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  1. Hypomethylation of Long Interspersed Nucleotide Element-1 (LINE-1) is associated with worse prognosis in colorectal cancer (CRC). However, little is known about the relevance of this marker for the prognosis a...

    Authors: Mami Kaneko, Masanori Kotake, Hiroyuki Bando, Tetsuji Yamada, Hirofumi Takemura and Toshinari Minamoto
    Citation: BMC Cancer 2016 16:945
    Content type: Research article Published on:

  2. To investigate the impact of biological gender on operative parameters, especially operative time, in laparoscopic partial nephrectomy (LPN) for T1 renal tumor.

    Authors: Hiroki Ito, Kazuhide Makiyama, Takashi Kawahara, Kimito Osaka, Koji Izumi, Yumiko Yokomizo, Noboru Nakaigawa and Masahiro Yao
    Citation: BMC Cancer 2016 16:944
    Content type: Research article Published on:

  3. Circulating cell-free DNA (ccf-DNA) in plasma may contain both specific and non-specific of tumor markers. The concentration and integrity of ccf-DNA may be clinical useful for detecting and predicting cancer ...

    Authors: Wang-Yang Pu, Rong Zhang, Li Xiao, Yong-You Wu, Wei Gong, Xiao-Dong Lv, Feng-Yun Zhong, Zhi-Xiang Zhuang, Xu-Ming Bai, Kai Li and Chun-Gen Xing
    Citation: BMC Cancer 2016 16:943
    Content type: Research article Published on:

  4. Colorectal cancer is the second most common cause of cancer deaths for both men and women, and the third most common cause of cancer in the U.S. Toxicity of current chemotherapeutic agents for colorectal cance...

    Authors: Jeffrey Wimsatt, Meghan Villers, Laurel Thomas, Stacey Kamarec, Caitlin Montgomery, Leo W. Y. Yeung, Yanqing Hu and Kim Innes
    Citation: BMC Cancer 2016 16:942
    Content type: Research article Published on:

  5. Neuroendocrine cells (NECs) reside adjacent to colonic stem cells (SCs) in the crypt stem cell (SC) niche, but how NECs are involved in regulation of SCs is unclear. We investigated NECs expressing somatostati...

    Authors: Shirin R. Modarai, Lynn M. Opdenaker, Vignesh Viswanathan, Jeremy Z. Fields and Bruce M. Boman
    Citation: BMC Cancer 2016 16:941
    Content type: Research article Published on:

  6. Using killed microorganisms or their parts to stimulate immunity for cancer treatment dates back to the end of 19th century. Since then, it undergone considerable development. Our novel approach binds ligands to ...

    Authors: Veronika Caisová, Andra Vieru, Zuzana Kumžáková, Simona Glaserová, Hana Husníková, Nikol Vácová, Gabriela Krejčová, Lucie Paďouková, Ivana Jochmanová, Katherine I. Wolf, Jindřich Chmelař, Jan Kopecký and Jan Ženka
    Citation: BMC Cancer 2016 16:940
    Content type: Research article Published on:

  8. Intracellular signaling through cyclic nucleotides, both cyclic AMP and cyclic GMP, is altered in colorectal cancer. Accordingly, it is hypothesized that an underlying mechanism for colorectal neoplasia involv...

    Authors: Badar Mahmood, Morten Matthiesen Bach Damm, Thorbjørn Søren Rønn Jensen, Marie Balslev Backe, Mattias Salling Dahllöf, Steen Seier Poulsen, Niels Bindslev and Mark Berner Hansen
    Citation: BMC Cancer 2016 16:938
    Content type: Research article Published on:

  9. Decisions on palliative chemotherapy (CT) for locally advanced or metastatic gastric cancer (mGC) require trade-offs between potential benefits and risks for patients. Healthcare providers and payers agree tha...

    Authors: R. Hofheinz, J. Clouth, J. Borchardt-Wagner, U. Wagner, E. Weidling, M. H. Jen and P. Brück
    Citation: BMC Cancer 2016 16:937
    Content type: Research article Published on:

  10. Over the past two decades, there has been a rising trend in malignant melanoma incidence worldwide. In 2008, Germany introduced a nationwide skin cancer screening program starting at age 35. The aims of this s...

    Authors: Olaf Schoffer, Stefanie Schülein, Gerlinde Arand, Hans Arnholdt, Dieter Baaske, Ralf C. Bargou, Nikolaus Becker, Matthias W. Beckmann, Yves Bodack, Beatrix Böhme, Tayfun Bozkurt, Regine Breitsprecher, Andre Buchali, Elke Burger, Ulrike Burger, Klaus Dommisch…
    Citation: BMC Cancer 2016 16:936
    Content type: Research article Published on:

  12. Approximately 8–15% epithelial ovarian cancer patients are BRCA1 or BRCA2 germline mutation carriers. Brazilian inhabitants may have peculiar genetic characteristics associated with ethnic diversity, and studies ...

    Authors: Simone Maistro, Natalia Teixeira, Giselly Encinas, Maria Lucia Hirata Katayama, Vivian Dionisio Tavares Niewiadonski, Larissa Garcia Cabral, Roberto Marques Ribeiro, Nelson Gaburo Junior, Ana Carolina Ribeiro Chaves de Gouvêa, Dirce Maria Carraro, Ester Cerdeira Sabino, Maria del Pilar Estevez Diz, Roger Chammas, Geertruida Hendrika de Bock and Maria Aparecida Azevedo Koike Folgueira
    Citation: BMC Cancer 2016 16:934
    Content type: Research article Published on:

  14. In the general geriatric population, programs linking geriatric evaluation with interventions are effective for improving functional status and survival of the patients. Whether or not these interventions impr...

    Authors: Pierre Soubeyran, Catherine Terret, Carine Bellera, Franck Bonnetain, Olivier Saint Jean, Angéline Galvin, Camille Chakiba, Marie-Dominique Zwolakowski, Simone Mathoulin-Pélissier and Muriel Rainfray
    Citation: BMC Cancer 2016 16:932
    Content type: Study protocol Published on:

  15. Colorectal cancer (CRC) remains the most commonly diagnosed cancer among Korean Americans (KAs) in part due to low screening rates. Recent studies suggest that some KA patients engage in medical tourism and re...

    Authors: Linda K. Ko, Victoria M. Taylor, Jihye Yoon, Wade K. Copeland, Joo Ha Hwang, Eun Jeong Lee and John Inadomi
    Citation: BMC Cancer 2016 16:931
    Content type: Research article Published on:

  16. Non-Islet Cell Tumor Hypoglycemia (NICTH) is a rare paraneoplastic cause of hypoglycemia arising from excess tumor production of insulin-like growth factor. The objective of this report is to describe an unusu...

    Authors: Zeb Saeed, Solaema Taleb and Carmella Evans-Molina
    Citation: BMC Cancer 2016 16:930
    Content type: Case report Published on:

  17. Multidisciplinary team (MDT) meetings are used to optimise expert decision-making about treatment options, but such expertise is not digitally transferable between centres. To help standardise medical decision...

    Authors: Frank P. Y. Lin, Adrian Pokorny, Christina Teng, Rachel Dear and Richard J. Epstein
    Citation: BMC Cancer 2016 16:929
    Content type: Research article Published on:

  19. There still is no evidence which neoadjuvant therapy regimen for stage II–III rectal cancer is superior. The aim of this study was to compare results achieved after long-course chemoradiotherapy (CRT) with sho...

    Authors: Tadas Latkauskas, Henrikas Pauzas, Laura Kairevice, Aleksandras Petrauskas, Zilvinas Saladzinskas, Rasa Janciauskiene, Jurate Gudaityte, Paulius Lizdenis, Saulius Svagzdys, Algimantas Tamelis and Dainius Pavalkis
    Citation: BMC Cancer 2016 16:927
    Content type: Research article Published on:

  22. Approximately 5–10% of breast cancers are hereditary and their biology and prognosis appear to differ from those of sporadic breast cancers. In this study we compared the biological features and clinical chara...

    Authors: G. Arpino, M. Pensabene, C. Condello, R. Ruocco, I. Cerillo, R. Lauria, V. Forestieri, M. Giuliano, C. De Angelis, M. Montella, A. Crispo and S. De Placido
    Citation: BMC Cancer 2016 16:924
    Content type: Research article Published on:

  23. The aim of the study was to evaluate the association of two SNPs of EVER1/2 genes’ region (rs2290907, rs16970849) and the FAS-670 polymorphism with the susceptibility to precancerous lesions and cervical cance...

    Authors: Evangelia Pavlidou, Alexandros Daponte, Raquel Egea, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Antonio Barbadilla and Theodoros Agorastos
    Citation: BMC Cancer 2016 16:923
    Content type: Research article Published on:

  24. Primary high risk (hr)HPV screening will be introduced in The Netherlands in January 2017. Our aim was to determine the hrHPV prevalence in the Dutch cervical cancer screening population (DuSC study).

    Authors: Cornelis Johannes Jacobus Huijsmans, Willemina Rosalia Rita Geurts-Giele, Cindy Leeijen, Hendrikus Lambertus Cornelius Maria Hazenberg, Jenneke van Beek, Carola de Wild, Johannes Cornelis van der Linden and Adrianus Johannes Christiaan van den Brule
    Citation: BMC Cancer 2016 16:922
    Content type: Research article Published on:

  26. Menopausal symptoms are common and may be particularly severe in younger women who undergo treatment-induced menopause. Medications to reduce menopausal symptoms are either contra-indicated or have bothersome ...

    Authors: Vera Atema, Marieke van Leeuwen, Hester S. A. Oldenburg, Valesca Retèl, Marc van Beurden, Myra S. Hunter and Neil K. Aaronson
    Citation: BMC Cancer 2016 16:920
    Content type: Study protocol Published on:

  27. Cancer-related fatigue (CrF) is a common and disruptive symptom that may be experienced during and after cancer. Research into the subjective experience of fatigue in this group is required. The common sense m...

    Authors: Teresa Corbett, AnnMarie Groarke, Jane C. Walsh and Brian E. McGuire
    Citation: BMC Cancer 2016 16:919
    Content type: Research article Published on:

  28. Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in ...

    Authors: Francesco Caponigro, Elena Di Gennaro, Franco Ionna, Francesco Longo, Corrado Aversa, Ettore Pavone, Maria Grazia Maglione, Massimiliano Di Marzo, Paolo Muto, Ernesta Cavalcanti, Antonella Petrillo, Fabio Sandomenico, Piera Maiolino, Roberta D’Aniello, Gerardo Botti, Rossella De Cecio…
    Citation: BMC Cancer 2016 16:918
    Content type: Study protocol Published on:

  29. Cancer has become a global burden due to its high incidence and mortality rates, with an estimated 14.1 million cancer cases reported worldwide in 2012 particularly as a result of metastasis. Metastasis involv...

    Authors: Thalia M. Rebelo, Carryn J. Chetty, Eloise Ferreira and Stefan F. T. Weiss
    Citation: BMC Cancer 2016 16:917
    Content type: Research article Published on:

  30. Authors: Sigurd M. Hald, Yury Kiselev, Samer Al-Saad, Elin Richardsen, Charles Johannessen, Marte Eilertsen, Thomas K. Kilvaer, Khalid Al-Shibli, Sigve Andersen, Lill-Tove Busund, Roy M. Bremnes and Tom Donnem
    Citation: BMC Cancer 2016 16:916
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2015 15:441

  31. Angiogenesis is important both in normal tissue function and disease and represents a key target in lung cancer (LC) therapy. Unfortunately, the two main subtypes of non-small-cell lung cancers (NSCLC) namely,...

    Authors: J. Rapp, E. Kiss, M. Meggyes, E. Szabo-Meleg, D. Feller, G. Smuk, T. Laszlo, V. Sarosi, T. F. Molnar, K. Kvell and J. E. Pongracz
    Citation: BMC Cancer 2016 16:915
    Content type: Research article Published on:

  32. The treatment goal for recurrent malignant gliomas centers on disease stabilization while minimizing therapy-related side effects. Metronomic dosing of cytotoxic chemotherapy has emerged as a promising option ...

    Authors: Eric T. Wong, Joshua Timmons, Amy Callahan, Lauren O’Loughlin, Bridget Giarusso and David C. Alsop
    Citation: BMC Cancer 2016 16:914
    Content type: Research article Published on:

  33. Detection and localization of genomic alterations and breakpoints are crucial in cancer research. The purpose of this study was to investigate, in a methodological and biological perspective, different female,...

    Authors: Fatemeh Kaveh, Lars O. Baumbusch, Daniel Nebdal, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Hege Edvardsen, Vessela N. Kristensen and Hiroko K. Solvang
    Citation: BMC Cancer 2016 16:913
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:80

  34. Hypertension is commonly reported in multiple myeloma (MM) patients and may be associated with older age, disease-related complications and consequences of MM treatments. This study evaluated the incidence rat...

    Authors: Ajai Chari, Khalid Mezzi, Shao Zhu, Winifred Werther, Diana Felici and Alexander R. Lyon
    Citation: BMC Cancer 2016 16:912
    Content type: Research article Published on:

  35. Tumor-infiltrating leukocytes can either limit cancer growth or facilitate its spread. Diagnostic strategies that comprehensively assess the functional complexity of tumor immune infiltrates could have wide-re...

    Authors: Julia Chifman, Ashok Pullikuth, Jeff W. Chou, Davide Bedognetti and Lance D. Miller
    Citation: BMC Cancer 2016 16:911
    Content type: Research Article Published on:

  36. Prognostic factors aid in the stratification and treatment of cancer. This study evaluated the prognostic significance of human epidermal growth factor receptor (HER) family members (HER1–4) expression in pati...

    Authors: Qin Li, Lei Zhang, XiuHong Li, Han Yan, Liuting Yang, Yingying Li, Teng Li, Jing Wang and Bangwei Cao
    Citation: BMC Cancer 2016 16:910
    Content type: Research article Published on:

  37. Standard radiotherapy is the treatment of first choice in patients with symptomatic spinal metastases, but is only moderately effective. Stereotactic body radiation therapy is increasingly used to treat spinal...

    Authors: Joanne M. van der Velden, Helena M. Verkooijen, Enrica Seravalli, Jochem Hes, A. Sophie Gerlich, Nicolien Kasperts, Wietse S. C. Eppinga, Jorrit-Jan Verlaan and Marco van Vulpen
    Citation: BMC Cancer 2016 16:909
    Content type: Study protocol Published on:

  38. The role of radiation therapy in addition to chemotherapy has not been well established in non-oligometastatic Stage IV non-small cell lung cancer (NSCLC). We aimed to investigate overall survival (OS) of non-...

    Authors: ShengFa Su, YinXiang Hu, WeiWei Ouyang, Zhu Ma, QingSong Li, HuiQin Li, Yu Wang, XiaoHu Wang, Tao Li, JianCheng Li, Ming Chen, You Lu, YuJu Bai, ZhiXu He and Bing Lu
    Citation: BMC Cancer 2016 16:908
    Content type: Research article Published on:

  39. PEP02 (also known as MM-398, nal-IRI) is a novel nanoparticle formulation of irinotecan encapsulated in liposomes. The aims of this study were to investigate the dose-limiting toxicity (DLT), maximum tolerated...

    Authors: Nai-Jung Chiang, Tsu-Yi Chao, Ruey-Kuen Hsieh, Cheng-Hsu Wang, Yi-Wen Wang, C. Grace Yeh and Li-Tzong Chen
    Citation: BMC Cancer 2016 16:907
    Content type: Research article Published on:

  41. In clinical practice the gold standard method to assess BRAF status in patients with metastatic melanoma is based on molecular assays. Recently, a mutation-specific monoclonal antibody (VE1), which detects the BR...

    Authors: Laura Schirosi, Sabino Strippoli, Francesca Gaudio, Giusi Graziano, Ondina Popescu, Michele Guida, Giovanni Simone and Anita Mangia
    Citation: BMC Cancer 2016 16:905
    Content type: Research article Published on:

  42. Anillin (ANLN), an actin-binding protein required for cytokinesis, has recently been presented as part of a prognostic marker panel in breast cancer. The objective of the current study was to further explore t...

    Authors: Kristina Magnusson, Gabriela Gremel, Lisa Rydén, Victor Pontén, Mathias Uhlén, Anna Dimberg, Karin Jirström and Fredrik Pontén
    Citation: BMC Cancer 2016 16:904
    Content type: Research article Published on:

  43. Keratin (K) 19-positive hepatocellular carcinoma (HCC) is well known to have a higher malignant potential than K19-negative HCC: However, the molecular mechanisms involved in K19-mediated progression of HCC re...

    Authors: Masato Takano, Keiji Shimada, Tomomi Fujii, Kohei Morita, Maiko Takeda, Yoshiyuki Nakajima, Akitaka Nonomura, Noboru Konishi and Chiho Obayashi
    Citation: BMC Cancer 2016 16:903
    Content type: Research article Published on:

  44. The metabolic inhibitor 3-bromopyruvate (3-BrPA) is a promising anti-cancer alkylating agent, shown to inhibit growth of some colorectal carcinoma with KRAS mutation. Recently, we demonstrated increased resist...

    Authors: Andrea Orue, Valery Chavez, Mary Strasberg-Rieber and Manuel Rieber
    Citation: BMC Cancer 2016 16:902
    Content type: Research article Published on:

  45. Breast cancer is one of the most common malignancies with increasing incidences every year and a leading cause of death among women. Although early stage breast cancer can be effectively treated, there are lim...

    Authors: Zeynep Kosaloglu, Julia Bitzer, Niels Halama, Zhiqin Huang, Marc Zapatka, Andreas Schneeweiss, Dirk Jäger and Inka Zörnig
    Citation: BMC Cancer 2016 16:901
    Content type: Research article Published on:

  46. Malnutrition in gastrectomized patients receiving chemotherapy is associated with the susceptibility to chemotherapy-related adverse events. This study evaluated pre-operative nutritional status-related indice...

    Authors: Seung Hee Seo, Sung-Eun Kim, Yoon-Koo Kang, Baek-Yeol Ryoo, Min-Hee Ryu, Jae Ho Jeong, Shin Sook Kang, Mihi Yang, Jung Eun Lee and Mi-Kyung Sung
    Citation: BMC Cancer 2016 16:900
    Content type: Research article Published on:

  47. The study was designed to develop a platform to verify whether the extract of herbs combined with chemotherapy drugs play a synergistic role in anti-tumor effects, and to provide experimental evidence and theo...

    Authors: Jun Xie, Jia-Hui Liu, Heng Liu, Xiao-Zhong Liao, Yuling Chen, Mei-Gui Lin, Yue-Yu Gu, Tao-Li Liu, Dong-Mei Wang, Hui Ge and Sui-Lin Mo
    Citation: BMC Cancer 2016 16:899
    Content type: Research article Published on:

  48. Prognostic value of immune cells is not clear in testicular germ cell tumors (TGCTs). We aimed to investigate the prognostic value of tumor-infiltrating neutrophils in TGCTs.

    Authors: Yuta Yamada, Tohru Nakagawa, Toru Sugihara, Takamasa Horiuchi, Uran Yoshizaki, Tetsuya Fujimura, Hiroshi Fukuhara, Tomohiko Urano, Kenichi Takayama, Satoshi Inoue, Haruki Kume and Yukio Homma
    Citation: BMC Cancer 2016 16:898
    Content type: Research article Published on:

  49. Previous studies have shown that the cell polarity protein partitioning defective 3 (Par3) plays an essential role in the formation of tight junctions and definition of apical-basal polarity. Aberrant function...

    Authors: Hiroe Nakamura, Kazunori Nagasaka, Kei Kawana, Ayumi Taguchi, Yuriko Uehara, Mitsuyo Yoshida, Masakazu Sato, Haruka Nishida, Asaha Fujimoto, Tomoko Inoue, Katsuyuki Adachi, Takeshi Nagamatsu, Takahide Arimoto, Katsutoshi Oda, Yutaka Osuga and Tomoyuki Fujii
    Citation: BMC Cancer 2016 16:897
    Content type: Research article Published on:

  50. NUT midline carcinoma (NMC) is a rare and highly aggressive malignancy. Although more information on NMC has been recently accumulating in the literature, most oncologists and pathologists remain unfamiliar wi...

    Authors: Yohei Harada, Takafumi Koyama, Kengo Takeuchi, Kazufusa Shoji, Kazuei Hoshi and Yu Oyama
    Citation: BMC Cancer 2016 16:895
    Content type: Case report Published on:

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