Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5–29.
Article
PubMed
Google Scholar
Pal T, Permuth-Wey J, Betts JA, Krischer JP, Fiorica J, Arango H, et al. BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer. 2005;104(12):2807–16.
Article
CAS
PubMed
Google Scholar
Malander S, Rambech E, Kristoffersson U, Halvarsson B, Ridderheim M, Borg A, et al. The contribution of the hereditary nonpolyposis colorectal cancer syndrome to the development of ovarian cancer. Gynecol Oncol. 2006;101(2):238–43.
Article
CAS
PubMed
Google Scholar
Hollis RL, Gourley C. Genetic and molecular changes in ovarian cancer. Cancer Biol Med. 2016;13(2):236–47.
Article
PubMed
PubMed Central
Google Scholar
Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, et al. Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. Proc Natl Acad Sci U S A. 2011;108(44):18032–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Alsop K, Fereday S, Meldrum C, deFazio A, Emmanuel C, George J, et al. BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian ovarian cancer study group. J Clin Oncol. 2012;30(21):2654–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Moynahan ME, Chiu JW, Koller BH, Jasin M. Brca1 controls homology-directed DNA repair. Mol Cell. 1999;4(4):511–8.
Article
CAS
PubMed
Google Scholar
Tutt A, Bertwistle D, Valentine J, Gabriel A, Swift S, Ross G, et al. Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. EMBO J. 2001;20(17):4704–16.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tan DS, Rothermundt C, Thomas K, Bancroft E, Eeles R, Shanley S, et al. BRCAness syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations. J Clin Oncol Off J Am Soc Clin Oncol. 2008;26(34):5530–6.
Article
Google Scholar
Bolton KL, Chenevix-Trench G, Goh C, Sadetzki S, Ramus SJ, Karlan BY, et al. Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA. 2012;307(4):382–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Candido-dos-Reis FJ, Song H, Goode EL, Cunningham JM, Fridley BL, Larson MC, et al. Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer. Clin Cancer Res. 2015;21(3):652–7.
Article
CAS
PubMed
Google Scholar
Gourley C, Michie CO, Roxburgh P, Yap TA, Harden S, Paul J, et al. Increased incidence of visceral metastases in scottish patients with BRCA1/2-defective ovarian cancer: an extension of the ovarian BRCAness phenotype. J Clin Oncol Off J Am Soc Clin Oncol. 2010;28(15):2505–11.
Article
Google Scholar
Piek JM, Torrenga B, Hermsen B, Verheijen RH, Zweemer RP, Gille JJ, et al. Histopathological characteristics of BRCA1- and BRCA2-associated intraperitoneal cancer: a clinic-based study. Familial Cancer. 2003;2(2):73–8.
Article
PubMed
Google Scholar
Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, Rustin G, et al. Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. The Lancet Oncology. 2014;15(8):852–61.
Article
CAS
PubMed
Google Scholar
Safra T, Muggia F, Jeffers S, Tsao-Wei DD, Groshen S, Lyass O, et al. Pegylated liposomal doxorubicin (doxil): reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2. Ann Oncol. 2000;11(8):1029–33.
Article
CAS
PubMed
Google Scholar
Gabizon A, Martin F. Polyethylene glycol-coated (pegylated) liposomal doxorubicin. Rationale for use in solid tumours. Drugs. 1997;54(Suppl 4):15–21.
Article
CAS
PubMed
Google Scholar
Campos SM, Penson RT, Mays AR, Berkowitz RS, Fuller AF, Goodman A, et al. The clinical utility of liposomal doxorubicin in recurrent ovarian cancer. Gynecol Oncol. 2001;81(2):206–12.
Article
CAS
PubMed
Google Scholar
Gordon AN, Granai CO, Rose PG, Hainsworth J, Lopez A, Weissman C, et al. Phase II study of liposomal doxorubicin in platinum- and paclitaxel-refractory epithelial ovarian cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2000;18(17):3093–100.
Article
CAS
Google Scholar
Gewirtz DAA. Critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol. 1999;57(7):727–41.
Article
CAS
PubMed
Google Scholar
Kaye SB, Lubinski J, Matulonis U, Ang JE, Gourley C, Karlan BY, et al. Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30(4):372–9.
Article
CAS
Google Scholar
Safra T, Borgato L, Nicoletto MO, Rolnitzky L, Pelles-Avraham S, Geva R, et al. BRCA mutation status and determinant of outcome in women with recurrent epithelial ovarian cancer treated with pegylated liposomal doxorubicin. Mol Cancer Ther. 2011;10(10):2000–7.
Article
CAS
PubMed
Google Scholar
Safra T, Rogowski O, Muggia FM. The effect of germ-line BRCA mutations on response to chemotherapy and outcome of recurrent ovarian cancer. International journal of gynecological cancer: official journal of the international gynecological cancer. Society. 2014;24(3):488–95.
Google Scholar
Adams SF, Marsh EB, Elmasri W, Halberstadt S, Vandecker S, Sammel MD, et al. A high response rate to liposomal doxorubicin is seen among women with BRCA mutations treated for recurrent epithelial ovarian cancer. Gynecol Oncol. 2011;123(3):486–91.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pennington KP, Walsh T, Harrell MI, Lee MK, Pennil CC, Rendi MH, et al. Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas. Clin Cancer Res. 2014;20(3):764–75.
Article
CAS
PubMed
Google Scholar
Integrated genomic analyses of ovarian carcinoma. Nature. 2011;474(7353):609–15.
Moller P, Hagen AI, Apold J, Maehle L, Clark N, Fiane B, et al. Genetic epidemiology of BRCA mutations--family history detects less than 50% of the mutation carriers. European journal of cancer (Oxford, England: 1990). 2007;43(11):1713–7.
Article
Google Scholar
Hennessy BT, Timms KM, Carey MS, Gutin A, Meyer LA, Flake DD, 2nd, et al. Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer. J Clin Oncol Off J Am Soc Clin Oncol 2010;28(22):3570–3576.
Quach N, Goodman MF, Shibata D. Vitro mutation artifacts after formalin fixation and error prone translesion synthesis during PCR. BMC Clin Pathol. 2004;4(1):1.
Article
PubMed
PubMed Central
Google Scholar
Hofreiter M, Jaenicke V, Serre D, von Haeseler A, Paabo SDNA. Sequences from multiple amplifications reveal artifacts induced by cytosine deamination in ancient DNA. Nucleic Acids Res. 2001;29(23):4793–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen G, Mosier S, Gocke CD, Lin MT, Eshleman JR. Cytosine deamination is a major cause of baseline noise in next-generation sequencing. Mol Diagn Ther. 2014;18(5):587–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ng PC, Henikoff SSIFT. Predicting amino acid changes that affect protein function. Nucleic Acids Res. 2003;31(13):3812–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, et al. A method and server for predicting damaging missense mutations. Nat Methods. 2010;7(4):248–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Loman NJ, Misra RV, Dallman TJ, Constantinidou C, Gharbia SE, Wain J, et al. Performance comparison of benchtop high-throughput sequencing platforms. Nat Biotechnol. 2012;30(5):434–9.
Article
CAS
PubMed
Google Scholar
Boyd J, Sonoda Y, Federici MG, Bogomolniy F, Rhei E, Maresco DL, et al. Clinicopathologic features of BRCA-linked and sporadic ovarian cancer. JAMA. 2000;283(17):2260–5.
Article
CAS
PubMed
Google Scholar
Wilailak S, Linasmita VA. Study of pegylated liposomal doxorubicin in platinum-refractory epithelial ovarian cancer. Oncology. 2004;67(3–4):183–6.
Article
CAS
PubMed
Google Scholar
Sugiyama T, Kamura T, Kigawa J, Terakawa N, Kikuchi Y, Kita T, et al. Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy. Cancer. 2000;88(11):2584–9.
Article
CAS
PubMed
Google Scholar
Schmeler KM, Sun CC, Bodurka DC, Deavers MT, Malpica A, Coleman RL, et al. Neoadjuvant chemotherapy for low-grade serous carcinoma of the ovary or peritoneum. Gynecol Oncol. 2008;108(3):510–4.
Article
CAS
PubMed
Google Scholar
Hess V, A'Hern R, Nasiri N, King DM, Blake PR, Barton DP, et al. Mucinous epithelial ovarian cancer: a separate entity requiring specific treatment. J Clin Oncol Off J Am Soc Clin Oncol. 2004;22(6):1040–4.
Article
CAS
Google Scholar
Douglas JA, Levin AM, Zuhlke KA, Ray AM, Johnson GR, Lange EM, et al. Common variation in the BRCA1 gene and prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 2007;16(7):1510–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Merdad A, Gari MA, Hussein S, Al-Khayat S, Tashkandi H, Al-Maghrabi J, et al. Characterization of familial breast cancer in Saudi Arabia. BMC genomics. 2015;16 Suppl 1:S3.
Clarke B, Tinker AV, Lee CH, Subramanian S, van de Rijn M, Turbin D, et al. Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss. Mod Pathol. 2009;22(3):393–402.
Article
CAS
PubMed
Google Scholar
Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med. 2003;348(3):203–13.
Article
CAS
PubMed
Google Scholar
Sato E, Olson SH, Ahn J, Bundy B, Nishikawa H, Qian F, et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A. 2005;102(51):18538–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mantia-Smaldone G, Ronner L, Blair A, Gamerman V, Morse C, Orsulic S, et al. The immunomodulatory effects of pegylated liposomal doxorubicin are amplified in BRCA1--deficient ovarian tumors and can be exploited to improve treatment response in a mouse model. Gynecol Oncol. 2014;133(3):584–90.
Article
CAS
PubMed
Google Scholar