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  1. In the last decade many studies showed that the exhaled breath of subjects suffering from several pathological conditions has a peculiar volatile organic compound (VOC) profile. The objective of the present wo...

    Authors: Andrea Princivalle, Lorenzo Monasta, Giovanni Butturini, Claudio Bassi and Luigi Perbellini
    Citation: BMC Cancer 2018 18:529
    Content type: Research article Published on:

  2. Several studies have reported the role of CYP2A6 genetic polymorphisms in smoking and lung cancer risk with some contradictory results in different populations. The purpose of the current study is to assess th...

    Authors: Nada Ezzeldin, Dalia El-Lebedy, Amira Darwish, Ahmed El Bastawisy, Shereen Hamdy Abd Elaziz, Mirhane Mohamed Hassan and Amal Saad-Hussein
    Citation: BMC Cancer 2018 18:525
    Content type: Research article Published on:

  3. The phosphatase chronophin (CIN/PDXP) has been shown to be an important regulator of glioma cell migration and invasion. It has two known substrates: p-Ser3-cofilin, the phosphorylated form of the actin bindin...

    Authors: Markus Schulze, Maria Hutterer, Anja Sabo, Sabine Hoja, Julia Lorenz, Tanja Rothhammer-Hampl, Christel Herold-Mende, Lucia Floßbach, Camelia Monoranu and Markus J. Riemenschneider
    Citation: BMC Cancer 2018 18:524
    Content type: Research article Published on:

  6. Standardized treatment in pediatric patients with Hodgkin’s lymphoma (HL) follows risk stratification by tumor stage, erythrocyte sedimentation rate and tumor bulk. We aimed to identify quantitative parameters...

    Authors: Julian M. M. Rogasch, Patrick Hundsdoerfer, Frank Hofheinz, Florian Wedel, Imke Schatka, Holger Amthauer and Christian Furth
    Citation: BMC Cancer 2018 18:521
    Content type: Research article Published on:

  7. Melanoma is a rare, deadly disease without effective treatment options in China. Vemurafenib is a selective inhibitor of oncogenic BRAFV600 kinase approved in more than 90 countries, based on results obtained pri...

    Authors: Lu Si, Xiaoshi Zhang, Zhen Xu, Qiudi Jiang, Lilian Bu, Xuan Wang, Lili Mao, Weijiang Zhang, Nicole Richie and Jun Guo
    Citation: BMC Cancer 2018 18:520
    Content type: Research article Published on:

  10. Colorectal cancer (CRC) is a leading cause of cancer-related death. The biologic response of CRC to standard of care adjuvant therapies such as chemotherapy and radiation are poorly understood. MicroRNAs (miRs...

    Authors: Rebecca Ruhl, Shushan Rana, Katherine Kelley, Cristina Espinosa-Diez, Clayton Hudson, Christian Lanciault, Charles R. Thomas Jr, V. Liana Tsikitis and Sudarshan Anand
    Citation: BMC Cancer 2018 18:517
    Content type: Research article Published on:

  11. 6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients. However, 6-MP also has dose-limiting toxicities, particular...

    Authors: Hong Zhou, Lei Li, Peng Yang, Lin Yang, Jin E. Zheng, Ying Zhou and Yong Han
    Citation: BMC Cancer 2018 18:516
    Content type: Research article Published on:

  12. Gastric cancer is common in developing regions, and we hope to find out an economical but practical prognostic indicator. It was reported that pre-treatment peripheral neutrophil-to-lymphocyte ratio (NLR) and ...

    Authors: Zhenhua Huang, Yantan Liu, Chen Yang, Xiaoyin Li, Changqie Pan, Jinjun Rao, Nailin Li, Wangjun Liao and Li Lin
    Citation: BMC Cancer 2018 18:515
    Content type: Research article Published on:

  14. Short telomeres have been associated with increased risk of many cancers, particularly cancers of the gastrointestinal tract including esophagus and stomach. However, the association between telomere length (T...

    Authors: Sheetal Hardikar, Andrea N. Burnett-Hartman, Amanda I. Phipps, Melissa P. Upton, Lee-Ching Zhu and Polly A. Newcomb
    Citation: BMC Cancer 2018 18:513
    Content type: Research article Published on:

  16. Hepatocellular carcinoma (HCC) often arises in the setting of chronic inflammation with multiple inhibitory immune signals. V-domain Ig suppressor of T cell activation (VISTA) is identified as a novel negative...

    Authors: Ming Zhang, Hua-Jin Pang, Wei Zhao, Yu-Fa Li, Li-Xu Yan, Zhong-Yi Dong and Xiao-Feng He
    Citation: BMC Cancer 2018 18:511
    Content type: Research article Published on:

  17. Nausea/vomiting (N/V) not related to anti-cancer treatment is common in patients with advanced cancer. The standard approach to management is to define a dominant cause, and treat with an antiemetic selected t...

    Authors: Janet Hardy, Helen Skerman, Paul Glare, Jennifer Philip, Peter Hudson, Geoffrey Mitchell, Peter Martin, Odette Spruyt, David Currow and Patsy Yates
    Citation: BMC Cancer 2018 18:510
    Content type: Research article Published on:

  18. The fecal immunochemical test (FIT) is easier to use and more sensitive than the guaiac fecal occult blood test, but it is unclear how to optimize FIT performance. We compared the sensitivity and specificity f...

    Authors: Elizabeth G. Liles, Nancy Perrin, Ana G. Rosales, David H. Smith, Adrianne C. Feldstein, David M. Mosen and Theodore R. Levin
    Citation: BMC Cancer 2018 18:509
    Content type: Research article Published on:

  19. Gastric cancer is the eighth most common cancer in Taiwan, with a 40% 5-year survival rate. Approximately 40% of patients are refractory to chemotherapy. Currently, the anti-HER2 therapy is the only clinically...

    Authors: Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Chih-Wei Yen, Huang-Wei Xu, Yi-Fang Deng, Ying-Jhen Lin, Wan-Ting Hsu, Cheng-Shyong Wu and Chin Li
    Citation: BMC Cancer 2018 18:508
    Content type: Research article Published on:

  20. Tamoxifen is a frontline therapy for estrogen receptor (ER)-positive breast cancer in premenopausal women. However, many patients develop resistance to tamoxifen, and the mechanism underlying tamoxifen resista...

    Authors: Wei Li, Ling Xu, Xiaofang Che, Haizhou Li, Ye Zhang, Na Song, Ti Wen, Kezuo Hou, Yi Yang, Lu Zhou, Xing Xin, Lu Xu, Xue Zeng, Sha Shi, Yunpeng Liu, Xiujuan Qu…
    Citation: BMC Cancer 2018 18:507
    Content type: Research article Published on:

  21. Dickkopf-1 (DKK1) is a Wnt/ß-catenin pathway antagonist related to gastric cancer (GC) carcinogenesis. However, the prognostic role of combined DKK1 and ß-catenin expression in advanced GC (AGC) is not clear.

    Authors: Soon Auck Hong, Su Hyun Yoo, Han Hong Lee, Der Sheng Sun, Hye Sung Won, Okran Kim and Yoon Ho Ko
    Citation: BMC Cancer 2018 18:506
    Content type: Research article Published on:

  22. Glomus tumor is a rare benign neoplasm, which most frequently occurs in the subungual regions of digits. Tumor rupture and infection occurred in one patient with a glomus tumor have never been reported.

    Authors: Hui Lu, Li Feng Chen and Qiang Chen
    Citation: BMC Cancer 2018 18:505
    Content type: Case report Published on:

  23. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present also on cancer-derived exosomes. We hypothesized t...

    Authors: Mark Barok, Maija Puhka, Gyorgy Vereb, Janos Szollosi, Jorma Isola and Heikki Joensuu
    Citation: BMC Cancer 2018 18:504
    Content type: Research article Published on:

  24. Ewing’s sarcoma is a primary malignant tumor of bone occurring mostly in childhood. Few effective reconstruction techniques are available after wide resection of Ewing’s sarcoma at the distal end of the tibia....

    Authors: Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Yoshinobu Oka and Toshikazu Kubo
    Citation: BMC Cancer 2018 18:503
    Content type: Case report Published on:

  25. Laterally spreading tumours (LSTs) are superficial neoplasms that usually extend laterally along the intra-luminal wall of the gastrointestinal tract. Recently, the incidence of LSTs in the colorectal mucosa h...

    Authors: Samiullah Khan, Lan-ping Zhu, Yujie Zhang, Xin Chen and Bang-mao Wang
    Citation: BMC Cancer 2018 18:502
    Content type: Case report Published on:

  26. A computer-assisted diagnostic system for analyzing bone scans (BONENAVI) calculates the automated bone scan index (aBSI). Here we evaluated the aBSI as a prognostic imaging biomarker for men with metastatic c...

    Authors: Koichi Uemura, Yasuhide Miyoshi, Takashi Kawahara, Jikuya Ryosuke, Daisuke Yamashita, Shuko Yoneyama, Yumiko Yokomizo, Kazuki Kobayashi, Takeshi Kishida, Masahiro Yao and Hiroji Uemura
    Citation: BMC Cancer 2018 18:501
    Content type: Research article Published on:

  28. PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in cell proliferation and tumorigenesis. However, the precise mechanism of action of PCNP in the process of tumor growth has not yet...

    Authors: Dong-Dong Wu, Ying-Ran Gao, Tao Li, Da-Yong Wang, Dan Lu, Shi-Yu Liu, Ya Hong, Hui-Bin Ning, Jun-Ping Liu, Jia Shang, Jun-Feng Shi, Jian-She Wei and Xin-Ying Ji
    Citation: BMC Cancer 2018 18:499
    Content type: Research article Published on:

  29. NKX2.5 is a transcription factor transiently expressed during thyroid organogenesis. Recently, several works have pointed out the oncogenic role of NKX2.5 in a variety of tumors. We therefore hypothesized that...

    Authors: Ricardo Cortez Cardoso Penha, Luisa Aguirre Buexm, Fabiana Resende Rodrigues, Taciana Padilha de Castro, Maria Carolina S. Santos, Rodrigo Soares Fortunato, Denise P. Carvalho, Luciene C. Cardoso-Weide and Andrea C. F. Ferreira
    Citation: BMC Cancer 2018 18:498
    Content type: Research article Published on:

  30. Following the recommendation of lung cancer screening in the US, screening committees in several European countries are reviewing the evidence for implementing national programmes. However, inadequate particip...

    Authors: Samantha L. Quaife, Charlotte Vrinten, Mamta Ruparel, Samuel M. Janes, Rebecca J. Beeken, Jo Waller and Andy McEwen
    Citation: BMC Cancer 2018 18:497
    Content type: Research article Published on:

  31. The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highes...

    Authors: Beate Hegge, Eva Sjøttem and Ingvild Mikkola
    Citation: BMC Cancer 2018 18:496
    Content type: Research article Published on:

  32. The E-selectin ligands expressed by cancer cells mediate adhesion of circulating cancer cells to endothelial cells, as well as within tissue microenvironments important for tumor progression and metastasis. Th...

    Authors: Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein and Paula A. Videira
    Citation: BMC Cancer 2018 18:495
    Content type: Technical advance Published on:

  33. Somatic amplifications of the LYL1 gene are relatively common occurrences in patients who develop uterine corpus endometrial carcinoma (UCEC) as opposed to other cancers. This study was undertaken to determine wh...

    Authors: Se Ik Kim, Ji Won Lee, Nara Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song and Jeong-Sun Seo
    Citation: BMC Cancer 2018 18:494
    Content type: Research article Published on:

  34. There is growing evidence that the transcription factor nuclear factor E2-related factor 2 (Nrf2) is the major participant in regulating antioxidants and pathways for detoxifying reactive oxygen species (ROS),...

    Authors: Akinori Nukui, Takahiro Narimatsu, Tsunehito Kambara, Hideyuki Abe, Setsu Sakamoto, Ken-Ichiro Yoshida and Takao Kamai
    Citation: BMC Cancer 2018 18:493
    Content type: Research article Published on:

  35. Stage is a key predictor of cancer survival. Complete cancer staging is vital for understanding outcomes at population level and monitoring the efficacy of early diagnosis initiatives. Cancer registries usuall...

    Authors: Chiara Di Girolamo, Sarah Walters, Sara Benitez Majano, Bernard Rachet, Michel P. Coleman, Edmund Njeru Njagi and Melanie Morris
    Citation: BMC Cancer 2018 18:492
    Content type: Research article Published on:

  37. Melanoma brain metastasis is associated with an extremely poor prognosis, with a median overall survival of 4–5 months. Since 2011, the overall survival of patients with stage IV melanoma has been significantl...

    Authors: Elham Vosoughi, Jee Min Lee, James R. Miller, Mehdi Nosrati, David R. Minor, Roy Abendroth, John W. Lee, Brian T. Andrews, Lewis Z. Leng, Max Wu, Stanley P. Leong, Mohammed Kashani-Sabet and Kevin B. Kim
    Citation: BMC Cancer 2018 18:490
    Content type: Research article Published on:

  38. Transarterial chemoembolisation is the standard of care for intermediate stage (BCLC B) hepatocellular carcinoma, but it is challenging to decide when to repeat or stop treatment. Here we performed the first e...

    Authors: Aline Mähringer-Kunz, Arndt Weinmann, Irene Schmidtmann, Sandra Koch, Sebastian Schotten, Daniel Pinto dos Santos, Michael Bernhard Pitton, Christoph Dueber, Peter Robert Galle and Roman Kloeckner
    Citation: BMC Cancer 2018 18:489
    Content type: Research article Published on:

  39. In the United States, race and socioeconomic status are well known predictors of adverse outcomes in several different cancers. Existing evidence suggests that race and socioeconomic status may impact survival...

    Authors: Alexander L. Lazarides, Julia D. Visgauss, Daniel P. Nussbaum, Cindy L. Green, Dan G. Blazer III, Brian E. Brigman and William C. Eward
    Citation: BMC Cancer 2018 18:488
    Content type: Research article Published on:

  40. Human Papillomavirus (HPV) infection is the main risk factor for the development and progression of cervical cancer. HPV-16 E6 and E7 expression is essential for induction and maintenance of the transformed ph...

    Authors: Tatiana Rabachini, Enrique Boccardo, Rubiana Andrade, Katia Regina Perez, Suely Nonogaki, Iolanda Midea Cuccovia and Luisa Lina Villa
    Citation: BMC Cancer 2018 18:485
    Content type: Research article Published on:

  41. Microsatellite instability (MSI) is a major predictive and diagnostic marker in several cancers including colorectal carcinomas. Diagnostic testing for microsatellites is generally performed using capillary se...

    Authors: Isabel Förster, Michael Brockmann, Oliver Schildgen and Verena Schildgen
    Citation: BMC Cancer 2018 18:484
    Content type: Research article Published on:

  42. Extra-capsular growth (ECG) describes the extension of neoplastic cells beyond the lymph node capsule. Aim of this study was to investigate the prognostic value of ECG and its association with a stem cell like...

    Authors: Helena Link, Martin Angele, Miriam Schüller, Petra Ganschow, Lena Machetanz, Markus Guba, Jens Werner, Thomas Kirchner and Jens Neumann
    Citation: BMC Cancer 2018 18:483
    Content type: Research article Published on:

  43. A gradual decline in the incidence of breast cancer is documented in developed countries especially over last two decades, while in developing countries the incidence continues to rise. We conducted this study...

    Authors: Ashan Fernando, Umesh Jayarajah, Saumyakala Prabashani, Eshani A. Fernando and Sanjeewa A. Seneviratne
    Citation: BMC Cancer 2018 18:482
    Content type: Research article Published on:

  44. Surveillance, Epidemiology, and End Results (SEER) public research database does not include chemotherapy data due to concerns for incomplete ascertainment. To compensate for perceived lack of data quality man...

    Authors: Mark A. Healy, Arden M. Morris, Paul Abrahamse, Kevin C. Ward, Ikuko Kato and Christine M. Veenstra
    Citation: BMC Cancer 2018 18:481
    Content type: Research article Published on:

  45. Gene therapy is a potent method to increase the therapeutic efficacy against cancer. However, a gene that is specifically expressed in the tumor area has not been identified. In addition, nonspecific expressio...

    Authors: Shu-Yi Ho, Bo-Hau Chang, Chen-Han Chung, Yu-Ling Lin, Cheng-Hsun Chuang, Pei-Jung Hsieh, Wei-Chih Huang, Nu-Man Tsai, Sheng-Chieh Huang, Yen-Ku Liu, Yu-Chih Lo and Kuang-Wen Liao
    Citation: BMC Cancer 2018 18:480
    Content type: Research article Published on:

  46. Cetuximab, an anti-EGFR monoclonal antibody, is used in combination with chemotherapy in clinic to enhance the outcome in metastatic colorectal cancer (mCRC) patients with only ~ 20% response rate. To date onl...

    Authors: Zhu Mei, Yang W. Shao, Peinan Lin, Xiaomin Cai, Biao Wang, Yan Ding, Xiangyuan Ma, Xue Wu, Yewei Xia, Dongqin Zhu, Yongqian Shu, Zan Fu and Yanhong Gu
    Citation: BMC Cancer 2018 18:479
    Content type: Research article Published on:

  48. This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer.

    Authors: Stephan P. Bauersfeld, Christian S. Kessler, Manfred Wischnewsky, Annette Jaensch, Nico Steckhan, Rainer Stange, Barbara Kunz, Barbara Brückner, Jalid Sehouli and Andreas Michalsen
    Citation: BMC Cancer 2018 18:476
    Content type: Research article Published on:

  49. The calcium-binding protein calretinin (gene name: CALB2) is currently considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma (MM). MM is a very aggressive tumor strongly...

    Authors: Walter Blum, László Pecze, Janine Wörthmüller Rodriguez, Martine Steinauer and Beat Schwaller
    Citation: BMC Cancer 2018 18:475
    Content type: Research article Published on:

  50. Calcification in primary gastric cancer is very rare. In this report, we describe the computerized tomography (CT) changes in calcification in a patient with locally advanced signet-ring gastric cancer treated...

    Authors: Ting Wang, Zhi-Yong Lu, Xin-Fei Tu, Shui-Hong Zhang, Fang Huang and Long Huang
    Citation: BMC Cancer 2018 18:474
    Content type: Case report Published on:

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