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  1. Globally, cancer is one of the leading causes of mortality. High treatment cost, partly owing to higher prices of anti-cancer drugs, presents a significant burden on patients and healthcare systems. The aim of...

    Authors: Shahrzad Salmasi, Kah Seng Lee, Long Chiau Ming, Chin Fen Neoh, Mahmoud E. Elrggal, Zaheer-Ud- Din Babar, Tahir Mehmood Khan and Muhammad Abdul Hadi
    Citation: BMC Cancer 2017 17:903
    Content type: Research article Published on:

  2. No consensus treatment has been reached for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). Hepatic resection (HR) and transarterial chemoembolization (TACE) have been recommended as eff...

    Authors: Xiu-Ping Zhang, Kang Wang, Nan Li, Cheng-Qian Zhong, Xu-Biao Wei, Yu-Qiang Cheng, Yu-Zhen Gao, Han Wang and Shu-Qun Cheng
    Citation: BMC Cancer 2017 17:902
    Content type: Research article Published on:

  4. TP53 is the most frequently mutated gene in human cancers. Previous studies reported that TP53 mutations correlated with poor prognoses in patients with head and neck squamous cell car...

    Authors: Go Omura, Mizuo Ando, Yasuhiro Ebihara, Yuki Saito, Kenya Kobayashi, Osamu Fukuoka, Ken Akashi, Masafumi Yoshida, Takahiro Asakage and Tatsuya Yamasoba
    Citation: BMC Cancer 2017 17:898
    Content type: Research article Published on:

  5. Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation of tumor clusters with a pseudopapillary arrangeme...

    Authors: María F. Mercogliano, Gloria Inurrigarro, Mara De Martino, Leandro Venturutti, Martín A. Rivas, Rosalía Cordo-Russo, Cecilia J. Proietti, Elmer A. Fernández, Isabel Frahm, Sabrina Barchuk, Daniel H. Allemand, Silvina Figurelli, Ernesto Gil Deza, Sandra Ares, Felipe G. Gercovich, Eduardo Cortese…
    Citation: BMC Cancer 2017 17:895
    Content type: Research article Published on:

  6. Adoptive immunotherapy offers great potential for treating many types of cancer but its clinical application is hampered by cross-reactive T cell responses in healthy human tissues, representing serious safety...

    Authors: Victor Jaravine, Anja Mösch, Silke Raffegerst, Dolores J. Schendel and Dmitrij Frishman
    Citation: BMC Cancer 2017 17:892
    Content type: Software Published on:

  7. The aim of this study was to evaluate the value of 18F–FDG PET/CT (PET/CT) and MRI for local and/or whole-body restaging of adenoid cystic carcinoma of the head and neck (ACC).

    Authors: Verena Ruhlmann, Thorsten D. Poeppel, Johannes Veit, James Nagarajah, Lale Umutlu, Thomas K. Hoffmann, Andreas Bockisch, Ken Herrmann and Wolfgang Sauerwein
    Citation: BMC Cancer 2017 17:887
    Content type: Research article Published on:

  8. EphA2 is a crucial oncogene in gastric cancer (GC) development and metastasis, this study aims to identify microRNAs that target it and serve as key regulators of gastric carcinogenesis.

    Authors: Jin Huang, Yijing He, Howard L. Mcleod, Yanchun Xie, Desheng Xiao, Huabin Hu, Pan Chen, Liangfang Shen, Shan Zeng, Xianli Yin, Jie Ge, Li Li, Lanhua Tang, Jian Ma and Zihua Chen
    Citation: BMC Cancer 2017 17:886
    Content type: Research article Published on:

  9. This phase II bridging study assessed the safety and efficacy of nab-paclitaxel/gemcitabine (Metastatic Pancreatic Adenocarcinoma Clinical Trial [MPACT] regimen) in Chinese patients with metastatic pancreatic can...

    Authors: Ruihua Xu, Xianjun Yu, Jihui Hao, Liwei Wang, Hongming Pan, Guohong Han, Jianming Xu, Yanqiao Zhang, Shujun Yang, Jia Chen, Jieer Ying, Guanghai Dai, Mingyu Li, Damir Begic, Brian Lu and Lin Shen
    Citation: BMC Cancer 2017 17:885
    Content type: Research article Published on:

  10. The primary aim of this study was to evaluate the safety of a novel dendritic cell (DC) vaccine pulsed with survivin and MUC1, silenced with suppressor of cytokine signaling 1 (SOCS1), and immune stimulated wi...

    Authors: Chunlei Ge, Ruilei Li, Haifeng Song, Tao Geng, Jinyan Yang, Qinghua Tan, Linfeng Song, Ying Wang, Yuanbo Xue, Zhen Li, Suwei Dong, Zhiwei Zhang, Na Zhang, Jiyin Guo, Lin Hua, Siyi Chen…
    Citation: BMC Cancer 2017 17:884
    Content type: Research article Published on:

  11. Cisplatin (CP), an effective anticancer agent, carries the risk of impairing testicular function leading to infertility. The present study aimed at evaluating the protective effect of A. hydaspica ethyl acetate e...

    Authors: Tayyaba Afsar, Suhail Razak, Muhammad Rashid khan and Ali Almajwal
    Citation: BMC Cancer 2017 17:883
    Content type: Research article Published on:

  12. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are easily obtained from routine blood tests. We investigated the associations of the NLR and PLR with the clinical parameters an...

    Authors: Dan Liu, Yi Huang, Lei Li, Juan Song, Li Zhang and Weimin Li
    Citation: BMC Cancer 2017 17:882
    Content type: Research article Published on:

  13. Because glycosylation is one of the most common post-translational modifications of proteins and because changes in glycosylation have been shown to have a significant correlation with the development of many ...

    Authors: Jie Chen, Meng Fang, Xiaoling Chen, Changhong Yi, Jun Ji, Cheng Cheng, Mengmeng Wang, Xing Gu, Quansheng Sun and Chunfang Gao
    Citation: BMC Cancer 2017 17:881
    Content type: Research article Published on:

  14. It is well known that patient characteristics and survival outcomes in randomized trials may not necessarily be similar to those in real-life clinical practice. The aim of the present study was to analyse seco...

    Authors: Radek Lakomy, Alexandr Poprach, Zbynek Bortlicek, Bohuslav Melichar, Renata Chloupkova, Rostislav Vyzula, Milada Zemanova, Katerina Kopeckova, Marek Svoboda, Ondrej Slaby, Igor Kiss, Hana Studentova, Jaroslav Juracek, Ondrej Fiala, Jindrich Kopecky, Jindrich Finek…
    Citation: BMC Cancer 2017 17:880
    Content type: Research article Published on:

  15. Chlorella vulgaris (ChV), a unicellular green algae has been reported to have anticancer and antioxidant effects. The aim of this study was to determine the chemopreventive effect of C...

    Authors: Khaizurin Tajul Arifin, Suhaniza Sulaiman, Suhana Md Saad, Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah and Yasmin Anum Mohd Yusof
    Citation: BMC Cancer 2017 17:879
    Content type: Research article Published on:

  16. Prostate is susceptible to infection and pro-inflammatory agents in a man’s whole life. Chronic inflammation might play important roles in the development and progression of prostate cancer. Mesenchymal stem c...

    Authors: Ke-Qin Yang, Yan Liu, Qing-Hua Huang, Ning Mo, Qing-Yun Zhang, Qing-Gui Meng and Ji-Wen Cheng
    Citation: BMC Cancer 2017 17:878
    Content type: Research article Published on:

  17. Ultrasonography (US) is recommended as a standard surveillance tool for patients with a high risk of developing hepatocellular carcinoma (HCC). However, the low sensitivity of US for small HCC can lead to surv...

    Authors: Hyun A Kim, Kyung Ah Kim, Joon-Il Choi, Jeong Min Lee, Chang Hee Lee, Tae Wook Kang, Young-Mi Ku, Su Lim Lee, Yang Shin Park, Jeong Hee Yoon, Seong Hyun Kim and Moon Hyung Choi
    Citation: BMC Cancer 2017 17:877
    Content type: Study protocol Published on:

  19. The role of stress signals in regulating gastric cancer initiation and progression is not quite clear. It is known that stress signals modulate multiple processes such as immune function, cell migration and an...

    Authors: Yanjie Lu, Qian Xu, Yanzhen Zuo, Lei Liu, Shaochen Liu, Lei Chen, Kang Wang, Yuntao Lei, Xiangyang Zhao and Yuhong Li
    Citation: BMC Cancer 2017 17:875
    Content type: Research article Published on:

  20. Histones undergo extensive post-translational modifications and this epigenetic regulation plays an important role in modulating transcriptional programs capable of driving cancer progression. Acetylation of h...

    Authors: Shivashankar Damodaran, Nathan Damaschke, Joseph Gawdzik, Bing Yang, Cedric Shi, Glenn O. Allen, Wei Huang, John Denu and David Jarrard
    Citation: BMC Cancer 2017 17:874
    Content type: Research article Published on:

  21. Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) differ with respect to their biology and genomic patterns, but inflammatory index variation did not fully investigate. This study aimed to exami...

    Authors: Lin Yang, Wenzhuo He, Pengfei Kong, Chang Jiang, Qiong Yang, Qiankun Xie and Liang Ping Xia
    Citation: BMC Cancer 2017 17:873
    Content type: Research article Published on:

  22. Cervical cancer is the most common cancer in women living in Vientiane, Lao People’s Democratic Republic (PDR). This study examines cervical cytology using a liquid-based cytology (LBC) method and reports the ...

    Authors: Reika Takamatsu, Viengvansay Nabandith, Vatsana Pholsena, Phouthasone Mounthisone, Katsu Nakasone, Kentarou Ohtake and Naoki Yoshimi
    Citation: BMC Cancer 2017 17:872
    Content type: Research article Published on:

  23. Case reports, retrospective analyses, and observational studies have linked the use of cisplatin to increased risk of second cancers, especially life-threatening secondary leukemia. We therefore performed a sy...

    Authors: Fei Liang, Sheng Zhang, Hongxi Xue and Qiang Chen
    Citation: BMC Cancer 2017 17:871
    Content type: Research article Published on:

  24. Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug’s survival benefits is challenging be...

    Authors: Tomoyuki Hayashi, Taro Yamashita, Takeshi Terashima, Tsuyoshi Suda, Hikari Okada, Yoshiro Asahina, Takehiro Hayashi, Yasumasa Hara, Kouki Nio, Hajime Sunagozaka, Hajime Takatori, Kuniaki Arai, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda…
    Citation: BMC Cancer 2017 17:870
    Content type: Research article Published on:

  27. Preliminary evidence suggests that changes in plasma brain-derived neurotrophic factor (BDNF) levels may contribute to the occurrence of chemotherapy-associated cognitive impairment (CACI), and a previous stud...

    Authors: Terence Ng, Ying Yun Lee, Jung-woo Chae, Angie Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Raymond C. H. Ng, Pat Pak Yan Chu, Chiea Chuen Khor, Han Kiat Ho and Alexandre Chan
    Citation: BMC Cancer 2017 17:867
    Content type: Research article Published on:

  28. Capecitabine is an oral prodrug of fluorouracil, which is a common agent used in the management of many solid tumor malignancies. Dermatologic reaction is common with various chemotherapy agents but is not com...

    Authors: Rena A. Shah, Daniel D. Bennett and Mark E. Burkard
    Citation: BMC Cancer 2017 17:866
    Content type: Case report Published on:

  29. Low income and uninsured individuals often have lower adherence to cancer screening for breast, cervical and colorectal cancer. Health fairs are a common community outreach strategy used to provide cancer-rela...

    Authors: Cam Escoffery, Shuting Liang, Kirsten Rodgers, Regine Haardoerfer, Grace Hennessy, Kendra Gilbertson, Natalia I. Heredia, Leticia A. Gatus and Maria E. Fernandez
    Citation: BMC Cancer 2017 17:865
    Content type: Research article Published on:

  30. The global incidence of melanoma has been increasing faster than any other form of cancer. New therapies offer exciting prospects for improved survival, but the development of resistance is a major problem and...

    Authors: Liang Song, Ewan M. McNeil, Ann-Marie Ritchie, Katy R. Astell, Charlie Gourley and David W. Melton
    Citation: BMC Cancer 2017 17:864
    Content type: Research article Published on:

  31. Obesity is linked to poor disease outcomes in breast cancer patients. However, this link was mostly based on body weight or BMI rather than body-fat. The purpose of this study was to evaluate the relationship ...

    Authors: Li-Ni Liu, Yung-Chang Lin, Christine Miaskowski, Shin-Cheh Chen and Mei-Ling Chen
    Citation: BMC Cancer 2017 17:863
    Content type: Research article Published on:

  32. Hepatocellular carcinoma (HCC) is the leading cause of cancer mortality. Chemical and virus induction are two major risk factors, however, the potential molecular mechanisms of their differences remain elusive...

    Authors: Qin Tang, Qi Wang, Qiong Zhang, Sheng-Yan Lin, Yanhong Zhu, Xiangliang Yang and An-Yuan Guo
    Citation: BMC Cancer 2017 17:862
    Content type: Research article Published on:

  33. The significance of PLK1 (polo-like kinase 1) has become increasingly essential as both a biomarker and a target for cancer treatment. Here, we aimed to determine the downstream genes of PLK1 and their effects...

    Authors: Zhe Zhang, Guojun Zhang, Zhipeng Gao, Shiguang Li, Zeliang Li, Jianbin Bi, Xiankui Liu, Zhenhua Li and Chuize Kong
    Citation: BMC Cancer 2017 17:861
    Content type: Research article Published on:

  34. Physician recommendations for colorectal cancer (CRC) screening have consistently been shown to be a strong predictor of screening. The aim of this study was to investigate perceptions of CRC screening modalit...

    Authors: Hye Young Shin, Mina Suh, Boyoung Park, Jae Kwan Jun and Kui Son Choi
    Citation: BMC Cancer 2017 17:860
    Content type: Research article Published on:

  35. In a previous paper, we had assumed that the risk of screen-detected breast cancer mostly reflects inherent risk, and the risk of whether a breast cancer is interval versus screen-detected mostly reflects risk...

    Authors: Kavitha Krishnan, Laura Baglietto, Jennifer Stone, Catriona McLean, Melissa C. Southey, Dallas R. English, Graham G. Giles and John L. Hopper
    Citation: BMC Cancer 2017 17:859
    Content type: Research article Published on:

  36. Well-known anti-malarial drug artemisinin exhibits potent anti-cancerous activities. In-vivo and in-vitro studies showed its anti-tumor and immunomodulatory properties signifying it as a potent drug candidate ...

    Authors: Kanchan Kumari, Sunita Keshari, Debomita Sengupta, Surendra C. Sabat and Sandip K. Mishra
    Citation: BMC Cancer 2017 17:858
    Content type: Research article Published on:

  37. Primary liver cancer is a lethal malignancy with a high mortality worldwide. Currently, sorafenib is the most effective molecular-targeted drug against hepatocellular carcinoma (HCC). However, the sorafenib re...

    Authors: Yinzong Xiao, Lunquan Sun, Yongming Fu, Yan Huang, Rongrong Zhou, Xingwang Hu, Pengcheng Zhou, Jun Quan, Ning Li and Xue-Gong Fan
    Citation: BMC Cancer 2017 17:857
    Content type: Research article Published on:

  40. Histone demethylase JARID1B plays several context dependent roles in epigenetic regulation of cellular differentiation in normal development and is highly expressed in multiple human cancers. The protein is a ...

    Authors: Łukasz Kuźbicki, Dariusz Lange, Agata Stanek-Widera and Barbara W. Chwirot
    Citation: BMC Cancer 2017 17:854
    Content type: Research article Published on:

  41. Pancreatic schwannoma is a rare tumor. Preoperative diagnosis of pancreatic schwannoma is challenging due to its tendency to mimic other lesions of the pancreas. We describe a case of pancreatic schwannoma and...

    Authors: Yuntong Ma, Bingqi Shen, Yingmei Jia, Yanji Luo, Yisu Tian, Zhi Dong, Wei Chen, Zi-Ping Li and Shi-Ting Feng
    Citation: BMC Cancer 2017 17:853
    Content type: Case report Published on:

  42. Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to hav...

    Authors: John F. Seymour, Hartmut Döhner, Aleksandra Butrym, Agnieszka Wierzbowska, Dominik Selleslag, Jun Ho Jang, Rajat Kumar, James Cavenagh, Andre C. Schuh, Anna Candoni, Christian Récher, Irwindeep Sandhu, Teresa Bernal del Castillo, Haifa Kathrin Al-Ali, Jose Falantes, Richard M. Stone…
    Citation: BMC Cancer 2017 17:852
    Content type: Research article Published on:

  44. Over the last decades numerous initiatives have been set up that aim at translating the best available medical knowledge and treatment into clinical practice. The inherent complexity of the programs and discre...

    Authors: Christoph Kowalski, Ullrich Graeven, Christof von Kalle, Hauke Lang, Matthias W. Beckmann, Jens-Uwe Blohmer, Martin Burchardt, Michael Ehrenfeld, Jan Fichtner, Stephan Grabbe, Hans Hoffmann, Heinrich Iro, Stefan Post, Anton Scharl, Uwe Schlegel, Thomas Seufferlein…
    Citation: BMC Cancer 2017 17:850
    Content type: Debate Published on:

  45. Colorectal carcinoma (CRC) is one of the most common causes of cancer-related deaths. The mean age of patients with CRC ranges from 49 to 60 years. Pediatric CRC is unusual, which often escapes early diagnosis...

    Authors: Yung-Sung Yeh, Yu-Tang Chang, Cheng-Jen Ma, Ching-Wen Huang, Hsiang-Lin Tsai, Yi-Ting Chen and Jaw-Yuan Wang
    Citation: BMC Cancer 2017 17:849
    Content type: Case report Published on:

  46. Evidence suggests that risk of colorectal and prostate cancer is increased among those with a family history of the same disease, particularly among first-degree relatives. However, the aggregation of colorect...

    Authors: Jennifer L. Beebe-Dimmer, Cecilia Yee, Electra Paskett, Ann G. Schwartz, Dorothy Lane, Nynikka R. A. Palmer, Cathryn H. Bock, Rami Nassir and Michael S. Simon
    Citation: BMC Cancer 2017 17:848
    Content type: Research article Published on:

  47. In Chile, more than 500 women die every year from cervical cancer, and a majority of Chilean women are not up-to-date with their Papanicolau (Pap) test. Mobile health has great potential in many health areas, ...

    Authors: McKenzie C. Momany, Javiera Martinez-Gutierrez, Mauricio Soto, Daniel Capurro, Francis Ciampi, Beti Thompson and Klaus Puschel
    Citation: BMC Cancer 2017 17:847
    Content type: Study protocol Published on:

  48. p53R2 is a target of p53 gene, which is essential for DNA repair, mitochondrial DNA synthesis, protection against oxidative stress, chromosomal instability, chronic inflammation and tumorigenesis. This study i...

    Authors: Jiewei Chen, Shuman Li, Yongbo Xiao, Xuan Zou, Xinke Zhang, Mingshu Zhu, Muyan Cai and Dan Xie
    Citation: BMC Cancer 2017 17:846
    Content type: Research article Published on:

  49. Gastric cancers frequently overexpress the epidermal growth factor receptor (EGFR), which has been implicated in pathological processes including tumor cell motility, invasion and metastasis. Targeting EGFR wi...

    Authors: Simone Keller, Julia Kneissl, Verena Grabher-Meier, Stefan Heindl, Jan Hasenauer, Dieter Maier, Julian Mattes, Peter Winter and Birgit Luber
    Citation: BMC Cancer 2017 17:845
    Content type: Research article Published on:

  50. The prevalence of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is 2 to 5% in the Caucasian population. HNPCC is caused by genomic mutations in DNA mismatch repair genes (MMR), namely MLH1, MSH2, MSH6, PMS2,

    Authors: Jasmine Lee, Yin-Yi Xiao, Yan Yu Sun, Jasminka Balderacchi, Bradley Clark, Jatin Desani, Vivek Kumar, Angela Saverimuthu, Khin Than Win, Yiwu Huang and Yiqing Xu
    Citation: BMC Cancer 2017 17:843
    Content type: Research article Published on:

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