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  1. The objective of this study is to develop, implement, and evaluate a training program for healthcare providers to improve ability to provide psychosocial support to breast cancer survivors in Korea.

    Authors: Eunyoung Park, Junghee Yoon, Eun-kyung Choi, Im Ryung Kim, Danbee Kang, Se-Kyung Lee, Jeong Eon Lee, Seok Jin Nam, Jin Seok Ahn, Adriaan Visser and Juhee Cho
    Citation: BMC Cancer 2018 18:45
    Content type: Research article Published on:

  2. Bone metastases commonly occur in conjunction with solid tumors, and are associated with serious bone complications. Population-based estimates of bone metastasis incidence are limited, often based on autopsy ...

    Authors: Rohini K. Hernandez, Sally W. Wade, Adam Reich, Melissa Pirolli, Alexander Liede and Gary H. Lyman
    Citation: BMC Cancer 2018 18:44
    Content type: Research article Published on:

  3. Interventions to improve fecal testing for colorectal cancer (CRC) exist, but are not yet routine practice. We conducted this systematic review to determine how implementation strategies and contextual factors...

    Authors: Melinda M. Davis, Michele Freeman, Jackilen Shannon, Gloria D. Coronado, Kurt C. Stange, Jeanne-Marie Guise, Stephanie B. Wheeler and David I. Buckley
    Citation: BMC Cancer 2018 18:40
    Content type: Research article Published on:

  5. Colorectal cancer is the 4th common cancer in China. Most colorectal cancers are due to modifiable lifestyle factors, but few studies have provided a systematic evidence-based assessment of the burden of color...

    Authors: Meng-Jia Gu, Qiu-Chi Huang, Cheng-Zhen Bao, Ying-Jun Li, Xiao-Qin Li, Ding Ye, Zhen-Hua Ye, Kun Chen and Jian-Bing Wang
    Citation: BMC Cancer 2018 18:38
    Content type: Research article Published on:

  6. Breast cancer anti-estrogen resistance 1 (BCAR1/p130cas) is a hub for diverse oncogenic signaling cascades and promotes tumor development and progression.

    Authors: Asmus Heumann, Nina Heinemann, Claudia Hube-Magg, Dagmar S. Lang, Katharina Grupp, Martina Kluth, Sarah Minner, Christina Möller-Koop, Markus Graefen, Hans Heinzer, Maria Christina Tsourlakis, Waldemar Wilczak, Corinna Wittmer, Frank Jacobsen, Hartwig Huland, Ronald Simon…
    Citation: BMC Cancer 2018 18:37
    Content type: Research article Published on:

  7. Activated pancreatic stellate cells (PaSCs) are the key cellular source of cancer-associated fibroblasts in the pancreatic stroma of patients with pancreatic ductal adenocarcinoma (PDAC), however, the activati...

    Authors: Haiyan Song and Yuxiang Zhang
    Citation: BMC Cancer 2018 18:36
    Content type: Research article Published on:

  8. Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair d...

    Authors: Lochlan J. Fennell, Saara Jamieson, Diane McKeone, Tracie Corish, Megan Rohdmann, Tori Furner, Mark Bettington, Cheng Liu, Futoshi Kawamata, Catherine Bond, Jolieke Van De Pols, Barbara Leggett and Vicki Whitehall
    Citation: BMC Cancer 2018 18:35
    Content type: Research article Published on:

  11. Breast cancer has a high case fatality rate in sub-Saharan Africa, and this is chiefly because of late detection and inadequate treatment resources. Progressive renovations in diagnostic and management modalit...

    Authors: Bibiana Ateh Nzeangung, Martin Essomba Biwole, Benjamin Momo Kadia, Ndemazie Nkafu Bechem, Christian Akem Dimala and Albert Mouelle Sone
    Citation: BMC Cancer 2018 18:32
    Content type: Research article Published on:

  12. The Intratumoral Microvessel Density (IMVD) is commonly used to quantify tumoral vascularization and is usually assessed by pan-endothelial markers, such as CD31. Endoglin (CD105) is a protein predominantly ex...

    Authors: Virginia Di Paolo, Ida Russo, Renata Boldrini, Lucilla Ravà, Marco Pezzullo, Maria Chiara Benedetti, Angela Galardi, Marta Colletti, Rossella Rota, Domenico Orlando, Alessandro Crocoli, Hector Peinado, Giuseppe Maria Milano and Angela Di Giannatale
    Citation: BMC Cancer 2018 18:31
    Content type: Research article Published on:

  13. Protein neddylation is a post-translational modification by a covalent conjugation with the neural precursor cell expressed, developmentally downregulated 8 (NEDD8). Although this process has been reported to ...

    Authors: Sung Yeon Park, Jong-Wan Park, Gun-Woo Lee, Lan Li and Yang-Sook Chun
    Citation: BMC Cancer 2018 18:30
    Content type: Research article Published on:

  14. The goal of this exploratory study was to develop and assess a prediction model which can potentially be used as a biomarker of breast cancer, based on anthropometric data and parameters which can be gathered ...

    Authors: Miguel Patrício, José Pereira, Joana Crisóstomo, Paulo Matafome, Manuel Gomes, Raquel Seiça and Francisco Caramelo
    Citation: BMC Cancer 2018 18:29
    Content type: Research article Published on:

  15. Neuroblastoma is a paediatric cancer that despite multimodal therapy still has a poor outcome for many patients with high risk tumours. Retinoic acid (RA) promotes differentiation of some neuroblastoma tumours...

    Authors: Rasha Swadi, Grace Mather, Barry L. Pizer, Paul D. Losty, Violaine See and Diana Moss
    Citation: BMC Cancer 2018 18:28
    Content type: Research article Published on:

  16. Lin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells. Because Lin28B parti...

    Authors: Ting-ting Qu, Fei Chen, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen and Ye Zhang
    Citation: BMC Cancer 2018 18:27
    Content type: Research article Published on:

  17. Early diagnosis of colorectal cancer (CRC) simplifies treatment and improves treatment outcomes. We previously described a diagnostic metabolomic biomarker derived from semi-quantitative gas chromatography-mas...

    Authors: Farshad Farshidfar, Karen A. Kopciuk, Robert Hilsden, S. Elizabeth McGregor, Vera C. Mazurak, W. Donald Buie, Anthony MacLean, Hans J. Vogel and Oliver F. Bathe
    Citation: BMC Cancer 2018 18:26
    Content type: Research article Published on:

  18. We examined incidence and survival in relation to age, gender, socioeconomic deprivation, rurality and trends over time. We also examined the association between volume of patients treated by hospitals and sur...

    Authors: Ravi Maheswaran and Nick Morley
    Citation: BMC Cancer 2018 18:25
    Content type: Research article Published on:

  19. Although cases of multiple primary malignant neoplasms are increasing, reports of more than three or four primary metachronous malignant neoplasms are extremely rare. Moreover, very few publications have provi...

    Authors: Keiichi Arakawa, Keisuke Hata, Yoko Yamamoto, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Masafumi Yoshida, Hiroshi Fukuhara, Mitsuhiro Fujishiro, Teppei Morikawa, Tatsuya Yamasoba, Kazuhiko Koike, Masashi Fukayama and Toshiaki Watanabe
    Citation: BMC Cancer 2018 18:24
    Content type: Case report Published on:

  20. The Grainyhead-like (GRHL) transcription factors have been linked to many different types of cancer. However, no previous study has attempted to investigate potential correlations in expression of different GRHL ...

    Authors: Agnieszka Kikulska, Tobias Rausch, Ewa Krzywinska, Magdalena Pawlak, Bartek Wilczynski, Vladimir Benes, Piotr Rutkowski and Tomasz Wilanowski
    Citation: BMC Cancer 2018 18:23
    Content type: Research article Published on:

  22. Though the incidence of Testicular cancer among young is rising, little attention is given to promoting testicular self-examination which is recommended for its early prevention in developing countries. This stud...

    Authors: Hordofa Gutema, Yamrot Debela, Bizuayehu Walle, Kidist Reba and Habtamu Wondiye
    Citation: BMC Cancer 2018 18:21
    Content type: Research article Published on:

  23. Aberrant overexpression of PIWI/piRNA pathway proteins is shown for many types of tumors. Interestingly, these proteins are downregulated in testicular germ cell tumors (TGCTs) compared to normal testis tissue...

    Authors: Ildar V. Gainetdinov, Yulia V. Skvortsova, Sofia A. Kondratieva, Alexey Klimov, Alexey A. Tryakin and Tatyana L. Azhikina
    Citation: BMC Cancer 2018 18:20
    Content type: Research article Published on:

  24. Body image is a complex post-treatment concern among female patients with breast cancer, and various tools have been developed and applied to measure this multifaceted issue. However, these available tools wer...

    Authors: Kaina Zhou, Xiaole He, Lanting Huo, Jinghua An, Minjie Li, Wen Wang and Xiaomei Li
    Citation: BMC Cancer 2018 18:19
    Content type: Research article Published on:

  25. Cancer survival comes at a price: pediatric cancer survivors bear a high risk for a wide range of cognitive difficulties. Therefore, interventions targeting these difficulties are required. The aim of the pres...

    Authors: Valentin Benzing, Noëmi Eggenberger, Janine Spitzhüttl, Valerie Siegwart, Manuela Pastore-Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Theda Heinks, Mirko Schmidt, Achim Conzelmann, Maja Steinlin, Regula Everts and Kurt Leibundgut
    Citation: BMC Cancer 2018 18:18
    Content type: Study protocol Published on:

  26. The key-stone-pathogen, Porphyromonas gingivalis associates not only with periodontal diseases but with a variety of other chronic diseases such as cancer. We previously reported an association between the presen...

    Authors: She-Gan Gao, Jun-Qiang Yang, Zhi-Kun Ma, Xiang Yuan, Chen Zhao, Guang-Chao Wang, Hua Wei, Xiao-Shan Feng and Yi-Jun Qi
    Citation: BMC Cancer 2018 18:17
    Content type: Research article Published on:

  27. Approximately 10–15% of ovarian carcinomas (OC) are attributed to inherited susceptibility, the majority of which are due to mutations in BRCA1 or BRCA2 (BRCA1/2). These patients display superior clinical outcome...

    Authors: Robert L. Hollis, Alison M. Meynert, Michael Churchman, Tzyvia Rye, Melanie Mackean, Fiona Nussey, Mark J. Arends, Andrew H. Sims, Colin A. Semple, C. Simon Herrington and Charlie Gourley
    Citation: BMC Cancer 2018 18:16
    Content type: Research article Published on:

  28. Glioblastoma relapses in the vast majority of cases within 1 year. Maximum safe resection of the recurrent glioblastoma can be offered in some cases. Re-irradiation has been established for the treatment of re...

    Authors: Christoph Straube, Hagen Scherb, Jens Gempt, Jan Kirschke, Claus Zimmer, Friederike Schmidt-Graf, Bernhard Meyer and Stephanie E. Combs
    Citation: BMC Cancer 2018 18:15
    Content type: Study protocol Published on:

  29. Availability and affordability of anticancer medicines is a matter of great concern especially for low and middle income countries e.g., Pakistan. Prime focus of this study was to evaluate the availability of ...

    Authors: Muhammad Rehan Sarwar, Sadia Iftikhar and Anum Saqib
    Citation: BMC Cancer 2018 18:14
    Content type: Research article Published on:

  30. Regulated cell death (RCD) is a mechanism by which the cell activates its own machinery to self-destruct. RCD is important for the maintenance of tissue homeostasis and its deregulation is involved in diseases...

    Authors: Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Milena Benítez-Londoño, Moises Armides Franco-Molina and Cristina Rodríguez-Padilla
    Citation: BMC Cancer 2018 18:13
    Content type: Research article Published on:

  31. Currently, some studies have demonstrated that miR-34a could serve as a suppressor of several cancers including hepatocellular carcinoma (HCC). Previously, we discovered that miR-34a was downregulated in HCC a...

    Authors: Fang-Hui Ren, Hong Yang, Rong-quan He, Jing-ning Lu, Xing-gu Lin, Hai-Wei Liang, Yi-Wu Dang, Zhen-Bo Feng, Gang Chen and Dian-Zhong Luo
    Citation: BMC Cancer 2018 18:12
    Content type: Research article Published on:

  32. In metastatic colorectal cancer (mCRC), the localization of the primary tumour has been shown to be of prognostic as well as predictive relevance.

    Authors: Florian Huemer, Josef Thaler, Gudrun Piringer, Hubert Hackl, Lisa Pleyer, Clemens Hufnagl, Lukas Weiss and Richard Greil
    Citation: BMC Cancer 2018 18:11
    Content type: Research article Published on:

  33. To compare the efficacy of crizotinib, pemetrexed and other chemotherapy regimens as a first-line treatment in patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in real...

    Authors: Jianya Zhou, Jing Zheng, Xiaochen Zhang, Jing Zhao, Yanping Zhu, Qian Shen, Yuehong Wang, Ke Sun, Zeying Zhang, Zhijie Pan, Yihong Shen and Jianying Zhou
    Citation: BMC Cancer 2018 18:10
    Content type: Research article Published on:

  34. To investigate the predictive value of chemokine CCL27 for identifying early stage nasopharyngeal carcinoma (NPC) patients within a population seropositive for Epstein-Barr virus (EBV) capsid antigen-specific ...

    Authors: Min-jie Mao, Ning Xue, Xue-ping Wang, Pei-dong Chi, Yi-jun Liu, Qi Huang, Shu-qin Dai and Wan-li Liu
    Citation: BMC Cancer 2018 18:9
    Content type: Research article Published on:

  35. Invasive cribriform and intraductal carcinoma (CR/IDC) is associated with adverse outcome of prostate cancer patients. The aim of this study was to determine the molecular aberrations associated with CR/IDC in...

    Authors: René Böttcher, Charlotte F. Kweldam, Julie Livingstone, Emilie Lalonde, Takafumi N. Yamaguchi, Vincent Huang, Fouad Yousif, Michael Fraser, Robert G. Bristow, Theodorus van der Kwast, Paul C. Boutros, Guido Jenster and Geert J. L. H. van Leenders
    Citation: BMC Cancer 2018 18:8
    Content type: Research article Published on:

  36. Extra-abdominal metastases in low grade endometrial carcinoma are rare events. Inguinal lymphatic spread occurs usually in advanced disease and is associated with abdominal lymph nodes involvement. To our know...

    Authors: Anna Myriam Perrone, Giulia Girolimetti, Simona Cima, Ivana Kurelac, Alessandra Livi, Giacomo Caprara, Donatella Santini, Paolo Castellucci, Alessio Giuseppe Morganti, Giuseppe Gasparre and Pierandrea De Iaco
    Citation: BMC Cancer 2018 18:7
    Content type: Case report Published on:

  37. LUX-Lung 3 showed afatinib improved progression-free survival (PFS) compared with cisplatin plus pemetrexed in patients with epidermal growth factor receptor (EGFR) mutations. In this study, chemotherapy efficacy...

    Authors: Toshihiko Kaneda, Hiroshige Yoshioka, Motohiro Tamiya, Akihiro Tamiya, Akito Hata, Asukaka Okada, Takashi Niwa, Takayuki Shiroyama, Masaki Kanazu, Tadashi Ishida and Nobuyuki Katakami
    Citation: BMC Cancer 2018 18:6
    Content type: Research article Published on:

  38. Systemic inflammatory parameters are associated with poor outcomes in malignant patients. Several inflammation-based cumulative prognostic score systems were established for various solid tumors. However, ther...

    Authors: Feifei Sun, Jia Zhu, Suying Lu, Zijun Zhen, Juan Wang, Junting Huang, Zonghui Ding, Musheng Zeng and Xiaofei Sun
    Citation: BMC Cancer 2018 18:5
    Content type: Research article Published on:

  39. Programmed cell death ligand 1 (PD-L1) is a potential predictive biomarker of the response to anti-PD-L1/anti- programmed cell death 1 (PD-1) therapy in multiple cancers, including triple negative breast cance...

    Authors: Ming Li, Anqi Li, Shuling Zhou, Yan Xu, Yaoxing Xiao, Rui Bi and Wentao Yang
    Citation: BMC Cancer 2018 18:4
    Content type: Research article Published on:

  40. Zebrafish (Danio rerio) is a model organism that has emerged as a tool for cancer research, cancer being the second most common cause of death after cardiovascular disease for humans in the developed world. Zebra...

    Authors: Pablo Cabezas-Sainz, Jorge Guerra-Varela, María J. Carreira, Javier Mariscal, María Roel, Juan A. Rubiolo, Andrés A. Sciara, Miguel Abal, Luis M. Botana, Rafael López and Laura Sánchez
    Citation: BMC Cancer 2018 18:3
    Content type: Research article Published on:

  41. Prostate Cancer (PCa) is the second most prevalent cancer among U.S. males. In recent decades many men with low risk PCa have been over diagnosed and over treated. Given significant co-morbidities associated w...

    Authors: Katerina Pestova, Adam J. Koch, Charles P. Quesenberry, Jun Shan, Ying Zhang, Amethyst D. Leimpeter, Beth Blondin, Svetlana Sitailo, Lela Buckingham, Jing Du, Huixin Fei and Stephen K. Van Den Eeden
    Citation: BMC Cancer 2018 18:2
    Content type: Research article Published on:

  42. Head and neck cancer squamous cell carcinoma (HNSSC) patients report substantial rates of clinically significant depression and/or anxiety, with dysphagia being a predictor of distress and poorer quality of li...

    Authors: J. M. Patterson, M. Fay, C. Exley, E. McColl, M. Breckons and V. Deary
    Citation: BMC Cancer 2018 18:1
    Content type: Research article Published on:

  43. Immunologic factors can promote the progression of oral squamous cell carcinomas (oscc). The phylogenetic highly conserved protein Galectin 3 (Gal3) contributes to cell differentiation and immune homeostasis. ...

    Authors: Manuel Weber, Maike Büttner-Herold, Luitpold Distel, Jutta Ries, Patrick Moebius, Raimund Preidl, Carol I. Geppert, Friedrich W. Neukam and Falk Wehrhan
    Citation: BMC Cancer 2017 17:906
    Content type: Research article Published on:

  44. Glioma stem cells (GSCs) contribute to tumor recurrence and drug resistance. This study characterizes the tumorigenesis of CD133+ cells and their sensitivity to pharmacological inhibition.

    Authors: Chia-Hsin Chang, Wei-Ting Liu, Hui-Chi Hung, Chia-Yu Gean, Hong-Ming Tsai, Chun-Lin Su and Po-Wu Gean
    Citation: BMC Cancer 2017 17:905
    Content type: Research article Published on:

  45. The purpose of this study was to determine prognostic factors influencing outcomes of surgical treatment in patients with T4a hypopharyngeal cancer.

    Authors: Sang-Yeon Kim, Young-Soo Rho, Eun-Chang Choi, Min-Sik Kim, Joo-Hyun Woo, Dong Hoon Lee, Eun Jae Chung, Min Woo Park, Da-Hee Kim and Young-Hoon Joo
    Citation: BMC Cancer 2017 17:904
    Content type: Research article Published on:

  46. This study provides a comprehensive examination of the histological features of non-neoplastic parenchyma in renal cell carcinoma (RCC). We prospectively collected radical nephrectomy (RN) specimens, to analyz...

    Authors: Xun Wang, Qiang Liu, Wen Kong, Jiwei Huang, Yonghui Chen, Yiran Huang and Jin Zhang
    Citation: BMC Cancer 2017 17:900
    Content type: Research article Published on:

  47. In Denmark, national roll-out of a population-based, screening mammography program took place in 2007–2010. We report on outcome of the first four biennial invitation rounds.

    Authors: Elsebeth Lynge, Martin Bak, My von Euler-Chelpin, Niels Kroman, Anders Lernevall, Nikolaj Borg Mogensen, Walter Schwartz, Adam Jan Wronecki and Ilse Vejborg
    Citation: BMC Cancer 2017 17:897
    Content type: Research article Published on:

  48. A wide range of studies has investigated the diagnostic proficiency of extracellular microRNAs (miRNAs) in hepatocellular cancer (HCC). HCC is expected to increase in Sub-Saharan Africa (SSA), due to endemic l...

    Authors: K. Sartorius, B. Sartorius, A. Kramvis, E. Singh, A. Turchinovich, B. Burwinkel, T. Madiba and C. A. Winkler
    Citation: BMC Cancer 2017 17:894
    Content type: Study protocol Published on:

  49. Historical data indicate that surgical resection may benefit select patients with metastatic gastric and gastroesophageal junction cancer. However, randomized clinical trials are lacking. The current RENAISSAN...

    Authors: Salah-Eddin Al-Batran, Thorsten O. Goetze, Daniel W. Mueller, Arndt Vogel, Michael Winkler, Sylvie Lorenzen, Alexander Novotny, Claudia Pauligk, Nils Homann, Thomas Jungbluth, Christoph Reissfelder, Karel Caca, Steffen Retter, Eva Horndasch, Julia Gumpp, Claus Bolling…
    Citation: BMC Cancer 2017 17:893
    Content type: Study protocol Published on:

  50. Survivin, belonging to the inhibitor of apoptosis (IAP) gene family, is abundantly expressed in tumors. It has been hypothesized that Survivin facilitates carcinogenesis by inhibition of apoptosis resulting in...

    Authors: Marina Conde, Susanne Michen, Ralf Wiedemuth, Barbara Klink, Evelin Schröck, Gabriele Schackert and Achim Temme
    Citation: BMC Cancer 2017 17:889
    Content type: Research article Published on:

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