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  1. The genetic variation underlying atorvastatin (ATV) pharmacokinetics was evaluated in a Mexican population. Aims of this study were: 1) to reveal the frequency of 87 polymorphisms in 36 genes related to drug m...

    Authors: Rafael B. R. León-Cachón, Jorge A. Ascacio-Martínez, María E. Gamino-Peña, Ricardo M. Cerda-Flores, Irene Meester, Hugo L. Gallardo-Blanco, Magdalena Gómez-Silva, Everardo Piñeyro-Garza and Hugo A. Barrera-Saldaña
    Citation: BMC Cancer 2016 16:74
    Content type: Research article Published on:

  2. FAS/FASL promoter variants are considered in altering transcriptional activity of those genes and consequently alter regulation of cell death. However, no studies have investigated whe...

    Authors: Yan Sun, Wenbin Yu, Erich M. Sturgis, Wei Peng, Dapeng Lei, Qingyi Wei, Xicheng Song and Guojun Li
    Citation: BMC Cancer 2016 16:70
    Content type: Research article Published on:

  3. Next Generation Sequencing (NGS) is expected to lift molecular diagnostics in clinical oncology to the next level. It enables simultaneous identification of mutations in a patient tumor, after which targeted t...

    Authors: S.E.P. Joosten, V.P. Retèl, V.M.H. Coupé, M.M. van den Heuvel and W.H. van Harten
    Citation: BMC Cancer 2016 16:66
    Content type: Research article Published on:

  4. Survival after diagnosis is a fundamental concern in cancer epidemiology. In resource-rich settings, ambient clinical databases, municipal data and cancer registries make survival estimation in real-world popu...

    Authors: Esther Freeman, Aggrey Semeere, Megan Wenger, Mwebesa Bwana, F. Chite Asirwa, Naftali Busakhala, Emmanuel Oga, Elima Jedy-Agba, Vivian Kwaghe, Kenneth Iregbu, Antoine Jaquet, Francois Dabis, Habakkuk Azinyui Yumo, Jean Claude Dusingize, David Bangsberg, Kathryn Anastos…
    Citation: BMC Cancer 2016 16:65
    Content type: Research article Published on:

  5. Germline mutations in the BRCA1 and BRCA2 genes greatly increase a woman’s risk of developing breast and/or ovarian cancer. The prevalence and distribution of such mutations differ across races/ethnicities. Sever...

    Authors: Wen-Ming Cao, Yun Gao, Hong-Jian Yang, Shang-Nao Xie, Xiao-Wen Ding, Zhi-Wen Pan, Wei-Wu Ye and Xiao-Jia Wang
    Citation: BMC Cancer 2016 16:64
    Content type: Research article Published on:

  6. Pseudomonas fluorescens lectin (PFL) belongs to a recently discovered anti-HIV lectin family and induces anoikis-like cell death of MKN28 gastric cancer cells by causing α2 integrin internalization through recogn...

    Authors: Yuichiro Sato, Takanori Kubo, Kinjiro Morimoto, Kazuyoshi Yanagihara and Toshio Seyama
    Citation: BMC Cancer 2016 16:63
    Content type: Research article Published on:

  7. Rebiopsy is highly recommended to identify the mechanism of acquired resistance to EGFR-TKIs in advanced lung cancer. Recent advances in multiplex genotyping based on circulating tumor DNA (ctDNA) provide a st...

    Authors: Wenhua Liang, Qihua He, Ying Chen, Shaokun Chuai, Weiqiang Yin, Wei Wang, Guilin Peng, Caicun Zhou and Jianxing He
    Citation: BMC Cancer 2016 16:62
    Content type: Case report Published on:

  8. Obesity is associated with tumor aggressiveness and disease-specific mortality for more than 15 defined malignancies, including prostate cancer. Preclinical studies suggest that weight loss from caloric restri...

    Authors: Wendy Demark-Wahnefried, Jeffery W. Nix, Gary R. Hunter, Soroush Rais-Bahrami, Renee A. Desmond, Balu Chacko, Casey D. Morrow, Maria Azrad, Andrew D. Frugé, Yuko Tsuruta, Travis Ptacek, Scott A. Tully, Roanne Segal and William E. Grizzle
    Citation: BMC Cancer 2016 16:61
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:71

  9. Aberrant TGF-β1 signaling is suggested to be involved in gastric carcinogenesis. However, the role of TGF-β1 in intestinal-type [i-GC] and diffuse-type [d-GC] gastric cancer remains largely unknown. In this st...

    Authors: Kyung Ho Pak, Dong Hoon Kim, Hyunki Kim, Do Hyung Lee and Jae-Ho Cheong
    Citation: BMC Cancer 2016 16:60
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:99

  10. To test in multicenter setting if patients affected of metabolic syndrome (MetS) and initial widespread high grade prostatic intraepithelial neoplasia (wHGPIN) diagnosis are at higher risk of prostate cancer (...

    Authors: Antonio Cicione, Cosimo De Nunzio, Andrea Tubaro, Francesco Cantiello, Stefano Manno, Carlos Oliveira, Estevao Lima and Rocco Damiano
    Citation: BMC Cancer 2016 16:59
    Content type: Research article Published on:

  11. The occurrence of cancer during pregnancy merges two complex, poorly understood metabolic and hormonal conditions. This association can exacerbate the conditions of both the mother and the foetus. The branched...

    Authors: Bread Leandro Gomes Cruz, Priscila Cristina da Silva, Rebeka Tomasin, Andre Gustavo Oliveira, Lais Rosa Viana, Emilianne Miguel Salomao and Maria Cristina Cintra Gomes-Marcondes
    Citation: BMC Cancer 2016 16:58
    Content type: Research article Published on:

  12. This study investigated whether patients with acquired haemolytic anaemia (AHA) would have elevated cancer risk including that for non-haematological solid tumours. We further examined whether the cancer risk ...

    Authors: Victor C. Kok, Fung-Chang Sung, Chia-Hung Kao, Che-Chen Lin and Chun-Hung Tseng
    Citation: BMC Cancer 2016 16:57
    Content type: Research article Published on:

  13. Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fus...

    Authors: Ran Wang, Shuxun Chen, Changxian Li, Kevin Tak Pan Ng, Chi-wing Kong, Jinping Cheng, Shuk Han Cheng, Ronald A. Li, Chung Mau Lo, Kwan Man and Dong Sun
    Citation: BMC Cancer 2016 16:56
    Content type: Research article Published on:

  14. Transgelin is an actin-binding protein that promotes motility in normal cells. Although the role of transgelin in cancer is controversial, a number of studies have shown that elevated levels correlate with agg...

    Authors: Hui-min Zhou, Yuan-yuan Fang, Paul M. Weinberger, Ling-ling Ding, John K. Cowell, Farlyn Z. Hudson, Mingqiang Ren, Jeffrey R. Lee, Qi-kui Chen, Hong Su, William S. Dynan and Ying Lin
    Citation: BMC Cancer 2016 16:55
    Content type: Research article Published on:

  15. A mouse model of metastasis of human gastric cancer is one of the most important tools for studying the biological mechanisms underlying human gastric cancer metastasis. In this paper, we established a mouse m...

    Authors: Kesheng Li, Huifen Du, Xiaowen Lian, Dandan Chai, Xinwen Li, Rong Yang and Chunya Wang
    Citation: BMC Cancer 2016 16:54
    Content type: Research article Published on:

  16. Uterine carcinosarcoma (UCS) represents a true example of cancer associated with epithelial-mesenchymal transition (EMT), which exhibits cancer stem cell (CSC)-like traits. Both Sox and β-catenin signal transd...

    Authors: Hisako Inoue, Hiroyuki Takahashi, Miki Hashimura, Koji Eshima, Masashi Akiya, Toshihide Matsumoto and Makoto Saegusa
    Citation: BMC Cancer 2016 16:53
    Content type: Research article Published on:

  17. Toll-like receptors (TLRs) recognize known molecules from microbes and have an established role in tumorigenesis. Using a rat model of esophageal adenocarcinoma, and human clinical samples, we investigated gen...

    Authors: Ali H. Zaidi, Lori A. Kelly, Rachael E. Kreft, Mark Barlek, Ashten N. Omstead, Daisuke Matsui, Natalie H. Boyd, Kathryn E. Gazarik, Megan I. Heit, Laura Nistico, Pashtoon M. Kasi, Tracy L. Spirk, Barbara Byers, Emily J. Lloyd, Rodney J. Landreneau and Blair A. Jobe
    Citation: BMC Cancer 2016 16:52
    Content type: Research article Published on:

  18. Overcoming resistance to treatment is an essential issue in many cancers including glioblastoma (GBM), the deadliest primary tumor of the central nervous system. As dependence on iron is a key feature of tumor...

    Authors: Claire Legendre, Sylvie Avril, Catherine Guillet and Emmanuel Garcion
    Citation: BMC Cancer 2016 16:51
    Content type: Research article Published on:

  19. To correlate parameters of Ultrasonography-guided Diffuse optical tomography (US-DOT) with pharmacokinetic features of Dynamic contrast-enhanced (DCE)-MRI and pathologic markers of breast cancer.

    Authors: Min Jung Kim, Min-Ying Su, Hon J Yu, Jeon-Hor Chen, Eun-Kyung Kim, Hee Jung Moon and Ji Soo Choi
    Citation: BMC Cancer 2016 16:50
    Content type: Research article Published on:

  20. Dual specificity phosphatases are a class of tumor-associated proteins involved in the negative regulation of the MAP kinase pathway. Downregulation of the dual specificity phosphatase 2 (DUSP2) has been reported...

    Authors: Tanja Haag, Antje M. Richter, Martin B. Schneider, Adriana P. Jiménez and Reinhard H. Dammann
    Citation: BMC Cancer 2016 16:49
    Content type: Research article Published on:

  22. Centrosome amplification (CA) has been reported in nearly all types of human cancer and is associated with deleterious clinical factors such as higher grade and stage. However, previous reports have not shown ...

    Authors: Ryan A. Denu, Lauren M. Zasadil, Craig Kanugh, Jennifer Laffin, Beth A. Weaver and Mark E. Burkard
    Citation: BMC Cancer 2016 16:47
    Content type: Research article Published on:

  23. The efficacy and safety of lenalidomide plus low-dose dexamethasone (Rd) in Chinese patients with relapsed/refractory multiple myeloma (RRMM) was demonstrated in a phase 2, multicenter trial (MM-021). MM-024 w...

    Authors: Xin Du, Jie Jin, Zhen Cai, Fangping Chen, Dao-bin Zhou, Li Yu, Xiaoyan Ke, Xiao Li, Depei Wu, Fanyi Meng, Dena DeMarco, Jingshan Zhang, Jay Mei and Jian Hou
    Citation: BMC Cancer 2016 16:46
    Content type: Research article Published on:

  24. Talin-1 (TLN-1) and TLN-2 are implicated in many cellular processes, but their roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to assess cell cycle distribution, anoikis, invasion and ...

    Authors: Kun-peng Fang, Wei Dai, Yan-Hong Ren, Ye-Chuan Xu, She-min Zhang and Ye-Ben Qian
    Citation: BMC Cancer 2016 16:45
    Content type: Research article Published on:

  25. Utilisation of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and guide sheath (EBUS-GS) for diagnosis and staging of lung cancer is gaining popularity, however, its impact on cli...

    Authors: Neli S. Slavova-Azmanova, Catalina Lizama, Claire E. Johnson, Herbert P. Ludewick, Leanne Lester, Shanka Karunarathne and Martin Phillips
    Citation: BMC Cancer 2016 16:44
    Content type: Research article Published on:

  26. Over 20 % of ovarian cancer patients have preoperative thrombocytosis or hyperfibrinogenemia. We aimed to demonstrate the clinical and prognostic significance of thrombocytosis and hyperfibrinogenemia in high-...

    Authors: Zheng Feng, Hao Wen, Rui Bi, Yachen Duan, Wentao Yang and Xiaohua Wu
    Citation: BMC Cancer 2016 16:43
    Content type: Research article Published on:

  27. With increasing numbers of patients with unresectable locoregionally advanced (LA) head and neck squamous cell carcinoma (HNSCC) receiving cetuximab/radiotherapy (RT), several guidelines on the early detection...

    Authors: Guopei Zhu, Jin-Ching Lin, Sung-Bae Kim, Jacques Bernier, Jai Prakash Agarwal, Jan B. Vermorken, Dang Huy Quoc Thinh, Hoi-Ching Cheng, Hwan Jung Yun, Imjai Chitapanarux, Prasert Lertsanguansinchai, Vijay Anand Reddy and Xia He
    Citation: BMC Cancer 2016 16:42
    Content type: Correspondence Published on:

  28. The Neutrophil to lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. However, its prognostic significance in oral squamous cell carcinoma (OSCC) patients has not been fully expl...

    Authors: Hikaru Nakashima, Yuichiro Matsuoka, Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hidetaka Arita, Akimitsu Hiraki and Hideki Nakayama
    Citation: BMC Cancer 2016 16:41
    Content type: Research article Published on:

  29. There is considerable information on the methylation of the promoter regions of different genes involved in gastric carcinogenesis. However, there is a lack of information on how this epigenetic process differ...

    Authors: Rita Kupcinskaite-Noreikiene, Rasa Ugenskiene, Alius Noreika, Viktoras Rudzianskas, Jurgita Gedminaite, Jurgita Skieceviciene and Elona Juozaityte
    Citation: BMC Cancer 2016 16:40
    Content type: Research article Published on:

  30. Cancer metastasis is one of the most common causes of treatment failure and death in cancer patients. It has been acknowledged that aberrant activation of epithelial-to-mesenchymal transition (EMT) program, en...

    Authors: Poulami Khan, Argha Manna, Shilpi Saha, Suchismita Mohanty, Shravanti Mukherjee, Minakshi Mazumdar, Deblina Guha and Tanya Das
    Citation: BMC Cancer 2016 16:39
    Content type: Research article Published on:

  31. Long Interspersed Nuclear Element-1 (L1) is an oncogenic mammalian retroelement silenced early in development via tightly controlled epigenetic mechanisms. We have previously shown that the regulatory region o...

    Authors: Diego E. Montoya-Durango, Kenneth A. Ramos, Pasano Bojang, Lorell Ruiz, Irma N. Ramos and Kenneth S. Ramos
    Citation: BMC Cancer 2016 16:38
    Content type: Research article Published on:

  32. Photoimmunotherapy (PIT) is a novel type of molecular optical imaging-guided cancer phototherapy based on a monoclonal antibody conjugated to a photosensitizer, IR700, in combination with near-infrared (NIR) l...

    Authors: Kimihiro Ito, Makoto Mitsunaga, Seiji Arihiro, Masayuki Saruta, Mika Matsuoka, Hisataka Kobayashi and Hisao Tajiri
    Citation: BMC Cancer 2016 16:37
    Content type: Research article Published on:

  33. A neuroendocrine tumor (NET) can develop anywhere in the body, but is mainly found in the pancreas, gastrointestinal tract, and lungs. This report is a retrospective study of the clinicopathological features o...

    Authors: Jiro Akimoto, Hirokazu Fukuhara, Tomohiro Suda, Kenta Nagai, Megumi Ichikawa, Shinjiro Fukami, Michihiro Kohno, Jun Matsubayashi and Toshitaka Nagao
    Citation: BMC Cancer 2016 16:36
    Content type: Research article Published on:

  34. c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good...

    Authors: Chi Hoon Park, Sung Yun Cho, Jae Du Ha, Heejung Jung, Hyung Rae Kim, Chong Ock Lee, In-Young Jang, Chong Hak Chae, Heung Kyoung Lee and Sang Un Choi
    Citation: BMC Cancer 2016 16:35
    Content type: Research article Published on:

  35. Studies in taxane and/or anthracycline refractory metastatic breast cancer (mBC) patients have shown approximately 30 % response rates to irinotecan. Hence, a significant number of patients will experience iri...

    Authors: Haatisha Jandu, Kristina Aluzaite, Louise Fogh, Sebastian Wingaard Thrane, Julie B. Noer, Joanna Proszek, Khoa Nguyen Do, Stine Ninel Hansen, Britt Damsgaard, Signe Lykke Nielsen, Magnus Stougaard, Birgitta R. Knudsen, José Moreira, Petra Hamerlik, Madhavsai Gajjar, Marcel Smid…
    Citation: BMC Cancer 2016 16:34
    Content type: Research article Published on:

  36. miRNAs can regulate cellular survival in various cancer cell types. Recent evidence implicates the formation of lipid droplets as a hallmark event during apoptotic cell death response. It is presently unknown ...

    Authors: Punashi Dutta, Edward Haller, Arielle Sharp and Meera Nanjundan
    Citation: BMC Cancer 2016 16:33
    Content type: Research article Published on:

  37. The three members of the human heterochromatin protein 1 (HP1) family of proteins, HP1α, HP1β, and HPγ, are involved in chromatin packing and epigenetic gene regulation. HP1α is encoded from the CBX5 gene and is ...

    Authors: Johan Vad-Nielsen, Kristine Raaby Jakobsen, Tina Fuglsang Daugaard, Rune Thomsen, Anja Brügmann, Boe Sandahl Sørensen and Anders Lade Nielsen
    Citation: BMC Cancer 2016 16:32
    Content type: Research article Published on:

  38. Sorafenib is an orally active multikinase tyrosine kinase inhibitor (TKI) that targets B-type Raf kinase (BRAF), vascular endothelial growth factor receptors (VEGFR) 1 and 2, and rearranged during transfection...

    Authors: Tatiana C. Schneider, Ellen Kapiteijn, Tom van Wezel, Jan W. A. Smit, Jacobus J. M. van der Hoeven and Hans Morreau
    Citation: BMC Cancer 2016 16:31
    Content type: Case report Published on:

  39. Trabectedin is an antineoplastic agent used for patients with soft tissue sarcoma (STS) who fail standard-of-care treatment. Real-world data of its performance is scarce. This study evaluates the safety and ef...

    Authors: Fernando A. Angarita, Amanda J. Cannell, Albiruni R. Abdul Razak, Brendan C. Dickson and Martin E. Blackstein
    Citation: BMC Cancer 2016 16:30
    Content type: Research article Published on:

  40. Preoperative chemotherapy (PCT) and chemoradiotherapy (PCRT) showed promising results for gastric cancers. However, the influence of preoperative adverse events (AEs) on postoperative complications remains unk...

    Authors: Shuang-Xi Li, Sang Hyuk Seo, Yoon Young Choi, Masatoshi Nakagawa, Ji Yeong An, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung and Sung Hoon Noh
    Citation: BMC Cancer 2016 16:29
    Content type: Research article Published on:

  41. Amplifications of the transcription factor, SRY (sex determining region Y)-box 2 (SOX2), are common in non-small cell lung cancer (NSCLC). SOX2 signaling is important in maintaining the stem cell-like phenotype o...

    Authors: Johanna Samulin Erdem, Vidar Skaug, Per Bakke, Amund Gulsvik, Aage Haugen and Shanbeh Zienolddiny
    Citation: BMC Cancer 2016 16:28
    Content type: Research article Published on:

  42. Biopsy for lung cancer diagnosis is usually done at a single site. But it is unclear that genetic information at one biopsy site represents that of other lesions and is sufficient for therapeutic decision making.

    Authors: Eun Young Kim, Eun Na Cho, Heae Surng Park, Arum Kim, Ji Young Hong, Seri Lim, Jong Pil Youn, Seung Yong Hwang and Yoon Soo Chang
    Citation: BMC Cancer 2016 16:27
    Content type: Research article Published on:

  44. It has been previously demonstrated in several cancer models, that Dronabinol (THC) may have anti-tumor activity – however, controversial data exists for acute leukemia. We have anecdotal evidence that THC may...

    Authors: Kerstin Maria Kampa-Schittenhelm, Olaf Salitzky, Figen Akmut, Barbara Illing, Lothar Kanz, Helmut Rainer Salih and Marcus Matthias Schittenhelm
    Citation: BMC Cancer 2016 16:25
    Content type: Research article Published on:

  45. Pancreatic ductal adenocarcinoma remains one of the most lethal of all solid tumours. Treatment options are limited and gemcitabine-based chemotherapy remains the standard of care. Although growing evidence sh...

    Authors: Dannel Yeo, Hong He, Oneel Patel, Andrew M. Lowy, Graham S. Baldwin and Mehrdad Nikfarjam
    Citation: BMC Cancer 2016 16:24
    Content type: Research article Published on:

  46. Betulinic acid (BA), a member of pentacyclic triterpenes has shown important biological activities like anti-bacterial, anti-malarial, anti-inflammatory and most interestingly anticancer property. To overcome ...

    Authors: Debasmita Dutta, Biswajit Chakraborty, Ankita Sarkar, Chinmay Chowdhury and Padma Das
    Citation: BMC Cancer 2016 16:23
    Content type: Research article Published on:

  47. Several small studies indicated that the genotype of KIT or platelet-derived growth factor receptor-α (PDGFRA) contributes in part to the level of clinical effectiveness of sunitinib in gastrointestinal stromal t...

    Authors: Peter Reichardt, George D. Demetri, Hans Gelderblom, Piotr Rutkowski, Seock-Ah Im, Sudeep Gupta, Yoon-Koo Kang, Patrick Schöffski, Jochen Schuette, Denis Soulières, Jean-Yves Blay, David Goldstein, Kolette Fly, Xin Huang, Massimo Corsaro, Maria Jose Lechuga…
    Citation: BMC Cancer 2016 16:22
    Content type: Research article Published on:

  48. The current study was conducted to examine the activity of a docetaxel/oxaliplatin (DocOx) combination as second line treatment for advanced pancreatic ductal adenocarcinoma (Trial registration: NCT00690300. R...

    Authors: Thomas J. Ettrich, Lukas Perkhofer, Goetz von Wichert, Thomas M. Gress, Patrick Michl, Holger F. Hebart, Petra Büchner-Steudel, Michael Geissler, Rainer Muche, Bettina Danner, Volker Kächele, Andreas W. Berger, Melanie Güthle and Thomas Seufferlein
    Citation: BMC Cancer 2016 16:21
    Content type: Research article Published on:

  49. Deregulated signal transducer and activator of transcription 3 (STAT3) signaling has been well documented in certain cancers. Alterations in specific negative regulators, such as protein inhibitor of activated...

    Authors: Sheau-Fang Yang, Ming-Feng Hou, Fang-Ming Chen, Fu Ou-Yang, Yang-Chang Wu, Chee-Yin Chai and Yao-Tsung Yeh
    Citation: BMC Cancer 2016 16:20
    Content type: Research article Published on:

  50. To assess the clinical value of peritoneal washing cytology (PWC) in women with BRCA1 or BRCA2 mutations and women from a family with hereditary breast and/or ovarian cancer (HBOC) undergoing risk-reducing sal...

    Authors: F. Blok, E. M. Roes, G. J. L. H. van Leenders and H. J. van Beekhuizen
    Citation: BMC Cancer 2016 16:18
    Content type: Research article Published on:

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