type: Research article Published on:

  20. The nerve growth factor (NGF) receptor tyrosine-kinase TrkA is a well-known determinant of the melanocytic lineage, through modulation of the MAPK and AKT cascades. While TrkA gene is frequently rearranged in ...

    Authors: Luigi Pasini, Angela Re, Toma Tebaldi, Gianluca Ricci, Sebastiana Boi, Valentina Adami, Mattia Barbareschi and Alessandro Quattrone
    Citation: BMC Cancer 2015 15:777
    Content type: Research article Published on:

  21. Infection by the liver fluke, Opisthorchis viverrini, remains an important public health problem in Thailand and has resulted in the highest prevalence of infection and incidence of subsequent cholangiocarcinoma ...

    Authors: Supot Kamsa-ard, Vor Luvira, Ake Pugkhem, Varisara Luvira, Bandit Thinkhamrop, Krittika Suwanrungruang and Vajarabhongsa Bhudhisawasdi
    Citation: BMC Cancer 2015 15:776
    Content type: Research article Published on:

  23. Splenic marginal zone lymphoma (SMZL) is an indolent B-cell non-Hodgkin lymphoma and represents the most common primary malignancy of the spleen. Its precise molecular pathogenesis is still unknown and specifi...

    Authors: Jan Peveling-Oberhag, Franziska Wolters, Claudia Döring, Dirk Walter, Ludger Sellmann, René Scholtysik, Marco Lucioni, Max Schubach, Marco Paulli, Saskia Biskup, Stefan Zeuzem, Ralf Küppers and Martin-Leo Hansmann
    Citation: BMC Cancer 2015 15:773
    Content type: Research article Published on:

  24. Irreversible electroporation (IRE) is a novel image-guided tumor ablation technique that has shown promise for the ablation of lesions in proximity to vital structures such as blood vessels and bile ducts. The...

    Authors: Hester J. Scheffer, Laurien G P H Vroomen, Karin Nielsen, Aukje A J M van Tilborg, Emile F I Comans, Cornelis van Kuijk, Bram B. van der Meijs, Janneke van den Bergh, Petrousjka M P van den Tol and Martijn R. Meijerink
    Citation: BMC Cancer 2015 15:772
    Content type: Study protocol Published on:

  25. The prognosis for adult patients with Ph(-) B-precursor acute lymphoblastic leukaemia (ALL) who are refractory to treatment or experience relapse (R/R), is poor; over 90 % of these patients die from the diseas...

    Authors: Deborah Saltman, Arie Barlev, Divyagiri Seshagiri, Ioannis Katsoulis, Vincent Lin and Beth Barber
    Citation: BMC Cancer 2015 15:771
    Content type: Research article Published on:

  26. Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, howeve...

    Authors: Priscilla S. Simon, Sarah K. Sharman, Chunwan Lu, Dafeng Yang, Amy V. Paschall, Sidhartha S. Tulachan and Kebin Liu
    Citation: BMC Cancer 2015 15:770
    Content type: Research article Published on:

  27. Alterations in methylation patterns, miRNA expression, and stem cell protein expression occur in germ cell tumors (GCTs). Our goal is to integrate molecular data across platforms to identify molecular signatur...

    Authors: Jenny N. Poynter, Jessica R. B. M. Bestrashniy, Kevin A. T. Silverstein, Anthony J. Hooten, Christopher Lees, Julie A. Ross and Jakub Tolar
    Citation: BMC Cancer 2015 15:769
    Content type: Research article Published on:

  28. Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, wa...

    Authors: Mathangi Ravi, Shilpa Tentu, Ganga Baskar, Surabhi Rohan Prasad, Swetha Raghavan, Prajisha Jayaprakash, Jeyaraman Jeyakanthan, Suresh K Rayala and Ganesh Venkatraman
    Citation: BMC Cancer 2015 15:768
    Content type: Research article Published on:

  29. Treatment of patients with non-metastatic, locally advanced rectal cancer (LARC) includes pre-operative chemoradiation, total mesorectal excision (TME) and post-operative adjuvant chemotherapy. This trimodalit...

    Authors: J. Joshua Smith, Oliver S. Chow, Marc J. Gollub, Garrett M. Nash, Larissa K. Temple, Martin R. Weiser, José G. Guillem, Philip B. Paty, Karin Avila and Julio Garcia-Aguilar
    Citation: BMC Cancer 2015 15:767
    Content type: Study protocol Published on:

  30. CXC chemokine receptor 2 (CXCR2) has been reported to play an important role in the proliferation and invasion of gastric cancer cells. The present study aims to investigate the impact of CXCR2 expression on t...

    Authors: Zhenglin Wang, Hao Liu, Zhenbin Shen, Xuefei Wang, Heng Zhang, Jing Qin, Jiejie Xu, Yihong Sun and Xinyu Qin
    Citation: BMC Cancer 2015 15:766
    Content type: Research article Published on:

  31. About one third of breast cancer survivors suffer from persistent severe fatigue after completion of curative cancer treatment. Face-to-face cognitive behavioral therapy (F2F CBT), especially designed for fati...

    Authors: H. J. G. Abrahams, M. F. M. Gielissen, M. M. Goedendorp, T. Berends, M. E. W. J. Peters, H. Poort, C. A. H. H. V. M. Verhagen and H. Knoop
    Citation: BMC Cancer 2015 15:765
    Content type: Study protocol Published on:

  32. In locally advanced rectal cancer (LARC) preoperative chemoradiation (CRT) is the standard of care, but the risk of local recurrence is low with good quality total mesorectal excision (TME), although many stil...

    Authors: R. Glynne-Jones, N. Hava, V. Goh, S. Bosompem, J. Bridgewater, I. Chau, A. Gaya, H. Wasan, B. Moran, L. Melcher, A. MacDonald, M. Osborne, S. Beare, M. Jitlal, A. Lopes, M. Hall…
    Citation: BMC Cancer 2015 15:764
    Content type: Study protocol Published on:

  33. Considering cell cycle dependent cytotoxicity, intercalation of chemotherapy and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) may be a treatment option in non-small cell lung cancer ...

    Authors: Yoon Ji Choi, Dae Ho Lee, Chang Min Choi, Jung Shin Lee, Seung Jin Lee, Jin-Hee Ahn and Sang-We Kim
    Citation: BMC Cancer 2015 15:763
    Content type: Research article Published on:

  34. Resistance to chemotherapy is common in gastroesophageal cancer. Mechanisms of resistance are incompletely characterised and there are no predictive biomarkers in clinical practice for cytotoxic drugs. We used...

    Authors: Kasia Matula, Elaina Collie-Duguid, Graeme Murray, Khyati Parikh, Heike Grabsch, Patrick Tan, Salina Lalwani, Roberta Garau, Yuhan Ong, Gillian Bain, Asa-Dahle Smith, Gordon Urquhart, Jacek Bielawski, Michael Finnegan and Russell Petty
    Citation: BMC Cancer 2015 15:762
    Content type: Research article Published on:

  35. Microcalcifications can be the early and only presenting sign of breast cancer. One shared characteristic of breast cancer is the appearance of mammographic mammary microcalcifications that can routinely be us...

    Authors: Andrés M. Castellaro, Alfredo Tonda, Hugo H. Cejas, Héctor Ferreyra, Beatriz L. Caputto, Oscar A. Pucci and German A. Gil
    Citation: BMC Cancer 2015 15:761
    Content type: Research article Published on:

  36. TP53 gene mutation is widely known as one of the determinants of impaired chemosensitivity. p53 is a tumor-suppressor protein in humans encoded by the TP53 gene. Some studies have shown that TP53 gene mutation an...

    Authors: Hiroki Osumi, Eiji Shinozaki, Mitsukuni Suenaga, Yosuke Kumekawa, Mariko Ogura, Masato Ozaka, Satoshi Matsusaka, Keisho Chin, Noriko Yamamoto and Nobuyuki Mizunuma
    Citation: BMC Cancer 2015 15:760
    Content type: Research article Published on:

  37. Neovascularization and peritumoral edema are hallmarks of glioblastoma (GBM). Programmed cell death 10 (PDCD10) plays a pivotal role in regulating apoptosis, neoangiogenesis and vessel permeability and is impl...

    Authors: Nicole Lambertz, Nicolai El Hindy, Ilonka Kreitschmann-Andermahr, Klaus Peter Stein, Philipp Dammann, Neriman Oezkan, Oliver Mueller, Ulrich Sure and Yuan Zhu
    Citation: BMC Cancer 2015 15:759
    Content type: Research article Published on:

  38. Head and neck mucosal melanoma (HNMM) is a rare type of malignant tumor that frequently exhibits postoperative recurrence and distant metastasis. Many clinicians administer postoperative adjuvant radiotherapy ...

    Authors: Wei Li, Yalian Yu, Hailong Wang, Aihui Yan and Xuejun Jiang
    Citation: BMC Cancer 2015 15:758
    Content type: Research article Published on:

  40. Acute myeloid leukemia (AML) is the second-most common form of leukemia in children. Aberrant DNA methylation patterns are a characteristic feature of AML. GATA4 has been suggested to be a tumor suppressor gen...

    Authors: Yan-Fang Tao, Fang Fang, Shao-Yan Hu, Jun Lu, Lan Cao, Wen-Li Zhao, Pei-Fang Xiao, Zhi-Heng Li, Na-Na Wang, Li-Xiao Xu, Xiao-Juan Du, Li-Chao Sun, Yan-Hong Li, Yi-Ping Li, Yun-Yun Xu, Jian Ni…
    Citation: BMC Cancer 2015 15:756
    Content type: Research article Published on:

  41. The BRCA1 gene plays a key role in triple negative breast cancers (TNBCs), in which its expression can be lost by multiple mechanisms: germinal mutation followed by deletion of the second allele; negative regulat...

    Authors: Meriem Boukerroucha, Claire Josse, Sonia ElGuendi, Bouchra Boujemla, Pierre Frères, Raphaël Marée, Stephane Wenric, Karin Segers, Joelle Collignon, Guy Jerusalem and Vincent Bours
    Citation: BMC Cancer 2015 15:755
    Content type: Research article Published on:

  42. This study was designed to investigate the impact of liver cirrhosis due to chronic hepatitis C virus (HCV) infection on the disease-free and overall survival of ovarian cancer patients undergoing a standard p...

    Authors: Basel Refky, Sherif Kotb, Tamer Fady, Ahmad Marwan, Doaa Abd El-Khalek, Waleed Elnahas, Mohamed T. Hafez, Eduard Malik and Amr A. Soliman
    Citation: BMC Cancer 2015 15:754
    Content type: Research article Published on:

  43. The aetiology of urological cancers is poorly understood and variations in incidence by ethnic group may provide insights into the relative importance of genetic and environmental risk factors. Our objective w...

    Authors: Mahiben Maruthappu, Isobel Barnes, Shameq Sayeed and Raghib Ali
    Citation: BMC Cancer 2015 15:753
    Content type: Research article Published on:

  44. Osteosarcoma is a typical bone cancer that primarily affects adolescents. The therapeutic activity of drugs is limited by their severe drug-related toxicities, therefore, a therapeutic approach which is less t...

    Authors: Bin Chen, Jie-Zuan Yang, Li-Feng Wang, Yi-Jun Zhang and Xiang-Jin Lin
    Citation: BMC Cancer 2015 15:752
    Content type: Research article Published on:

  45. No screening programs are available for ovarian or endometrial cancer. One reason for this is the low incidence of the conditions, resulting in low positive predictive values for tests, which are not very spec...

    Authors: Stefanie Burghaus, Lothar Häberle, Michael G. Schrauder, Katharina Heusinger, Falk C. Thiel, Alexander Hein, David Wachter, Johanna Strehl, Arndt Hartmann, Arif B. Ekici, Stefan P. Renner, Matthias W. Beckmann and Peter A. Fasching
    Citation: BMC Cancer 2015 15:751
    Content type: Research article Published on:

  46. Excellent dosimetric characteristics were demonstrated for volumetric modulated arc therapy (VMAT) in preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). In a single-center retrospe...

    Authors: Leif Hendrik Dröge, Hanne Elisabeth Weber, Manuel Guhlich, Martin Leu, Lena-Christin Conradi, Jochen Gaedcke, Steffen Hennies, Markus Karl Herrmann, Margret Rave-Fränk and Hendrik Andreas Wolff
    Citation: BMC Cancer 2015 15:750
    Content type: Research article Published on:

  47. To evaluate whether apparent diffusion coefficient (ADC) value of gastric cancer obtained from diffusion weighted imaging (DWI) correlates with the HER2 status.

    Authors: Jian He, Hua Shi, Zhuping Zhou, Jun Chen, Wenxian Guan, Hao Wang, Haiping Yu, Song Liu, Zhengyang Zhou, Xiaofeng Yang and Tian Liu
    Citation: BMC Cancer 2015 15:749
    Content type: Research article Published on:

  48. More than half of the patients selected based on KRAS mutation status fail to respond to the treatment with cetuximab in metastatic colorectal cancer (mCRC). We designed a study to identify additional biomarkers ...

    Authors: Seung Tae Kim, Tae Jin Ahn, Eunjin Lee, In-Gu Do, Su Jin Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Suk Hyeong Kim, Jeeyun Lee and Hee Cheol Kim
    Citation: BMC Cancer 2015 15:747
    Content type: Research article Published on:

  49. Clinical care of unstable spinal bone metastases in many centers often includes patient immobilization by means of an orthopedic corset in order to prevent pathological fractures. The aim of this retrospective...

    Authors: Harald Rief, Robert Förster, Stefan Rieken, Thomas Bruckner, Ingmar Schlampp, Tilman Bostel and Jürgen Debus
    Citation: BMC Cancer 2015 15:745
    Content type: Research article Published on:

  50. Neutrophil-lymphocyte ratio (NLR) has been shown to be associated with prognosis in various solid tumors. This study aimed to evaluate the prognostic role of NLR in patients with laryngeal squamous cell carcin...

    Authors: Xiu-Ping Tu, Qian-Hui Qiu, Liang-Si Chen, Xiao-Ning Luo, Zhong-Ming Lu, Si-Yi Zhang and Shao-Hua Chen
    Citation: BMC Cancer 2015 15:743
    Content type: Research article Published on:

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