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  1. The incidence of breast cancer has increased since the 1970s. Despite favorable trends in prognosis, the role of changes in clinical practice and the introduction of screening remain controversial. We examined...

    Authors: José Antonio Baeyens-Fernández, Elena Molina-Portillo, Marina Pollán, Miguel Rodríguez-Barranco, Rosario Del Moral, Lorenzo Arribas-Mir, Emilio Sánchez-Cantalejo Ramírez and María-José Sánchez
    Citation: BMC Cancer 2018 18:781
    Content type: Research article Published on:

  2. The first-generation epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have both been proven effective for treating advanced non–small cell lung cancer (NSCLC), especially in ...

    Authors: Wenxiong Zhang, Yiping Wei, Dongliang Yu, Jianjun Xu and Jinhua Peng
    Citation: BMC Cancer 2018 18:780
    Content type: Research article Published on:

  3. In digital mammography, finding accurate breast profile segmentation of women’s mammogram is considered a challenging task. The existence of the pectoral muscle may mislead the diagnosis of cancer due to its h...

    Authors: Bushra Mughal, Nazeer Muhammad, Muhammad Sharif, Amjad Rehman and Tanzila Saba
    Citation: BMC Cancer 2018 18:778
    Content type: Research article Published on:

  4. The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adeno...

    Authors: Jan-Paul Gundlach, Charlotte Hauser, Franka Maria Schlegel, Christine Böger, Christian Röder, Christoph Röcken, Thomas Becker, Jan-Hendrik Egberts, Holger Kalthoff and Anna Trauzold
    Citation: BMC Cancer 2018 18:777
    Content type: Research article Published on:

  5. 18F-FDG PET-CT is commonly used to monitor treatment response in patients with metastatic colorectal cancer (mCRC). With improvement in systemic therapy, complete metabolic response (CMR) is increasingly encou...

    Authors: Keith W. H. Chiu, Ka-On Lam, H. An, Gavin T. C. Cheung, Johnny K. S. Lau, Tim-Shing Choy and Victor H. F. Lee
    Citation: BMC Cancer 2018 18:776
    Content type: Research article Published on:

  6. The primary aim of this trial was to determine the recommended phase II dose (RP2D) of weekly paclitaxel (wP) administered in combination with oral metronomic cyclophosphamide (OMC).

    Authors: Diane Pannier, Antoine Adenis, Emilie Bogart, Eric Dansin, Stéphanie Clisant-Delaine, Emilie Decoupigny, Anne Lesoin, Eric Amela, Sandrine Ducornet, Jean-Pierre Meurant, Marie-Cécile Le Deley and Nicolas Penel
    Citation: BMC Cancer 2018 18:775
    Content type: Research article Published on:

  7. In hepatocellular carcinoma (HCC), the third leading cause of cancer-related mortality worldwide, the Child-Turcotte-Pugh score (CTP) is one of the most established tools to assess hepatic reserve and determin...

    Authors: Yvonne Huber, Franziska Bierling, Christian Labenz, Sandra Koch, Irene Schmidtmann, Roman Kloeckner, Sebastian Schotten, Tobias Huber, Hauke Lang, Marcus A. Woerns, Peter R. Galle, Arndt Weinmann and Julia Weinmann-Menke
    Citation: BMC Cancer 2018 18:774
    Content type: Research article Published on:

  8. High-grade gliomas (HGGs) exhibit marked heterogeneity in clinical behavior. The purpose of this study was to identify a novel biomarker that predicts patient outcome, which is helpful in HGG patient management.

    Authors: Di Du, Jian Yuan, Wencai Ma, Jing Ning, John N. Weinstein, Xianrui Yuan, Greg N. Fuller and Yuexin Liu
    Citation: BMC Cancer 2018 18:773
    Content type: Research article Published on:

  9. Label-retaining cancer cells (LRCC) have been proposed as a model of slowly cycling cancer stem cells (CSC) which mediate resistance to chemotherapy, tumor recurrence, and metastasis. The molecular mechanisms ...

    Authors: Dandan Li, John E. Mullinax, Taylor Aiken, Hongwu Xin, Gordon Wiegand, Andrew Anderson, Snorri Thorgeirsson, Itzhak Avital and Udo Rudloff
    Citation: BMC Cancer 2018 18:772
    Content type: Research article Published on:

  10. We present the study rationale and design of the JGOG3023 study, an open-label, parallel-arm, randomized, phase II trial that aimed to assess the efficacy and safety of chemotherapy with or without bevacizumab...

    Authors: Tadahiro Shoji, Shinichi Komiyama, Junzo Kigawa, Hiroshi Tanabe, Kazuyoshi Kato, Hiroaki Itamochi, Hiroyuki Fujiwara, Shoji Kamiura, Tetsutaro Hamano and Toru Sugiyama
    Citation: BMC Cancer 2018 18:771
    Content type: Study protocol Published on:

  11. There has been interest in the potential benefit of vitamin D (VD) to improve breast cancer outcomes. Pre-clinical studies suggest VD enhances chemotherapy-induced cell death. Vitamin D deficiency was associat...

    Authors: Marie Viala, Akiko Chiba, Simon Thezenas, Laure Delmond, Pierre-Jean Lamy, Sarah L. Mott, Mary C. Schroeder, Alexandra Thomas and William Jacot
    Citation: BMC Cancer 2018 18:770
    Content type: Research article Published on:

  12. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with high metastatic potential. Clinical observations suggest that there is disease heterogeneity among patients with different sit...

    Authors: Ibrahim H. Sahin, Harold Elias, Joanne F. Chou, Marinela Capanu and Eileen M. O’Reilly
    Citation: BMC Cancer 2018 18:769
    Content type: Research article Published on:

  13. Although lung adenocarcinoma with activating epidermal growth factor receptor (EGFR) mutations is common in never smokers, one-third of the patients are ever-smokers. We aimed to investigate the effect of cumu...

    Authors: In Ae Kim, Jong Sik Lee, Hee Joung Kim, Wan Seop Kim and Kye Young Lee
    Citation: BMC Cancer 2018 18:768
    Content type: Research article Published on:

  14. Ovarian cancer is one of the most lethal cancers and women with type 2 diabetes (T2D) have even poorer survival from it. We assessed the prognosis of ovarian cancer in women with type 2 diabetes treated with m...

    Authors: Elina Urpilainen, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Pirjo Ilanne-Parikka, Reetta Arima, Jenni Kangaskokko, Ulla Puistola, Marianne Hinkula and Esa Läärä
    Citation: BMC Cancer 2018 18:767
    Content type: Research article Published on:

  15. Programmed death ligand 1/2 (PD-L1/PD-L2) expression has been established as a prognostic factor for various solid tumors and as a predictive factor for PD-1 blockade therapy, but scant data on its role in gal...

    Authors: Jianzhen Lin, Junyu Long, Xueshuai Wan, Jingci Chen, Yi Bai, Anqiang Wang, Xiaobo Yang, Yan Wu, Simon C. Robson, Xinting Sang and Haitao Zhao
    Citation: BMC Cancer 2018 18:766
    Content type: Research article Published on:

  16. Subsyndromal delirium, a condition in which patients exhibit some, but not all, of the symptoms of delirium, can negatively affect the outcomes of patients with cancer. However, the incidence of subsyndromal d...

    Authors: Heesung Hwang, Kwang-Min Lee, Kyung-Lak Son, Dooyoung Jung, Won-Hyoung Kim, Joo-Young Lee, Seong-Ho Kong, Yun-Suhk Suh, Hyuk-Joon Lee, Han-Kwang Yang and Bong-Jin Hahm
    Citation: BMC Cancer 2018 18:765
    Content type: Research article Published on:

  17. Small intestinal neuroendocrine tumors (SI-NETs) originate from enterochromaffin cells scattered in the intestinal mucosa of the ileum and jejunum. Loss of one copy of chromosome 18 is the most frequent observ...

    Authors: Elham Barazeghi, Surendra Prabhawa, Olov Norlén, Per Hellman, Peter Stålberg and Gunnar Westin
    Citation: BMC Cancer 2018 18:764
    Content type: Research article Published on:

  18. Bladder cancer often recurs due to incomplete elimination of the cancer stem cells (CSCs). Therefore, new strategies targeting bladder CSCs are needed and the aim of this study was to investigate the effect of...

    Authors: Yongtong Zhu, Yao Zhou, Xuan Zhou, Yangchun Guo, Daxiong Huang, Jialin Zhang, Chunyan Wang and Longmei Cai
    Citation: BMC Cancer 2018 18:763
    Content type: Research article Published on:

  19. At time of diagnosis, less than 10% of patients with pancreatic adenocarcinomas (PDAC) are considered to be immediately operable (i.e. resectable). Considering their poor overall survival (OS), only tumours wi...

    Authors: Lilian Schwarz, Dewi Vernerey, Jean-Baptiste Bachet, Jean-Jacques Tuech, Fabienne Portales, Pierre Michel and Antonio Sa Cunha
    Citation: BMC Cancer 2018 18:762
    Content type: Study protocol Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:168

  20. Controversy exists for the use of Ki67 protein expression as a predictive marker to select patients who do or do not derive benefit from adjuvant endocrine therapy. Whether other proliferation markers, like Cy...

    Authors: Karin Beelen, Mark Opdam, Tesa Severson, Rutger Koornstra, Andrew Vincent, Jelle Wesseling, Joyce Sanders, Jan Vermorken, Paul van Diest and Sabine Linn
    Citation: BMC Cancer 2018 18:761
    Content type: Research article Published on:

  21. Maximum (MIP) and average intensity projection (AIP) CTs allow rapid definition of internal target volumes in a 4D-CT. The purpose of this study was to assess the accuracy of these techniques in a large patien...

    Authors: Kai Joachim Borm, Markus Oechsner, Moritz Wiegandt, Andreas Hofmeister, Stephanie E. Combs and Marciana Nona Duma
    Citation: BMC Cancer 2018 18:760
    Content type: Research article Published on:

  22. The Zc3h8 gene encodes a protein with three zinc finger motifs in the C-terminal region. The protein has been identified as a component of the Little Elongation Complex, involved in transcription of small nuclear...

    Authors: John A. Schmidt, Keith G. Danielson, Emily R. Duffner, Sara G. Radecki, Gerard T. Walker, Amber Shelton, Tianjiao Wang and Janice E. Knepper
    Citation: BMC Cancer 2018 18:759
    Content type: Research article Published on:

  23. With the development of sequencing technologies, there may be some disputes on sequencing analysis. The aim of this study was to investigate different allele frequency thresholds of mutations in targeted genes...

    Authors: Jie Ma, Yong Fu, Yao-yao Tu, Ying Liu, Yi-ran Tan, Wu-tong Ju, Curtis R. Pickering, Jeffrey N. Myers, Zhi-yuan Zhang and Lai-ping Zhong
    Citation: BMC Cancer 2018 18:758
    Content type: Research article Published on:

  24. Cancer-related fatigue (CRF) is a common and distressing symptom of cancer and/or cancer treatment that persists for years after treatment completion in approximately one third of cancer survivors. Exercise is...

    Authors: Rosie Twomey, Tristan Martin, John Temesi, S. Nicole Culos-Reed and Guillaume Y. Millet
    Citation: BMC Cancer 2018 18:757
    Content type: Study protocol Published on:

  25. The impact of sarcopenia on the prognosis of patients with hepatocellular carcinoma (HCC) who receive transcatheter intra-arterial therapies, including transcatheter arterial chemoembolization and transcathete...

    Authors: Takamasa Kobayashi, Hirokazu Kawai, Oki Nakano, Satoshi Abe, Hiroteru Kamimura, Akira Sakamaki, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Satoshi Yamagiwa and Shuji Terai
    Citation: BMC Cancer 2018 18:756
    Content type: Research article Published on:

  26. This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL).

    Authors: Zhenglei Shen, Xuezhong Gu, Wenwen Mao, Liefen Yin, Ling Yang, Zhe Zhang, Kunmei Liu, Lilan Wang and Yunchao Huang
    Citation: BMC Cancer 2018 18:755
    Content type: Research article Published on:

  27. Lung cancer is the leading cause of cancer mortality worldwide. Early diagnosis and treatment is a key factor in reducing mortality and improving patient outcomes. To achieve this, it is important to understan...

    Authors: Danielle Mazza, Xiaoping Lin, Fiona M. Walter, Jane M. Young, David J. Barnes, Paul Mitchell, Bianca Brijnath, Andrew Martin and Jon D. Emery
    Citation: BMC Cancer 2018 18:754
    Content type: Study protocol Published on:

  28. Disulfiram (DS), an antialcoholism medicine, demonstrated strong anticancer activity in the laboratory but did not show promising results in clinical trials. The anticancer activity of DS is copper dependent. ...

    Authors: Kate Butcher, Vinodh Kannappan, Rajagopal Sharada Kilari, Mark R. Morris, Christopher McConville, Angel L. Armesilla and Weiguang Wang
    Citation: BMC Cancer 2018 18:753
    Content type: Research article Published on:

  29. Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In ...

    Authors: M. B. Mogensen, M. Rossing, O. Østrup, P. N. Larsen, P. J. Heiberg Engel, L. N. Jørgensen, E. V. Hogdall, J. Eriksen, P. Ibsen, P. Jess, M. Grauslund, H. J. Nielsen, F. C. Nielsen, B. Vainer and K. Osterlind
    Citation: BMC Cancer 2018 18:752
    Content type: Research article Published on:

  30. This prospective multicentre-study aimed to analyze return to work (RTW) among prostate cancer survivors 12 months after having attended a cancer rehabilitation program and to identify risk factors for no and ...

    Authors: Anneke Ullrich, Hilke Maria Rath, Ullrich Otto, Christa Kerschgens, Martin Raida, Christa Hagen-Aukamp and Corinna Bergelt
    Citation: BMC Cancer 2018 18:751
    Content type: Research article Published on:

  31. We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological features, yet favorable clinical outcome. We identifi...

    Authors: Minji Lee, Farnoosh Tayyari, Dushanthi Pinnaduwage, Jane Bayani, John M. S. Bartlett, Anna Marie Mulligan, Shelley B. Bull and Irene L. Andrulis
    Citation: BMC Cancer 2018 18:750
    Content type: Research article Published on:

  32. After publication of the original article [1], the authors found that Fig. 3 contained an incorrect version of Fig. 3c. This does not affect the Figure legend, results and conclusions of the article.

    Authors: Jessica A. Gibbons, Jagat R. Kanwar and Rupinder K. Kanwar
    Citation: BMC Cancer 2018 18:749
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2015 15:425

  33. Approximately one third of the colorectal cancer survivors (CRCS) experience high levels of psychological distress. Common concerns experienced by CRCS include distress related to physical problems, anxiety, f...

    Authors: L. Leermakers, S. Döking, B. Thewes, A. M. J. Braamse, M. F. M. Gielissen, J. H. W. de Wilt, E. H. Collette, J. Dekker and J. B. Prins
    Citation: BMC Cancer 2018 18:748
    Content type: Study protocol Published on:

  34. In the group of elderly patients (≥70 years) with metastatic pancreatic ductal adenocarcinoma (mPDAC), it is not known who benefits from intensive 1st line nab-paclitaxel/gemcitabine (nab-p/gem) combination ch...

    Authors: Johannes Betge, Jing Chi-Kern, Nadine Schulte, Sebastian Belle, Tobias Gutting, Elke Burgermeister, Ralf Jesenofsky, Martin Maenz, Ulrich Wedding, Matthias P. Ebert and Nicolai Haertel
    Citation: BMC Cancer 2018 18:747
    Content type: Study protocol Published on:

  35. Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to in...

    Authors: Ke Jiang, Cuiping Song, Lingkai Kong, Lulu Hu, Guibin Lin, Tian Ye, Gang Yao, Yupeng Wang, Haibo Chen, Wei Cheng, Martin P. Barr, Quentin Liu, Guirong Zhang, Chan Ding and Songshu Meng
    Citation: BMC Cancer 2018 18:746
    Content type: Research article Published on:

  36. Cervical cancer is the most common cancer among women in Kenya. However, only 3% of women are routinely screened. This study aimed to assess women’s knowledge and attitudes towards cervical cancer and cervical...

    Authors: Murithi Gatumo, Susan Gacheri, Abdul-Rauf Sayed and Andrew Scheibe
    Citation: BMC Cancer 2018 18:745
    Content type: Research article Published on:

  37. Despite the significant, empirically supported benefits of physical activity, the majority of breast cancer survivors do not meet recommended guidelines for physical activity. A variety of effective strategies...

    Authors: Chad D. Rethorst, Heidi A. Hamann, Thomas J. Carmody, Kendall J. Sharp, Keith E. Argenbright, Barbara B. Haley, Celette Sugg Skinner and Madhukar H. Trivedi
    Citation: BMC Cancer 2018 18:744
    Content type: Study protocol Published on:

  39. Aberrant AKT activation is prevalent across human cancer lineages, providing an important therapeutic target. AKT comprises three isoforms that mediate critical non-redundant, even opposing functions in cancer...

    Authors: Jue Wang, Wei Zhao, Huifang Guo, Yong Fang, Sarah Elizabeth Stockman, Shanshan Bai, Patrick Kwok-Shing Ng, Yang Li, Qinghua Yu, Yiling Lu, Kang Jin Jeong, Xiaohua Chen, Meng Gao, Jiyong Liang, Wentao Li, Xingsong Tian…
    Citation: BMC Cancer 2018 18:742
    Content type: Research article Published on:

  40. The receptor CXCR4 and its ligand CXCL12 play crucial roles in breast cancer. Despite the fact that the spontaneous feline mammary carcinoma (FMC) is considered a suitable model for breast cancer studies, the ...

    Authors: Cláudia S. Marques, Ana Rita Santos, Andreia Gameiro, Jorge Correia and Fernando Ferreira
    Citation: BMC Cancer 2018 18:741
    Content type: Research article Published on:

  41. Previous studies have reported radiotherapy interruption (RTI) is associated with poor local control in two-dimensional radiotherapy (2DRT) era. However, it remains unclear whether RTI still affects local cont...

    Authors: Ji-Jin Yao, Ya-Nan Jin, Si-Yang Wang, Fan Zhang, Guan-Qun Zhou, Wang-Jian Zhang, Zhi-Bin, Cheng, Jun Ma, Zhen-Yu Qi and Ying Sun
    Citation: BMC Cancer 2018 18:740
    Content type: Research article Published on:

  42. The development of both chronic obstructive pulmonary disease (COPD) and lung cancer (LC) is influenced by smoking related chronic pulmonary inflammation caused by an excessive innate immune response to smoke ...

    Authors: Janna Berg, Ann Rita Halvorsen, May-Bente Bengtson, Kristin A. Taskén, Gunhild M. Mælandsmo, Arne Yndestad, Bente Halvorsen, Odd Terje Brustugun, Pål Aukrust, Thor Ueland and Åslaug Helland
    Citation: BMC Cancer 2018 18:739
    Content type: Research article Published on:

  43. HER2 positive (HER2+) breast cancers involve chromosomal structural alterations that act as oncogenic driver events.

    Authors: George Vasmatzis, Xue Wang, James B. Smadbeck, Stephen J. Murphy, Katherine B. Geiersbach, Sarah H. Johnson, Athanasios G. Gaitatzes, Yan W. Asmann, Farhad Kosari, Mitesh J. Borad, Daniel J. Serie, Sarah A. McLaughlin, Jennifer M. Kachergus, Brian M. Necela and E. Aubrey Thompson
    Citation: BMC Cancer 2018 18:738
    Content type: Research article Published on:

  44. The incidence of recurrent laryngeal nerve (RLN) injury has increased due to RLN lymph node dissection. The aim of this study was to evaluate the ability of intraoperative ultrasonography (IU) to detect RLN no...

    Authors: Jianwei Wang, Min Liu, Jingxian Shen, Haichao Ouyang, Xiuying Xie, Ting Lin, Anhua Li and Hong Yang
    Citation: BMC Cancer 2018 18:737
    Content type: Research article Published on:

  45. MLKL is the most important executor of necroptosis pathway. Recent studies have demonstrated that MLKL could serve as a potential prognostic biomarker for cancer patients. However, most studies reported so far...

    Authors: Binwu Hu, Deyao Shi, Xiao Lv, Songfeng Chen, Qin Huang, Mao Xie and Zengwu Shao
    Citation: BMC Cancer 2018 18:736
    Content type: Research article Published on:

  46. Bone and soft tissue masses of the foot and ankle are not particularly rare but true neoplasia has to be strictly differentiated from pseudotumorous lesions. Diagnosis is often delayed as diagnostic errors are...

    Authors: Andreas Toepfer, Norbert Harrasser, Maximiliane Recker, Ulrich Lenze, Florian Pohlig, Ludger Gerdesmeyer and Rüdiger von Eisenhart-Rothe
    Citation: BMC Cancer 2018 18:735
    Content type: Research article Published on:

  48. Quality of cancer care (QoCC) has become an important item for providers, regulators and purchasers of care worldwide. Aim of this study is to present the results of some evidence-based quality indicators (QI)...

    Authors: Laura Ortelli, Alessandra Spitale, Luca Mazzucchelli and Andrea Bordoni
    Citation: BMC Cancer 2018 18:733
    Content type: Research article Published on:

  49. Adjuvant endocrine therapy (AET) significantly decreases the risk of breast cancer recurrence and mortality. Notwithstanding the demonstrated efficacy of AET, 31–73% of breast cancer survivors do not persist w...

    Authors: Leah K. Lambert, Lynda G. Balneaves, A. Fuchsia Howard, Stephen K. Chia and Carolyn C. Gotay
    Citation: BMC Cancer 2018 18:732
    Content type: Research article Published on:

  50. Targeted therapy has always been the focus in developing therapeutic approaches in cancer, especially in the treatment of acute myeloid leukemia (AML). A new small molecular inhibitor, JQ1, targeting BRD4, whi...

    Authors: Yafeng Zhou, Jianbiao Zhou, Xiao Lu, Tuan-Zea Tan and Wee-Joo Chng
    Citation: BMC Cancer 2018 18:731
    Content type: Research article Published on:

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