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  1. Combining cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors with endocrine therapy is an effective strategy to improve progression-free survival in hormone receptor-positive (HR+), human epidermal growth fa...

    Authors: A. van Ommen-Nijhof, I. R. Konings, C. J. J. van Zeijl, C. A. Uyl-de Groot, V. van der Noort, A. Jager and G. S. Sonke
    Citation: BMC Cancer 2018 18:1146
    Content type: Study protocol Published on:

  2. The clinical factors that accurately predict the response to preoperative treatment in rectal cancer were yet unknown. The carcinoembryonic antigen (CEA) clearance pattern during neoadjuvant treatment has been...

    Authors: Huabin Hu, Jin Huang, Ping Lan, Lei Wang, Meijin Huang, Jianping Wang and Yanhong Deng
    Citation: BMC Cancer 2018 18:1145
    Content type: Research article Published on:

  3. A minority of European countries have participated in international comparisons with high level data on lung cancer. However, the nature and extent of data collection across the continent is simply unknown, an...

    Authors: Anna Rich, David Baldwin, Inmaculada Alfageme, Paul Beckett, Thierry Berghmans, Stephen Brincat, Otto Burghuber, Alexandru Corlateanu, Tanja Cufer, Ronald Damhuis, Edvardas Danila, Joanna Domagala-Kulawik, Stefano Elia, Mina Gaga, Tuncay Goksel, Bogdan Grigoriu…
    Citation: BMC Cancer 2018 18:1144
    Content type: Research article Published on:

  4. This study aimed to explore hyper-O-linked N-acetylglucosaminylation (O-GlcNAcylation) with an elevation of the expression of O-linked-β-N-acetylglucosamine transferase (OGT) in human bladder cancer.

    Authors: Longsheng Wang, Shaojun Chen, Ziwei Zhang, Junfeng Zhang, Shiyu Mao, Jiayi Zheng, Yang Xuan, Mengnan Liu, Keke Cai, Wentao Zhang, Yadong Guo, Wei Zhai and Xudong Yao
    Citation: BMC Cancer 2018 18:1141
    Content type: Research article Published on:

  5. African American adults experience a disproportionate burden and increased mortality for most solid tumor cancers and their adolescent children are negatively impacted by the illness experience. The purpose of...

    Authors: Nicole S. McKinney, Shannon Virtue, Frances Marcus Lewis, Alliric I. Willis, Tanisha Pettyjohn, La-Rhonda Harmon and Adam Davey
    Citation: BMC Cancer 2018 18:1140
    Content type: Study protocol Published on:

  6. The lymphocyte-to-monocyte ratio (LMR) has been used as a parameter reflecting systemic inflammation in several tumors, and is reportedly associated with prognosis in cancer patients. In this study, we evaluat...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2018 18:1137
    Content type: Research article Published on:

  7. On-target resistance mechanisms found in one-third of patients receiving anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are secondary ALK mutations in ALK-rearranged non-small cell lung cancer...

    Authors: Ryohei Yoshida, Takaaki Sasaki, Yasuhiro Umekage, Sachie Tanno, Yusuke Ono, Munehiko Ogata, Shinichi Chiba, Yusuke Mizukami and Yoshinobu Ohsaki
    Citation: BMC Cancer 2018 18:1136
    Content type: Research article Published on:

  8. Oesophageal carcinoma (OC) is one of the leading cancers in Sri Lanka. Its increasing incidence despite the implementation of various preventive activities addressing the conventional risk factors indicates th...

    Authors: Ishanka Ayeshwari Talagala, Metthananda Nawarathne and Carukshi Arambepola
    Citation: BMC Cancer 2018 18:1135
    Content type: Research article Published on:

  9. Nuclear protein in testis (NUT) carcinoma (NC) is a rare epithelial malignancy characterized by rearrangement of the NUT gene on chromosome 15. If NC is not suspected, it is often diagnosed as other malignancies....

    Authors: Kohei Arimizu, Gen Hirano, Chinatsu Makiyama, Mioko Matsuo, Takakazu Sasaguri and Akitaka Makiyama
    Citation: BMC Cancer 2018 18:1134
    Content type: Case report Published on:

  10. Circulating tumor cells (CTCs) have been considered great clinical significance in various cancers. However, it remains unknown that how is the role of CTCs in patients with nasopharyngeal carcinoma (NPC). We ...

    Authors: Jing Zhang, Huashan Shi, Tingting Jiang, Zhe Liu, Peter P. Lin and Nianyong Chen
    Citation: BMC Cancer 2018 18:1133
    Content type: Research article Published on:

  11. Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such...

    Authors: Nikolas von Bubnoff, Gabriele Ihorst, Olga Grishina, Nadine Röthling, Hartmut Bertz, Justus Duyster, Jürgen Finke and Robert Zeiser
    Citation: BMC Cancer 2018 18:1132
    Content type: Study protocol Published on:

  12. Hepatocellular carcinoma (HCC) is a common cancer worldwide, with a poor prognosis. Most patients are diagnosed at advanced stages and are only eligible for palliative therapy. Therefore, this study aimed to e...

    Authors: Shiguang Chen, Wenchang Yu, Kongzhi Zhang and Weifu Liu
    Citation: BMC Cancer 2018 18:1131
    Content type: Research article Published on:

  13. The French West-Indies rank first for both prostate cancer incidence and mortality rates. Analyzing diagnostic and therapeutic procedures among patients with prostate cancer, using data from a population-based...

    Authors: Clarisse Joachim, Jacqueline Veronique-Baudin, Stephen Ulric-Gervaise, Jonathan Macni, Thierry Almont, Olivier Pierre-Louis, Lidvine Godaert, Moustapha Drame, Jean-Luc Novella, Karim Farid, Vincent Vinh-Hung and Patrick Escarmant
    Citation: BMC Cancer 2018 18:1130
    Content type: Research article Published on:

  14. Interactions between the protein synthesis inhibitor homoharringtonine (HHT) and the proteasome inhibitor bortezomib were investigated in DLBCL and mantle cell lymphoma cells (MCL).

    Authors: Tri Nguyen, Rebecca Parker, Yu Zhang, Elisa Hawkins, Maciej Kmieciak, William Craun and Steven Grant
    Citation: BMC Cancer 2018 18:1129
    Content type: Research article Published on:

  15. The large-conductance, voltage-gated, calcium (Ca (2+))-activated potassium channel (BKCa) plays an important role in regulating Ca (2+) signaling and cell physiological function, and is aberrantly expressed i...

    Authors: Fenfen Wang, Qin Chen, Genping Huang, Xuedong Guo, Na Li, Yang Li and Baohua Li
    Citation: BMC Cancer 2018 18:1128
    Content type: Research article Published on:

  16. The ZOHé study was a prospective, non-interventional, multicentre study in France to assess the use of biosimilar filgrastim Zarzio® (Sandoz filgrastim) in routine clinical practice in patients at risk of neut...

    Authors: Henri Roché, Jean-Christophe Eymard, Abderraouf Radji, Alain Prevost, Rafik Diab, Michele Lamuraglia, Ravaka-Fatoma Soumoudronga, Isabelle Gasnereau and Alain Toledano
    Citation: BMC Cancer 2018 18:1127
    Content type: Research article Published on:

  17. Outpatient autologous stem cell transplantations (ASCTs) in multiple myeloma and lymphoma patients have been shown to reduce the overall costs and improve the quality of life relative to inpatient ASCTs. This ...

    Authors: Weerapat Owattanapanich, Kittima Suphadirekkul, Chutima Kunacheewa, Patompong Ungprasert and Kannadit Prayongratana
    Citation: BMC Cancer 2018 18:1126
    Content type: Research article Published on:

  18. Liver fibrosis is involved in hepatocellular carcinoma (HCC), but its effect on the survival of patients with HCC remains controversial. This study aims to explore whether the severity of liver fibrosis has an...

    Authors: Hui Liu, Dong Cen, Yunxian Yu, Yanting Wang, Xiao Liang, Hui Lin and Xiujun Cai
    Citation: BMC Cancer 2018 18:1125
    Content type: Research article Published on:

  19. Trifluridine/tipiracil (TAS-102, Lonsurf®), a novel oral anti-tumor agent combining an anti-neoplastic thymidine-based nucleoside analogue (trifluridine, FTD) with a thymidine phosphorylase inhibitor (tipiraci...

    Authors: Stefan Kasper, Jens Kisro, Martin Fuchs, Christian Müller, Armin Schulz-Abelius, Meinolf Karthaus, Mohammad-Reza Rafiyan and Alexander Stein
    Citation: BMC Cancer 2018 18:1124
    Content type: Research article Published on:

  20. Karyopherin β1 (Kpnβ1) is the main nuclear import protein involved in the transport of cargoes from the cytoplasm into the cell nucleus. Previous research has found Kpnβ1 to be significantly overexpressed in c...

    Authors: Sarah Carden, Pauline van der Watt, Alicia Chi, Aderonke Ajayi-Smith, Katie Hadley and Virna D. Leaner
    Citation: BMC Cancer 2018 18:1123
    Content type: Research article Published on:

  21. Neuroendocrine tumours are uncommon tumours; there is often a long period between the onset of symptoms and diagnosis. This study aims to address the symptoms prior to diagnosis of people with known neuroendoc...

    Authors: Ron Basuroy, Catherine Bouvier, John Keith Ramage, Maia Sissons and Raj Srirajaskanthan
    Citation: BMC Cancer 2018 18:1122
    Content type: Research article Published on:

  23. To compare dual energy CT iodine imaging and standardized iodine concentration before and after chemoradiotherapy (CRT) for esophageal cancer and evaluate the efficacy of CRT for EC by examining DECT iodine ma...

    Authors: Xiaomin Ge, Jingping Yu, Zhongling Wang, Yiqun Xu, Changjie Pan, Lu Jiang, Yanling Yang, Kai Yuan and Wei Liu
    Citation: BMC Cancer 2018 18:1120
    Content type: Research article Published on:

  24. Intracranial germinomas are one of the most radiosensitive tumors and are curable by radiotherapy (RT) alone. RT-only therapy without chemotherapy is effective. But, as patients with germinoma can expect long-...

    Authors: Kihwan Hwang, Kyu Sang Lee, Gheeyoung Choe, Byung-Gyu Cho and Chae-Yong Kim
    Citation: BMC Cancer 2018 18:1119
    Content type: Case report Published on:

  25. Gastric cancer is one of the most common malignant tumors worldwide. With the rapid aging of global population, the number of elderly patients with local advanced gastric cancer is increasing. Surgery is the e...

    Authors: Ziyu Li, Fei Shan, Xiangji Ying, Kan Xue and Jiafu Ji
    Citation: BMC Cancer 2018 18:1118
    Content type: Study protocol Published on:

  26. Extramedullary involvement of B-cell Acute Lymphoblastic Leukemia (EM-ALL) is a rare occurrence, characterized by dismal outcome and the absence of a defined and shared therapeutic approach. In the landscape o...

    Authors: Luca Bertamini, Jacopo Nanni, Giovanni Marconi, Mariachiara Abbenante, Valentina Robustelli, Francesco Bacci, Antonella Matti, Stefania Paolini, Chiara Sartor, Silvia Lo Monaco, Maria Chiara Fontana, Stefano De Polo, Michele Cavo, Antonio Curti, Giovanni Martinelli and Cristina Papayannidis
    Citation: BMC Cancer 2018 18:1117
    Content type: Case report Published on:

  27. With advances in gastric cancer chemotherapy, conversion surgery has drawn attention as a new strategy to improve the outcome of stage IV disease. We investigated the efficacy of conversion surgery following c...

    Authors: Seung-Hoon Beom, Yoon Young Choi, Song-Ee Baek, Shuang-Xi Li, Joon Seok Lim, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Seung Ho Choi, Minkyu Jung, Hyo Song Kim, Hei-Cheul Jeung, Hyun Cheol Chung, Sun Young Rha and Sung Hoon Noh
    Citation: BMC Cancer 2018 18:1116
    Content type: Research article Published on:

  28. Intravascular lymphoma is a rare type of non-Hodgkin lymphoma mostly of B-cell lineage. A few cases of intravascular lymphoma have been found to be of NK/T-cell origin, mainly affecting the skin and central ne...

    Authors: Magda Zanelli, Maria Cecilia Mengoli, Rachele Del Sordo, Angelo Cagini, Loredana De Marco, Edoardo Simonetti, Giovanni Martino, Maurizio Zizzo and Stefano Ascani
    Citation: BMC Cancer 2018 18:1115
    Content type: Case report Published on:

  29. To identify potential therapeutic target in clear cell renal cell carcinoma (ccRCC), we performed a transcriptome analysis. Our analysis showed that fatty acid binding protein 7 (FABP7) has the highest mean di...

    Authors: Kazuhiro Nagao, Nachi Shinohara, Frank Smit, Mirjam de Weijert, Sander Jannink, Yuji Owada, Peter Mulders, Egbert Oosterwijk and Hideyasu Matsuyama
    Citation: BMC Cancer 2018 18:1114
    Content type: Research article Published on:

  30. Cancer has a lot of consequences on patients’ quality of life (such as cancer-related fatigue (CRF), sleep difficulties and emotional distress) and on patients’ partners and their relationship, such as distres...

    Authors: Charlotte Grégoire, Marie-Elisabeth Faymonville, Audrey Vanhaudenhuyse, Vanessa Charland-Verville, Guy Jerusalem and Isabelle Bragard
    Citation: BMC Cancer 2018 18:1113
    Content type: Study protocol Published on:

  31. Sacral chordoma is a locally aggressive malignant tumour originating from ectopic notochordal cells. The natural history of sacral chordoma is a slow growing tumour arising at the midline of the lower sacrum t...

    Authors: Zi Hao Phang, Xue Yi Saw, Noreen Fadzlina Binti Mat Nor, Zolqarnain Bin Ahmad and Sa’adon Bin Ibrahim
    Citation: BMC Cancer 2018 18:1112
    Content type: Case report Published on:

  32. Colorectal cancer has been found to be attenuated either with prophylactic manipulation of gut microbiome with probiotics or celecoxib, a non-steroidal anti-inflammatory drug mainly by suppressing early pro-ca...

    Authors: Leila Kaeid Sharaf, Mridul Sharma, Deepika Chandel and Geeta Shukla
    Citation: BMC Cancer 2018 18:1111
    Content type: Research article Published on:

  33. Earlier diagnosis is beneficial for the prognosis of hepatocellular carcinoma (HCC). Alpha fetoprotein (AFP) is the most widely used biomarker for HCC, but its sensitivity and specificity are only 60 and 90%, ...

    Authors: Chenghua Zhang, Ran Xia, Bo Zhang and Haibo Wang
    Citation: BMC Cancer 2018 18:1110
    Content type: Research article Published on:

  34. Various efforts to understand the relationship between biological information and disease have been done using many different types of highthroughput data such as genomics and metabolomics. However, informatio...

    Authors: Jaesik Jeong, Kwangok Seo and Eung-Sam Kim
    Citation: BMC Cancer 2018 18:1109
    Content type: Research article Published on:

  35. To compare the efficacy of low dose (27 mg) Bacillus Calmette-Guérin (BCG) and a full dose (81 mg) BCG immunotherapy for patients with intermediate and high-risk non-muscle invasive bladder cancer (NMIBC) afte...

    Authors: Zongren Wang, Han Xiao, Guangyan Wei, Ning Zhang, Mengchao Wei, Zebin Chen, Zhenwei Peng, Sui Peng, Shaopeng Qiu, Heping Li and Jianting Long
    Citation: BMC Cancer 2018 18:1108
    Content type: Research article Published on:

  36. RBM3 expression has been suggested as prognostic marker in several cancer types. The purpose of this study was to assess the prevalence and clinical significance of altered RBM3 expression in esophageal cancer.

    Authors: Katharina Grupp, Bianca Hofmann, Asad Kutup, Kai Bachmann, Dean Bogoevski, Nathaniel Melling, Faik Guntac Uzunoglu, Alexander Tarek El Gammal, Christina Koop, Ronald Simon, Stefan Steurer, Till Krech, Susanne Burdak-Rothkamm, Frank Jacobsen, Guido Sauter, Jakob Izbicki…
    Citation: BMC Cancer 2018 18:1106
    Content type: Research article Published on:

  37. Cholangiocarcinoma, or bile duct cancer, is a gastrointestinal cancer with limited therapeutic options and a poor outcome. Studies have revealed that some major driver genes are associated with cholangiocarcin...

    Authors: Haibo Mou, Lanfang Yu, Qin Liao, Xuehua Hou, Yinfang Wu, Qiang Cui, Na Yan, Ruobing Ma, Lingjian Wang, Ming Yao and Kai Wang
    Citation: BMC Cancer 2018 18:1105
    Content type: Case report Published on:

  38. Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various can...

    Authors: Seung Tae Kim, Sun Young Kim, Jeeyun Lee, Kyung Kim, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang and Joon Oh Park
    Citation: BMC Cancer 2018 18:1103
    Content type: Research article Published on:

  39. The modified Glasgow Prognostic Score (mGPS) and the neutrophil-to-lymphocyte ratio (NLR) are conventional inflammation-based scores for colorectal cancer (CRC). The systemic inflammation score (SIS) has been ...

    Authors: Fang Wang, Wenzhuo He, Chang Jiang, Guifang Guo, Bin Ke, Qiangsheng Dai, Jianting Long and Liangping Xia
    Citation: BMC Cancer 2018 18:1102
    Content type: Research article Published on:

  40. In acute lymphoblastic leukemia (ALL), the presence of minimal residual disease (MRD) after induction/consolidation chemotherapy is a strong prognostic factor for subsequent relapse and mortality. Accordingly,...

    Authors: Arnaud Pigneux, Pau Montesinos, Ze Cong, Xinke Zhang, Anja K. Pownell, Heather Wieffer, Jan McKendrick and Monika Brüggemann
    Citation: BMC Cancer 2018 18:1100
    Content type: Research article Published on:

  41. Chronic myeloid leukemia can be effectively treated with BCR-ABL1 tyrosine kinase inhibitors. However, BCR-ABL1 mutations can develop and cause secondary resistance to these inhibitors. For each of the availab...

    Authors: Radowan Elnair and Ahmed Galal
    Citation: BMC Cancer 2018 18:1097
    Content type: Case report Published on:

  42. In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression wa...

    Authors: Dingyuan Hu, Daniel Ansari, Qimin Zhou, Agata Sasor, Katarzyna Said Hilmersson, Monika Bauden, Yi Jiang and Roland Andersson
    Citation: BMC Cancer 2018 18:1096
    Content type: Research article Published on:

  43. Inter-patient heterogeneity in radiation-induced DNA damage responses is proposed to reflect intrinsic variations in tumour and normal tissue radiation sensitivity, but the prediction of phenotype by a molecul...

    Authors: Kevin Lee Min Chua, Eugenia Li Ling Yeo, Waseem Ahamed Shihabudeen, Sze Huey Tan, Than Than Shwe, Enya Hui Wen Ong, Paula Yeng Po Lam, Khee Chee Soo, Yoke Lim Soong, Kam Weng Fong, Terence Wee Kiat Tan, Joseph Tien Seng Wee and Melvin Lee Kiang Chua
    Citation: BMC Cancer 2018 18:1095
    Content type: Research article Published on:

  44. In patients with locally advanced rectal cancer treated by neoadjuvant chemoradiation, pathological complete response in the surgical specimen is associated with favourable long-term oncologic outcome. Based o...

    Authors: Claudio Belluco, Marco Forlin, Paolo Delrio, Daniela Rega, Maurizio Degiuli, Silvia Sofia, Matteo Olivieri, Salvatore Pucciarelli, Matteo Zuin, Giovanni De Manzoni, Alberto Di Leo, Stefano Scabini, Luigi Zorcolo and Angelo Restivo
    Citation: BMC Cancer 2018 18:1094
    Content type: Research article Published on:

  45. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcin...

    Authors: Yu Qiao, Meng Xu, Junyan Tao, Li Che, Antonio Cigliano, Satdarshan P Monga, Diego F Calvisi and Xin Chen
    Citation: BMC Cancer 2018 18:1093
    Content type: Research article Published on:

  46. Survival rates of lung cancer remains poor and the impact of comorbidities on the prognosis is discussed. The objective of this study was to assess if the Charlson Comorbidity Index (CCI) was associated with 8...

    Authors: A. Seigneurin, P. Delafosse, B. Trétarre, A. S. Woronoff, M. Velten, P. Grosclaude, A. V. Guizard, B. Lapôtre-Ledoux, S. Bara, F. Molinié and M. Colonna
    Citation: BMC Cancer 2018 18:1091
    Content type: Research article Published on:

  47. Experimental models of prostate cancer have demonstrated increased levels of protoporphyrin IX (PpIX) in the blood and faeces of mice. Hence, the quantification of these autofluorescent molecules could be hypo...

    Authors: Daniel Riani Gotardelo, Lilia Coronato Courrol, Maria Helena Bellini, Flávia Rodrigues de Oliveira Silva and Carlos Roberto Jorge Soares
    Citation: BMC Cancer 2018 18:1090
    Content type: Research article Published on:

  48. This study aims to establish a radiomics analysis system for the diagnosis and clinical behaviour prediction of hepatocellular carcinoma (HCC) based on multi-parametric ultrasound imaging.

    Authors: Zhao Yao, Yi Dong, Guoqing Wu, Qi Zhang, Daohui Yang, Jin-Hua Yu and Wen-Ping Wang
    Citation: BMC Cancer 2018 18:1089
    Content type: Research article Published on:

  49. Colorectal cancer (CRC) is the most common type of gastrointestinal cancer. CRC gene therapy mediated by adenovirus holds great promise for the treatment of malignancies. However, intravenous delivery of adeno...

    Authors: Fang-Rui Liu, Shuang Bai, Qiang Feng, Xin-Yan Pan, Shu-Ling Song, Hong Fang, Jing Cui and Ju-Lun Yang
    Citation: BMC Cancer 2018 18:1087
    Content type: Research article Published on:

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